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Protein

Putative zinc finger protein 727

Gene

ZNF727

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

May be involved in transcriptional regulation.By similarity

Caution

Could be the product of a pseudogene.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri143 – 167C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri200 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri424 – 446C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Putative zinc finger protein 727
Alternative name(s):
Zinc finger protein 727 pseudogene
Gene namesi
Name:ZNF727
Synonyms:ZNF727P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000214652.5
HGNCiHGNC:22785 ZNF727
neXtProtiNX_A8MUV8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410231

Polymorphism and mutation databases

BioMutaiZNF727

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003461571 – 499Putative zinc finger protein 727Add BLAST499

Proteomic databases

PaxDbiA8MUV8
PRIDEiA8MUV8
ProteomicsDBi2136

PTM databases

iPTMnetiA8MUV8
PhosphoSitePlusiA8MUV8

Expressioni

Gene expression databases

BgeeiENSG00000214652 Expressed in 81 organ(s), highest expression level in corpus callosum

Organism-specific databases

HPAiHPA051027
HPA061215

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000447987

Structurei

3D structure databases

ProteinModelPortaliA8MUV8
SMRiA8MUV8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri143 – 167C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri200 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri424 – 446C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144042
InParanoidiA8MUV8
KOiK09228
OMAiRIHMEVR
OrthoDBiEOG091G02KC
PhylomeDBiA8MUV8
TreeFamiTF342117

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

Sequencei

Sequence statusi: Complete.

A8MUV8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRVLTFRDVA VEFSPEEWEC LDSAQQRLYR DVMLENYGNL FSLGLAIFKP
60 70 80 90 100
DLITYLEQRK EPWNARRQKT VAKHPAGSLH FTAEILLEHD INDSFQKVIL
110 120 130 140 150
RKSGSCDLNT LRLKKDYQRV GNCKGQKSSY NGIHQCLSAT RSKTCQYNKC
160 170 180 190 200
GKAFGLCSIF TEHKKIFSRE KCYKCEECGK DCRLSDFTIQ KRIHTADRSY
210 220 230 240 250
KCEECGKACK KFSNLTEHNR VHTGKKPYKC EECGKTFTCS SALTKHKRNH
260 270 280 290 300
TGDRPYKCEE CHKAFRCCSD LTKHKRIHTG EKPYKCKECH KAFRCCSDLT
310 320 330 340 350
KHKRIHTGEK PYKCNECGKA FMWISALSQH NRIHTGEKPY ICEECGKAFT
360 370 380 390 400
YSSTLISHKR IHMELRPYKC EECGKTFKWF SDLTNHKRIH TGEKPYKCEE
410 420 430 440 450
CGKSFTCSSN LIKHKRIHME VRPYKCEECG KTFKWFPDLT NHKRIHTGEK
460 470 480 490
PYKCEECGKT FTCSSSLIKH KRSHTGDRPT SAKNVAKPLG GSQTLLNIR
Length:499
Mass (Da):57,972
Last modified:September 22, 2009 - v3
Checksum:iDA3CC3D5F0BFD7A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115220 Genomic DNA No translation available.
CCDSiCCDS55113.1
RefSeqiNP_001152994.1, NM_001159522.1
UniGeneiHs.640774

Genome annotation databases

EnsembliENST00000456806; ENSP00000485448; ENSG00000214652
GeneIDi442319
KEGGihsa:442319
UCSCiuc011kdm.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115220 Genomic DNA No translation available.
CCDSiCCDS55113.1
RefSeqiNP_001152994.1, NM_001159522.1
UniGeneiHs.640774

3D structure databases

ProteinModelPortaliA8MUV8
SMRiA8MUV8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000447987

PTM databases

iPTMnetiA8MUV8
PhosphoSitePlusiA8MUV8

Polymorphism and mutation databases

BioMutaiZNF727

Proteomic databases

PaxDbiA8MUV8
PRIDEiA8MUV8
ProteomicsDBi2136

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000456806; ENSP00000485448; ENSG00000214652
GeneIDi442319
KEGGihsa:442319
UCSCiuc011kdm.2 human

Organism-specific databases

CTDi442319
EuPathDBiHostDB:ENSG00000214652.5
GeneCardsiZNF727
HGNCiHGNC:22785 ZNF727
HPAiHPA051027
HPA061215
neXtProtiNX_A8MUV8
PharmGKBiPA162410231
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144042
InParanoidiA8MUV8
KOiK09228
OMAiRIHMEVR
OrthoDBiEOG091G02KC
PhylomeDBiA8MUV8
TreeFamiTF342117

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

GenomeRNAii442319

Gene expression databases

BgeeiENSG00000214652 Expressed in 81 organ(s), highest expression level in corpus callosum

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN727_HUMAN
AccessioniPrimary (citable) accession number: A8MUV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 22, 2009
Last modified: October 10, 2018
This is version 93 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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