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Protein

Urocanate hydratase

Gene

hutU

Organism
Salinispora arenicola (strain CNS-205)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-histidine degradation into L-glutamate

This protein is involved in step 2 of the subpathway that synthesizes N-formimidoyl-L-glutamate from L-histidine.UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Histidine ammonia-lyase (Sare_0996)
  2. Urocanate hydratase (hutU)
  3. Imidazolonepropionase (hutI)
This subpathway is part of the pathway L-histidine degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N-formimidoyl-L-glutamate from L-histidine, the pathway L-histidine degradation into L-glutamate and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei124NADUniRule annotation1
Binding sitei190NADUniRule annotation1
Binding sitei195NADUniRule annotation1
Binding sitei315NAD; via carbonyl oxygenUniRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei403UniRule annotation1
Binding sitei485NAD; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi46 – 47NADUniRule annotation2
Nucleotide bindingi170 – 172NADUniRule annotation3
Nucleotide bindingi236 – 237NADUniRule annotation2
Nucleotide bindingi257 – 261NADUniRule annotation5
Nucleotide bindingi266 – 267NADUniRule annotation2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotationImported
Biological processHistidine metabolismUniRule annotationSAAS annotation
LigandNADUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
SARE391037:G1GA7-1020-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00379;UER00550

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Urocanate hydrataseUniRule annotationSAAS annotation (EC:4.2.1.49UniRule annotationSAAS annotation)
Short name:
UrocanaseUniRule annotation
Alternative name(s):
Imidazolonepropionate hydrolaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hutUUniRule annotation
Ordered Locus Names:Sare_1000Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSalinispora arenicola (strain CNS-205)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri391037 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaMicromonosporalesMicromonosporaceaeSalinispora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001153 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
391037.Sare_1000

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A8M4I7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 131Urocanase_NInterPro annotationAdd BLAST127
Domaini134 – 341UrocanaseInterPro annotationAdd BLAST208
Domaini344 – 538Urocanase_CInterPro annotationAdd BLAST195

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the urocanase family.UniRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105CGP Bacteria
COG2987 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000237606

KEGG Orthology (KO)

More...
KOi
K01712

Identification of Orthologs from Complete Genome Data

More...
OMAi
VSFHHGG

Database of Orthologous Groups

More...
OrthoDBi
POG091H0CXO

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10730, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00577 HutU, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023637 Urocanase
IPR035401 Urocanase_C
IPR038364 Urocanase_central_sf
IPR023636 Urocanase_CS
IPR035400 Urocanase_N
IPR035085 Urocanase_Rossmann-like
IPR036190 Urocanase_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12216 PTHR12216, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01175 Urocanase, 1 hit
PF17392 Urocanase_C, 1 hit
PF17391 Urocanase_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001423 Urocanate_hydrat, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111326 SSF111326, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01228 hutU, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01233 UROCANASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A8M4I7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTQPIRATRG TTRTAQGWPQ EAARRMLMNN LDPEVAERPE DLVVYGGTGK
60 70 80 90 100
AARDWPSYRA LLDTLTDLRD DETMLVQSGR PVAVMRTHEW APRVLLANSN
110 120 130 140 150
LVGDWATWPE FRRLEQLGLT MYGQMTAGSW IYIGTQGILQ GTYETFAAVA
160 170 180 190 200
AKRFGGSLAG TLTLTAGCGG MGGAQPLAVT MNGGSCLIVD VDRSRLERRV
210 220 230 240 250
REHYLDEVAD SLDDAVQRAL AARDQRRARS VGVVGNAATI FPELLRRGVP
260 270 280 290 300
VDVVTDQTSA HDPLSYLPEG VELTDARDYA AAKPAEFTDR ARASMARHVE
310 320 330 340 350
AMVGFLDAGA EVFDYGNSIR GEAQLGGYSR AFDFPGFVPA YIRPLFCAGK
360 370 380 390 400
GPFRWAALSG DPADIAATDR AILDLFPENE PLARWIRMAG ERVAFQGLPA
410 420 430 440 450
RICWLGYGER DRAGVRFNEM VAAGELSAPV VIGRDHLDCG SVASPYRETE
460 470 480 490 500
AMADGSDAIA DWPLLNALVN TASGASWVSI HHGGGVGIGR SIHAGQVCVA
510 520 530 540
DGSALAGQKI ERVLTNDPAM GVVRHVDAGY DEARQVAERT GLHIPMTAA
Length:549
Mass (Da):59,139
Last modified:December 4, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2D011233090C1C13
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP000850 Genomic DNA Translation: ABV96911.1

NCBI Reference Sequences

More...
RefSeqi
WP_012181221.1, NC_009953.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ABV96911; ABV96911; Sare_1000

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5704682

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
saq:Sare_1000

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|391037.6.peg.1016

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000850 Genomic DNA Translation: ABV96911.1
RefSeqiWP_012181221.1, NC_009953.1

3D structure databases

ProteinModelPortaliA8M4I7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi391037.Sare_1000

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV96911; ABV96911; Sare_1000
GeneIDi5704682
KEGGisaq:Sare_1000
PATRICifig|391037.6.peg.1016

Phylogenomic databases

eggNOGiENOG4105CGP Bacteria
COG2987 LUCA
HOGENOMiHOG000237606
KOiK01712
OMAiVSFHHGG
OrthoDBiPOG091H0CXO

Enzyme and pathway databases

UniPathwayi
UPA00379;UER00550

BioCyciSARE391037:G1GA7-1020-MONOMER

Family and domain databases

Gene3Di3.40.50.10730, 1 hit
HAMAPiMF_00577 HutU, 1 hit
InterProiView protein in InterPro
IPR023637 Urocanase
IPR035401 Urocanase_C
IPR038364 Urocanase_central_sf
IPR023636 Urocanase_CS
IPR035400 Urocanase_N
IPR035085 Urocanase_Rossmann-like
IPR036190 Urocanase_sf
PANTHERiPTHR12216 PTHR12216, 1 hit
PfamiView protein in Pfam
PF01175 Urocanase, 1 hit
PF17392 Urocanase_C, 1 hit
PF17391 Urocanase_N, 1 hit
PIRSFiPIRSF001423 Urocanate_hydrat, 1 hit
SUPFAMiSSF111326 SSF111326, 1 hit
TIGRFAMsiTIGR01228 hutU, 1 hit
PROSITEiView protein in PROSITE
PS01233 UROCANASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA8M4I7_SALAI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8M4I7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: December 5, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health

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