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UniProtKB - A8MTZ7 (CL071_HUMAN)

Entry version 73 (12 Aug 2020)
Sequence version 3 (11 Jan 2011)
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Protein

Uncharacterized protein C12orf71

Gene

C12orf71

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein C12orf71
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C12orf71
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000214700.5

Human Gene Nomenclature Database

More...HGNCi		HGNC:34452, C12orf71

neXtProt; the human protein knowledge platform

More...neXtProti		NX_A8MTZ7

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		A8MTZ7, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		C12orf71

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003435771 – 269Uncharacterized protein C12orf71Add BLAST269

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		A8MTZ7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		A8MTZ7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A8MTZ7

PeptideAtlas

More...PeptideAtlasi		A8MTZ7

PRoteomics IDEntifications database

More...PRIDEi		A8MTZ7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		2067

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		A8MTZ7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		A8MTZ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000214700, Expressed in brain and 82 other tissues

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000214700, Group enriched (blood, bone marrow, skin, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000413728

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		A8MTZ7, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RTYV, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000018322

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_081160_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A8MTZ7

Identification of Orthologs from Complete Genome Data

More...OMAi		WVFRWLR

Database of Orthologous Groups

More...OrthoDBi		1541158at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A8MTZ7

TreeFam database of animal gene trees

More...TreeFami		TF338465

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027908, DUF4640

The PANTHER Classification System

More...PANTHERi		PTHR36462, PTHR36462, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15480, DUF4640, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A8MTZ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAYSSSNSDI EDDSSKSNSN LSLSVGYFPC EDTPCEDTTS WEDAPSKGPS 
        60         70         80         90        100
IHFLPPVQGA WGTERIGRRM KRQDQIQDEP EQFCKLSIFL AWDVDIGSDN 
       110        120        130        140        150
TDSRANRLLN GDNLWIDKLP KERTKLSVGK LNNLVQEFQI FLENLKDDDA 
       160        170        180        190        200
VFPETAQQDF QLSSGSPPEM VQMISQATAS QRTSAPEISS ILSEQPEKDD 
       210        220        230        240        250
TPSHTQAQCC LNFGWAFSWL RQRILPSLLR RDHPVNATKS PHRSAPTKRL 
       260 
FHRGKRIQPQ ETLELGHPI
Length:269
Mass (Da):30,355
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3BEA8CD84E707584
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_056837140I → V. Corresponds to variant dbSNP:rs708167Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC092747 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44851.1

NCBI Reference Sequences

More...RefSeqi		NP_001073875.1, NM_001080406.1
XP_011519149.1, XM_011520847.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000429849; ENSP00000413728; ENSG00000214700

Database of genes from NCBI RefSeq genomes

More...GeneIDi		728858

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:728858

UCSC genome browser

More...UCSCi		uc001rhq.4, human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092747 Genomic DNA No translation available.
CCDSiCCDS44851.1
RefSeqiNP_001073875.1, NM_001080406.1
XP_011519149.1, XM_011520847.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi9606.ENSP00000413728

PTM databases

iPTMnetiA8MTZ7
PhosphoSitePlusiA8MTZ7

Polymorphism and mutation databases

BioMutaiC12orf71

Proteomic databases

jPOSTiA8MTZ7
MassIVEiA8MTZ7
PaxDbiA8MTZ7
PeptideAtlasiA8MTZ7
PRIDEiA8MTZ7
ProteomicsDBi2067

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		49080, 4 antibodies

Genome annotation databases

EnsembliENST00000429849; ENSP00000413728; ENSG00000214700
GeneIDi728858
KEGGihsa:728858
UCSCiuc001rhq.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		728858
EuPathDBiHostDB:ENSG00000214700.5

GeneCards: human genes, protein and diseases

More...GeneCardsi		C12orf71
HGNCiHGNC:34452, C12orf71
HPAiENSG00000214700, Group enriched (blood, bone marrow, skin, testis)
neXtProtiNX_A8MTZ7

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RTYV, Eukaryota
GeneTreeiENSGT00390000018322
HOGENOMiCLU_081160_0_0_1
InParanoidiA8MTZ7
OMAiWVFRWLR
OrthoDBi1541158at2759
PhylomeDBiA8MTZ7
TreeFamiTF338465

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		728858, 8 hits in 854 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		728858
PharosiA8MTZ7, Tdark

Protein Ontology

More...PROi		PR:A8MTZ7
RNActiA8MTZ7, protein

Gene expression databases

BgeeiENSG00000214700, Expressed in brain and 82 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR027908, DUF4640
PANTHERiPTHR36462, PTHR36462, 2 hits
PfamiView protein in Pfam
PF15480, DUF4640, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCL071_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8MTZ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: January 11, 2011
Last modified: August 12, 2020
This is version 73 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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