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UniProtKB - A8MTK3 (A8MTK3_HUMAN)
Protein
Submitted name:
POT1 protection of telomeres 1 homolog (S. pombe), isoform CRA_a
Gene
POT1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- single-stranded telomeric DNA binding Source: InterPro
GO - Biological processi
- telomere maintenance Source: InterPro
Keywordsi
Molecular function | DNA-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: POT1 protection of telomeres 1 homolog (S. pombe), isoform CRA_aImportedSubmitted name: Protection of telomeres protein 1 |
Gene namesi | Name:POT1Imported ORF Names:hCG_32923Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17284, POT1 |
VEuPathDBi | HostDB:ENSG00000128513 |
Subcellular locationi
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- chromosome, telomeric region Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000128513, Expressed in stomach and 229 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 21 – 165 | POT1PCInterPro annotationAdd BLAST | 145 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 154 – 174 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the telombin family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00390000018285 |
Family and domain databases
Gene3Di | 2.40.50.140, 1 hit |
InterProi | View protein in InterPro IPR012340, NA-bd_OB-fold IPR028389, POT1 IPR032042, POT1PC |
PANTHERi | PTHR14513, PTHR14513, 1 hit |
Pfami | View protein in Pfam PF16686, POT1PC, 1 hit |
SUPFAMi | SSF50249, SSF50249, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All
A8MTK3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVEALRVWAS THMSPSWTLL KLCDVQPMQY FDLTCQLLGK AEVDGASFLL
60 70 80 90 100
KVWDGTRTPF PSWRVLIQDL VLEGDLSHIH RLQNLTIDIL VYDNHVHVAR
110 120 130 140 150
SLKVGSFLRI YSLHTKLQSM NSENQTMLSL EFHLHGGTSY GRGIRVLPES
160 170 180 190 200
NSDVDQLKKD LESANLTANQ HSDVICQSEP DDSFPSSGSV SLYEVERCQQ
210 220 230 240 250
LSATILTDHQ YLERTPLCAI LKQKAPQQYR IRAKLRSYKP RRLFQSVKLH
260 270 280 290 300
CPKCHLLQEV PHEGDLDIIF QDGATKTPDV KLQNTSLYDS KIWTTKNQKG
310 320 330 340 350
RKVAVHFVKN NGILPLSNEC LLLIEGGTLS EICKLSNKFN SVIPVRSGHE
360 370 380 390 400
DLELLDLSAP FLIQGTIHHY GCKQCSSLRS IQNLNSLVDK TSWIPSSVAE
410 420 430 440 450
ALGIVPLQYV FVMTFTLDDG TGVLEAYLMD SDKFFQIPAS EVLMDDDLQK
460 470 480 490 500
SVDMIMDMFC PPGIKIDAYP WLECFIKSYN VTNGTDNQIC YQIFDTTVAE
DVI
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9NUX5 | POTE1_HUMAN | Protection of telomeres protein 1 | POT1 | 634 | Annotation score: | ||
A0A590UJF7 | A0A590UJF7_HUMAN | Protection of telomeres protein 1 | POT1 | 559 | Annotation score: | ||
Q5MJ34 | Q5MJ34_HUMAN | Protection of telomeres protein 1 | POT1 | 518 | Annotation score: | ||
Q5MJ35 | Q5MJ35_HUMAN | Protection of telomeres protein 1 | POT1 | 340 | Annotation score: | ||
B7Z7M5 | B7Z7M5_HUMAN | Protection of telomeres protein 1 | POT1 | 580 | Annotation score: | ||
A0A590UJF2 | A0A590UJF2_HUMAN | Protection of telomeres protein 1 | POT1 | 567 | Annotation score: | ||
A0A590UJP0 | A0A590UJP0_HUMAN | Protection of telomeres protein 1 | POT1 | 509 | Annotation score: | ||
C9JPG9 | C9JPG9_HUMAN | Protection of telomeres protein 1 | POT1 | 213 | Annotation score: | ||
V9GZ00 | V9GZ00_HUMAN | Protection of telomeres protein 1 | POT1 | 73 | Annotation score: | ||
Q5MJ33 | Q5MJ33_HUMAN | Protection of telomeres protein 1 | POT1 | 45 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004925 Genomic DNA No translation available. AC096665 Genomic DNA No translation available. AC110791 Genomic DNA No translation available. CH471070 Genomic DNA Translation: EAW83615.1 |
RefSeqi | NP_001036059.1, NM_001042594.1 XP_011514308.1, XM_011516006.1 XP_011514309.1, XM_011516007.1 XP_016867431.1, XM_017011942.1 |
Genome annotation databases
Ensembli | ENST00000393329.5; ENSP00000377002.1; ENSG00000128513.16 |
GeneIDi | 25913 |
UCSCi | uc003vlo.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004925 Genomic DNA No translation available. AC096665 Genomic DNA No translation available. AC110791 Genomic DNA No translation available. CH471070 Genomic DNA Translation: EAW83615.1 |
RefSeqi | NP_001036059.1, NM_001042594.1 XP_011514308.1, XM_011516006.1 XP_011514309.1, XM_011516007.1 XP_016867431.1, XM_017011942.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
ProteomicsDBi | 2030 |
Protocols and materials databases
Antibodypediai | 31798, 317 antibodies from 32 providers |
DNASUi | 25913 |
Genome annotation databases
Ensembli | ENST00000393329.5; ENSP00000377002.1; ENSG00000128513.16 |
GeneIDi | 25913 |
UCSCi | uc003vlo.4, human |
Organism-specific databases
CTDi | 25913 |
HGNCi | HGNC:17284, POT1 |
OpenTargetsi | ENSG00000128513 |
PharmGKBi | PA134934904 |
VEuPathDBi | HostDB:ENSG00000128513 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000018285 |
Miscellaneous databases
BioGRID-ORCSi | 25913, 369 hits in 1090 CRISPR screens |
ChiTaRSi | POT1, human |
GenomeRNAii | 25913 |
Gene expression databases
Bgeei | ENSG00000128513, Expressed in stomach and 229 other tissues |
Family and domain databases
Gene3Di | 2.40.50.140, 1 hit |
InterProi | View protein in InterPro IPR012340, NA-bd_OB-fold IPR028389, POT1 IPR032042, POT1PC |
PANTHERi | PTHR14513, PTHR14513, 1 hit |
Pfami | View protein in Pfam PF16686, POT1PC, 1 hit |
SUPFAMi | SSF50249, SSF50249, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A8MTK3_HUMAN | |
Accessioni | A8MTK3Primary (citable) accession number: A8MTK3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 4, 2007 |
Last sequence update: | December 4, 2007 | |
Last modified: | May 25, 2022 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |