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Entry version 104 (17 Jun 2020)
Sequence version 2 (08 Mar 2011)
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Protein

Zinc finger protein 850

Gene

ZNF850

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri197 – 219C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 499C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri505 – 527C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri533 – 555C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri561 – 583C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri589 – 611C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri617 – 639C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri645 – 667C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri673 – 695C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri701 – 723C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri729 – 751C2H2-type 20; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri757 – 779C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri785 – 807C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri813 – 835C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri841 – 863C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri869 – 891C2H2-type 25PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri897 – 919C2H2-type 26PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri925 – 947C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri953 – 975C2H2-type 28PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri981 – 1003C2H2-type 29PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1009 – 1031C2H2-type 30PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1037 – 1059C2H2-type 31PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1065 – 1087C2H2-type 32PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 850
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF850
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000267041.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:27994 ZNF850

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A8MQ14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000267041

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
A8MQ14 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF850

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003322691 – 1090Zinc finger protein 850Add BLAST1090

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A8MQ14

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A8MQ14

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
A8MQ14

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A8MQ14

PeptideAtlas

More...
PeptideAtlasi
A8MQ14

PRoteomics IDEntifications database

More...
PRIDEi
A8MQ14

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
1933

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A8MQ14

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A8MQ14

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000267041 Expressed in oocyte and 121 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A8MQ14 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A8MQ14 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000267041 Tissue enhanced (placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
131203, 2 interactors

Protein interaction database and analysis system

More...
IntActi
A8MQ14, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000464976

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
A8MQ14 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A8MQ14

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 78KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri197 – 219C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 499C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri505 – 527C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri533 – 555C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri561 – 583C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri589 – 611C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri617 – 639C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri645 – 667C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri673 – 695C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri701 – 723C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri729 – 751C2H2-type 20; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri757 – 779C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri785 – 807C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri813 – 835C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri841 – 863C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri869 – 891C2H2-type 25PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri897 – 919C2H2-type 26PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri925 – 947C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri953 – 975C2H2-type 28PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri981 – 1003C2H2-type 29PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1009 – 1031C2H2-type 30PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1037 – 1059C2H2-type 31PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1065 – 1087C2H2-type 32PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182806

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_17_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A8MQ14

KEGG Orthology (KO)

More...
KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
PCACKEY

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A8MQ14

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 28 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 30 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 19 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 29 hits
PS50157 ZINC_FINGER_C2H2_2, 32 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A8MQ14-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNMEGLVMFQ DLSIDFSQEE WECLDAAQKD LYRDVMMENY SSLVSLGLSI
60 70 80 90 100
PKPDVISLLE QGKEPWMVSR DVLGGWCRDS EFRCKTKDSC LPKEIYEVTS
110 120 130 140 150
SQWVRMEKCH SLVGSSVRDD WECKGQFQHQ DINQERYLEK AIMTYETTPT
160 170 180 190 200
FCLQTSLTLH HRIHPGEKLY KSTECMAFKY GSELTQQQET HTGEKLYKCK
210 220 230 240 250
ECGKAFHHFS YLVKHQRIHT GEKPCACKEY GKAFISGSHL IQHQKMYTDE
260 270 280 290 300
RPHECQESVK AFRPSAHLIQ HWRIHTGDKP YECKECGKSF TSGSTLNQHQ
310 320 330 340 350
QIHTGEKPYH CKQCGKSFTV GSTLIRHQQI HTGEKPYDCK ECGKSFASGS
360 370 380 390 400
ALIRHQRIHT GEKPYDCKEC GKSFTFHSAL IRHQRIHTGE KPYDCKECGK
410 420 430 440 450
SFTFRSGLIG HQAIHTGEKP YDCKECGKSF TAGSTLIQHQ RIHTGEKPYD
460 470 480 490 500
CKECGKSFAS GSALLQHQRI HTGEKPYCCK ECGKSFTFRS TRNRHQRIHT
510 520 530 540 550
GEKPYNCKEC GKSFASGSAL LQHQRIHTGE KPYHCKECGK SFTFRSGLIG
560 570 580 590 600
HQAVHTGEKP YDCKECGKSF TSRSALIQHQ RIHTGEKPYH CKECGKSFTV
610 620 630 640 650
GSTLLQHQQI HTGEKPYDCK ECGKAFRLRL RLTQHQQIHT GEKPYQCQEC
660 670 680 690 700
GKAFVSVSGL TQHHRIHTGE KPYECPDCGK AFRQRTYLNQ HRRIHTGEKP
710 720 730 740 750
YECKECGKSF TFCSGLIQHQ QNHTDEKPYD GKECGKSFTS HSTLIQHQQI
760 770 780 790 800
HTGEKPYDCK ECGKSFTSHS TLIQHQQIHT GEKLYDCKEC GKSFTSHSTL
810 820 830 840 850
IQHQPLHTGE KPYHCKECGK SFTLRSALIQ HRPVHTGEKR YSCKECGKSF
860 870 880 890 900
TSRSTLIEHQ RIHTGEKPYH CKECGKSFAF RSAIIQHRRI HTGEKPYDCK
910 920 930 940 950
ECGKAFRRRS KLTQHQRIHT GEKPYRCHEC GKAFVRFSGL TKHHSIHTGE
960 970 980 990 1000
KPYECKTCGK SFRQRTHLTL HQRIHTGDRP YECKECGKSF TCGSELIRHQ
1010 1020 1030 1040 1050
RTHTGEKPYD CKECGKAFRC PSQLSQHKRI HTGEKTYQCP ECGKAFFYAS
1060 1070 1080 1090
GLSRHQSVHT GEKPYECKTC GKAFKQLTQL TRHQRIHDLT
Length:1,090
Mass (Da):125,431
Last modified:March 8, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6A02205E3BFB8F30
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0M6A0A087X0M6_HUMAN
Zinc finger protein 850
ZNF850
1,058Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJI8K7EJI8_HUMAN
Zinc finger protein 850
ZNF850
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC020928 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS59379.1

NCBI Reference Sequences

More...
RefSeqi
NP_001180481.1, NM_001193552.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000591344; ENSP00000464976; ENSG00000267041

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
342892

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:342892

UCSC genome browser

More...
UCSCi
uc010efc.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020928 Genomic DNA No translation available.
CCDSiCCDS59379.1
RefSeqiNP_001180481.1, NM_001193552.1

3D structure databases

SMRiA8MQ14
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi131203, 2 interactors
IntActiA8MQ14, 1 interactor
STRINGi9606.ENSP00000464976

PTM databases

iPTMnetiA8MQ14
PhosphoSitePlusiA8MQ14

Polymorphism and mutation databases

BioMutaiZNF850

Proteomic databases

EPDiA8MQ14
jPOSTiA8MQ14
MassIVEiA8MQ14
PaxDbiA8MQ14
PeptideAtlasiA8MQ14
PRIDEiA8MQ14
ProteomicsDBi1933

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
71746 4 antibodies

Genome annotation databases

EnsembliENST00000591344; ENSP00000464976; ENSG00000267041
GeneIDi342892
KEGGihsa:342892
UCSCiuc010efc.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
342892
EuPathDBiHostDB:ENSG00000267041.5

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF850
HGNCiHGNC:27994 ZNF850
HPAiENSG00000267041 Tissue enhanced (placenta)
neXtProtiNX_A8MQ14
OpenTargetsiENSG00000267041

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00950000182806
HOGENOMiCLU_002678_17_1_1
InParanoidiA8MQ14
KOiK09228
OMAiPCACKEY
OrthoDBi1318335at2759
PhylomeDBiA8MQ14

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
342892 4 hits in 780 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF850 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
342892
PharosiA8MQ14 Tdark

Protein Ontology

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PROi
PR:A8MQ14
RNActiA8MQ14 protein

Gene expression databases

BgeeiENSG00000267041 Expressed in oocyte and 121 other tissues
ExpressionAtlasiA8MQ14 baseline and differential
GenevisibleiA8MQ14 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 28 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 30 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 19 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 29 hits
PS50157 ZINC_FINGER_C2H2_2, 32 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN850_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8MQ14
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 8, 2011
Last modified: June 17, 2020
This is version 104 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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