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Protein

Golgin subfamily A member 8B

Gene

GOLGA8B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in maintaining Golgi structure.By similarity

Miscellaneous

Antibodies against GM88 are present in serum from a patient with Sjoegren syndrome. Sera from patients with Sjoegren syndrome often contain antibodies that react with normal components of the Golgi complex.

Caution

A family of highly similar proteins (GOLGA8A, GOLGA8B, GOLGA8C, GOLGA8D, GOLGA8E, GOLGA8F, GOLGA8G) are encoded by a repeated region on chromosome 15q11-15q13. Our sequences are in agreement with HGNC nomenclature.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Golgin subfamily A member 8B
Alternative name(s):
Golgin-67
Gene namesi
Name:GOLGA8B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000215252.11
HGNCiHGNC:31973 GOLGA8B
MIMi609619 gene
neXtProtiNX_A8MQT2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000215252
PharmGKBiPA142671717

Polymorphism and mutation databases

BioMutaiGOLGA8B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003160911 – 603Golgin subfamily A member 8BAdd BLAST603

Proteomic databases

MaxQBiA8MQT2
PaxDbiA8MQT2
PRIDEiA8MQT2
ProteomicsDBi1950
1951 [A8MQT2-2]

PTM databases

GlyConnecti1283
iPTMnetiA8MQT2
PhosphoSitePlusiA8MQT2

Expressioni

Tissue specificityi

Highly expressed in brain, heart and kidney. Detected at lower levels in liver, thymus, spleen, lung and peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000215252 Expressed in 95 organ(s), highest expression level in left lobe of thyroid gland
ExpressionAtlasiA8MQT2 baseline and differential
GenevisibleiA8MQT2 HS

Organism-specific databases

HPAiHPA051808

Interactioni

Protein-protein interaction databases

BioGridi136421, 1 interactor
STRINGi9606.ENSP00000267731

Structurei

3D structure databases

ProteinModelPortaliA8MQT2
SMRiA8MQT2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni491 – 603Golgi-targeting domainAdd BLAST113

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili82 – 173Sequence analysisAdd BLAST92
Coiled coili212 – 440Sequence analysisAdd BLAST229

Domaini

Extended rod-like protein with coiled-coil domains.

Sequence similaritiesi

Belongs to the GOLGA8 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4725 Eukaryota
ENOG410ZIE4 LUCA
GeneTreeiENSGT00530000062932
HOVERGENiHBG051752
InParanoidiA8MQT2
PhylomeDBiA8MQT2
TreeFamiTF316990

Family and domain databases

InterProiView protein in InterPro
IPR024858 Golgin_A
PANTHERiPTHR10881 PTHR10881, 1 hit
PfamiView protein in Pfam
PF15070 GOLGA2L5, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: A8MQT2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEETGQSKL AAAKKKFKEY WQRNRPGVPA AAKRNTKANG SSPETAASGG
60 70 80 90 100
CHSSEASSSA SSSLHARQSP CQEQAAVLNS RSIKISRLND TIKSLKQQKK
110 120 130 140 150
QVEHQLEEEK KANNEKQKAE RELEGQIQRL NTEKKKLNTD LYHMKHSLRY
160 170 180 190 200
FEEESKDLAG RLQRSSQRIG ELEWSLCAVA ATQKKKPDGF SSRSKALLKR
210 220 230 240 250
QLEQSIREQI LLKGHVTQLK ESLKEVQLER DQYAEQIKGE RAQWQQRMRK
260 270 280 290 300
MSQEVCTLKE EKKHDTHRVE ELERSLSRLK NQMAEPLPPD APAVSSEVEL
310 320 330 340 350
QDLRKELERV AGELQAQVEN NQCISLLNRG QKERLREQEE RLQEQQERLR
360 370 380 390 400
EREKRLQQLA EPQSDLEELK HENKSALQLE QQVKELQEKL GQVMETLTSA
410 420 430 440 450
EKEPEAAVPA SGTGGESSGL MDLLEEKADL REHVEKLELG FIQYRRERCH
460 470 480 490 500
QKVHRLLTEP GDSAKDASPG GGHHQAGPGQ GGEEGEAAGA AGDGVAACGS
510 520 530 540 550
YSEGHGKFLA AARNPAAEPS PGAPAPQELG AADKHGDLCE ASLTNSVEPA
560 570 580 590 600
QGEAREGSSQ DNPTAQPVLQ LLGEMQDHQE HPGLGSNCCV PCFCWAWLPR

RRR
Length:603
Mass (Da):67,278
Last modified:January 15, 2008 - v2
Checksum:iE314724D662AC0E4
GO
Isoform 2 (identifier: A8MQT2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-143: Missing.

Show »
Length:460
Mass (Da):51,408
Checksum:i528FAE1BD8341C60
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J1B5C9J1B5_HUMAN
Golgin subfamily A member 8B
GOLGA8B
633Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti181A → T in AAF34136 (PubMed:10660574).Curated1
Sequence conflicti352R → Q in AAF40308 (PubMed:10677249).Curated1
Sequence conflicti352R → Q in AAF34136 (PubMed:10660574).Curated1
Sequence conflicti352R → Q in AAI04801 (PubMed:15489334).Curated1
Sequence conflicti360A → S in AAF40308 (PubMed:10677249).Curated1
Sequence conflicti370Missing in AAF40308 (PubMed:10677249).Curated1
Sequence conflicti394M → T in AAF40308 (PubMed:10677249).Curated1
Sequence conflicti394M → T in AAF34136 (PubMed:10660574).Curated1
Sequence conflicti394M → T in AAI04801 (PubMed:15489334).Curated1
Sequence conflicti428A → V in AAF40308 (PubMed:10677249).Curated1
Sequence conflicti428A → V in AAI04801 (PubMed:15489334).Curated1
Sequence conflicti452K → N in AAF34136 (PubMed:10660574).Curated1
Sequence conflicti468S → A in AAF34136 (PubMed:10660574).Curated1
Sequence conflicti480Q → R in AAF40308 (PubMed:10677249).Curated1
Sequence conflicti480Q → R in AAF34136 (PubMed:10660574).Curated1
Sequence conflicti480Q → R in AAI04801 (PubMed:15489334).Curated1
Sequence conflicti488A → V in AAF40308 (PubMed:10677249).Curated1
Sequence conflicti488A → V in AAF34136 (PubMed:10660574).Curated1
Sequence conflicti488A → V in AAI04801 (PubMed:15489334).Curated1
Sequence conflicti493D → N in AAF34136 (PubMed:10660574).Curated1
Sequence conflicti569L → V in AAF40308 (PubMed:10677249).Curated1
Sequence conflicti569L → V in AAF34136 (PubMed:10660574).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0304961 – 143Missing in isoform 2. 2 PublicationsAdd BLAST143

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164622 mRNA Translation: AAF40308.1
AF163441 mRNA Translation: AAF34136.1
AC027139 Genomic DNA No translation available.
BC104800 mRNA Translation: AAI04801.1
CCDSiCCDS45211.1 [A8MQT2-1]
RefSeqiNP_001018861.3, NM_001023567.4 [A8MQT2-1]
XP_011519898.1, XM_011521596.1
XP_011519899.1, XM_011521597.1
XP_016877699.1, XM_017022210.1 [A8MQT2-1]
XP_016877700.1, XM_017022211.1
XP_016877701.1, XM_017022212.1
XP_016877702.1, XM_017022213.1
XP_016877704.1, XM_017022215.1 [A8MQT2-2]
XP_016877705.1, XM_017022216.1 [A8MQT2-2]
XP_016877706.1, XM_017022217.1 [A8MQT2-2]
XP_016877707.1, XM_017022218.1
UniGeneiHs.182982
Hs.720151

Genome annotation databases

EnsembliENST00000342314; ENSP00000343064; ENSG00000215252 [A8MQT2-1]
GeneIDi440270
KEGGihsa:440270
UCSCiuc001ziq.4 human [A8MQT2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164622 mRNA Translation: AAF40308.1
AF163441 mRNA Translation: AAF34136.1
AC027139 Genomic DNA No translation available.
BC104800 mRNA Translation: AAI04801.1
CCDSiCCDS45211.1 [A8MQT2-1]
RefSeqiNP_001018861.3, NM_001023567.4 [A8MQT2-1]
XP_011519898.1, XM_011521596.1
XP_011519899.1, XM_011521597.1
XP_016877699.1, XM_017022210.1 [A8MQT2-1]
XP_016877700.1, XM_017022211.1
XP_016877701.1, XM_017022212.1
XP_016877702.1, XM_017022213.1
XP_016877704.1, XM_017022215.1 [A8MQT2-2]
XP_016877705.1, XM_017022216.1 [A8MQT2-2]
XP_016877706.1, XM_017022217.1 [A8MQT2-2]
XP_016877707.1, XM_017022218.1
UniGeneiHs.182982
Hs.720151

3D structure databases

ProteinModelPortaliA8MQT2
SMRiA8MQT2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi136421, 1 interactor
STRINGi9606.ENSP00000267731

PTM databases

GlyConnecti1283
iPTMnetiA8MQT2
PhosphoSitePlusiA8MQT2

Polymorphism and mutation databases

BioMutaiGOLGA8B

Proteomic databases

MaxQBiA8MQT2
PaxDbiA8MQT2
PRIDEiA8MQT2
ProteomicsDBi1950
1951 [A8MQT2-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342314; ENSP00000343064; ENSG00000215252 [A8MQT2-1]
GeneIDi440270
KEGGihsa:440270
UCSCiuc001ziq.4 human [A8MQT2-1]

Organism-specific databases

CTDi440270
EuPathDBiHostDB:ENSG00000215252.11
GeneCardsiGOLGA8B
H-InvDBiHIX0026849
HIX0026857
HIX0172620
HIX0172622
HIX0172638
HIX0172640
HIX0172767
HIX0193611
HIX0193615
HIX0193625
HGNCiHGNC:31973 GOLGA8B
HPAiHPA051808
MIMi609619 gene
neXtProtiNX_A8MQT2
OpenTargetsiENSG00000215252
PharmGKBiPA142671717
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4725 Eukaryota
ENOG410ZIE4 LUCA
GeneTreeiENSGT00530000062932
HOVERGENiHBG051752
InParanoidiA8MQT2
PhylomeDBiA8MQT2
TreeFamiTF316990

Miscellaneous databases

ChiTaRSiGOLGA8B human
GenomeRNAii440270
PROiPR:A8MQT2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000215252 Expressed in 95 organ(s), highest expression level in left lobe of thyroid gland
ExpressionAtlasiA8MQT2 baseline and differential
GenevisibleiA8MQT2 HS

Family and domain databases

InterProiView protein in InterPro
IPR024858 Golgin_A
PANTHERiPTHR10881 PTHR10881, 1 hit
PfamiView protein in Pfam
PF15070 GOLGA2L5, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiGOG8B_HUMAN
AccessioniPrimary (citable) accession number: A8MQT2
Secondary accession number(s): A6NLZ2
, O94937, Q2M3S9, Q9NZG8, Q9NZW0, Q9NZW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: October 10, 2018
This is version 79 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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