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Entry version 60 (05 Jun 2019)
Sequence version 1 (04 Dec 2007)
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Protein
Submitted name:

cDNA FLJ78685, highly similar to Homo sapiens myosin binding protein C, slow type (MYBPC1), transcript variant 2, mRNA

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
cDNA FLJ78685, highly similar to Homo sapiens myosin binding protein C, slow type (MYBPC1), transcript variant 2, mRNAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

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PeptideAtlasi
A8KAB1

PRoteomics IDEntifications database

More...
PRIDEi
A8KAB1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
A8KAB1 HS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini365 – 452Ig-likeInterPro annotationAdd BLAST88
Domaini547 – 640Ig-likeInterPro annotationAdd BLAST94
Domaini647 – 746Fibronectin type-IIIInterPro annotationAdd BLAST100
Domaini747 – 840Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini844 – 932Ig-likeInterPro annotationAdd BLAST89
Domaini941 – 1036Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini1054 – 1142Ig-likeInterPro annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 59DisorderedSequence analysisAdd BLAST59

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 34PolyampholyteSequence analysisAdd BLAST34

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFCI Eukaryota
ENOG4110AYI LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000220906

KEGG Orthology (KO)

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KOi
K12557

Database of Orthologous Groups

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OrthoDBi
67092at2759

Family and domain databases

Conserved Domains Database

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CDDi
cd00063 FN3, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 10 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR040849 MyBP-C_THB

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 3 hits
PF07679 I-set, 7 hits
PF18362 THB, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 3 hits
SM00409 IG, 7 hits
SM00408 IGc2, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 7 hits
SSF49265 SSF49265, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A8KAB1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPEPTKKEEN EVPAPAPPPE EPSKEKEAGT TPAKDEEEVS PPSALPPGLG
60 70 80 90 100
SRALERKDSD WTLVETPPGE EQAKQNANSQ LSILFIEKPQ GGTVKVGEDI
110 120 130 140 150
TFIAKVKAED LLRKPTIKWF KGKWMDLASK AGKHLQLKET FERHSRVYTF
160 170 180 190 200
EMQIIKAKDN FAGNYRCEVT YKDKFDSCSF DLEVHESTGT TPNIDIRSAF
210 220 230 240 250
KRSGEGQEDA GELDFSGLLK RREVKQQEEE PQVDVWELLK NAKPSEYEKI
260 270 280 290 300
AFQYGITDLR GMLKRLKRMR REEKKSAAFA KILDPAYQVD KGGRVRFVVE
310 320 330 340 350
LADPKLEVKW YKNGQEIRPS TKYIFEHKGC QRILFINNCQ MTDDSEYYVT
360 370 380 390 400
AGDEKCSTEL FVREPPIMVT KQLEDTTAYC GERVELECEV SEDDANVKWF
410 420 430 440 450
KNGEEIIPGP KSRYRIRVEG KKHILIIEGA TKADAAEYSV MTTGGQSSAK
460 470 480 490 500
LSVDLKPLKI LTPLTDQTVN LGKEICLKCE ISENIPGKWT KNGLPVQESD
510 520 530 540 550
RLKVVHKGRI HKLVIANALT EDEGDYVFAP DAYNVTLPAK VHVIDPPKII
560 570 580 590 600
LDGLDADNTV TVIAGNKLRL EIPISGEPPP KTMWSRGDKA IMEGSGRIRT
610 620 630 640 650
ESYPDSSTLV IDIAERDDSG VYHINLKNEA GEAHASIKVK VVDFPDPPVA
660 670 680 690 700
PTVTEVGDDW CIMNWEPPAY DGGSPILGYF IERKKKQSSR WMRLNFDLCK
710 720 730 740 750
ETTFEPKKMI EGVAYEVRIF AVNAIGISKP SMPSRPFVPL AVTSPPTLLT
760 770 780 790 800
VDSVTDTTVT MRWRPPDHIG AAGLDGYVLE YCFEGTEDWI VANKDLIDKT
810 820 830 840 850
KFTITGLPTD AKIFVRVKAV NAAGASEPKY YSQPILVKEI IEPPKIRIPR
860 870 880 890 900
HLKQTYIRRV GEAVNLVIPF QGKPRPELTW KKDGAEIDKN QINIRNSETD
910 920 930 940 950
TIIFIRKAER SHSGKYDLQV KVDKFVETAS IDIQIIDRPG PPQIVKIEDV
960 970 980 990 1000
WGENVALTWT PPKDDGNAAI TGYTIQKADK KSMEWFTVIE HYHRTSATIT
1010 1020 1030 1040 1050
ELVIGNEYYF RVFSENMCGL SEDATMTKES AVIARDGKIY KNPVYEDFDF
1060 1070 1080 1090 1100
SEAPMFTQPL VNTYAIAGYN ATPNCSVRGN PKPKITWMKN KVAIVDDPRY
1110 1120 1130 1140
RMFSNQGVCT LEIRKPSPYD GGTYCCKAVN DLGTVEIECK LEVKVIAQ
Length:1,148
Mass (Da):129,092
Last modified:December 4, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD6C158B6B79CCBD2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK292976 mRNA Translation: BAF85665.1

NCBI Reference Sequences

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RefSeqi
NP_996555.1, NM_206819.2
NP_996556.1, NM_206820.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4604

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4604

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292976 mRNA Translation: BAF85665.1
RefSeqiNP_996555.1, NM_206819.2
NP_996556.1, NM_206820.2

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiA8KAB1
PRIDEiA8KAB1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4604
KEGGihsa:4604

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4604

Phylogenomic databases

eggNOGiENOG410IFCI Eukaryota
ENOG4110AYI LUCA
HOGENOMiHOG000220906
KOiK12557
OrthoDBi67092at2759

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4604

Gene expression databases

GenevisibleiA8KAB1 HS

Family and domain databases

CDDicd00063 FN3, 3 hits
Gene3Di2.60.40.10, 10 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR040849 MyBP-C_THB
PfamiView protein in Pfam
PF00041 fn3, 3 hits
PF07679 I-set, 7 hits
PF18362 THB, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SM00409 IG, 7 hits
SM00408 IGc2, 4 hits
SUPFAMiSSF48726 SSF48726, 7 hits
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA8KAB1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8KAB1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: June 5, 2019
This is version 60 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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