UniProtKB - A8MUP2 (CSKMT_HUMAN)
Protein
Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial
Gene
CSKMT
Organism
Homo sapiens (Human)
Status
Functioni
Protein-lysine methyltransferase that selectively trimethylates citrate synthase (CS) in mitochondria (PubMed:28391595, PubMed:28887308). Seems to conduct trimethylation in a highly distributive manner rather than in a processive manner, and thus introduces a single methly group per binding event (PubMed:28887308).2 Publications
Catalytic activityi
Activity regulationi
Citrate synthase-lysine methyltransferase activity is inhibited by S-adenosylhomocysteine (AdoHcy) and oxaloacetate (OAA) (PubMed:28887308).1 Publication
GO - Molecular functioni
- lysine N-methyltransferase activity Source: UniProtKB
- protein-lysine N-methyltransferase activity Source: UniProtKB
GO - Biological processi
- peptidyl-lysine dimethylation Source: UniProtKB
- peptidyl-lysine monomethylation Source: UniProtKB
- peptidyl-lysine trimethylation Source: UniProtKB
- protein methylation Source: UniProtKB
Keywordsi
Molecular function | Methyltransferase, Transferase |
Ligand | S-adenosyl-L-methionine |
Names & Taxonomyi
Protein namesi | Recommended name: Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial1 PublicationCurated (EC:2.1.1.-1 Publication)Short name: CS-KMT1 Publication Alternative name(s): Methyltransferase-like protein 12, mitochondrialImported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000214756.7 |
HGNCi | HGNC:33113 CSKMT |
MIMi | 617897 gene |
neXtProti | NX_A8MUP2 |
Subcellular locationi
Mitochondrion
- Mitochondrion 2 Publications
Mitochondrion
- mitochondrion Source: UniProtKB-SubCell
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 107 | D → A: Inhibits citrate synthase-lysine methyltransferase activity. 1 Publication | 1 |
Organism-specific databases
OpenTargetsi | ENSG00000214756 |
PharmGKBi | PA164722245 |
Polymorphism and mutation databases
BioMutai | METTL12 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 28 | Mitochondrion1 PublicationAdd BLAST | 28 | |
ChainiPRO_0000349199 | 29 – 240 | Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrialAdd BLAST | 212 |
Proteomic databases
MaxQBi | A8MUP2 |
PaxDbi | A8MUP2 |
PRIDEi | A8MUP2 |
ProteomicsDBi | 2121 |
Expressioni
Gene expression databases
Bgeei | ENSG00000214756 Expressed in 99 organ(s), highest expression level in right adrenal gland cortex |
Genevisiblei | A8MUP2 HS |
Organism-specific databases
HPAi | HPA038115 HPA038533 |
Structurei
3D structure databases
ProteinModelPortali | A8MUP2 |
SMRi | A8MUP2 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the methyltransferase superfamily.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | ENOG410IYTJ Eukaryota ENOG4111PAK LUCA |
GeneTreei | ENSGT00510000049875 |
HOGENOMi | HOG000113682 |
InParanoidi | A8MUP2 |
KOi | K00614 |
OMAi | TYFAYLV |
PhylomeDBi | A8MUP2 |
TreeFami | TF354334 |
Family and domain databases
InterProi | View protein in InterPro IPR025714 Methyltranfer_dom IPR029063 SAM-dependent_MTases |
Pfami | View protein in Pfam PF13847 Methyltransf_31, 1 hit |
SUPFAMi | SSF53335 SSF53335, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
A8MUP2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAALRRMLHL PSLMMGTCRP FAGSLADSCL ADRCLWDRLH AQPRLGTVPT
60 70 80 90 100
FDWFFGYDEV QGLLLPLLQE AQAASPLRVL DVGCGTSSLC TGLYTKSPHP
110 120 130 140 150
VDVLGVDFSP VAVAHMNSLL EGGPGQTPLC PGHPASSLHF MHADAQNLGA
160 170 180 190 200
VASSGSFQLL LDKGTWDAVA RGGLPRAYQL LSECLRVLNP QGTLIQFSDE
210 220 230 240
DPDVRLPCLE QGSYGWTVTV QELGPFRGIT YFAYLIQGSH
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_046283 | 125 | G → S. Corresponds to variant dbSNP:rs11231181Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK297138 mRNA Translation: BAH12507.1 AP001458 Genomic DNA No translation available. BC147001 mRNA Translation: AAI47002.1 BC147011 mRNA Translation: AAI47012.1 |
CCDSi | CCDS41657.1 |
RefSeqi | NP_001036694.1, NM_001043229.1 |
UniGenei | Hs.640726 |
Genome annotation databases
Ensembli | ENST00000532971; ENSP00000431287; ENSG00000214756 |
GeneIDi | 751071 |
KEGGi | hsa:751071 |
UCSCi | uc001nug.2 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK297138 mRNA Translation: BAH12507.1 AP001458 Genomic DNA No translation available. BC147001 mRNA Translation: AAI47002.1 BC147011 mRNA Translation: AAI47012.1 |
CCDSi | CCDS41657.1 |
RefSeqi | NP_001036694.1, NM_001043229.1 |
UniGenei | Hs.640726 |
3D structure databases
ProteinModelPortali | A8MUP2 |
SMRi | A8MUP2 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
IntActi | A8MUP2, 6 interactors |
Polymorphism and mutation databases
BioMutai | METTL12 |
Proteomic databases
MaxQBi | A8MUP2 |
PaxDbi | A8MUP2 |
PRIDEi | A8MUP2 |
ProteomicsDBi | 2121 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000532971; ENSP00000431287; ENSG00000214756 |
GeneIDi | 751071 |
KEGGi | hsa:751071 |
UCSCi | uc001nug.2 human |
Organism-specific databases
CTDi | 751071 |
EuPathDBi | HostDB:ENSG00000214756.7 |
GeneCardsi | CSKMT |
HGNCi | HGNC:33113 CSKMT |
HPAi | HPA038115 HPA038533 |
MIMi | 617897 gene |
neXtProti | NX_A8MUP2 |
OpenTargetsi | ENSG00000214756 |
PharmGKBi | PA164722245 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IYTJ Eukaryota ENOG4111PAK LUCA |
GeneTreei | ENSGT00510000049875 |
HOGENOMi | HOG000113682 |
InParanoidi | A8MUP2 |
KOi | K00614 |
OMAi | TYFAYLV |
PhylomeDBi | A8MUP2 |
TreeFami | TF354334 |
Miscellaneous databases
GenomeRNAii | 751071 |
PROi | PR:A8MUP2 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000214756 Expressed in 99 organ(s), highest expression level in right adrenal gland cortex |
Genevisiblei | A8MUP2 HS |
Family and domain databases
InterProi | View protein in InterPro IPR025714 Methyltranfer_dom IPR029063 SAM-dependent_MTases |
Pfami | View protein in Pfam PF13847 Methyltransf_31, 1 hit |
SUPFAMi | SSF53335 SSF53335, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | CSKMT_HUMAN | |
Accessioni | A8MUP2Primary (citable) accession number: A8MUP2 Secondary accession number(s): B7Z4C1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 2, 2008 |
Last sequence update: | December 4, 2007 | |
Last modified: | January 16, 2019 | |
This is version 83 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations