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Entry version 88 (31 Jul 2019)
Sequence version 1 (04 Dec 2007)
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Protein
Submitted name:

Eukaryotic translation initiation factor 4G

Gene

EIF4G

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionInitiation factorImported
Biological processProtein biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Eukaryotic translation initiation factor 4GImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EIF4GImported
Synonyms:CUCUMOVIRUS MULTIPLICATION 2Imported, CUM2Imported
Ordered Locus Names:At3g60240Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT3G60240

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

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PRIDEi
A8MR97

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A8MR97

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A8MR97 baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A8MR97

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1535 – 1659MIInterPro annotationAdd BLAST125

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 248DisorderedSequence analysisAdd BLAST248
Regioni356 – 419DisorderedSequence analysisAdd BLAST64
Regioni548 – 577DisorderedSequence analysisAdd BLAST30
Regioni674 – 732DisorderedSequence analysisAdd BLAST59
Regioni767 – 811DisorderedSequence analysisAdd BLAST45
Regioni973 – 1003DisorderedSequence analysisAdd BLAST31
Regioni1184 – 1208DisorderedSequence analysisAdd BLAST25
Regioni1332 – 1371DisorderedSequence analysisAdd BLAST40
Regioni1442 – 1488DisorderedSequence analysisAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi17 – 36PolarSequence analysisAdd BLAST20
Compositional biasi52 – 71PolarSequence analysisAdd BLAST20
Compositional biasi84 – 157PolarSequence analysisAdd BLAST74
Compositional biasi177 – 212PolarSequence analysisAdd BLAST36
Compositional biasi213 – 228PolyampholyteSequence analysisAdd BLAST16
Compositional biasi373 – 394PolyampholyteSequence analysisAdd BLAST22
Compositional biasi548 – 574PolarSequence analysisAdd BLAST27
Compositional biasi674 – 709PolarSequence analysisAdd BLAST36
Compositional biasi710 – 732PolyampholyteSequence analysisAdd BLAST23
Compositional biasi767 – 802PolarSequence analysisAdd BLAST36
Compositional biasi1340 – 1360PolarSequence analysisAdd BLAST21

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPIB Eukaryota
ENOG410ZIZB LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000015159

Database of Orthologous Groups

More...
OrthoDBi
594395at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A8MR97

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.180, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR003891 Initiation_fac_eIF4g_MI
IPR016021 MIF4-like_sf
IPR003890 MIF4G-like_typ-3

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02847 MA3, 1 hit
PF02854 MIF4G, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00544 MA3, 1 hit
SM00543 MIF4G, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51366 MI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A8MR97-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYNQSRPDR SETQYRRTGR STGNQQQQQQ HRSSSAAGYG KGAGAPGSAP
60 70 80 90 100
APSTYPDNSS LSSNRSFKKP GNAQGGGQPR VNLPPVNHPN NHNNGPNAHS
110 120 130 140 150
RSQGEPGVGG PTNPTESFNR NTGPIPKAPT SQSTVMSSKI NETPNTAKAS
160 170 180 190 200
GDASQAFPLQ FGSLGPDLMV PARTTSAPPN MDDQKRAQMQ QSSLRTASNV
210 220 230 240 250
PASVPKKDSS NKGADNQLMR KEGHNPSSEK ADIQVPHIAP PSQTQKSPIT
260 270 280 290 300
NIRMPSVQTP YQHTQVPHPV HFGGPNMHMQ TPVTATSFQM PMPMALSMGN
310 320 330 340 350
TPQIPPQVFY QGHPPHPMHH QGMMHQAQGH GFATPMGAQI HPQLGHVGVG
360 370 380 390 400
LSPQYPQQQG GKYGGARKTT PVKITHPDTH EELRLDRRGD PYSEGDSTAL
410 420 430 440 450
KPHSNPPPRS QPVSSFAPRP VNLVQPSYNS NTMIYPPVSV PLNNGPMSSA
460 470 480 490 500
QAPRYHYPVI DGSQRVQLIN QPAHTAPQLI RPAAPAHLSS DSTSSVKARN
510 520 530 540 550
AQNVMSSALP VNAKVSVKPA GVSEKLGSPK DRSHGEVNIS LSQKNVEACS
560 570 580 590 600
LSSSQQPKPS FVSGVPNSSA PPAKSPVETV PLAKSSVETV PPVKSSVETA
610 620 630 640 650
PVTTTEIRRA EMVSESISVE DQTCKVEPPH NLTENRGQTM PDSLVSDPET
660 670 680 690 700
ATVAAKENLS LPATNGFRKQ LLKVSTTSDA PTSDSVDTSI DKSTEGSSHA
710 720 730 740 750
SSEISGSSPQ EKDLKCDNRT ASDKLDERSV ISDAKHETLS GVLEKAQNEV
760 770 780 790 800
DGATDVCPVS EKLAVTDDTS SDLPHSTHVL SSTVPLGHSE THKSAVETNT
810 820 830 840 850
RRNTSTKGKK KIKEILQKAD AAGTTSDLYM AYKGPEEKKE SSNVVHDVSN
860 870 880 890 900
QNLLPAIPQA VEAIVDTEPV KNEPEDWEDA ADVSTPKLET ADNSVNAKRG
910 920 930 940 950
SSDEVSDNCI NTEKKYSRDF LLKFADLCTA LPEGFDVSPD IANALIVAYM
960 970 980 990 1000
GASHHEHDSY PTPGKVMDRQ ASGARLDRRP SNVAGDDRWT KNQGSLPAGY
1010 1020 1030 1040 1050
GGNVGFRPGQ GGNSGVLRNP RMQGPIISRP MQPVGPMGGM GRNTPDLERW
1060 1070 1080 1090 1100
QRGSNFQQKG LFPSPHTPMQ VMHKAERKYQ VGTIADEEQA KQRQLKSILN
1110 1120 1130 1140 1150
KLTPQNFEKL FEQVKSVNID NAVTLSGVIS QIFDKALMEP TFCEMYADFC
1160 1170 1180 1190 1200
FHLSGALPDF NENGEKITFK RLLLNKCQEE FERGEKEEEE ASRVAEEGQV
1210 1220 1230 1240 1250
EQTEEEREEK RLQVRRRMLG NIRLIGELYK KRMLTEKIMH ACIQKLLGYN
1260 1270 1280 1290 1300
QDPHEENIEA LCKLMSTIGV MIDHNKAKFQ MDGYFEKMKM LSCKQELSSR
1310 1320 1330 1340 1350
VRFMLINAID LRKNKWQERM KVEGPKKIEE VHRDAAQERQ TQANRLSRGP
1360 1370 1380 1390 1400
SMNSSGRRGH MEFSSPRGGG GMLSPPAAQM GSYHGPPQGR GFSNQDIRFD
1410 1420 1430 1440 1450
DRPSYEPRMV PMPQRSVCEE PITLGPQGGL GQGMSIRRPA VASNTYQSDA
1460 1470 1480 1490 1500
TQAGGGDSRR PAGGLNGFGS HRPASPVTHG RSSPQERGTA YVHREFASLS
1510 1520 1530 1540 1550
RASDLSPEVS SARQVLQGPS ATVNSPRENA LSEEQLENLS LSAIKEYYSA
1560 1570 1580 1590 1600
RDENEIGMCM KDMNSPAYHP TMISLWVTDS FERKDKERDL LAKLLVNLVK
1610 1620 1630 1640 1650
SADNALNEVQ LVKGFESVLK TLEDAVNDAP KAAEFLGRIF GKSVTEKVVT
1660 1670 1680 1690 1700
LTEIGRLIQE GGEEPGSLIE FGLGGDVLGS VLEMIKTEAG EETLVEIRRS
1710 1720
SGLRIENFKP HAPNRSKILE KFT
Length:1,723
Mass (Da):187,551
Last modified:December 4, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1605A7D3F06F2C0F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q76E23IF4G_ARATH
Eukaryotic translation initiation f...
EIF4G CUM2, At3g60240, F27H5_30
1,727Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP002686 Genomic DNA Translation: AEE80026.1

NCBI Reference Sequences

More...
RefSeqi
NP_001078317.1, NM_001084848.1

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT3G60240.2; AT3G60240.2; AT3G60240

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
825194

Gramene; a comparative resource for plants

More...
Gramenei
AT3G60240.2; AT3G60240.2; AT3G60240

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002686 Genomic DNA Translation: AEE80026.1
RefSeqiNP_001078317.1, NM_001084848.1

3D structure databases

SMRiA8MR97
ModBaseiSearch...

PTM databases

iPTMnetiA8MR97

Proteomic databases

PRIDEiA8MR97

Genome annotation databases

EnsemblPlantsiAT3G60240.2; AT3G60240.2; AT3G60240
GeneIDi825194
GrameneiAT3G60240.2; AT3G60240.2; AT3G60240

Organism-specific databases

AraportiAT3G60240

Phylogenomic databases

eggNOGiENOG410IPIB Eukaryota
ENOG410ZIZB LUCA
HOGENOMiHOG000015159
OrthoDBi594395at2759
PhylomeDBiA8MR97

Gene expression databases

ExpressionAtlasiA8MR97 baseline and differential

Family and domain databases

Gene3Di1.25.40.180, 2 hits
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR003891 Initiation_fac_eIF4g_MI
IPR016021 MIF4-like_sf
IPR003890 MIF4G-like_typ-3
PfamiView protein in Pfam
PF02847 MA3, 1 hit
PF02854 MIF4G, 1 hit
SMARTiView protein in SMART
SM00544 MA3, 1 hit
SM00543 MIF4G, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS51366 MI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA8MR97_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8MR97
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: July 31, 2019
This is version 88 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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