UniProtKB - A8KAF4 (A8KAF4_HUMAN)
Protein
Estrogen receptor
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.UniRule annotation
GO - Molecular functioni
- DNA-binding transcription factor activity Source: InterPro
- estrogen receptor activity Source: InterPro
- sequence-specific DNA binding Source: InterPro
- steroid binding Source: UniProtKB-KW
- zinc ion binding Source: InterPro
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation, ReceptorUniRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Ligand | Lipid-binding, Metal-binding, Steroid-bindingUniRule annotationARBA annotation, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Estrogen receptorUniRule annotationShort name: ERUniRule annotation Alternative name(s): ER-alphaUniRule annotation Estradiol receptorUniRule annotation Nuclear receptor subfamily 3 group A member 1UniRule annotation |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationInteractioni
Subunit structurei
Binds DNA as a homodimer.
UniRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 182 – 257 | Nuclear receptorInterPro annotationAdd BLAST | 76 | |
Domaini | 310 – 546 | NR LBDInterPro annotationAdd BLAST | 237 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 147 – 174 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 258 – 281 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 552 – 572 | DisorderedSequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 557 – 572 | PolarSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Keywords - Domaini
Zinc-fingerARBA annotationPhylogenomic databases
OMAi | LHAPANF |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR024178, Oest_rcpt/oest-rel_rcp IPR001292, Oestr_rcpt IPR024736, Oestrogen-typ_rcpt_final_C_dom IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF12743, ESR1_C, 1 hit PF00104, Hormone_recep, 1 hit PF02159, Oest_recep, 1 hit PF00105, zf-C4, 1 hit |
PIRSFi | PIRSF500101, ER-a, 1 hit PIRSF002527, ER-like_NR, 1 hit |
PRINTSi | PR00543, OESTROGENR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A8KAF4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKIPLERPLG EVYLDSSKPA
60 70 80 90 100
VYNYPEGAAY EFNAAAAANA QVYGQTGLPY GPGSEAAAFG SNGLGGFPPL
110 120 130 140 150
NSVSPSPLML LHPPPQLSPF LQPHGQQVPY YLENEPSGYT VREAGPPAFY
160 170 180 190 200
RPNSDNRRQG GRERLASTND KGSMAMESAK ETRYCAVCND YASGYHYGVW
210 220 230 240 250
SCEGCKAFFK RSIQGHNDYM CPATNQCTID KNRRKSCQAC RLRKCYEVGM
260 270 280 290 300
MKGIRKDRRG GRMLKHKRQR DDGEGRGEVG SAGDMRAANL WPSPLMIKRS
310 320 330 340 350
KKNSLALSLT ADQMVSALLD AEPPILYPEY DPTRPFSEAS MMGLLTNLAD
360 370 380 390 400
RELVHMINWA KRVPGFVDLT LHDQVHLLEC AWLEILMIGL VWRSMEHPGK
410 420 430 440 450
LLFAPNLLLD RNQGKCVEGM VEIFDMLLAT SSRFRMMNLQ GEEFVCLKSI
460 470 480 490 500
ILLNSGVYTF LSSTLKSLEE KDHIHRVLDK ITDTLIHLMA KAGLTLQQQH
510 520 530 540 550
QRLAQLLLIL SHIRHMSNKG MEHLYSMKCK NVVPLYDLLL EMLDAHRLHA
560 570 580 590
PTSRGGASVE ETDQSHLATA GSTSSHSLQK YYITGEAEGF PATV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK293019 mRNA Translation: BAF85708.1 |
RefSeqi | NP_001278170.1, NM_001291241.1 |
Genome annotation databases
GeneIDi | 2099 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK293019 mRNA Translation: BAF85708.1 |
RefSeqi | NP_001278170.1, NM_001291241.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | A8KAF4 |
Protocols and materials databases
DNASUi | 2099 |
Genome annotation databases
GeneIDi | 2099 |
Organism-specific databases
CTDi | 2099 |
Phylogenomic databases
OMAi | LHAPANF |
Miscellaneous databases
BioGRID-ORCSi | 2099, 23 hits in 1010 CRISPR screens |
GenomeRNAii | 2099 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR024178, Oest_rcpt/oest-rel_rcp IPR001292, Oestr_rcpt IPR024736, Oestrogen-typ_rcpt_final_C_dom IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF12743, ESR1_C, 1 hit PF00104, Hormone_recep, 1 hit PF02159, Oest_recep, 1 hit PF00105, zf-C4, 1 hit |
PIRSFi | PIRSF500101, ER-a, 1 hit PIRSF002527, ER-like_NR, 1 hit |
PRINTSi | PR00543, OESTROGENR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A8KAF4_HUMAN | |
Accessioni | A8KAF4Primary (citable) accession number: A8KAF4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 4, 2007 |
Last sequence update: | December 4, 2007 | |
Last modified: | April 7, 2021 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |