UniProtKB - A8MTK3 (A8MTK3_HUMAN)

BLAST

>tr|A8MTK3|A8MTK3_HUMAN POT1 protection of telomeres 1 homolog (S. pombe), isoform CRA_a OS=Homo sapiens OX=9606 GN=POT1 PE=1 SV=1
MVEALRVWASTHMSPSWTLLKLCDVQPMQYFDLTCQLLGKAEVDGASFLLKVWDGTRTPF
PSWRVLIQDLVLEGDLSHIHRLQNLTIDILVYDNHVHVARSLKVGSFLRIYSLHTKLQSM
NSENQTMLSLEFHLHGGTSYGRGIRVLPESNSDVDQLKKDLESANLTANQHSDVICQSEP
DDSFPSSGSVSLYEVERCQQLSATILTDHQYLERTPLCAILKQKAPQQYRIRAKLRSYKP
RRLFQSVKLHCPKCHLLQEVPHEGDLDIIFQDGATKTPDVKLQNTSLYDSKIWTTKNQKG
RKVAVHFVKNNGILPLSNECLLLIEGGTLSEICKLSNKFNSVIPVRSGHEDLELLDLSAP
FLIQGTIHHYGCKQCSSLRSIQNLNSLVDKTSWIPSSVAEALGIVPLQYVFVMTFTLDDG
TGVLEAYLMDSDKFFQIPASEVLMDDDLQKSVDMIMDMFCPPGIKIDAYPWLECFIKSYN
VTNGTDNQICYQIFDTTVAEDVI

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History
Entry version 92 (10 Oct 2018)
Sequence version 1 (04 Dec 2007)
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Protein

Submitted name:

POT1 protection of telomeres 1 homolog (S. pombe), isoform CRA_a

Gene

POT1

Organism

Homo sapiens (Human)

Status

Unreviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GO - Molecular functionⁱ

single-stranded telomeric DNA binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

telomere maintenance Source: InterPro

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: POT1 protection of telomeres 1 homolog (S. pombe), isoform CRA_aImported Submitted name: Protection of telomeres protein 1Imported
Gene namesⁱ	Name:POT1Imported ORF Names:hCG_32923Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000128513.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17284 POT1

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000128513
PharmGKBⁱ	PA134934904

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	A8MTK3
PRIDEⁱ	A8MTK3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000128513 Expressed in 215 organ(s), highest expression level in stomach
ExpressionAtlasⁱ	A8MTK3 baseline and differential

Structureⁱ

3D structure databases

SMRⁱ	A8MTK3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	21 – 165	POT1PCInterPro annotationAdd BLAST		145

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	154 – 174	Sequence analysisAdd BLAST		21

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG4757 Eukaryota ENOG410Z1J0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018285
HOGENOMⁱ	HOG000015271
HOVERGENⁱ	HBG053641

Family and domain databases

InterProⁱ	View protein in InterPro IPR012340 NA-bd_OB-fold IPR028389 POT1 IPR032042 POT1PC
PANTHERⁱ	PTHR14513 PTHR14513, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16686 POT1PC, 1 hit
SUPFAMⁱ	SSF50249 SSF50249, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show all Align All

A8MTK3-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MVEALRVWAS THMSPSWTLL KLCDVQPMQY FDLTCQLLGK AEVDGASFLL 
        60         70         80         90        100
KVWDGTRTPF PSWRVLIQDL VLEGDLSHIH RLQNLTIDIL VYDNHVHVAR 
       110        120        130        140        150
SLKVGSFLRI YSLHTKLQSM NSENQTMLSL EFHLHGGTSY GRGIRVLPES 
       160        170        180        190        200
NSDVDQLKKD LESANLTANQ HSDVICQSEP DDSFPSSGSV SLYEVERCQQ 
       210        220        230        240        250
LSATILTDHQ YLERTPLCAI LKQKAPQQYR IRAKLRSYKP RRLFQSVKLH 
       260        270        280        290        300
CPKCHLLQEV PHEGDLDIIF QDGATKTPDV KLQNTSLYDS KIWTTKNQKG 
       310        320        330        340        350
RKVAVHFVKN NGILPLSNEC LLLIEGGTLS EICKLSNKFN SVIPVRSGHE 
       360        370        380        390        400
DLELLDLSAP FLIQGTIHHY GCKQCSSLRS IQNLNSLVDK TSWIPSSVAE 
       410        420        430        440        450
ALGIVPLQYV FVMTFTLDDG TGVLEAYLMD SDKFFQIPAS EVLMDDDLQK 
       460        470        480        490        500
SVDMIMDMFC PPGIKIDAYP WLECFIKSYN VTNGTDNQIC YQIFDTTVAE 

DVI

Length:503

Mass (Da):56,817

Last modified:December 4, 2007 - v1

Checksum:ⁱ2CF6B188449D8AE3

Computationally mapped potential isoform sequencesⁱ

There are 12 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	Q9NUX5	POTE1_HUMAN	Protection of telomeres protein 1 Protection of telomeres protein 1, hPot1 (POT1-like telomere end-binding protein)	POT1	634	Annotation score:
	Q5MJ35	Q5MJ35_HUMAN	Protection of telomeres protein 1 v... Protection of telomeres protein 1 variant 2	POT1	340	Annotation score:
	Q5MJ34	Q5MJ34_HUMAN	Protection of telomeres protein 1 v... Protection of telomeres protein 1 variant 3	POT1	518	Annotation score:
	B7Z7M5	B7Z7M5_HUMAN	Protection of telomeres protein 1 Protection of telomeres protein 1 (cDNA FLJ58706, highly similar to Protection of telomeres 1)	POT1	580	Annotation score:
	V9GYE6	V9GYE6_HUMAN	Protection of telomeres protein 1 Protection of telomeres protein 1	POT1	119	Annotation score:
	C9JPG9	C9JPG9_HUMAN	Protection of telomeres protein 1 Protection of telomeres protein 1	POT1	82	Annotation score:
	V9GZ00	V9GZ00_HUMAN	Protection of telomeres protein 1 Protection of telomeres protein 1	POT1	73	Annotation score:
	Q5MJ33	Q5MJ33_HUMAN	Protection of telomeres protein 1 v... Protection of telomeres protein 1 variant 4	POT1	45	Annotation score:
	V9GY10	V9GY10_HUMAN	Protection of telomeres protein 1 Protection of telomeres protein 1	POT1	77	Annotation score:
	H7C0Z6	H7C0Z6_HUMAN	Protection of telomeres protein 1 Protection of telomeres protein 1	POT1	85	Annotation score:
There are more potential isoformsShow all

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC004925 Genomic DNA No translation available. AC096665 Genomic DNA No translation available. AC110791 Genomic DNA No translation available. CH471070 Genomic DNA Translation: EAW83615.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001036059.1, NM_001042594.1 XP_011514308.1, XM_011516006.1 XP_011514309.1, XM_011516007.1 XP_016867431.1, XM_017011942.1
UniGeneⁱ	Hs.31968

Genome annotation databases

Ensemblⁱ	ENST00000393329; ENSP00000377002; ENSG00000128513
GeneIDⁱ	25913
UCSC genome browser More...UCSCⁱ	uc003vlo.4 human

Protein	Similar proteins		Species	Score	Length	Source
A8MTK3	Protection of telomeres protein 1	)	HUMAN		634	UniRef100_Q9NUX5
POT1 protection of telomeres 1 homolog (S. pombe), isoform CRA_b		HUMAN		634
UPI000B34A7F8		HUMAN		294

Protein	Similar proteins		Species	Score	Length	Source
A8MTK3	Protection of telomeres protein 1	)	HUMAN		634	UniRef90_Q9NUX5
Protection of telomeres protein 1		MACFA		634
Uncharacterized protein		Cebus capucinus imitator		666
Uncharacterized protein		MACMU		658
Protection of telomeres 1		CALJA		648
+83

Protein	Similar proteins		Species	Score	Length	Source
A8MTK3	Protection of telomeres protein 1	)	HUMAN		634	UniRef50_Q9NUX5
Protection of telomeres protein 1		MACFA		634
Protection of telomeres protein 1		CHICK		778
Uncharacterized protein		Cebus capucinus imitator		666
Uncharacterized protein		MACMU		658
+372

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC004925 Genomic DNA No translation available. AC096665 Genomic DNA No translation available. AC110791 Genomic DNA No translation available. CH471070 Genomic DNA Translation: EAW83615.1
RefSeqⁱ	NP_001036059.1, NM_001042594.1 XP_011514308.1, XM_011516006.1 XP_011514309.1, XM_011516007.1 XP_016867431.1, XM_017011942.1
UniGeneⁱ	Hs.31968

3D structure databases

SMRⁱ	A8MTK3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQBⁱ	A8MTK3
PRIDEⁱ	A8MTK3

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	25913
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000393329; ENSP00000377002; ENSG00000128513
GeneIDⁱ	25913
UCSCⁱ	uc003vlo.4 human

Organism-specific databases

CTDⁱ	25913
EuPathDBⁱ	HostDB:ENSG00000128513.14
HGNCⁱ	HGNC:17284 POT1
OpenTargetsⁱ	ENSG00000128513
PharmGKBⁱ	PA134934904
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4757 Eukaryota ENOG410Z1J0 LUCA
GeneTreeⁱ	ENSGT00390000018285
HOGENOMⁱ	HOG000015271
HOVERGENⁱ	HBG053641

Miscellaneous databases

ChiTaRSⁱ	POT1 human
GenomeRNAiⁱ	25913

Gene expression databases

Bgeeⁱ	ENSG00000128513 Expressed in 215 organ(s), highest expression level in stomach
ExpressionAtlasⁱ	A8MTK3 baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR012340 NA-bd_OB-fold IPR028389 POT1 IPR032042 POT1PC
PANTHERⁱ	PTHR14513 PTHR14513, 1 hit
Pfamⁱ	View protein in Pfam PF16686 POT1PC, 1 hit
SUPFAMⁱ	SSF50249 SSF50249, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A8MTK3_HUMAN
Accessionⁱ	A8MTK3Primary (citable) accession number: A8MTK3
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	December 4, 2007
	Last sequence update:	December 4, 2007
	Last modified:	October 10, 2018
	This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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UniProtKB - A8MTK3 (A8MTK3_HUMAN)

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POT1 protection of telomeres 1 homolog (S. pombe), isoform CRA_a

POT1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ