UniProtKB - A8MQ02 (A8MQ02_HUMAN)
Protein
Submitted name:
Afadin
Gene
AFDN
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- cell adhesion Source: UniProtKB-KW
- signal transduction Source: InterPro
Keywordsi
Biological process | Cell adhesionARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: AfadinImported |
Gene namesi | Name:AFDNImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7137, AFDN |
VEuPathDBi | HostDB:ENSG00000130396.20 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear speck Source: HPA
- nucleoplasm Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- cell junction Source: HPA
Expressioni
Gene expression databases
Bgeei | ENSG00000130396, Expressed in oviduct epithelium and 216 other tissues |
ExpressionAtlasi | A8MQ02, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 92 | Ras-associatingInterPro annotationAdd BLAST | 92 | |
Domaini | 205 – 307 | Ras-associatingInterPro annotationAdd BLAST | 103 | |
Domaini | 627 – 867 | DiluteInterPro annotationAdd BLAST | 241 | |
Domaini | 966 – 1052 | PDZInterPro annotationAdd BLAST | 87 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 87 – 153 | DisorderedSequence analysisAdd BLAST | 67 | |
Regioni | 308 – 337 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 493 – 554 | DisorderedSequence analysisAdd BLAST | 62 | |
Regioni | 1066 – 1182 | DisorderedSequence analysisAdd BLAST | 117 | |
Regioni | 1194 – 1432 | DisorderedSequence analysisAdd BLAST | 239 | |
Regioni | 1460 – 1487 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 1528 – 1676 | DisorderedSequence analysisAdd BLAST | 149 | |
Regioni | 1693 – 1781 | DisorderedSequence analysisAdd BLAST | 89 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 102 – 153 | PolyampholyteSequence analysisAdd BLAST | 52 | |
Compositional biasi | 308 – 328 | PolyampholyteSequence analysisAdd BLAST | 21 | |
Compositional biasi | 503 – 527 | PolarSequence analysisAdd BLAST | 25 | |
Compositional biasi | 1088 – 1104 | PolarSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1113 – 1128 | PolyampholyteSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1130 – 1168 | PolarSequence analysisAdd BLAST | 39 | |
Compositional biasi | 1233 – 1259 | PolyampholyteSequence analysisAdd BLAST | 27 | |
Compositional biasi | 1261 – 1299 | PolarSequence analysisAdd BLAST | 39 | |
Compositional biasi | 1319 – 1334 | Pro-richSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1365 – 1401 | PolyampholyteSequence analysisAdd BLAST | 37 | |
Compositional biasi | 1402 – 1432 | PolarSequence analysisAdd BLAST | 31 | |
Compositional biasi | 1473 – 1487 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1549 – 1633 | PolyampholyteSequence analysisAdd BLAST | 85 | |
Compositional biasi | 1639 – 1668 | Pro-richSequence analysisAdd BLAST | 30 | |
Compositional biasi | 1719 – 1733 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1734 – 1765 | PolarSequence analysisAdd BLAST | 32 | |
Compositional biasi | 1766 – 1781 | PolyampholyteSequence analysisAdd BLAST | 16 |
Phylogenomic databases
GeneTreei | ENSGT00940000155237 |
OrthoDBi | 23029at2759 |
Family and domain databases
CDDi | cd00060, FHA, 1 hit cd15471, Myo5p-like_CBD_afadin, 1 hit |
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR037977, CBD_Afadin IPR002710, Dilute_dom IPR000253, FHA_dom IPR001478, PDZ IPR036034, PDZ_sf IPR000159, RA_dom IPR008984, SMAD_FHA_dom_sf IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF01843, DIL, 1 hit PF00498, FHA, 1 hit PF00595, PDZ, 1 hit PF00788, RA, 2 hits |
SMARTi | View protein in SMART SM01132, DIL, 1 hit SM00240, FHA, 1 hit SM00228, PDZ, 1 hit SM00314, RA, 2 hits |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF50156, SSF50156, 1 hit SSF54236, SSF54236, 2 hits |
PROSITEi | View protein in PROSITE PS51126, DILUTE, 1 hit PS50106, PDZ, 1 hit PS50200, RA, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All
A8MQ02-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRFYFQDKAA GNFATKCIRV SSTATTQDVI ETLAEKFRPD MRMLSSPKYS
60 70 80 90 100
LYEVHVSGEE RRLDIDEKPL VVQLNWNKDD REGRFVLKNE NDAIPPKKAQ
110 120 130 140 150
SNGPEKQEKE GVIQNFKRTL SKKEKKEKKK REKEALRQAS DKDDRPFQGE
160 170 180 190 200
DVENSRLAAE VYKDMPETSF TRTISNPEVV MKRRRQQKLE KRMQEFRSSD
210 220 230 240 250
GRPDSGGTLR IYADSLKPNI PYKTILLSTT DPADFAVAEA LEKYGLEKEN
260 270 280 290 300
PKDYCIARVM LPPGAQHSDE KGAKEIILDD DECPLQIFRE WPSDKGILVF
310 320 330 340 350
QLKRRPPDHI PKKTKKHLEG KTPKGKERAD GSGYGSTLPP EKLPYLVELS
360 370 380 390 400
PGRRNHFAYY NYHTYEDGSD SRDKPKLYRL QLSVTEVGTE KLDDNSIQLF
410 420 430 440 450
GPGIQPHHCD LTNMDGVVTV TPRSMDAETY VEGQRISETT MLQSGMKVQF
460 470 480 490 500
GASHVFKFVD PSQDHALAKR SVDGGLMVKG PRHKPGIVQE TTFDLGGDIH
510 520 530 540 550
SGTALPTSKS TTRLDSDRVS SASSTAERGM VKPMIRVEQQ PDYRRQESRT
560 570 580 590 600
QDASGPELIL PASIEFRESS EDSFLSAIIN YTNSSTVHFK LSPTYVLYMA
610 620 630 640 650
CRYVLSNQYR PDISPTERTH KVIAVVNKMV SMMEGVIQKQ KNIAGALAFW
660 670 680 690 700
MANASELLNF IKQDRDLSRI TLDAQDVLAH LVQMAFKYLV HCLQSELNNY
710 720 730 740 750
MPAFLDDPEE NSLQRPKIDD VLHTLTGAMS LLRRCRVNAA LTIQLFSQLF
760 770 780 790 800
HFINMWLFNR LVTDPDSGLC SHYWGAIIRQ QLGHIEAWAE KQGLELAADC
810 820 830 840 850
HLSRIVQATT LLTMDKYAPD DIPNINSTCF KLNSLQLQAL LQNYHCAPDE
860 870 880 890 900
PFIPTDLIEN VVTVAENTAD ELARSDGREV QLEEDPDLQL PFLLPEDGYS
910 920 930 940 950
CDVVRNIPNG LQEFLDPLCQ RGFCRLIPHT RSPGTWTIYF EGADYESHLL
960 970 980 990 1000
RENTELAQPL RKEPEIITVT LKKQNGMGLS IVAAKGAGQD KLGIYVKSVV
1010 1020 1030 1040 1050
KGGAADVDGR LAAGDQLLSV DGRSLVGLSQ ERAAELMTRT SSVVTLEVAK
1060 1070 1080 1090 1100
QGAIYHGLAT LLNQPSPMMQ RISDRRGSGK PRPKSEGFEL YNNSTQNGSP
1110 1120 1130 1140 1150
ESPQLPWAEY SEPKKLPGDD RLMKNRADHR SSPNVANQPP SPGGKSAYAS
1160 1170 1180 1190 1200
GTTAKITSVS TGNLCTEEQT PPPRPEAYPI PTQTYTREYF TFPASKSQDR
1210 1220 1230 1240 1250
MAPPQNQWPN YEEKPHMHTD SNHSSIAIQR VTRSQEELRE DKAYQLERHR
1260 1270 1280 1290 1300
IEAAMDRKSD SDMWINQSSS LDSSTSSQEH LNHSSKSVTP ASTLTKSGPG
1310 1320 1330 1340 1350
RWKTPAAIPA TPVAVSQPIR TDLPPPPPPP PVHYAGDFDG MSMDLPLPPP
1360 1370 1380 1390 1400
PSANQIGLPS AQVAAAERRK REEHQRWYEK EKARLEEERE RKRREQERKL
1410 1420 1430 1440 1450
GQMRTQSLNP APFSPLTAQQ MKPEKPSTLQ RPQETVIREL QPQQQPRTIE
1460 1470 1480 1490 1500
RRDLQYITVS KEELSSGDSL SPDPWKRDAK EKLEKQQQMH IVDMLSKEIQ
1510 1520 1530 1540 1550
ELQSKPDRSA EESDRLRKLM LEWQFQKRLQ ESKQKDEDDE EEEDDDVDTM
1560 1570 1580 1590 1600
LIMQRLEAER RARDEERRRQ QQLEEMRKRE AEDRARQEEE RRRQEEERTK
1610 1620 1630 1640 1650
RDAEEKRRQE EGYYSRLEAE RRRQHDEAAR RLLEPEAPGL CRPPLPRDYE
1660 1670 1680 1690 1700
PPSPSPAPGA PPPPPQRNAS YLKTQVLSPD SLFTAKFVAY NEEEEEEDCS
1710 1720 1730 1740 1750
LAGPNSYPGS TGAAVGAHDA CRDAKEKRSK SQDADSPGSS GAPENLTFKE
1760 1770 1780
RQRLFSQGQD VSNKVKASRK LTELENELNT K
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP55196 | AFAD_HUMAN | Afadin | AFDN AF6, MLLT4 | 1,824 | Annotation score: | ||
J3KN01 | J3KN01_HUMAN | Afadin | AFDN | 1,831 | Annotation score: | ||
Q5TIG5 | Q5TIG5_HUMAN | Afadin | AFDN | 1,665 | Annotation score: | ||
H0Y7R8 | H0Y7R8_HUMAN | Afadin | AFDN | 389 | Annotation score: | ||
E9PFY5 | E9PFY5_HUMAN | Afadin | AFDN | 250 | Annotation score: | ||
F8W9I4 | F8W9I4_HUMAN | Afadin | AFDN | 247 | Annotation score: | ||
H0YA98 | H0YA98_HUMAN | Afadin | AFDN | 167 | Annotation score: | ||
H0Y8L4 | H0Y8L4_HUMAN | Afadin | AFDN | 313 | Annotation score: | ||
H0Y8U8 | H0Y8U8_HUMAN | Afadin | AFDN | 124 | Annotation score: | ||
H0Y948 | H0Y948_HUMAN | Afadin | AFDN | 191 | Annotation score: | ||
There is more potential isoformShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL009178 Genomic DNA No translation available. AL049698 Genomic DNA No translation available. AL731868 Genomic DNA No translation available. KF458344 Genomic DNA No translation available. |
RefSeqi | NP_001278893.1, NM_001291964.1 |
Genome annotation databases
Ensembli | ENST00000366806; ENSP00000355771; ENSG00000130396 |
GeneIDi | 4301 |
KEGGi | hsa:4301 |
UCSCi | uc021zik.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL009178 Genomic DNA No translation available. AL049698 Genomic DNA No translation available. AL731868 Genomic DNA No translation available. KF458344 Genomic DNA No translation available. |
RefSeqi | NP_001278893.1, NM_001291964.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | A8MQ02, 1 interactor |
Proteomic databases
EPDi | A8MQ02 |
PeptideAtlasi | A8MQ02 |
PRIDEi | A8MQ02 |
ProteomicsDBi | 1928 |
Protocols and materials databases
Antibodypediai | 4608, 260 antibodies |
Genome annotation databases
Ensembli | ENST00000366806; ENSP00000355771; ENSG00000130396 |
GeneIDi | 4301 |
KEGGi | hsa:4301 |
UCSCi | uc021zik.2, human |
Organism-specific databases
CTDi | 4301 |
HGNCi | HGNC:7137, AFDN |
OpenTargetsi | ENSG00000130396 |
VEuPathDBi | HostDB:ENSG00000130396.20 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155237 |
OrthoDBi | 23029at2759 |
Miscellaneous databases
BioGRID-ORCSi | 4301, 23 hits in 880 CRISPR screens |
ChiTaRSi | AFDN, human |
GenomeRNAii | 4301 |
Gene expression databases
Bgeei | ENSG00000130396, Expressed in oviduct epithelium and 216 other tissues |
ExpressionAtlasi | A8MQ02, baseline and differential |
Family and domain databases
CDDi | cd00060, FHA, 1 hit cd15471, Myo5p-like_CBD_afadin, 1 hit |
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR037977, CBD_Afadin IPR002710, Dilute_dom IPR000253, FHA_dom IPR001478, PDZ IPR036034, PDZ_sf IPR000159, RA_dom IPR008984, SMAD_FHA_dom_sf IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF01843, DIL, 1 hit PF00498, FHA, 1 hit PF00595, PDZ, 1 hit PF00788, RA, 2 hits |
SMARTi | View protein in SMART SM01132, DIL, 1 hit SM00240, FHA, 1 hit SM00228, PDZ, 1 hit SM00314, RA, 2 hits |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF50156, SSF50156, 1 hit SSF54236, SSF54236, 2 hits |
PROSITEi | View protein in PROSITE PS51126, DILUTE, 1 hit PS50106, PDZ, 1 hit PS50200, RA, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A8MQ02_HUMAN | |
Accessioni | A8MQ02Primary (citable) accession number: A8MQ02 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 4, 2007 |
Last sequence update: | October 29, 2014 | |
Last modified: | February 10, 2021 | |
This is version 101 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |