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Entry version 103 (07 Apr 2021)
Sequence version 1 (04 Dec 2007)
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Protein

Transcription cofactor vestigial-like protein 3

Gene

VGLL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a specific coactivator for the mammalian TEFs.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
A8MV65

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription cofactor vestigial-like protein 3
Short name:
Vgl-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VGLL3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24327, VGLL3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609980, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A8MV65

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000206538.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
389136

Open Targets

More...
OpenTargetsi
ENSG00000206538

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670628

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
A8MV65, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
VGLL3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003246611 – 326Transcription cofactor vestigial-like protein 3Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki62Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki126Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
A8MV65

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A8MV65

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A8MV65

PeptideAtlas

More...
PeptideAtlasi
A8MV65

PRoteomics IDEntifications database

More...
PRIDEi
A8MV65

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
2156 [A8MV65-1]
2157 [A8MV65-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A8MV65

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A8MV65

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Enriched in placenta.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000206538, Expressed in placenta and 183 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A8MV65, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A8MV65, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000206538, Tissue enriched (placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Isoform 2 [A8MV65-2]
With#Exp.IntAct
CDPF1 [Q6NVV7]3EBI-11957216,EBI-2802782
CERCAM [Q5T4B2]3EBI-11957216,EBI-12261896
CNFN [Q9BYD5]3EBI-11957216,EBI-12819063
CTRC [Q99895]3EBI-11957216,EBI-10295404
CYSRT1 [A8MQ03]3EBI-11957216,EBI-3867333
DTX2 [Q86UW9]3EBI-11957216,EBI-740376
ESM1 [Q9NQ30]3EBI-11957216,EBI-12260294
FAM168B - isoform 2 [A1KXE4-2]3EBI-11957216,EBI-12193763
FRS3 [O43559]3EBI-11957216,EBI-725515
hCG_1987119 [A0A024R8L2]3EBI-11957216,EBI-14103818
HGS [O14964]3EBI-11957216,EBI-740220
INCA1 [Q0VD86]3EBI-11957216,EBI-6509505
KPRP [Q5T749]3EBI-11957216,EBI-10981970
KRTAP1-1 [Q07627]3EBI-11957216,EBI-11959885
KRTAP10-7 [P60409]3EBI-11957216,EBI-10172290
KRTAP10-8 [P60410]3EBI-11957216,EBI-10171774
KRTAP10-9 [P60411]3EBI-11957216,EBI-10172052
KRTAP11-1 [Q8IUC1]3EBI-11957216,EBI-1052037
KRTAP12-1 [P59990]3EBI-11957216,EBI-10210845
KRTAP12-2 [P59991]3EBI-11957216,EBI-10176379
KRTAP12-3 [P60328]3EBI-11957216,EBI-11953334
KRTAP13-2 [Q52LG2]3EBI-11957216,EBI-11953846
KRTAP15-1 [Q3LI76]3EBI-11957216,EBI-11992140
KRTAP19-1 [Q8IUB9]3EBI-11957216,EBI-12811111
KRTAP19-2 [Q3LHN2]5EBI-11957216,EBI-12196745
KRTAP19-6 [Q3LI70]3EBI-11957216,EBI-12805508
KRTAP19-7 [Q3SYF9]3EBI-11957216,EBI-10241353
KRTAP3-1 [Q9BYR8]3EBI-11957216,EBI-9996449
KRTAP3-3 [Q9BYR6]3EBI-11957216,EBI-3957694
KRTAP4-11 [Q9BYQ6]3EBI-11957216,EBI-10302392
KRTAP4-2 [Q9BYR5]3EBI-11957216,EBI-10172511
KRTAP5-11 [Q6L8G4]3EBI-11957216,EBI-11993296
KRTAP5-6 [Q6L8G9]3EBI-11957216,EBI-10250562
KRTAP6-1 [Q3LI64]3EBI-11957216,EBI-12111050
KRTAP6-2 [Q3LI66]3EBI-11957216,EBI-11962084
KRTAP9-2 [Q9BYQ4]3EBI-11957216,EBI-1044640
KRTAP9-3 [Q9BYQ3]3EBI-11957216,EBI-1043191
KRTAP9-8 [Q9BYQ0]3EBI-11957216,EBI-11958364
LASP1 - isoform 2 [Q14847-2]3EBI-11957216,EBI-9088686
LENG8 [Q96PV6]3EBI-11957216,EBI-739546
MDFI [Q99750]3EBI-11957216,EBI-724076
OXER1 [Q8TDS5]3EBI-11957216,EBI-12813389
PCSK5 - isoform PC6A [Q92824-2]3EBI-11957216,EBI-11956269
PITX1 [P78337]3EBI-11957216,EBI-748265
PITX2 - isoform PTX2C [Q99697-2]3EBI-11957216,EBI-12138495
PLA2G10 [O15496]3EBI-11957216,EBI-726466
POGZ [Q7Z3K3]3EBI-11957216,EBI-1389308
POU2AF1 [Q16633]3EBI-11957216,EBI-943588
RBPMS - isoform C [Q93062-3]3EBI-11957216,EBI-740343
RUSC1 [Q9BVN2]3EBI-11957216,EBI-6257312
SMARCC1 [Q92922]3EBI-11957216,EBI-355653
SMOC1 - isoform 2 [Q9H4F8-2]3EBI-11957216,EBI-12162539
TBX15 [Q96SF7]3EBI-11957216,EBI-10191361
TEAD1 - isoform 2 [P28347-2]3EBI-11957216,EBI-12151837
TEAD2 - isoform 2 [Q15562-2]3EBI-11957216,EBI-9370956
TEAD3 [Q99594]3EBI-11957216,EBI-746720
TEAD4 [Q15561]3EBI-11957216,EBI-747736
TEX37 [Q96LM6]3EBI-11957216,EBI-743976
TRIM42 [Q8IWZ5]3EBI-11957216,EBI-5235829
TSC1 [Q86WV8]3EBI-11957216,EBI-12806590
TSPAN4 [O14817]3EBI-11957216,EBI-8652667
UFSP1 [Q6NVU6]3EBI-11957216,EBI-12068150

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
132991, 69 interactors

Protein interaction database and analysis system

More...
IntActi
A8MV65, 63 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000381436

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
A8MV65, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A8MV65

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi221 – 248His-richSequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the vestigial family.Sequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502R6G3, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063353

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_056560_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A8MV65

Identification of Orthologs from Complete Genome Data

More...
OMAi
HQTGPPP

Database of Orthologous Groups

More...
OrthoDBi
1146285at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A8MV65

TreeFam database of animal gene trees

More...
TreeFami
TF326340

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006627, TDU_repeat
IPR011520, Vg_fam

The PANTHER Classification System

More...
PANTHERi
PTHR15950, PTHR15950, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07545, Vg_Tdu, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00711, TDU, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A8MV65-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSCAEVMYHP QPYGASQYLP NPMAATTCPT AYYQPAPQPG QQKKLAVFSK
60 70 80 90 100
MQDSLEVTLP SKQEEEDEEE EEEEKDQPAE MEYLNSRCVL FTYFQGDIGS
110 120 130 140 150
VVDEHFSRAL GQAITLHPES AISKSKMGLT PLWRDSSALS SQRNSFPTSF
160 170 180 190 200
WTSSYQPPPA PCLGGVHPDF QVTGPPGTFS AADPSPWPGH NLHQTGPAPP
210 220 230 240 250
PAVSESWPYP LTSQVSPSYS HMHDVYMRHH HPHAHMHHRH RHHHHHHHPP
260 270 280 290 300
AGSALDPSYG PLLMPSVHAA RIPAPQCDIT KTEPTTVTSA TSAWAGAFHG
310 320
TVDIVPSVGF DTGLQHQDKS KESPWY
Length:326
Mass (Da):36,009
Last modified:December 4, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i08D015C2A4297FE8
GO
Isoform 21 Publication (identifier: A8MV65-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     314-326: LQHQDKSKESPWY → WSAMARS

Show »
Length:320
Mass (Da):35,171
Checksum:i2FFF6081DD363630
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C571H7C571_HUMAN
Transcription cofactor vestigial-li...
VGLL3
208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GTF5A0A1B0GTF5_HUMAN
Transcription cofactor vestigial-li...
VGLL3
28Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_052713314 – 326LQHQD…ESPWY → WSAMARS in isoform 2. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC108709 Genomic DNA No translation available.
CH471110 Genomic DNA Translation: EAW68870.1
CH471110 Genomic DNA Translation: EAW68871.1
BC094780 mRNA Translation: AAH94780.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43110.1 [A8MV65-1]
CCDS82807.1 [A8MV65-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001307422.1, NM_001320493.1 [A8MV65-2]
NP_057290.2, NM_016206.3 [A8MV65-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000383698; ENSP00000373199; ENSG00000206538 [A8MV65-2]
ENST00000398399; ENSP00000381436; ENSG00000206538 [A8MV65-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
389136

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:389136

UCSC genome browser

More...
UCSCi
uc003dqn.4, human [A8MV65-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108709 Genomic DNA No translation available.
CH471110 Genomic DNA Translation: EAW68870.1
CH471110 Genomic DNA Translation: EAW68871.1
BC094780 mRNA Translation: AAH94780.1
CCDSiCCDS43110.1 [A8MV65-1]
CCDS82807.1 [A8MV65-2]
RefSeqiNP_001307422.1, NM_001320493.1 [A8MV65-2]
NP_057290.2, NM_016206.3 [A8MV65-1]

3D structure databases

SMRiA8MV65
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi132991, 69 interactors
IntActiA8MV65, 63 interactors
STRINGi9606.ENSP00000381436

PTM databases

iPTMnetiA8MV65
PhosphoSitePlusiA8MV65

Genetic variation databases

BioMutaiVGLL3

Proteomic databases

MassIVEiA8MV65
MaxQBiA8MV65
PaxDbiA8MV65
PeptideAtlasiA8MV65
PRIDEiA8MV65
ProteomicsDBi2156 [A8MV65-1]
2157 [A8MV65-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
32031, 95 antibodies

Genome annotation databases

EnsembliENST00000383698; ENSP00000373199; ENSG00000206538 [A8MV65-2]
ENST00000398399; ENSP00000381436; ENSG00000206538 [A8MV65-1]
GeneIDi389136
KEGGihsa:389136
UCSCiuc003dqn.4, human [A8MV65-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
389136
DisGeNETi389136

GeneCards: human genes, protein and diseases

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GeneCardsi
VGLL3
HGNCiHGNC:24327, VGLL3
HPAiENSG00000206538, Tissue enriched (placenta)
MIMi609980, gene
neXtProtiNX_A8MV65
OpenTargetsiENSG00000206538
PharmGKBiPA142670628
VEuPathDBiHostDB:ENSG00000206538.7

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502R6G3, Eukaryota
GeneTreeiENSGT00530000063353
HOGENOMiCLU_056560_0_0_1
InParanoidiA8MV65
OMAiHQTGPPP
OrthoDBi1146285at2759
PhylomeDBiA8MV65
TreeFamiTF326340

Enzyme and pathway databases

PathwayCommonsiA8MV65

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
389136, 15 hits in 990 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
VGLL3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
389136
PharosiA8MV65, Tbio

Protein Ontology

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PROi
PR:A8MV65
RNActiA8MV65, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000206538, Expressed in placenta and 183 other tissues
ExpressionAtlasiA8MV65, baseline and differential
GenevisibleiA8MV65, HS

Family and domain databases

InterProiView protein in InterPro
IPR006627, TDU_repeat
IPR011520, Vg_fam
PANTHERiPTHR15950, PTHR15950, 1 hit
PfamiView protein in Pfam
PF07545, Vg_Tdu, 1 hit
SMARTiView protein in SMART
SM00711, TDU, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVGLL3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8MV65
Secondary accession number(s): D3DU37, Q504T7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 4, 2007
Last modified: April 7, 2021
This is version 103 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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