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Entry version 109 (12 Aug 2020)
Sequence version 1 (04 Dec 2007)
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Protein

Centromere protein X

Gene

CENPX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:20347428, PubMed:20347429). In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428, PubMed:20347429). In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression (PubMed:19620631). As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure (PubMed:20347428, PubMed:20347429). DNA-binding function is fulfilled in the presence of CENPS, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own (PubMed:20347429).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Cell division, DNA damage, DNA repair, Mitosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
A8MT69

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-606279, Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-6783310, Fanconi Anemia Pathway

SIGNOR Signaling Network Open Resource

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SIGNORi
A8MT69

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Centromere protein X
Short name:
CENP-X
Alternative name(s):
FANCM-associated histone fold protein 21 Publication
FANCM-interacting histone fold protein 21 Publication
Fanconi anemia-associated polypeptide of 10 kDa
Retinoic acid-inducible gene D9 protein homolog
Stimulated by retinoic acid gene 13 protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CENPX
Synonyms:FAAP10, MHF22 Publications, STRA13
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000169689.14

Human Gene Nomenclature Database

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HGNCi
HGNC:11422, CENPX

Online Mendelian Inheritance in Man (OMIM)

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MIMi
615128, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A8MT69

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
201254

Open Targets

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OpenTargetsi
ENSG00000169689

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA36223

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
A8MT69, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CENPX

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003371801 – 81Centromere protein XAdd BLAST81

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
A8MT69

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
A8MT69

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
A8MT69

MaxQB - The MaxQuant DataBase

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MaxQBi
A8MT69

PeptideAtlas

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PeptideAtlasi
A8MT69

PRoteomics IDEntifications database

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PRIDEi
A8MT69

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
1998 [A8MT69-1]
1999 [A8MT69-2]
2000 [A8MT69-3]

Consortium for Top Down Proteomics

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TopDownProteomicsi
A8MT69-1 [A8MT69-1]
A8MT69-2 [A8MT69-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
A8MT69

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
A8MT69

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression varies across the cell cycle, with highest levels in S phase (at protein level). No statistically significant changes at the transcript level.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000169689, Expressed in mucosa of transverse colon and 221 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
A8MT69, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
A8MT69, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000169689, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with CENPX, sometimes called MHF; this interaction stabilizes both partners (PubMed:19620631, PubMed:20347428, PubMed:20347429, PubMed:24522885). MHF heterodimers can assemble to form tetrameric structures (PubMed:22304917). MHF also coassemble with CENPT-CENPW heterodimers at centromeres to form the tetrameric CENP-T-W-S-X complex (PubMed:22304917, PubMed:24522885).

Forms a discrete complex with FANCM and CENPX, called FANCM-MHF; this interaction, probably mediated by direct binding between CENPS and FANCM, leads to synergistic activation of double-stranded DNA binding and strongly stimulates FANCM-mediated DNA remodeling (PubMed:20347428, PubMed:20347429). Recruited by FANCM to the Fanconi anemia (FA) core complex, which consists of CENPS, CENPX, FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM, FAAP24 and FAAP100. The FA core complex associates with Bloom syndrome (BLM) complex, which consists of at least BLM, DNA topoisomerase 3-alpha (TOP3A), RMI1/BLAP75, RPA1/RPA70 and RPA2/RPA32. The super complex between FA and BLM is called BRAFT (PubMed:20347428, PubMed:20347429).

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
128376, 28 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
A8MT69

Protein interaction database and analysis system

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IntActi
A8MT69, 9 interactors

Molecular INTeraction database

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MINTi
A8MT69

STRING: functional protein association networks

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STRINGi
9606.ENSP00000376168

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
A8MT69, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

181
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
A8MT69

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CENP-X/MHF2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502S98G, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000165025

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_175684_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
A8MT69

KEGG Orthology (KO)

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KOi
K15360

Database of Orthologous Groups

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OrthoDBi
1560521at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
A8MT69

Family and domain databases

Intrinsically Disordered proteins with Extensive Annotations and Literature

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IDEALi
IID00424

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR018552, CENP-X

The PANTHER Classification System

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PANTHERi
PTHR28680, PTHR28680, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF09415, CENP-X, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A8MT69-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGAGAGSGF RKELVSRLLH LHFKDDKTKV SGDALQLMVE LLKVFVVEAA
60 70 80
VRGVRQAQAE DALRVDVDQL EKVLPQLLLD F
Length:81
Mass (Da):8,959
Last modified:December 4, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0BA47A4F0FFD2978
GO
Isoform 2 (identifier: A8MT69-2) [UniParc]FASTAAdd to basket
Also known as: Variant A

The sequence of this isoform differs from the canonical sequence as follows:
     30-47: Missing.

Show »
Length:63
Mass (Da):7,017
Checksum:iB751CBF3D27E6B1A
GO
Isoform 3 (identifier: A8MT69-3) [UniParc]FASTAAdd to basket
Also known as: Variant B

The sequence of this isoform differs from the canonical sequence as follows:
     30-47: Missing.
     73-77: Missing.

Show »
Length:58
Mass (Da):6,466
Checksum:i5166DA91818795E5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QRS1J3QRS1_HUMAN
Centromere protein X
CENPX
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QR35J3QR35_HUMAN
Centromere protein X
CENPX
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QR01J3QR01_HUMAN
Centromere protein X
CENPX
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti65V → A in AAH09571 (PubMed:15489334).Curated1
Sequence conflicti73V → L in AAB53638 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03394830 – 47Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST18
Alternative sequenceiVSP_03394973 – 77Missing in isoform 3. 2 Publications5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U95006 mRNA Translation: AAB53638.1
U95007 mRNA Translation: AAB53639.1
AC137723 Genomic DNA No translation available.
BC009571 mRNA Translation: AAH09571.1
BC011610 mRNA Translation: AAH11610.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32772.1 [A8MT69-2]
CCDS59302.1 [A8MT69-3]
CCDS59303.1 [A8MT69-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001257935.1, NM_001271006.1 [A8MT69-1]
NP_001257936.1, NM_001271007.1 [A8MT69-3]
NP_001317465.1, NM_001330536.1
NP_659435.2, NM_144998.3 [A8MT69-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000306704; ENSP00000302951; ENSG00000169689 [A8MT69-2]
ENST00000392359; ENSP00000376168; ENSG00000169689 [A8MT69-1]
ENST00000580435; ENSP00000462015; ENSG00000169689 [A8MT69-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
201254

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:201254

UCSC genome browser

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UCSCi
uc002kdc.5, human [A8MT69-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95006 mRNA Translation: AAB53638.1
U95007 mRNA Translation: AAB53639.1
AC137723 Genomic DNA No translation available.
BC009571 mRNA Translation: AAH09571.1
BC011610 mRNA Translation: AAH11610.1
CCDSiCCDS32772.1 [A8MT69-2]
CCDS59302.1 [A8MT69-3]
CCDS59303.1 [A8MT69-1]
RefSeqiNP_001257935.1, NM_001271006.1 [A8MT69-1]
NP_001257936.1, NM_001271007.1 [A8MT69-3]
NP_001317465.1, NM_001330536.1
NP_659435.2, NM_144998.3 [A8MT69-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DRAX-ray2.41E/F/G/H1-81[»]
4DRBX-ray2.63J/K/L/M/N/O1-81[»]
4E44X-ray2.10B/D1-81[»]
4E45X-ray2.00B/D/G/I/L/N1-81[»]
4NDYX-ray7.00B/D/H/L/M/N/U/V/W/X8-81[»]
4NE1X-ray6.50B/D/H/L/M/N/U/V/W/X/Z/b/d/h/i/j/o/p/q/r8-81[»]
4NE3X-ray1.80B8-81[»]
4NE5X-ray2.50B/D/F/H8-81[»]
4NE6X-ray2.10B/D8-81[»]
SMRiA8MT69
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi128376, 28 interactors
CORUMiA8MT69
IntActiA8MT69, 9 interactors
MINTiA8MT69
STRINGi9606.ENSP00000376168

PTM databases

iPTMnetiA8MT69
PhosphoSitePlusiA8MT69

Polymorphism and mutation databases

BioMutaiCENPX

Proteomic databases

EPDiA8MT69
jPOSTiA8MT69
MassIVEiA8MT69
MaxQBiA8MT69
PeptideAtlasiA8MT69
PRIDEiA8MT69
ProteomicsDBi1998 [A8MT69-1]
1999 [A8MT69-2]
2000 [A8MT69-3]
TopDownProteomicsiA8MT69-1 [A8MT69-1]
A8MT69-2 [A8MT69-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
32957, 68 antibodies

Genome annotation databases

EnsembliENST00000306704; ENSP00000302951; ENSG00000169689 [A8MT69-2]
ENST00000392359; ENSP00000376168; ENSG00000169689 [A8MT69-1]
ENST00000580435; ENSP00000462015; ENSG00000169689 [A8MT69-3]
GeneIDi201254
KEGGihsa:201254
UCSCiuc002kdc.5, human [A8MT69-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
201254
DisGeNETi201254
EuPathDBiHostDB:ENSG00000169689.14

GeneCards: human genes, protein and diseases

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GeneCardsi
CENPX
HGNCiHGNC:11422, CENPX
HPAiENSG00000169689, Low tissue specificity
MIMi615128, gene
neXtProtiNX_A8MT69
OpenTargetsiENSG00000169689
PharmGKBiPA36223

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502S98G, Eukaryota
GeneTreeiENSGT00940000165025
HOGENOMiCLU_175684_0_0_1
InParanoidiA8MT69
KOiK15360
OrthoDBi1560521at2759
PhylomeDBiA8MT69

Enzyme and pathway databases

PathwayCommonsiA8MT69
ReactomeiR-HSA-606279, Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-6783310, Fanconi Anemia Pathway
SIGNORiA8MT69

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
201254, 98 hits in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CENPX, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
201254
PharosiA8MT69, Tbio

Protein Ontology

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PROi
PR:A8MT69
RNActiA8MT69, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000169689, Expressed in mucosa of transverse colon and 221 other tissues
ExpressionAtlasiA8MT69, baseline and differential
GenevisibleiA8MT69, HS

Family and domain databases

IDEALiIID00424
InterProiView protein in InterPro
IPR018552, CENP-X
PANTHERiPTHR28680, PTHR28680, 1 hit
PfamiView protein in Pfam
PF09415, CENP-X, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCENPX_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8MT69
Secondary accession number(s): O00281
, O00282, Q96DD4, Q96F51
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 4, 2007
Last modified: August 12, 2020
This is version 109 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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