Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein SFI1 homolog

Gene

SFI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the dynamic structure of centrosome-associated contractile fibers via its interaction with CETN2.1 Publication

Caution

It is uncertain whether Met-1 or Met-24 is the initiator.Curated

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-8854518 AURKA Activation by TPX2

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SFI1 homolog
Short name:
hSFI1
Gene namesi
Name:SFI1
Synonyms:KIAA0542
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000198089.14
HGNCiHGNC:29064 SFI1
MIMi612765 gene
neXtProtiNX_A8K8P3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi9814
OpenTargetsiENSG00000198089
PharmGKBiPA142670930

Polymorphism and mutation databases

BioMutaiSFI1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003346211 – 1242Protein SFI1 homologAdd BLAST1242

Proteomic databases

EPDiA8K8P3
MaxQBiA8K8P3
PaxDbiA8K8P3
PRIDEiA8K8P3
ProteomicsDBi1880
1881 [A8K8P3-10]
1882 [A8K8P3-2]
1883 [A8K8P3-3]
1884 [A8K8P3-4]
1885 [A8K8P3-5]
1886 [A8K8P3-9]

PTM databases

iPTMnetiA8K8P3
PhosphoSitePlusiA8K8P3

Expressioni

Gene expression databases

BgeeiENSG00000198089 Expressed in 177 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_SFI1
ExpressionAtlasiA8K8P3 baseline and differential
GenevisibleiA8K8P3 HS

Interactioni

Subunit structurei

Interacts with CETN2 (via C-terminus).2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115153, 20 interactors
CORUMiA8K8P3
IntActiA8K8P3, 15 interactors
MINTiA8K8P3
STRINGi9606.ENSP00000383145

Structurei

Secondary structure

11242
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliA8K8P3
SMRiA8K8P3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA8K8P3

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati138 – 170HAT 1Add BLAST33
Repeati172 – 201HAT 2Add BLAST30
Repeati270 – 302HAT 3Add BLAST33
Repeati334 – 368HAT 4Add BLAST35
Repeati399 – 431HAT 5Add BLAST33
Repeati1148 – 1180HAT 6Add BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni111 – 130Interaction with CETN2Add BLAST20
Regioni475 – 494Interaction with CETN2Add BLAST20
Regioni641 – 660Interaction with CETN2Add BLAST20

Domaini

CETN2-binding regions contains a conserved Trp residue in their C-terminal ends, which seems critical for interaction with CETN2.

Sequence similaritiesi

Belongs to the SFI1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4775 Eukaryota
ENOG4111JHQ LUCA
GeneTreeiENSGT00390000018445
HOVERGENiHBG108479
InParanoidiA8K8P3
KOiK16489
OMAiMLWKQKV
OrthoDBiEOG091G0EXO
PhylomeDBiA8K8P3
TreeFamiTF328940

Family and domain databases

InterProiView protein in InterPro
IPR030516 SFI1
PANTHERiPTHR22028:SF4 PTHR22028:SF4, 1 hit

Sequences (7+)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A8K8P3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKNLLTEKCI SSHNFHQKVI KQRMEKKVDS RYFKDGAVKK PYSAKTLSNK
60 70 80 90 100
KSSASFGIRR ELPSTSHLVQ YRGTHTCTRQ GRLRELRIRC VARKFLYLWI
110 120 130 140 150
RMTFGRVFPS KARFYYEQRL LRKVFEEWKE EWWVFQHEWK LCVRADCHYR
160 170 180 190 200
YYLYNLMFQT WKTYVRQQQE MRNKYIRAEV HDAKQKMRQA WKSWLIYVVV
210 220 230 240 250
RRTKLQMQTT ALEFRQRIIL RVWWSTWRQR LGQVRVSRAL HASALKHRAL
260 270 280 290 300
SLQVQAWSQW REQLLYVQKE KQKVVSAVKH HQHWQKRRFL KAWLEYLQVR
310 320 330 340 350
RVKRQQNEMA ERFHHVTVLQ IYFCDWQQAW ERRESLYAHH AQVEKLARKM
360 370 380 390 400
ALRRAFTHWK HYMLLCAEEA AQFEMAEEHH RHSQLYFCFR ALKDNVTHAH
410 420 430 440 450
LQQIRRNLAH QQHGVTLLHR FWNLWRSQIE QKKERELLPL LHAAWDHYRI
460 470 480 490 500
ALLCKCIELW LQYTQKRRYK QLLQARADGH FQQRALPAAF HTWNRLWRWR
510 520 530 540 550
HQENVLSARA TRFHRETLEK QVFSLWRQKM FQHRENRLAE RMAILHAERQ
560 570 580 590 600
LLYRSWFMWH QQAAARHQEQ EWQTVACAHH RHGRLKKAFC LWRESAQGLR
610 620 630 640 650
TERTGRVRAA EFHMAQLLRW AWSQWRECLA LRGAERQKLM RADLHHQHSV
660 670 680 690 700
LHRALQAWVT YQGRVRSILR EVAARESQHN RQLLRGALRR WKENTMARVD
710 720 730 740 750
EAKKTFQAST HYRRTICSKV LVQWREAVSV QMYYRQQEDC AIWEAQKVLD
760 770 780 790 800
RGCLRTWFQR WWDCSRRSAQ QRLQLERAVQ HHHRQLLLEG LARWKTHHLQ
810 820 830 840 850
CVRKRLLHRQ STQLLAQRLS RTCFRQWRQQ LAARRQEQRA TVRALWFWAF
860 870 880 890 900
SLQAKVWATW LAFVLERRRK KARLQWALQA YQGQLLQEGA TRLLRFAASM
910 920 930 940 950
KASRQQLQAQ QQVQAAHSLH RAVRRCATLW KQKVLGRGGK PQPLAAIAPS
960 970 980 990 1000
RKVTFEGPLL NRIAAGAGDG TLETKRPQAS RPLGALGRLA AEEPHALELN
1010 1020 1030 1040 1050
TAHSARKQPR RPHFLLEPAQ SQRPQKPQEH GLGMAQPAAP SLTRPFLAEA
1060 1070 1080 1090 1100
PTALVPHSPL PGALSSAPGP KQPPTASTGP ELLLLPLSSF MPCGAAAPAR
1110 1120 1130 1140 1150
VSAQRATPRD KPPVPSSLAS VPDPHLLLPG DFSATRAGPG LSTAGSLDLE
1160 1170 1180 1190 1200
AELEEIQQQL LHYQTTKQNL WSCRRQASSL RRWLELNREE PGPEDQEVEQ
1210 1220 1230 1240
QVQKELEQVE MQIQLLAEEL QAQRQPIGAC VARIQALRQA LC
Length:1,242
Mass (Da):147,664
Last modified:May 20, 2008 - v2
Checksum:i7BE570BDD7F72B6E
GO
Isoform 2 (identifier: A8K8P3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     386-416: Missing.

Show »
Length:1,211
Mass (Da):143,978
Checksum:i4F7038E1D184A505
GO
Isoform 3 (identifier: A8K8P3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-112: Missing.

Note: No experimental confirmation available.
Show »
Length:1,160
Mass (Da):138,070
Checksum:iC3560EAD4217A72E
GO
Isoform 4 (identifier: A8K8P3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-112: Missing.
     150-220: Missing.
     1145-1242: GSLDLEAELE...RIQALRQALC → AWTLRLNLRR...KRAACAGGWS

Note: No experimental confirmation available.
Show »
Length:1,031
Mass (Da):121,826
Checksum:i108E39A21FE58AC5
GO
Isoform 5 (identifier: A8K8P3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-112: Missing.
     678-904: Missing.

Note: No experimental confirmation available.
Show »
Length:991
Mass (Da):117,079
Checksum:i677D443FAF8A82E5
GO
Isoform 9 (identifier: A8K8P3-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-112: Missing.
     386-416: Missing.

Note: No experimental confirmation available.
Show »
Length:1,187
Mass (Da):141,050
Checksum:i517294BE383E1B0F
GO
Isoform 10 (identifier: A8K8P3-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-112: Missing.
     708-719: Missing.

Note: No experimental confirmation available.
Show »
Length:1,148
Mass (Da):136,666
Checksum:i1859FC8789A47186
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YTJ2D3YTJ2_HUMAN
Protein SFI1 homolog
SFI1
1,089Annotation score:
F8WBU4F8WBU4_HUMAN
Developmentally-regulated GTP-bindi...
DRG1 SFI1
102Annotation score:
F8WEE0F8WEE0_HUMAN
Developmentally-regulated GTP-bindi...
DRG1
63Annotation score:
H0Y5I7H0Y5I7_HUMAN
Protein SFI1 homolog
SFI1
605Annotation score:
E5RJU6E5RJU6_HUMAN
Protein SFI1 homolog
SFI1
389Annotation score:
H7BZF3H7BZF3_HUMAN
Protein SFI1 homolog
SFI1
149Annotation score:
H7C2F1H7C2F1_HUMAN
Protein SFI1 homolog
SFI1
489Annotation score:
H0YI06H0YI06_HUMAN
Developmentally-regulated GTP-bindi...
DRG1
56Annotation score:
X6RJF9X6RJF9_HUMAN
Protein SFI1 homolog
SFI1
79Annotation score:
H0Y836H0Y836_HUMAN
Protein SFI1 homolog
SFI1
57Annotation score:

Sequence cautioni

The sequence AAI10815 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI29927 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA25468 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti353R → W in AAI10815 (PubMed:15489334).Curated1
Sequence conflicti622W → R in AAI29927 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04343913H → L. Corresponds to variant dbSNP:rs5749290Ensembl.1
Natural variantiVAR_04344072R → H. Corresponds to variant dbSNP:rs16989698Ensembl.1
Natural variantiVAR_043441167Q → H. Corresponds to variant dbSNP:rs7511430Ensembl.1
Natural variantiVAR_043442322Y → H3 PublicationsCorresponds to variant dbSNP:rs5753700Ensembl.1
Natural variantiVAR_043443330W → R. Corresponds to variant dbSNP:rs16989291Ensembl.1
Natural variantiVAR_043444549R → Q2 PublicationsCorresponds to variant dbSNP:rs2006771Ensembl.1
Natural variantiVAR_062234760R → H. Corresponds to variant dbSNP:rs9621295Ensembl.1
Natural variantiVAR_0434451087L → P3 PublicationsCorresponds to variant dbSNP:rs12171042Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03369931 – 112Missing in isoform 3, isoform 4 and isoform 10. 2 PublicationsAdd BLAST82
Alternative sequenceiVSP_03370089 – 112Missing in isoform 5 and isoform 9. 2 PublicationsAdd BLAST24
Alternative sequenceiVSP_033701150 – 220Missing in isoform 4. 1 PublicationAdd BLAST71
Alternative sequenceiVSP_033702386 – 416Missing in isoform 2 and isoform 9. 2 PublicationsAdd BLAST31
Alternative sequenceiVSP_033703678 – 904Missing in isoform 5. 1 PublicationAdd BLAST227
Alternative sequenceiVSP_038325708 – 719Missing in isoform 10. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_0337081145 – 1242GSLDL…RQALC → AWTLRLNLRRSSSNYCTTRP PSRTSGPVGGKRAACAGGWS in isoform 4. 1 PublicationAdd BLAST98

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011114 mRNA Translation: BAA25468.2 Different initiation.
AK292408 mRNA Translation: BAF85097.1
AK293987 mRNA Translation: BAH11642.1
AK303362 mRNA Translation: BAH13949.1
AL096701 Genomic DNA No translation available.
AL096768 Genomic DNA No translation available.
AL109802 Genomic DNA No translation available.
BC021576 mRNA Translation: AAH21576.1
BC110814 mRNA Translation: AAI10815.1 Different initiation.
BC129926 mRNA Translation: AAI29927.1 Different initiation.
BC129945 mRNA Translation: AAI29946.1
CCDSiCCDS43004.1 [A8K8P3-1]
CCDS43005.1 [A8K8P3-2]
CCDS58803.1 [A8K8P3-9]
CCDS58804.1 [A8K8P3-3]
PIRiT00322
RefSeqiNP_001007468.1, NM_001007467.2 [A8K8P3-1]
NP_001245254.1, NM_001258325.1 [A8K8P3-9]
NP_001245255.1, NM_001258326.1 [A8K8P3-3]
NP_001245256.1, NM_001258327.1 [A8K8P3-10]
NP_055590.2, NM_014775.3 [A8K8P3-2]
XP_006724453.1, XM_006724390.2 [A8K8P3-3]
XP_016884640.1, XM_017029151.1 [A8K8P3-2]
XP_016884643.1, XM_017029154.1 [A8K8P3-9]
UniGeneiHs.62209
Hs.742373

Genome annotation databases

EnsembliENST00000400288; ENSP00000383145; ENSG00000198089 [A8K8P3-1]
ENST00000400289; ENSP00000383146; ENSG00000198089 [A8K8P3-3]
ENST00000432498; ENSP00000402679; ENSG00000198089 [A8K8P3-2]
ENST00000540643; ENSP00000443025; ENSG00000198089 [A8K8P3-9]
GeneIDi9814
KEGGihsa:9814
UCSCiuc003ale.5 human [A8K8P3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011114 mRNA Translation: BAA25468.2 Different initiation.
AK292408 mRNA Translation: BAF85097.1
AK293987 mRNA Translation: BAH11642.1
AK303362 mRNA Translation: BAH13949.1
AL096701 Genomic DNA No translation available.
AL096768 Genomic DNA No translation available.
AL109802 Genomic DNA No translation available.
BC021576 mRNA Translation: AAH21576.1
BC110814 mRNA Translation: AAI10815.1 Different initiation.
BC129926 mRNA Translation: AAI29927.1 Different initiation.
BC129945 mRNA Translation: AAI29946.1
CCDSiCCDS43004.1 [A8K8P3-1]
CCDS43005.1 [A8K8P3-2]
CCDS58803.1 [A8K8P3-9]
CCDS58804.1 [A8K8P3-3]
PIRiT00322
RefSeqiNP_001007468.1, NM_001007467.2 [A8K8P3-1]
NP_001245254.1, NM_001258325.1 [A8K8P3-9]
NP_001245255.1, NM_001258326.1 [A8K8P3-3]
NP_001245256.1, NM_001258327.1 [A8K8P3-10]
NP_055590.2, NM_014775.3 [A8K8P3-2]
XP_006724453.1, XM_006724390.2 [A8K8P3-3]
XP_016884640.1, XM_017029151.1 [A8K8P3-2]
XP_016884643.1, XM_017029154.1 [A8K8P3-9]
UniGeneiHs.62209
Hs.742373

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K2INMR-B641-660[»]
ProteinModelPortaliA8K8P3
SMRiA8K8P3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115153, 20 interactors
CORUMiA8K8P3
IntActiA8K8P3, 15 interactors
MINTiA8K8P3
STRINGi9606.ENSP00000383145

PTM databases

iPTMnetiA8K8P3
PhosphoSitePlusiA8K8P3

Polymorphism and mutation databases

BioMutaiSFI1

Proteomic databases

EPDiA8K8P3
MaxQBiA8K8P3
PaxDbiA8K8P3
PRIDEiA8K8P3
ProteomicsDBi1880
1881 [A8K8P3-10]
1882 [A8K8P3-2]
1883 [A8K8P3-3]
1884 [A8K8P3-4]
1885 [A8K8P3-5]
1886 [A8K8P3-9]

Protocols and materials databases

DNASUi9814
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400288; ENSP00000383145; ENSG00000198089 [A8K8P3-1]
ENST00000400289; ENSP00000383146; ENSG00000198089 [A8K8P3-3]
ENST00000432498; ENSP00000402679; ENSG00000198089 [A8K8P3-2]
ENST00000540643; ENSP00000443025; ENSG00000198089 [A8K8P3-9]
GeneIDi9814
KEGGihsa:9814
UCSCiuc003ale.5 human [A8K8P3-1]

Organism-specific databases

CTDi9814
DisGeNETi9814
EuPathDBiHostDB:ENSG00000198089.14
GeneCardsiSFI1
H-InvDBiHIX0016393
HGNCiHGNC:29064 SFI1
MIMi612765 gene
neXtProtiNX_A8K8P3
OpenTargetsiENSG00000198089
PharmGKBiPA142670930
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4775 Eukaryota
ENOG4111JHQ LUCA
GeneTreeiENSGT00390000018445
HOVERGENiHBG108479
InParanoidiA8K8P3
KOiK16489
OMAiMLWKQKV
OrthoDBiEOG091G0EXO
PhylomeDBiA8K8P3
TreeFamiTF328940

Enzyme and pathway databases

ReactomeiR-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-8854518 AURKA Activation by TPX2

Miscellaneous databases

ChiTaRSiSFI1 human
EvolutionaryTraceiA8K8P3
GenomeRNAii9814
PROiPR:A8K8P3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198089 Expressed in 177 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_SFI1
ExpressionAtlasiA8K8P3 baseline and differential
GenevisibleiA8K8P3 HS

Family and domain databases

InterProiView protein in InterPro
IPR030516 SFI1
PANTHERiPTHR22028:SF4 PTHR22028:SF4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSFI1_HUMAN
AccessioniPrimary (citable) accession number: A8K8P3
Secondary accession number(s): A1L373
, A1L387, A2A2L2, B1AKL9, B5MDB7, B7Z1V6, B7Z8G3, B7ZBE2, B7ZBE3, O60289, Q2TAN8, Q5W1B5, Q86TK0, Q8N4U8, Q8N8C1, Q8WU14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 7, 2018
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again