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Entry version 94 (17 Jun 2020)
Sequence version 1 (04 Dec 2007)
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Protein
Submitted name:

Fibrillin 3

Gene

FBN3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Fibrillin 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FBN3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Sequence analysisAdd BLAST31
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500272225132 – 2809Sequence analysisAdd BLAST2778

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi151 ↔ 161PROSITE-ProRule annotation
Disulfide bondi169 ↔ 178PROSITE-ProRule annotation
Disulfide bondi453 ↔ 463PROSITE-ProRule annotation
Disulfide bondi770 ↔ 780PROSITE-ProRule annotation
Disulfide bondi1851 ↔ 1861PROSITE-ProRule annotation
Disulfide bondi2532 ↔ 2542PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A8KAY2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini147 – 179EGF-likeInterPro annotationAdd BLAST33
Domaini185 – 228TBInterPro annotationAdd BLAST44
Domaini247 – 284EGF-likeInterPro annotationAdd BLAST38
Domaini293 – 346TBInterPro annotationAdd BLAST54
Domaini408 – 446EGF-likeInterPro annotationAdd BLAST39
Domaini449 – 488EGF-likeInterPro annotationAdd BLAST40
Domaini489 – 530EGF-likeInterPro annotationAdd BLAST42
Domaini531 – 571EGF-likeInterPro annotationAdd BLAST41
Domaini572 – 612EGF-likeInterPro annotationAdd BLAST41
Domaini618 – 670TBInterPro annotationAdd BLAST53
Domaini682 – 723EGF-likeInterPro annotationAdd BLAST42
Domaini724 – 765EGF-likeInterPro annotationAdd BLAST42
Domaini766 – 805EGF-likeInterPro annotationAdd BLAST40
Domaini810 – 849TBInterPro annotationAdd BLAST40
Domaini869 – 910EGF-likeInterPro annotationAdd BLAST42
Domaini915 – 966TBInterPro annotationAdd BLAST52
Domaini986 – 1027EGF-likeInterPro annotationAdd BLAST42
Domaini1028 – 1070EGF-likeInterPro annotationAdd BLAST43
Domaini1071 – 1112EGF-likeInterPro annotationAdd BLAST42
Domaini1113 – 1154EGF-likeInterPro annotationAdd BLAST42
Domaini1155 – 1195EGF-likeInterPro annotationAdd BLAST41
Domaini1196 – 1237EGF-likeInterPro annotationAdd BLAST42
Domaini1238 – 1275EGF-likeInterPro annotationAdd BLAST38
Domaini1280 – 1318EGF-likeInterPro annotationAdd BLAST39
Domaini1321 – 1361EGF-likeInterPro annotationAdd BLAST41
Domaini1362 – 1403EGF-likeInterPro annotationAdd BLAST42
Domaini1404 – 1440EGF-likeInterPro annotationAdd BLAST37
Domaini1445 – 1485EGF-likeInterPro annotationAdd BLAST41
Domaini1490 – 1546TBInterPro annotationAdd BLAST57
Domaini1563 – 1604EGF-likeInterPro annotationAdd BLAST42
Domaini1605 – 1646EGF-likeInterPro annotationAdd BLAST42
Domaini1651 – 1703TBInterPro annotationAdd BLAST53
Domaini1721 – 1762EGF-likeInterPro annotationAdd BLAST42
Domaini1763 – 1804EGF-likeInterPro annotationAdd BLAST42
Domaini1805 – 1846EGF-likeInterPro annotationAdd BLAST42
Domaini1847 – 1882EGF-likeInterPro annotationAdd BLAST36
Domaini1886 – 1928EGF-likeInterPro annotationAdd BLAST43
Domaini1929 – 1968EGF-likeInterPro annotationAdd BLAST40
Domaini1969 – 2010EGF-likeInterPro annotationAdd BLAST42
Domaini2015 – 2068TBInterPro annotationAdd BLAST54
Domaini2084 – 2125EGF-likeInterPro annotationAdd BLAST42
Domaini2126 – 2165EGF-likeInterPro annotationAdd BLAST40
Domaini2166 – 2206EGF-likeInterPro annotationAdd BLAST41
Domaini2207 – 2251EGF-likeInterPro annotationAdd BLAST45
Domaini2252 – 2293EGF-likeInterPro annotationAdd BLAST42
Domaini2298 – 2351TBInterPro annotationAdd BLAST54
Domaini2363 – 2404EGF-likeInterPro annotationAdd BLAST42
Domaini2405 – 2445EGF-likeInterPro annotationAdd BLAST41
Domaini2446 – 2482EGF-likeInterPro annotationAdd BLAST37
Domaini2485 – 2527EGF-likeInterPro annotationAdd BLAST43
Domaini2528 – 2567EGF-likeInterPro annotationAdd BLAST40
Domaini2568 – 2605EGF-likeInterPro annotationAdd BLAST38
Domaini2610 – 2649EGF-likeInterPro annotationAdd BLAST40

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4193 Eukaryota
ENOG410XSD2 LUCA

KEGG Orthology (KO)

More...
KOi
K23342

Database of Orthologous Groups

More...
OrthoDBi
1174178at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.290.10, 9 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR040872 Fibrillin_U_N
IPR009030 Growth_fac_rcpt_cys_sf
IPR017878 TB_dom
IPR036773 TB_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12662 cEGF, 2 hits
PF07645 EGF_CA, 39 hits
PF18193 Fibrillin_U_N, 1 hit
PF12661 hEGF, 1 hit
PF00683 TB, 9 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 46 hits
SM00179 EGF_CA, 43 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184 SSF57184, 11 hits
SSF57581 SSF57581, 9 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 41 hits
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 28 hits
PS50026 EGF_3, 44 hits
PS01187 EGF_CA, 18 hits
PS51364 TB, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A8KAY2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTLEGLYLAR GPLARLLLAW SALLCMAGGQ GRWDGALEAA GPGRVRRRGS
60 70 80 90 100
PGILQGPNVC GSRFHAYCCP GWRTFPGRSQ CVVPICRRAC GEGFCSQPNL
110 120 130 140 150
CTCADGTLAP SCGVSRGSGC SVSCMNGGTC RGASCLCQKG YTGTVCGQPI
160 170 180 190 200
CDRGCHNGGR CIGPNRCACV YGFMGPQCER DYRTGPCFGQ VGPEGCQHQL
210 220 230 240 250
TGLVCTKALC CATVGRAWGL PCELCPAQPH PCRRGFIPNI HTGACQDVDE
260 270 280 290 300
CQAVPGLCQG GSCVNMVGSF HCRCPVGHRL SDSSAACEDY RAGACFSVLF
310 320 330 340 350
GGRCAGDLAG HYTRRQCCCD RGRCWAAGPV PELCPPRGSN EFQQLCAQRL
360 370 380 390 400
PLLPGHPGLF PGLLGFGSNG MGPPLGPARL NPHGSDARGI PSLGPGNSNI
410 420 430 440 450
GTATLNQTID ICRHFTNLCL NGRCLPTPSS YRCECNVGYT QDVRGECIDV
460 470 480 490 500
DECTSSPCHH GDCVNIPGTY HCRCYPGFQA TPTRQACVDV DECIVSGGLC
510 520 530 540 550
HLGRCVNTEG SFQCVCNAGF ELSPDGKNCV DHNECATSTM CVNGVCLNED
560 570 580 590 600
GSFSCLCKPG FLLAPGGHYC MDIDECQTPG ICVNGHCTNT EGSFRCQCLG
610 620 630 640 650
GLAVGTDGRV CVDTHVRSTC YGAIEKGSCA RPFPGTVTKS ECCCANPDHG
660 670 680 690 700
FGEPCQLCPA KNSAEFQALC SSGLGITTDG RDINECALDP EVCANGVCEN
710 720 730 740 750
LRGSYRCVCN LGYEAGASGK DCTDVDECAL NSLLCDNGWC QNSPGSYSCS
760 770 780 790 800
CPPGFHFWQD TEICKDVDEC LSSPCVSGVC RNLAGSYTCK CGPGSRLDPS
810 820 830 840 850
GTFCLDSTKG TCWLKIQESR CEVNLQGASL RSECCATLGA AWGSPCERCE
860 870 880 890 900
IDPACARGFA RMTGVTCDDV NECESFPGVC PNGRCVNTAG SFRCECPEGL
910 920 930 940 950
MLDASGRLCV DVRLEPCFLR WDEDECGVTL PGKYRMDVCC CSIGAVWGVE
960 970 980 990 1000
CEACPDPESL EFASLCPRGL GFASRDFLSG RPFYKDVNEC KVFPGLCTHG
1010 1020 1030 1040 1050
TCRNTVGSFH CACAGGFALD AQERNCTDID ECRISPDLCG QGTCVNTPGS
1060 1070 1080 1090 1100
FECECFPGYE SGFMLMKNCM DVDECARDPL LCRGGTCTNT DGSYKCQCPP
1110 1120 1130 1140 1150
GHELTAKGTA CEDIDECSLS DGLCPHGQCV NVIGAFQCSC HAGFQSTPDR
1160 1170 1180 1190 1200
QGCVDINECR VQNGGCDVHC INTEGSYRCS CGQGYSLMPD GRACADVDEC
1210 1220 1230 1240 1250
EENPRVCDQG HCTNMPGGHR CLCYDGFMAT PDMRTCVDVD ECDLNPHICL
1260 1270 1280 1290 1300
HGDCENTKGS FVCHCQLGYM VRKGATGCSD VDECEVGGHN CDSHASCLNI
1310 1320 1330 1340 1350
PGSFSCRCLP GWVGDGFECH DLDECISQEH RCSPRGDCLN VPGSYRCTCR
1360 1370 1380 1390 1400
QGFAGDGFFC EDRDECAENV DLCDNGQCLN APGGYRCECE MGFDPTEDHR
1410 1420 1430 1440 1450
ACQDVDECAQ GNLCAFGSCE NLPGMFRCIC NGGYELDRGG GNCTDINECA
1460 1470 1480 1490 1500
DPVNCINGVC INTPGSYLCS CPQDFELNPS GVGCVDTRAG NCFLETHDRG
1510 1520 1530 1540 1550
DSGISCSAEI GVGVTRASCC CSLGRAWGNP CELCPMANTT EYRTLCPGGE
1560 1570 1580 1590 1600
GFQPNRITVI LEDIDECQEL PGLCQGGDCV NTFGSFQCEC PPGYHLSEHT
1610 1620 1630 1640 1650
RICEDIDECS THSGICGPGT CYNTLGNYTC VCPAEYLQVN GGNNCMDMRK
1660 1670 1680 1690 1700
SVCFRHYNGT CQNELAFNVT RKMCCCSYNI GQAWNRPCEA CPTPISPDYQ
1710 1720 1730 1740 1750
ILCGNQAPGF LTDIHTGKPL DIDECGEIPA ICANGICINQ IGSFRCECPA
1760 1770 1780 1790 1800
GFNYNSILLA CEDVDECGSR ESPCQQNADC INIPGSYRCK CTRGYKLSPG
1810 1820 1830 1840 1850
GACVGQNECR EIPNVCSHGD CMDTEGSYMC LCHRGFQASA DQTLCMDIDE
1860 1870 1880 1890 1900
CDRQPCGNGT CKNIIGSYNC LCFPGFVVTH NGDCVDFDEC TTLVGQVCRF
1910 1920 1930 1940 1950
GHCLNTAGSF HCLCQDGFEL TADGKNCVDT NECLSLAGTC LPGTCQNLEG
1960 1970 1980 1990 2000
SFRCICPPGF QVQSDHCIDI DECSEEPNLC LFGTCTNSPG SFQCLCPPGF
2010 2020 2030 2040 2050
VLSDNGHRCF DTRQSFCFTR FEAGKCSVPK AFNTTKTRCC CSKRPGEGWG
2060 2070 2080 2090 2100
DPCELCPQEG SAAFQELCPF GHGAVPGPDD SREDVNECAE NPGVCTNGVC
2110 2120 2130 2140 2150
VNTDGSFRCE CPFGYSLDFT GINCVDTDEC SVGHPCGQGT CTNVIGGFEC
2160 2170 2180 2190 2200
ACADGFEPGL MMTCEDIDEC SLNPLLCAFR CHNTEGSYLC TCPAGYTLRE
2210 2220 2230 2240 2250
DGAMCRDVDE CADGQQDCHA RGMECKNLIG TFACVCPPGM RPLPGSGEGC
2260 2270 2280 2290 2300
TDDNECHAQP DLCVNGRCVN TAGSFRCDCD EGFQPSPTLT ECHDIRQGPC
2310 2320 2330 2340 2350
FAEVLQTMCR SLSSSSEAVT RAECCCGGGR GWGPRCELCP LPGTSAYRKL
2360 2370 2380 2390 2400
CPHGSGYTAE GRDVDECRML AHLCAHGECI NSLGSFRCHC QAGYTPDATA
2410 2420 2430 2440 2450
TTCLDMDECS QVPKPCTFLC KNTKGSFLCS CPRGYLLEED GRTCKDLDEC
2460 2470 2480 2490 2500
TSRQHNCQFL CVNTVGAFTC RCPPGFTQHH QACFDNDECS AQPGPCGAHG
2510 2520 2530 2540 2550
HCHNTPGSFR CECHQGFTLV SSGHGCEDVN ECDGPHRCQH GCQNQLGGYR
2560 2570 2580 2590 2600
CSCPQGFTQH SQWAQCVDEN ECALSPPTCG SASCRNTLGG FRCVCPSGFD
2610 2620 2630 2640 2650
FDQALGGCQD VDECAGRRGP CSYSCANTPG GFLCGCPQGY FRAGQGHCVS
2660 2670 2680 2690 2700
GLGFSPGPQD TPDKEELLSS EACYECKING LSPRDRPRRS AHRDHQVNLA
2710 2720 2730 2740 2750
TLDSEALLTL GLNLSHLGRA ERILELRPAL EGLEGRIRYV IVRGNEQGFF
2760 2770 2780 2790 2800
RMHHLRGVSS LQLGRRRPGP GTYRLEVVSH MAGPWGVQPE GQPGPWGQAL

RLKVQLQLL
Length:2,809
Mass (Da):300,327
Last modified:December 4, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i20C04CC006C0161F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC153882 mRNA Translation: AAI53883.1

NCBI Reference Sequences

More...
RefSeqi
NP_001308360.1, NM_001321431.1
NP_115823.3, NM_032447.4

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84467

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84467

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC153882 mRNA Translation: AAI53883.1
RefSeqiNP_001308360.1, NM_001321431.1
NP_115823.3, NM_032447.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiA8KAY2

Genome annotation databases

GeneIDi84467
KEGGihsa:84467

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84467

Phylogenomic databases

eggNOGiKOG4193 Eukaryota
ENOG410XSD2 LUCA
KOiK23342
OrthoDBi1174178at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
84467 20 hits in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FBN3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84467

Family and domain databases

Gene3Di3.90.290.10, 9 hits
InterProiView protein in InterPro
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR040872 Fibrillin_U_N
IPR009030 Growth_fac_rcpt_cys_sf
IPR017878 TB_dom
IPR036773 TB_dom_sf
PfamiView protein in Pfam
PF12662 cEGF, 2 hits
PF07645 EGF_CA, 39 hits
PF18193 Fibrillin_U_N, 1 hit
PF12661 hEGF, 1 hit
PF00683 TB, 9 hits
SMARTiView protein in SMART
SM00181 EGF, 46 hits
SM00179 EGF_CA, 43 hits
SUPFAMiSSF57184 SSF57184, 11 hits
SSF57581 SSF57581, 9 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 41 hits
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 28 hits
PS50026 EGF_3, 44 hits
PS01187 EGF_CA, 18 hits
PS51364 TB, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA8KAY2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8KAY2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: June 17, 2020
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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