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Entry version 95 (13 Feb 2019)
Sequence version 2 (02 Sep 2008)
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Protein

Zinc finger protein 891

Gene

ZNF891

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri320 – 342C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri348 – 370C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri376 – 398C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri404 – 426C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri432 – 454C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri460 – 482C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri488 – 510C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri516 – 538C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 891
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF891
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000214029.4

Human Gene Nomenclature Database

More...
HGNCi
HGNC:38709 ZNF891

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A8MT65

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000214029

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF891

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003491851 – 544Zinc finger protein 891Add BLAST544

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A8MT65

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A8MT65

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A8MT65

PRoteomics IDEntifications database

More...
PRIDEi
A8MT65

ProteomicsDB human proteome resource

More...
ProteomicsDBi
1996

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A8MT65

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A8MT65

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000214029 Expressed in 153 organ(s), highest expression level in forebrain

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A8MT65 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040301

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
136313, 1 interactor

Protein interaction database and analysis system

More...
IntActi
A8MT65, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000380480

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A8MT65

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A8MT65

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 113KRABPROSITE-ProRule annotationAdd BLAST71

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri320 – 342C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri348 – 370C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri376 – 398C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri404 – 426C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri432 – 454C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri460 – 482C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri488 – 510C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri516 – 538C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164587

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG018163

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A8MT65

KEGG Orthology (KO)

More...
KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
KHECNQC

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A8MT65

TreeFam database of animal gene trees

More...
TreeFami
TF337055

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A8MT65-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVMDLSSPW ALTKQDSACF HLRNAEEERM IAVFLTTWLQ EPMTFKDVAV
60 70 80 90 100
EFTQEEWMML DSAQRSLYRD VMLENYRNLT SVEYQLYRLT VISPLDQEEI
110 120 130 140 150
RNMKKRIPQA ICPDQKIQPK TKESTVQKIL WEEPSNAVKM IKLTMHNWSS
160 170 180 190 200
TLREDWECHK IRKQHKIPGG HWRQMIYAPK KTVPQELFRD YHELEENSKL
210 220 230 240 250
GSKLIFSQSI FTSKHCQKCY SEIGCLKHNS IINNYVKNSI SEKLYESHEC
260 270 280 290 300
DTTLWHFQRN QTVQKEYTYS KHGMHFTHNM FPVPNNLHMA QNACECNKDE
310 320 330 340 350
TLCHQSSLKK QGQTHTEKKH ECNQCGKAFK RISNLTLYKK SHMGEKQYEC
360 370 380 390 400
KECGKVFNDS STLRRHVRTH TGEKPYECNQ CGKAFSQKTS LKAHMRTHTG
410 420 430 440 450
EKPYECNQCG KSFGTSSYLI VHKRIHTGEK LYECSECGKA FNTSSHLKVH
460 470 480 490 500
KKIHTGENVY ECSDCGKVFS GVSSLRMHIR THTGEKPYEC KECRKAFSVS
510 520 530 540
SSLRRHVRIH TGEKPYECIQ CGKAFSQSSS LIIHKRIHTE RETL
Length:544
Mass (Da):63,592
Last modified:September 2, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB8639429E306B007
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BC017932 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC026786 Genomic DNA No translation available.
BC017932 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS59238.1

NCBI Reference Sequences

More...
RefSeqi
NP_001264220.1, NM_001277291.1
XP_016874155.1, XM_017018666.1
XP_016874156.1, XM_017018667.1
XP_016874157.1, XM_017018668.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.614816

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000537226; ENSP00000437590; ENSG00000214029

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
101060200

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:101060200

UCSC genome browser

More...
UCSCi
uc031qkm.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC026786 Genomic DNA No translation available.
BC017932 mRNA No translation available.
CCDSiCCDS59238.1
RefSeqiNP_001264220.1, NM_001277291.1
XP_016874155.1, XM_017018666.1
XP_016874156.1, XM_017018667.1
XP_016874157.1, XM_017018668.1
UniGeneiHs.614816

3D structure databases

ProteinModelPortaliA8MT65
SMRiA8MT65
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi136313, 1 interactor
IntActiA8MT65, 1 interactor
STRINGi9606.ENSP00000380480

PTM databases

iPTMnetiA8MT65
PhosphoSitePlusiA8MT65

Polymorphism and mutation databases

BioMutaiZNF891

Proteomic databases

jPOSTiA8MT65
MaxQBiA8MT65
PaxDbiA8MT65
PRIDEiA8MT65
ProteomicsDBi1996

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000537226; ENSP00000437590; ENSG00000214029
GeneIDi101060200
KEGGihsa:101060200
UCSCiuc031qkm.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
101060200
EuPathDBiHostDB:ENSG00000214029.4

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZNF891
HGNCiHGNC:38709 ZNF891
HPAiHPA040301
neXtProtiNX_A8MT65
OpenTargetsiENSG00000214029

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000164587
HOVERGENiHBG018163
InParanoidiA8MT65
KOiK09228
OMAiKHECNQC
OrthoDBi1318335at2759
PhylomeDBiA8MT65
TreeFamiTF337055

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZNF891 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
101060200

Protein Ontology

More...
PROi
PR:A8MT65

Gene expression databases

BgeeiENSG00000214029 Expressed in 153 organ(s), highest expression level in forebrain
GenevisibleiA8MT65 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN891_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8MT65
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: February 13, 2019
This is version 95 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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