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Protein

Zinc finger protein 724

Gene

ZNF724

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri170 – 192C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri198 – 220C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri226 – 248C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri254 – 276C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri478 – 500C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri534 – 556C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri562 – 584C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri590 – 612C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 724Curated
Gene namesi
Name:ZNF724Imported
Synonyms:ZNF724PImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000196081.9
HGNCiHGNC:32460 ZNF724
neXtProtiNX_A8MTY0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196081

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003322831 – 619Zinc finger protein 724Add BLAST619

Proteomic databases

EPDiA8MTY0
MaxQBiA8MTY0
PaxDbiA8MTY0
PRIDEiA8MTY0
ProteomicsDBi2060

PTM databases

iPTMnetiA8MTY0
PhosphoSitePlusiA8MTY0

Expressioni

Gene expression databases

BgeeiENSG00000196081
ExpressionAtlasiA8MTY0 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiA8MTY0, 2 interactors
STRINGi9606.ENSP00000413411

Structurei

3D structure databases

ProteinModelPortaliA8MTY0
SMRiA8MTY0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri170 – 192C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri198 – 220C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri226 – 248C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri254 – 276C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri478 – 500C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri534 – 556C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri562 – 584C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri590 – 612C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144042
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiA8MTY0
OMAiYVKDFHK
OrthoDBiEOG091G02KC
PhylomeDBiA8MTY0
TreeFamiTF342117

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 16 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 16 hits

Sequencei

Sequence statusi: Complete.

A8MTY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPLTFMDVA IEFSVEEWQC LDTAQQNLYR NVMLENYRNL VFLGIAVSKP
60 70 80 90 100
DLITCLEQGK EPWNMERHEM VAKPPGMCCY FAQDLRPEQS IKASLQRIIL
110 120 130 140 150
RKYEKCGHHN LQLKKGYKSV DEYKVHKGSY NGFNQCLTTT QSKIFQCDKY
160 170 180 190 200
VKDFHKFSNS NRHKTEKNPF KCKECGKSFC VLSHLTQHKR IHTTVNSYKL
210 220 230 240 250
EECGKAFNVS STLSQHKRIH TGQKHYKCEE CGIAFNKSSH LNTHKIIHTG
260 270 280 290 300
EKSYKREECG KAFNISSHLT THKIIHTGEN AYKCKECGKA FNQSSTLTRH
310 320 330 340 350
KIIHAGEKPY ICEHCGRAFN QSSNLTKHKR IHTGDKPYKC EECGKAFNVS
360 370 380 390 400
STLTQHKRIH TGEKPYKCEE CGKAFNVSST LTQHKRIHTG EKPYKCEECG
410 420 430 440 450
KAFNTSSHLT THKRIHTGEK PYKCEECGKA FNQFSQLTTH KIIHTGEKPY
460 470 480 490 500
KCKECGKAFK RSSNLTEHRI IHTGEKPYKC EECGKAFNLS SHLTTHKKIH
510 520 530 540 550
TGEKPYKCKE CGKAFNQSST LARHKIIHAG EKPYKCEECG KAFYQYSNLT
560 570 580 590 600
QHKIIHTGEK PYKCEECGKA FNWSSTLTKH KVIHTGEKPY KCKECGKAFN
610
QCSNLTTHKK IHAVEKSDK
Length:619
Mass (Da):71,172
Last modified:December 15, 2009 - v3
Checksum:i7E1F76A81721C9B4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti525K → R in BAG62802 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK301230 mRNA Translation: BAG62802.1
AC092329 Genomic DNA No translation available.
UniGeneiHs.675814

Genome annotation databases

EnsembliENST00000418100; ENSP00000413411; ENSG00000196081
UCSCiuc060wjr.1 human

Similar proteinsi

Entry informationi

Entry nameiZN724_HUMAN
AccessioniPrimary (citable) accession number: A8MTY0
Secondary accession number(s): B4DVU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 15, 2009
Last modified: June 20, 2018
This is version 88 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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