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Protein
Submitted name:

POT1 protection of telomeres 1 homolog (S. pombe), isoform CRA_a

Gene

POT1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
POT1 protection of telomeres 1 homolog (S. pombe), isoform CRA_aImported
Submitted name:
Protection of telomeres protein 1Imported
Gene namesi
Name:POT1Imported
ORF Names:hCG_32923Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000128513.14
HGNCiHGNC:17284 POT1

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000128513
PharmGKBiPA134934904

PTM / Processingi

Proteomic databases

MaxQBiA8MTK3
PRIDEiA8MTK3

Expressioni

Gene expression databases

BgeeiENSG00000128513 Expressed in 215 organ(s), highest expression level in stomach
ExpressionAtlasiA8MTK3 baseline and differential

Structurei

3D structure databases

SMRiA8MTK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 165POT1PCInterPro annotationAdd BLAST145

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili154 – 174Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4757 Eukaryota
ENOG410Z1J0 LUCA
GeneTreeiENSGT00390000018285
HOGENOMiHOG000015271
HOVERGENiHBG053641

Family and domain databases

InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR028389 POT1
IPR032042 POT1PC
PANTHERiPTHR14513 PTHR14513, 1 hit
PfamiView protein in Pfam
PF16686 POT1PC, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All

A8MTK3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVEALRVWAS THMSPSWTLL KLCDVQPMQY FDLTCQLLGK AEVDGASFLL
60 70 80 90 100
KVWDGTRTPF PSWRVLIQDL VLEGDLSHIH RLQNLTIDIL VYDNHVHVAR
110 120 130 140 150
SLKVGSFLRI YSLHTKLQSM NSENQTMLSL EFHLHGGTSY GRGIRVLPES
160 170 180 190 200
NSDVDQLKKD LESANLTANQ HSDVICQSEP DDSFPSSGSV SLYEVERCQQ
210 220 230 240 250
LSATILTDHQ YLERTPLCAI LKQKAPQQYR IRAKLRSYKP RRLFQSVKLH
260 270 280 290 300
CPKCHLLQEV PHEGDLDIIF QDGATKTPDV KLQNTSLYDS KIWTTKNQKG
310 320 330 340 350
RKVAVHFVKN NGILPLSNEC LLLIEGGTLS EICKLSNKFN SVIPVRSGHE
360 370 380 390 400
DLELLDLSAP FLIQGTIHHY GCKQCSSLRS IQNLNSLVDK TSWIPSSVAE
410 420 430 440 450
ALGIVPLQYV FVMTFTLDDG TGVLEAYLMD SDKFFQIPAS EVLMDDDLQK
460 470 480 490 500
SVDMIMDMFC PPGIKIDAYP WLECFIKSYN VTNGTDNQIC YQIFDTTVAE

DVI
Length:503
Mass (Da):56,817
Last modified:December 4, 2007 - v1
Checksum:i2CF6B188449D8AE3
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9NUX5POTE1_HUMAN
Protection of telomeres protein 1
POT1
634Annotation score:
Q5MJ35Q5MJ35_HUMAN
Protection of telomeres protein 1 v...
POT1
340Annotation score:
Q5MJ34Q5MJ34_HUMAN
Protection of telomeres protein 1 v...
POT1
518Annotation score:
B7Z7M5B7Z7M5_HUMAN
Protection of telomeres protein 1
POT1
580Annotation score:
V9GYE6V9GYE6_HUMAN
Protection of telomeres protein 1
POT1
119Annotation score:
C9JPG9C9JPG9_HUMAN
Protection of telomeres protein 1
POT1
82Annotation score:
V9GZ00V9GZ00_HUMAN
Protection of telomeres protein 1
POT1
73Annotation score:
Q5MJ33Q5MJ33_HUMAN
Protection of telomeres protein 1 v...
POT1
45Annotation score:
V9GY10V9GY10_HUMAN
Protection of telomeres protein 1
POT1
77Annotation score:
H7C0Z6H7C0Z6_HUMAN
Protection of telomeres protein 1
POT1
85Annotation score:
There are more potential isoformsShow all

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004925 Genomic DNA No translation available.
AC096665 Genomic DNA No translation available.
AC110791 Genomic DNA No translation available.
CH471070 Genomic DNA Translation: EAW83615.1
RefSeqiNP_001036059.1, NM_001042594.1
XP_011514308.1, XM_011516006.1
XP_011514309.1, XM_011516007.1
XP_016867431.1, XM_017011942.1
UniGeneiHs.31968

Genome annotation databases

EnsembliENST00000393329; ENSP00000377002; ENSG00000128513
GeneIDi25913
UCSCiuc003vlo.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004925 Genomic DNA No translation available.
AC096665 Genomic DNA No translation available.
AC110791 Genomic DNA No translation available.
CH471070 Genomic DNA Translation: EAW83615.1
RefSeqiNP_001036059.1, NM_001042594.1
XP_011514308.1, XM_011516006.1
XP_011514309.1, XM_011516007.1
XP_016867431.1, XM_017011942.1
UniGeneiHs.31968

3D structure databases

SMRiA8MTK3
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiA8MTK3
PRIDEiA8MTK3

Protocols and materials databases

DNASUi25913
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393329; ENSP00000377002; ENSG00000128513
GeneIDi25913
UCSCiuc003vlo.4 human

Organism-specific databases

CTDi25913
EuPathDBiHostDB:ENSG00000128513.14
HGNCiHGNC:17284 POT1
OpenTargetsiENSG00000128513
PharmGKBiPA134934904
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4757 Eukaryota
ENOG410Z1J0 LUCA
GeneTreeiENSGT00390000018285
HOGENOMiHOG000015271
HOVERGENiHBG053641

Miscellaneous databases

ChiTaRSiPOT1 human
GenomeRNAii25913

Gene expression databases

BgeeiENSG00000128513 Expressed in 215 organ(s), highest expression level in stomach
ExpressionAtlasiA8MTK3 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR028389 POT1
IPR032042 POT1PC
PANTHERiPTHR14513 PTHR14513, 1 hit
PfamiView protein in Pfam
PF16686 POT1PC, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA8MTK3_HUMAN
AccessioniPrimary (citable) accession number: A8MTK3
Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: October 10, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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