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UniProtKB - A8MQ02 (A8MQ02_HUMAN)

Entry version 101 (10 Feb 2021)
Sequence version 2 (29 Oct 2014)
Previous versions | rss
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Protein
Submitted name:

Afadin

Gene

AFDN

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesionARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
AfadinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AFDNImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7137, AFDN

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000130396.20

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000130396

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		A8MQ02

PeptideAtlas

More...PeptideAtlasi		A8MQ02

PRoteomics IDEntifications database

More...PRIDEi		A8MQ02

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		1928

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000130396, Expressed in oviduct epithelium and 216 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A8MQ02, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		A8MQ02, 1 interactor

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 92Ras-associatingInterPro annotationAdd BLAST92
Domaini205 – 307Ras-associatingInterPro annotationAdd BLAST103
Domaini627 – 867DiluteInterPro annotationAdd BLAST241
Domaini966 – 1052PDZInterPro annotationAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni87 – 153DisorderedSequence analysisAdd BLAST67
Regioni308 – 337DisorderedSequence analysisAdd BLAST30
Regioni493 – 554DisorderedSequence analysisAdd BLAST62
Regioni1066 – 1182DisorderedSequence analysisAdd BLAST117
Regioni1194 – 1432DisorderedSequence analysisAdd BLAST239
Regioni1460 – 1487DisorderedSequence analysisAdd BLAST28
Regioni1528 – 1676DisorderedSequence analysisAdd BLAST149
Regioni1693 – 1781DisorderedSequence analysisAdd BLAST89

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi102 – 153PolyampholyteSequence analysisAdd BLAST52
Compositional biasi308 – 328PolyampholyteSequence analysisAdd BLAST21
Compositional biasi503 – 527PolarSequence analysisAdd BLAST25
Compositional biasi1088 – 1104PolarSequence analysisAdd BLAST17
Compositional biasi1113 – 1128PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1130 – 1168PolarSequence analysisAdd BLAST39
Compositional biasi1233 – 1259PolyampholyteSequence analysisAdd BLAST27
Compositional biasi1261 – 1299PolarSequence analysisAdd BLAST39
Compositional biasi1319 – 1334Pro-richSequence analysisAdd BLAST16
Compositional biasi1365 – 1401PolyampholyteSequence analysisAdd BLAST37
Compositional biasi1402 – 1432PolarSequence analysisAdd BLAST31
Compositional biasi1473 – 1487PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1549 – 1633PolyampholyteSequence analysisAdd BLAST85
Compositional biasi1639 – 1668Pro-richSequence analysisAdd BLAST30
Compositional biasi1719 – 1733PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1734 – 1765PolarSequence analysisAdd BLAST32
Compositional biasi1766 – 1781PolyampholyteSequence analysisAdd BLAST16

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155237

Database of Orthologous Groups

More...OrthoDBi		23029at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd00060, FHA, 1 hit
cd15471, Myo5p-like_CBD_afadin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037977, CBD_Afadin
IPR002710, Dilute_dom
IPR000253, FHA_dom
IPR001478, PDZ
IPR036034, PDZ_sf
IPR000159, RA_dom
IPR008984, SMAD_FHA_dom_sf
IPR029071, Ubiquitin-like_domsf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01843, DIL, 1 hit
PF00498, FHA, 1 hit
PF00595, PDZ, 1 hit
PF00788, RA, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01132, DIL, 1 hit
SM00240, FHA, 1 hit
SM00228, PDZ, 1 hit
SM00314, RA, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49879, SSF49879, 1 hit
SSF50156, SSF50156, 1 hit
SSF54236, SSF54236, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51126, DILUTE, 1 hit
PS50106, PDZ, 1 hit
PS50200, RA, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All

A8MQ02-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRFYFQDKAA GNFATKCIRV SSTATTQDVI ETLAEKFRPD MRMLSSPKYS 
        60         70         80         90        100
LYEVHVSGEE RRLDIDEKPL VVQLNWNKDD REGRFVLKNE NDAIPPKKAQ 
       110        120        130        140        150
SNGPEKQEKE GVIQNFKRTL SKKEKKEKKK REKEALRQAS DKDDRPFQGE 
       160        170        180        190        200
DVENSRLAAE VYKDMPETSF TRTISNPEVV MKRRRQQKLE KRMQEFRSSD 
       210        220        230        240        250
GRPDSGGTLR IYADSLKPNI PYKTILLSTT DPADFAVAEA LEKYGLEKEN 
       260        270        280        290        300
PKDYCIARVM LPPGAQHSDE KGAKEIILDD DECPLQIFRE WPSDKGILVF 
       310        320        330        340        350
QLKRRPPDHI PKKTKKHLEG KTPKGKERAD GSGYGSTLPP EKLPYLVELS 
       360        370        380        390        400
PGRRNHFAYY NYHTYEDGSD SRDKPKLYRL QLSVTEVGTE KLDDNSIQLF 
       410        420        430        440        450
GPGIQPHHCD LTNMDGVVTV TPRSMDAETY VEGQRISETT MLQSGMKVQF 
       460        470        480        490        500
GASHVFKFVD PSQDHALAKR SVDGGLMVKG PRHKPGIVQE TTFDLGGDIH 
       510        520        530        540        550
SGTALPTSKS TTRLDSDRVS SASSTAERGM VKPMIRVEQQ PDYRRQESRT 
       560        570        580        590        600
QDASGPELIL PASIEFRESS EDSFLSAIIN YTNSSTVHFK LSPTYVLYMA 
       610        620        630        640        650
CRYVLSNQYR PDISPTERTH KVIAVVNKMV SMMEGVIQKQ KNIAGALAFW 
       660        670        680        690        700
MANASELLNF IKQDRDLSRI TLDAQDVLAH LVQMAFKYLV HCLQSELNNY 
       710        720        730        740        750
MPAFLDDPEE NSLQRPKIDD VLHTLTGAMS LLRRCRVNAA LTIQLFSQLF 
       760        770        780        790        800
HFINMWLFNR LVTDPDSGLC SHYWGAIIRQ QLGHIEAWAE KQGLELAADC 
       810        820        830        840        850
HLSRIVQATT LLTMDKYAPD DIPNINSTCF KLNSLQLQAL LQNYHCAPDE 
       860        870        880        890        900
PFIPTDLIEN VVTVAENTAD ELARSDGREV QLEEDPDLQL PFLLPEDGYS 
       910        920        930        940        950
CDVVRNIPNG LQEFLDPLCQ RGFCRLIPHT RSPGTWTIYF EGADYESHLL 
       960        970        980        990       1000
RENTELAQPL RKEPEIITVT LKKQNGMGLS IVAAKGAGQD KLGIYVKSVV 
      1010       1020       1030       1040       1050
KGGAADVDGR LAAGDQLLSV DGRSLVGLSQ ERAAELMTRT SSVVTLEVAK 
      1060       1070       1080       1090       1100
QGAIYHGLAT LLNQPSPMMQ RISDRRGSGK PRPKSEGFEL YNNSTQNGSP 
      1110       1120       1130       1140       1150
ESPQLPWAEY SEPKKLPGDD RLMKNRADHR SSPNVANQPP SPGGKSAYAS 
      1160       1170       1180       1190       1200
GTTAKITSVS TGNLCTEEQT PPPRPEAYPI PTQTYTREYF TFPASKSQDR 
      1210       1220       1230       1240       1250
MAPPQNQWPN YEEKPHMHTD SNHSSIAIQR VTRSQEELRE DKAYQLERHR 
      1260       1270       1280       1290       1300
IEAAMDRKSD SDMWINQSSS LDSSTSSQEH LNHSSKSVTP ASTLTKSGPG 
      1310       1320       1330       1340       1350
RWKTPAAIPA TPVAVSQPIR TDLPPPPPPP PVHYAGDFDG MSMDLPLPPP 
      1360       1370       1380       1390       1400
PSANQIGLPS AQVAAAERRK REEHQRWYEK EKARLEEERE RKRREQERKL 
      1410       1420       1430       1440       1450
GQMRTQSLNP APFSPLTAQQ MKPEKPSTLQ RPQETVIREL QPQQQPRTIE 
      1460       1470       1480       1490       1500
RRDLQYITVS KEELSSGDSL SPDPWKRDAK EKLEKQQQMH IVDMLSKEIQ 
      1510       1520       1530       1540       1550
ELQSKPDRSA EESDRLRKLM LEWQFQKRLQ ESKQKDEDDE EEEDDDVDTM 
      1560       1570       1580       1590       1600
LIMQRLEAER RARDEERRRQ QQLEEMRKRE AEDRARQEEE RRRQEEERTK 
      1610       1620       1630       1640       1650
RDAEEKRRQE EGYYSRLEAE RRRQHDEAAR RLLEPEAPGL CRPPLPRDYE 
      1660       1670       1680       1690       1700
PPSPSPAPGA PPPPPQRNAS YLKTQVLSPD SLFTAKFVAY NEEEEEEDCS 
      1710       1720       1730       1740       1750
LAGPNSYPGS TGAAVGAHDA CRDAKEKRSK SQDADSPGSS GAPENLTFKE 
      1760       1770       1780 
RQRLFSQGQD VSNKVKASRK LTELENELNT K
Length:1,781
Mass (Da):201,806
Last modified:October 29, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF68F525A0822AD73
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P55196AFAD_HUMAN
Afadin
AFDN AF6, MLLT4
1,824Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KN01J3KN01_HUMAN
Afadin
AFDN
1,831Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5TIG5Q5TIG5_HUMAN
Afadin
AFDN
1,665Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y7R8H0Y7R8_HUMAN
Afadin
AFDN
389Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PFY5E9PFY5_HUMAN
Afadin
AFDN
250Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W9I4F8W9I4_HUMAN
Afadin
AFDN
247Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YA98H0YA98_HUMAN
Afadin
AFDN
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8L4H0Y8L4_HUMAN
Afadin
AFDN
313Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8U8H0Y8U8_HUMAN
Afadin
AFDN
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y948H0Y948_HUMAN
Afadin
AFDN
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL009178 Genomic DNA No translation available.
AL049698 Genomic DNA No translation available.
AL731868 Genomic DNA No translation available.
KF458344 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		NP_001278893.1, NM_001291964.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000366806; ENSP00000355771; ENSG00000130396

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4301

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4301

UCSC genome browser

More...UCSCi		uc021zik.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009178 Genomic DNA No translation available.
AL049698 Genomic DNA No translation available.
AL731868 Genomic DNA No translation available.
KF458344 Genomic DNA No translation available.
RefSeqiNP_001278893.1, NM_001291964.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

IntActiA8MQ02, 1 interactor

Proteomic databases

EPDiA8MQ02
PeptideAtlasiA8MQ02
PRIDEiA8MQ02
ProteomicsDBi1928

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4608, 260 antibodies

Genome annotation databases

EnsembliENST00000366806; ENSP00000355771; ENSG00000130396
GeneIDi4301
KEGGihsa:4301
UCSCiuc021zik.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4301
HGNCiHGNC:7137, AFDN
OpenTargetsiENSG00000130396
VEuPathDBiHostDB:ENSG00000130396.20

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00940000155237
OrthoDBi23029at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4301, 23 hits in 880 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		AFDN, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4301

Gene expression databases

BgeeiENSG00000130396, Expressed in oviduct epithelium and 216 other tissues
ExpressionAtlasiA8MQ02, baseline and differential

Family and domain databases

CDDicd00060, FHA, 1 hit
cd15471, Myo5p-like_CBD_afadin, 1 hit
Gene3Di2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR037977, CBD_Afadin
IPR002710, Dilute_dom
IPR000253, FHA_dom
IPR001478, PDZ
IPR036034, PDZ_sf
IPR000159, RA_dom
IPR008984, SMAD_FHA_dom_sf
IPR029071, Ubiquitin-like_domsf
PfamiView protein in Pfam
PF01843, DIL, 1 hit
PF00498, FHA, 1 hit
PF00595, PDZ, 1 hit
PF00788, RA, 2 hits
SMARTiView protein in SMART
SM01132, DIL, 1 hit
SM00240, FHA, 1 hit
SM00228, PDZ, 1 hit
SM00314, RA, 2 hits
SUPFAMiSSF49879, SSF49879, 1 hit
SSF50156, SSF50156, 1 hit
SSF54236, SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS51126, DILUTE, 1 hit
PS50106, PDZ, 1 hit
PS50200, RA, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA8MQ02_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8MQ02
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: October 29, 2014
Last modified: February 10, 2021
This is version 101 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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