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Protein

Carbohydrate deacetylase

Gene

YDJC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei13Proton acceptorBy similarity1
Metal bindingi14MagnesiumBy similarity1
Metal bindingi134Magnesium; via pros nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Carbohydrate deacetylaseBy similarity (EC:3.5.1.-By similarity)
Gene namesi
Name:YDJC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000161179.13
HGNCiHGNC:27158 YDJC
neXtProtiNX_A8MPS7

Pathology & Biotechi

Organism-specific databases

DisGeNETi150223
OpenTargetsiENSG00000161179
PharmGKBiPA162409362

Polymorphism and mutation databases

BioMutaiYDJC

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003287741 – 323Carbohydrate deacetylaseAdd BLAST323

Proteomic databases

EPDiA8MPS7
MaxQBiA8MPS7
PaxDbiA8MPS7
PRIDEiA8MPS7
ProteomicsDBi1911
1912 [A8MPS7-2]
1913 [A8MPS7-3]

PTM databases

iPTMnetiA8MPS7
PhosphoSitePlusiA8MPS7

Expressioni

Gene expression databases

BgeeiENSG00000161179 Expressed in 139 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_YDJC
ExpressionAtlasiA8MPS7 baseline and differential
GenevisibleiA8MPS7 HS

Organism-specific databases

HPAiHPA061005

Interactioni

Protein-protein interaction databases

BioGridi127272, 4 interactors
STRINGi9606.ENSP00000292778

Structurei

3D structure databases

ProteinModelPortaliA8MPS7
SMRiA8MPS7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the YdjC deacetylase family.Curated

Phylogenomic databases

eggNOGiENOG410II1X Eukaryota
COG3394 LUCA
GeneTreeiENSGT00390000002575
HOGENOMiHOG000225034
HOVERGENiHBG054530
InParanoidiA8MPS7
OMAiGPDAFSC
OrthoDBiEOG091G0BCT
PhylomeDBiA8MPS7
TreeFamiTF329340

Family and domain databases

InterProiView protein in InterPro
IPR011330 Glyco_hydro/deAcase_b/a-brl
IPR006879 YdjC-like
PANTHERiPTHR31609 PTHR31609, 1 hit
PfamiView protein in Pfam
PF04794 YdjC, 1 hit
SUPFAMiSSF88713 SSF88713, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: A8MPS7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRPRMRLVV TADDFGYCPR RDEGIVEAFL AGAVTSVSLL VNGAATESAA
60 70 80 90 100
ELARRHSIPT GLHANLSEGR PVGPARRGAS SLLGPEGFFL GKMGFREAVA
110 120 130 140 150
AGDVDLPQVR EELEAQLSCF RELLGRAPTH ADGHQHVHVL PGVCQVFAEA
160 170 180 190 200
LQAYGVRFTR LPLERGVGGC TWLEAPARAF ACAVERDARA AVGPFSRHGL
210 220 230 240 250
RWTDAFVGLS TCGRHMSAHR VSGALARVLE GTLAGHTLTA ELMAHPGYPS
260 270 280 290 300
VPPTGGCGEG PDAFSCSWER LHELRVLTAP TLRAQLAQDG VQLCALDDLD
310 320
SKRPGEEVPC EPTLEPFLEP SLL
Length:323
Mass (Da):34,466
Last modified:December 4, 2007 - v1
Checksum:iCAD754CCCC4D99A4
GO
Isoform 2 (identifier: A8MPS7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-149: VCQVFAE → GQTPSWA
     150-323: Missing.

Show »
Length:149
Mass (Da):15,835
Checksum:iB3CB5BE8D53252EB
GO
Isoform 3 (identifier: A8MPS7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-136: EELEAQLSCFRELLGRAPTHADGHQH → SRSYRRMLARTPRAPPGGCGRSSRPN
     137-323: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:136
Mass (Da):14,446
Checksum:iF6B39A635F5B078C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042519263A → T. Corresponds to variant dbSNP:rs2298428Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032784111 – 136EELEA…DGHQH → SRSYRRMLARTPRAPPGGCG RSSRPN in isoform 3. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_032785137 – 323Missing in isoform 3. 1 PublicationAdd BLAST187
Alternative sequenceiVSP_032786143 – 149VCQVFAE → GQTPSWA in isoform 2. 1 Publication7
Alternative sequenceiVSP_032787150 – 323Missing in isoform 2. 1 PublicationAdd BLAST174

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000553 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59461.1
CH471095 Genomic DNA Translation: EAW59463.1
BC096754 mRNA No translation available.
BC110075 mRNA Translation: AAI10076.1
BC133043 mRNA Translation: AAI33044.1
BC133047 mRNA Translation: AAI33048.1
CCDSiCCDS33613.1 [A8MPS7-1]
RefSeqiNP_001017964.1, NM_001017964.1 [A8MPS7-1]
XP_011528208.1, XM_011529906.2 [A8MPS7-2]
UniGeneiHs.355952

Genome annotation databases

EnsembliENST00000292778; ENSP00000292778; ENSG00000161179 [A8MPS7-1]
ENST00000398873; ENSP00000381847; ENSG00000161179 [A8MPS7-2]
ENST00000415762; ENSP00000402481; ENSG00000161179 [A8MPS7-3]
GeneIDi150223
KEGGihsa:150223
UCSCiuc002zvb.4 human [A8MPS7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000553 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59461.1
CH471095 Genomic DNA Translation: EAW59463.1
BC096754 mRNA No translation available.
BC110075 mRNA Translation: AAI10076.1
BC133043 mRNA Translation: AAI33044.1
BC133047 mRNA Translation: AAI33048.1
CCDSiCCDS33613.1 [A8MPS7-1]
RefSeqiNP_001017964.1, NM_001017964.1 [A8MPS7-1]
XP_011528208.1, XM_011529906.2 [A8MPS7-2]
UniGeneiHs.355952

3D structure databases

ProteinModelPortaliA8MPS7
SMRiA8MPS7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127272, 4 interactors
STRINGi9606.ENSP00000292778

PTM databases

iPTMnetiA8MPS7
PhosphoSitePlusiA8MPS7

Polymorphism and mutation databases

BioMutaiYDJC

Proteomic databases

EPDiA8MPS7
MaxQBiA8MPS7
PaxDbiA8MPS7
PRIDEiA8MPS7
ProteomicsDBi1911
1912 [A8MPS7-2]
1913 [A8MPS7-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292778; ENSP00000292778; ENSG00000161179 [A8MPS7-1]
ENST00000398873; ENSP00000381847; ENSG00000161179 [A8MPS7-2]
ENST00000415762; ENSP00000402481; ENSG00000161179 [A8MPS7-3]
GeneIDi150223
KEGGihsa:150223
UCSCiuc002zvb.4 human [A8MPS7-1]

Organism-specific databases

CTDi150223
DisGeNETi150223
EuPathDBiHostDB:ENSG00000161179.13
GeneCardsiYDJC
HGNCiHGNC:27158 YDJC
HPAiHPA061005
neXtProtiNX_A8MPS7
OpenTargetsiENSG00000161179
PharmGKBiPA162409362
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II1X Eukaryota
COG3394 LUCA
GeneTreeiENSGT00390000002575
HOGENOMiHOG000225034
HOVERGENiHBG054530
InParanoidiA8MPS7
OMAiGPDAFSC
OrthoDBiEOG091G0BCT
PhylomeDBiA8MPS7
TreeFamiTF329340

Miscellaneous databases

ChiTaRSiYDJC human
GenomeRNAii150223
PROiPR:A8MPS7

Gene expression databases

BgeeiENSG00000161179 Expressed in 139 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_YDJC
ExpressionAtlasiA8MPS7 baseline and differential
GenevisibleiA8MPS7 HS

Family and domain databases

InterProiView protein in InterPro
IPR011330 Glyco_hydro/deAcase_b/a-brl
IPR006879 YdjC-like
PANTHERiPTHR31609 PTHR31609, 1 hit
PfamiView protein in Pfam
PF04794 YdjC, 1 hit
SUPFAMiSSF88713 SSF88713, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiYDJC_HUMAN
AccessioniPrimary (citable) accession number: A8MPS7
Secondary accession number(s): Q2YDT4, Q4V9R7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: December 4, 2007
Last modified: September 12, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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