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Entry version 84 (13 Feb 2019)
Sequence version 1 (04 Dec 2007)
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Protein

Protein FAM166B

Gene

FAM166B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM166B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM166B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000215187.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:34242 FAM166B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A8MTA8

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000215187

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162387040

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM166B

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003423831 – 275Protein FAM166BAdd BLAST275

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A8MTA8

PRoteomics IDEntifications database

More...
PRIDEi
A8MTA8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
2008
2009 [A8MTA8-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
A8MTA8-2 [A8MTA8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A8MTA8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A8MTA8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000215187 Expressed in 106 organ(s), highest expression level in right adrenal gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A8MTA8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A8MTA8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA045540

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
RBPMSQ93062-34EBI-12160437,EBI-740343

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
610500, 1 interactor

Protein interaction database and analysis system

More...
IntActi
A8MTA8, 19 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A8MTA8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UPF0605 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPQ1 Eukaryota
ENOG4111J2F LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154822

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231525

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG070076

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A8MTA8

Identification of Orthologs from Complete Genome Data

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OMAi
HTYGHLT

Database of Orthologous Groups

More...
OrthoDBi
851402at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A8MTA8

TreeFam database of animal gene trees

More...
TreeFami
TF325739

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018902 UPF0573/UPF0605

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10629 DUF2475, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: A8MTA8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVASTFIPG LNPQNPHYIP GYTGHCPLLR FSVGQTYGQV TGQLLRGPPG
60 70 80 90 100
LAWPPVHRTL LPPIRPPRSP EVPRESLPVR RGQERLSSSM IPGYTGFVPR
110 120 130 140 150
AQFIFAKNCS QVWAEALSDF THLHEKQGSE ELPKEAKGRK DTEKDQVPEP
160 170 180 190 200
EGQLEEPTLE VVEQASPYSM DDRDPRKFFM SGFTGYVPCA RFLFGSSFPV
210 220 230 240 250
LTNQALQEFG QKHSPGSAQD PKHLPPLPRT YPQNLGLLPN YGGYVPGYKF
260 270
QFGHTFGHLT HDALGLSTFQ KQLLA
Length:275
Mass (Da):30,575
Last modified:December 4, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFF307EA7A191945F
GO
Isoform 2 (identifier: A8MTA8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     183-239: FTGYVPCARF...TYPQNLGLLP → TAGIWAEALTRQCPGPQTSPPTSQNIPSEPGSFT
     240-275: Missing.

Show »
Length:216
Mass (Da):23,839
Checksum:iAA30258DEC259FC5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WXD4A0A087WXD4_HUMAN
Protein FAM166B
FAM166B
259Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_034438183 – 239FTGYV…LGLLP → TAGIWAEALTRQCPGPQTSP PTSQNIPSEPGSFT in isoform 2. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_034439240 – 275Missing in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL133476 Genomic DNA No translation available.
BC129999 mRNA Translation: AAI30000.1
BC146928 mRNA Translation: AAI46929.1
BC146933 mRNA Translation: AAI46934.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47963.1 [A8MTA8-2]
CCDS56572.1 [A8MTA8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001093421.1, NM_001099951.3 [A8MTA8-2]
NP_001157782.1, NM_001164310.2 [A8MTA8-1]
NP_001274168.1, NM_001287239.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.98959

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000399742; ENSP00000382646; ENSG00000215187 [A8MTA8-1]
ENST00000447837; ENSP00000412746; ENSG00000215187 [A8MTA8-2]
ENST00000639789; ENSP00000492818; ENSG00000215187 [A8MTA8-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
730112

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:730112

UCSC genome browser

More...
UCSCi
uc003zwy.4 human [A8MTA8-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133476 Genomic DNA No translation available.
BC129999 mRNA Translation: AAI30000.1
BC146928 mRNA Translation: AAI46929.1
BC146933 mRNA Translation: AAI46934.1
CCDSiCCDS47963.1 [A8MTA8-2]
CCDS56572.1 [A8MTA8-1]
RefSeqiNP_001093421.1, NM_001099951.3 [A8MTA8-2]
NP_001157782.1, NM_001164310.2 [A8MTA8-1]
NP_001274168.1, NM_001287239.1
UniGeneiHs.98959

3D structure databases

ProteinModelPortaliA8MTA8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi610500, 1 interactor
IntActiA8MTA8, 19 interactors

PTM databases

iPTMnetiA8MTA8
PhosphoSitePlusiA8MTA8

Polymorphism and mutation databases

BioMutaiFAM166B

Proteomic databases

PaxDbiA8MTA8
PRIDEiA8MTA8
ProteomicsDBi2008
2009 [A8MTA8-2]
TopDownProteomicsiA8MTA8-2 [A8MTA8-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399742; ENSP00000382646; ENSG00000215187 [A8MTA8-1]
ENST00000447837; ENSP00000412746; ENSG00000215187 [A8MTA8-2]
ENST00000639789; ENSP00000492818; ENSG00000215187 [A8MTA8-2]
GeneIDi730112
KEGGihsa:730112
UCSCiuc003zwy.4 human [A8MTA8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
730112
EuPathDBiHostDB:ENSG00000215187.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAM166B
HGNCiHGNC:34242 FAM166B
HPAiHPA045540
neXtProtiNX_A8MTA8
OpenTargetsiENSG00000215187
PharmGKBiPA162387040

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IPQ1 Eukaryota
ENOG4111J2F LUCA
GeneTreeiENSGT00940000154822
HOGENOMiHOG000231525
HOVERGENiHBG070076
InParanoidiA8MTA8
OMAiHTYGHLT
OrthoDBi851402at2759
PhylomeDBiA8MTA8
TreeFamiTF325739

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
730112

Protein Ontology

More...
PROi
PR:A8MTA8

Gene expression databases

BgeeiENSG00000215187 Expressed in 106 organ(s), highest expression level in right adrenal gland
ExpressionAtlasiA8MTA8 baseline and differential
GenevisibleiA8MTA8 HS

Family and domain databases

InterProiView protein in InterPro
IPR018902 UPF0573/UPF0605
PfamiView protein in Pfam
PF10629 DUF2475, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF166B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8MTA8
Secondary accession number(s): A1L3B2, B7ZBJ0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: December 4, 2007
Last modified: February 13, 2019
This is version 84 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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