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Protein

Ubiquitin carboxyl-terminal hydrolase 17-like protein 5

Gene

USP17L5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.By similarity

Caution

The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of the USP17 gene. It is present with an interindividual variation in copy number, ranging from 20 to 103, and can be found in the genome both on chromosome 4 and chromosome 8. The high similarity between the UPS17-like genes makes impossible to clearly assign data to one of the genes of the family. Oligonucleotides designed in RNAi experiments are for instance not specific of a given UPS17-like gene.Curated

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89NucleophilePROSITE-ProRule annotation1
Active sitei334Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processApoptosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-5689880 Ub-specific processing proteases

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 17-like protein 5 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 17-like protein 5
Ubiquitin thioesterase 17-like protein 5
Ubiquitin-specific-processing protease 17-like protein 5
Gene namesi
Name:USP17L5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000227140.3
HGNCiHGNC:37177 USP17L5
neXtProtiNX_A8MUK1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165664776

Polymorphism and mutation databases

BioMutaiUSP17L5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003316471 – 530Ubiquitin carboxyl-terminal hydrolase 17-like protein 5Add BLAST530

Proteomic databases

PaxDbiA8MUK1
PRIDEiA8MUK1
ProteomicsDBi2110

PTM databases

iPTMnetiA8MUK1
PhosphoSitePlusiA8MUK1

Expressioni

Gene expression databases

BgeeiENSG00000227140 Expressed in 1 organ(s), highest expression level in blood

Organism-specific databases

HPAiHPA045642

Interactioni

Protein-protein interaction databases

BioGridi608813, 1 interactor
STRINGi9606.ENSP00000425955

Structurei

3D structure databases

ProteinModelPortaliA8MUK1
SMRiA8MUK1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini80 – 375USPAdd BLAST296

Sequence similaritiesi

Belongs to the peptidase C19 family. USP17 subfamily.Curated

Phylogenomic databases

eggNOGiKOG1865 Eukaryota
ENOG410XQ92 LUCA
GeneTreeiENSGT00890000139343
HOGENOMiHOG000144638
HOVERGENiHBG007129
InParanoidiA8MUK1
KOiK11845
OMAiCKLCAME
OrthoDBiEOG091G06D5
PhylomeDBiA8MUK1
TreeFamiTF315281

Family and domain databases

InterProiView protein in InterPro
IPR006861 HABP4_PAIRBP1-bd
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF04774 HABP4_PAI-RBP1, 1 hit
PF00443 UCH, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

Sequencei

Sequence statusi: Complete.

A8MUK1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDDSLYLRG EWQFNHFSKL TSSRPDAAFA EIQRTSLPEK SPLSCETRVD
60 70 80 90 100
LCDDLAPVAR QLAPREKLPL SSRRPAAVGA GLQNMGNTCY VNASLQCLTY
110 120 130 140 150
TPPLANYMLS REHSQTCHRH KGCMLCTMQA HITRALHNPG HVIQPSQALA
160 170 180 190 200
AGFHRGKQED AHEFLMFTVD AMKKACLPGH KQVDHHSKDT TLIHQIFGGY
210 220 230 240 250
WRSQIKCLHC HGISDTFDPY LDIALDIQAA QSVQQALEQL AKPEELNGEN
260 270 280 290 300
AYHCGVCLQR APASKTLTLH TSAKVLILVL KRFSDVTGNK IAKNVQYPEC
310 320 330 340 350
LDMQPYMSQP NTGPLVYVLY AVLVHAGWSC HNGHYFSYVK AQEGQWYKMD
360 370 380 390 400
DAEVTASSIT SVLSQQAYVL FYIQKSEWER HSESVSRGRE PRALGAEDTD
410 420 430 440 450
RRATQGELKR DHPCLQAPEL DEHLVERATQ ESTLDHWKFL QEQNKTKPEF
460 470 480 490 500
NVRKVEGTLP PDVLVIHQSK YKCGMKNHHP EQQSSLLNLS SSTPTHQESM
510 520 530
NTGTLASLRG RARRSKGKNK HSKRALLVCQ
Length:530
Mass (Da):59,683
Last modified:April 29, 2008 - v2
Checksum:i625A1B0A52EFE2FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC116655 Genomic DNA No translation available.
CCDSiCCDS59467.1
RefSeqiNP_001229258.1, NM_001242329.1
UniGeneiHs.740243

Genome annotation databases

EnsembliENST00000507227; ENSP00000425955; ENSG00000227140
GeneIDi728386
KEGGihsa:728386
UCSCiuc021xlo.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC116655 Genomic DNA No translation available.
CCDSiCCDS59467.1
RefSeqiNP_001229258.1, NM_001242329.1
UniGeneiHs.740243

3D structure databases

ProteinModelPortaliA8MUK1
SMRiA8MUK1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi608813, 1 interactor
STRINGi9606.ENSP00000425955

PTM databases

iPTMnetiA8MUK1
PhosphoSitePlusiA8MUK1

Polymorphism and mutation databases

BioMutaiUSP17L5

Proteomic databases

PaxDbiA8MUK1
PRIDEiA8MUK1
ProteomicsDBi2110

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000507227; ENSP00000425955; ENSG00000227140
GeneIDi728386
KEGGihsa:728386
UCSCiuc021xlo.1 human

Organism-specific databases

CTDi728386
EuPathDBiHostDB:ENSG00000227140.3
GeneCardsiUSP17L5
HGNCiHGNC:37177 USP17L5
HPAiHPA045642
neXtProtiNX_A8MUK1
PharmGKBiPA165664776
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1865 Eukaryota
ENOG410XQ92 LUCA
GeneTreeiENSGT00890000139343
HOGENOMiHOG000144638
HOVERGENiHBG007129
InParanoidiA8MUK1
KOiK11845
OMAiCKLCAME
OrthoDBiEOG091G06D5
PhylomeDBiA8MUK1
TreeFamiTF315281

Enzyme and pathway databases

ReactomeiR-HSA-5689880 Ub-specific processing proteases

Miscellaneous databases

GenomeRNAii728386
PROiPR:A8MUK1

Gene expression databases

BgeeiENSG00000227140 Expressed in 1 organ(s), highest expression level in blood

Family and domain databases

InterProiView protein in InterPro
IPR006861 HABP4_PAIRBP1-bd
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF04774 HABP4_PAI-RBP1, 1 hit
PF00443 UCH, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiU17L5_HUMAN
AccessioniPrimary (citable) accession number: A8MUK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: September 12, 2018
This is version 88 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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