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UniProtKB - A8MV65 (VGLL3_HUMAN)
Protein
Transcription cofactor vestigial-like protein 3
Gene
VGLL3
Organism
Homo sapiens (Human)
Status
Functioni
May act as a specific coactivator for the mammalian TEFs.
By similarityGO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | A8MV65 |
SignaLinki | A8MV65 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription cofactor vestigial-like protein 3Short name: Vgl-3 |
Gene namesi | Name:VGLL3Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24327, VGLL3 |
MIMi | 609980, gene |
neXtProti | NX_A8MV65 |
VEuPathDBi | HostDB:ENSG00000206538 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 389136 |
OpenTargetsi | ENSG00000206538 |
PharmGKBi | PA142670628 |
Miscellaneous databases
Pharosi | A8MV65, Tbio |
Genetic variation databases
BioMutai | VGLL3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000324661 | 1 – 326 | Transcription cofactor vestigial-like protein 3Add BLAST | 326 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 62 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 126 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
MassIVEi | A8MV65 |
MaxQBi | A8MV65 |
PaxDbi | A8MV65 |
PeptideAtlasi | A8MV65 |
PRIDEi | A8MV65 |
ProteomicsDBi | 2156 [A8MV65-1] 2157 [A8MV65-2] |
PTM databases
iPTMneti | A8MV65 |
PhosphoSitePlusi | A8MV65 |
Expressioni
Tissue specificityi
Enriched in placenta.1 Publication
Gene expression databases
Bgeei | ENSG00000206538, Expressed in placenta and 184 other tissues |
ExpressionAtlasi | A8MV65, baseline and differential |
Genevisiblei | A8MV65, HS |
Organism-specific databases
HPAi | ENSG00000206538, Tissue enhanced (placenta) |
Interactioni
Binary interactionsi
Isoform 2 [A8MV65-2]
Protein-protein interaction databases
BioGRIDi | 132991, 69 interactors |
IntActi | A8MV65, 63 interactors |
STRINGi | 9606.ENSP00000381436 |
Miscellaneous databases
RNActi | A8MV65, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 57 – 80 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 175 – 203 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 233 – 256 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 62 – 78 | Acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 233 – 249 | Basic residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the vestigial family.Sequence analysis
Phylogenomic databases
eggNOGi | ENOG502R6G3, Eukaryota |
GeneTreei | ENSGT00530000063353 |
HOGENOMi | CLU_056560_0_0_1 |
InParanoidi | A8MV65 |
OMAi | AKTSVWF |
OrthoDBi | 1146285at2759 |
PhylomeDBi | A8MV65 |
TreeFami | TF326340 |
Family and domain databases
InterProi | View protein in InterPro IPR006627, TDU_repeat IPR011520, Vg_fam |
PANTHERi | PTHR15950, PTHR15950, 1 hit |
Pfami | View protein in Pfam PF07545, Vg_Tdu, 1 hit |
SMARTi | View protein in SMART SM00711, TDU, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: A8MV65-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSCAEVMYHP QPYGASQYLP NPMAATTCPT AYYQPAPQPG QQKKLAVFSK
60 70 80 90 100
MQDSLEVTLP SKQEEEDEEE EEEEKDQPAE MEYLNSRCVL FTYFQGDIGS
110 120 130 140 150
VVDEHFSRAL GQAITLHPES AISKSKMGLT PLWRDSSALS SQRNSFPTSF
160 170 180 190 200
WTSSYQPPPA PCLGGVHPDF QVTGPPGTFS AADPSPWPGH NLHQTGPAPP
210 220 230 240 250
PAVSESWPYP LTSQVSPSYS HMHDVYMRHH HPHAHMHHRH RHHHHHHHPP
260 270 280 290 300
AGSALDPSYG PLLMPSVHAA RIPAPQCDIT KTEPTTVTSA TSAWAGAFHG
310 320
TVDIVPSVGF DTGLQHQDKS KESPWY
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C571 | H7C571_HUMAN | Transcription cofactor vestigial-li... | VGLL3 | 208 | Annotation score: | ||
A0A1B0GTF5 | A0A1B0GTF5_HUMAN | Transcription cofactor vestigial-li... | VGLL3 | 28 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_052713 | 314 – 326 | LQHQD…ESPWY → WSAMARS in isoform 2. 1 PublicationAdd BLAST | 13 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC108709 Genomic DNA No translation available. CH471110 Genomic DNA Translation: EAW68870.1 CH471110 Genomic DNA Translation: EAW68871.1 BC094780 mRNA Translation: AAH94780.1 |
CCDSi | CCDS43110.1 [A8MV65-1] CCDS82807.1 [A8MV65-2] |
RefSeqi | NP_001307422.1, NM_001320493.1 [A8MV65-2] NP_057290.2, NM_016206.3 [A8MV65-1] |
Genome annotation databases
Ensembli | ENST00000383698; ENSP00000373199; ENSG00000206538 [A8MV65-2] ENST00000398399; ENSP00000381436; ENSG00000206538 |
GeneIDi | 389136 |
KEGGi | hsa:389136 |
MANE-Selecti | ENST00000398399.7; ENSP00000381436.2; NM_016206.4; NP_057290.2 |
UCSCi | uc003dqn.4, human [A8MV65-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC108709 Genomic DNA No translation available. CH471110 Genomic DNA Translation: EAW68870.1 CH471110 Genomic DNA Translation: EAW68871.1 BC094780 mRNA Translation: AAH94780.1 |
CCDSi | CCDS43110.1 [A8MV65-1] CCDS82807.1 [A8MV65-2] |
RefSeqi | NP_001307422.1, NM_001320493.1 [A8MV65-2] NP_057290.2, NM_016206.3 [A8MV65-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 132991, 69 interactors |
IntActi | A8MV65, 63 interactors |
STRINGi | 9606.ENSP00000381436 |
PTM databases
iPTMneti | A8MV65 |
PhosphoSitePlusi | A8MV65 |
Genetic variation databases
BioMutai | VGLL3 |
Proteomic databases
MassIVEi | A8MV65 |
MaxQBi | A8MV65 |
PaxDbi | A8MV65 |
PeptideAtlasi | A8MV65 |
PRIDEi | A8MV65 |
ProteomicsDBi | 2156 [A8MV65-1] 2157 [A8MV65-2] |
Protocols and materials databases
Antibodypediai | 32031, 95 antibodies from 17 providers |
DNASUi | 389136 |
Genome annotation databases
Ensembli | ENST00000383698; ENSP00000373199; ENSG00000206538 [A8MV65-2] ENST00000398399; ENSP00000381436; ENSG00000206538 |
GeneIDi | 389136 |
KEGGi | hsa:389136 |
MANE-Selecti | ENST00000398399.7; ENSP00000381436.2; NM_016206.4; NP_057290.2 |
UCSCi | uc003dqn.4, human [A8MV65-1] |
Organism-specific databases
CTDi | 389136 |
DisGeNETi | 389136 |
GeneCardsi | VGLL3 |
HGNCi | HGNC:24327, VGLL3 |
HPAi | ENSG00000206538, Tissue enhanced (placenta) |
MIMi | 609980, gene |
neXtProti | NX_A8MV65 |
OpenTargetsi | ENSG00000206538 |
PharmGKBi | PA142670628 |
VEuPathDBi | HostDB:ENSG00000206538 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502R6G3, Eukaryota |
GeneTreei | ENSGT00530000063353 |
HOGENOMi | CLU_056560_0_0_1 |
InParanoidi | A8MV65 |
OMAi | AKTSVWF |
OrthoDBi | 1146285at2759 |
PhylomeDBi | A8MV65 |
TreeFami | TF326340 |
Enzyme and pathway databases
PathwayCommonsi | A8MV65 |
SignaLinki | A8MV65 |
Miscellaneous databases
BioGRID-ORCSi | 389136, 15 hits in 1040 CRISPR screens |
ChiTaRSi | VGLL3, human |
GenomeRNAii | 389136 |
Pharosi | A8MV65, Tbio |
PROi | PR:A8MV65 |
RNActi | A8MV65, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000206538, Expressed in placenta and 184 other tissues |
ExpressionAtlasi | A8MV65, baseline and differential |
Genevisiblei | A8MV65, HS |
Family and domain databases
InterProi | View protein in InterPro IPR006627, TDU_repeat IPR011520, Vg_fam |
PANTHERi | PTHR15950, PTHR15950, 1 hit |
Pfami | View protein in Pfam PF07545, Vg_Tdu, 1 hit |
SMARTi | View protein in SMART SM00711, TDU, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | VGLL3_HUMAN | |
Accessioni | A8MV65Primary (citable) accession number: A8MV65 Secondary accession number(s): D3DU37, Q504T7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | December 4, 2007 | |
Last modified: | February 23, 2022 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families