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Entry version 101 (13 Feb 2019)
Sequence version 2 (20 May 2008)
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Protein

Protein SFI1 homolog

Gene

SFI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the dynamic structure of centrosome-associated contractile fibers via its interaction with CETN2.1 Publication

Caution

It is uncertain whether Met-1 or Met-24 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-8854518 AURKA Activation by TPX2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein SFI1 homolog
Short name:
hSFI1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SFI1
Synonyms:KIAA0542
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000198089.14

Human Gene Nomenclature Database

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HGNCi
HGNC:29064 SFI1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612765 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A8K8P3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9814

Open Targets

More...
OpenTargetsi
ENSG00000198089

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670930

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SFI1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003346211 – 1242Protein SFI1 homologAdd BLAST1242

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A8K8P3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A8K8P3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A8K8P3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A8K8P3

PRoteomics IDEntifications database

More...
PRIDEi
A8K8P3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
1880
1881 [A8K8P3-10]
1882 [A8K8P3-2]
1883 [A8K8P3-3]
1884 [A8K8P3-4]
1885 [A8K8P3-5]
1886 [A8K8P3-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A8K8P3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A8K8P3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198089 Expressed in 177 organ(s), highest expression level in right hemisphere of cerebellum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A8K8P3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A8K8P3 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CETN2 (via C-terminus).2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115153, 21 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
A8K8P3

Protein interaction database and analysis system

More...
IntActi
A8K8P3, 16 interactors

Molecular INTeraction database

More...
MINTi
A8K8P3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000383145

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11242
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K2INMR-B641-660[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A8K8P3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A8K8P3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
A8K8P3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati138 – 170HAT 1Add BLAST33
Repeati172 – 201HAT 2Add BLAST30
Repeati270 – 302HAT 3Add BLAST33
Repeati334 – 368HAT 4Add BLAST35
Repeati399 – 431HAT 5Add BLAST33
Repeati1148 – 1180HAT 6Add BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni111 – 130Interaction with CETN2Add BLAST20
Regioni475 – 494Interaction with CETN2Add BLAST20
Regioni641 – 660Interaction with CETN2Add BLAST20

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

CETN2-binding regions contains a conserved Trp residue in their C-terminal ends, which seems critical for interaction with CETN2.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SFI1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4775 Eukaryota
ENOG4111JHQ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154110

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108479

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A8K8P3

KEGG Orthology (KO)

More...
KOi
K16489

Identification of Orthologs from Complete Genome Data

More...
OMAi
MLWKQKV

Database of Orthologous Groups

More...
OrthoDBi
941268at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A8K8P3

TreeFam database of animal gene trees

More...
TreeFami
TF328940

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030516 SFI1

The PANTHER Classification System

More...
PANTHERi
PTHR22028:SF4 PTHR22028:SF4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A8K8P3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKNLLTEKCI SSHNFHQKVI KQRMEKKVDS RYFKDGAVKK PYSAKTLSNK
60 70 80 90 100
KSSASFGIRR ELPSTSHLVQ YRGTHTCTRQ GRLRELRIRC VARKFLYLWI
110 120 130 140 150
RMTFGRVFPS KARFYYEQRL LRKVFEEWKE EWWVFQHEWK LCVRADCHYR
160 170 180 190 200
YYLYNLMFQT WKTYVRQQQE MRNKYIRAEV HDAKQKMRQA WKSWLIYVVV
210 220 230 240 250
RRTKLQMQTT ALEFRQRIIL RVWWSTWRQR LGQVRVSRAL HASALKHRAL
260 270 280 290 300
SLQVQAWSQW REQLLYVQKE KQKVVSAVKH HQHWQKRRFL KAWLEYLQVR
310 320 330 340 350
RVKRQQNEMA ERFHHVTVLQ IYFCDWQQAW ERRESLYAHH AQVEKLARKM
360 370 380 390 400
ALRRAFTHWK HYMLLCAEEA AQFEMAEEHH RHSQLYFCFR ALKDNVTHAH
410 420 430 440 450
LQQIRRNLAH QQHGVTLLHR FWNLWRSQIE QKKERELLPL LHAAWDHYRI
460 470 480 490 500
ALLCKCIELW LQYTQKRRYK QLLQARADGH FQQRALPAAF HTWNRLWRWR
510 520 530 540 550
HQENVLSARA TRFHRETLEK QVFSLWRQKM FQHRENRLAE RMAILHAERQ
560 570 580 590 600
LLYRSWFMWH QQAAARHQEQ EWQTVACAHH RHGRLKKAFC LWRESAQGLR
610 620 630 640 650
TERTGRVRAA EFHMAQLLRW AWSQWRECLA LRGAERQKLM RADLHHQHSV
660 670 680 690 700
LHRALQAWVT YQGRVRSILR EVAARESQHN RQLLRGALRR WKENTMARVD
710 720 730 740 750
EAKKTFQAST HYRRTICSKV LVQWREAVSV QMYYRQQEDC AIWEAQKVLD
760 770 780 790 800
RGCLRTWFQR WWDCSRRSAQ QRLQLERAVQ HHHRQLLLEG LARWKTHHLQ
810 820 830 840 850
CVRKRLLHRQ STQLLAQRLS RTCFRQWRQQ LAARRQEQRA TVRALWFWAF
860 870 880 890 900
SLQAKVWATW LAFVLERRRK KARLQWALQA YQGQLLQEGA TRLLRFAASM
910 920 930 940 950
KASRQQLQAQ QQVQAAHSLH RAVRRCATLW KQKVLGRGGK PQPLAAIAPS
960 970 980 990 1000
RKVTFEGPLL NRIAAGAGDG TLETKRPQAS RPLGALGRLA AEEPHALELN
1010 1020 1030 1040 1050
TAHSARKQPR RPHFLLEPAQ SQRPQKPQEH GLGMAQPAAP SLTRPFLAEA
1060 1070 1080 1090 1100
PTALVPHSPL PGALSSAPGP KQPPTASTGP ELLLLPLSSF MPCGAAAPAR
1110 1120 1130 1140 1150
VSAQRATPRD KPPVPSSLAS VPDPHLLLPG DFSATRAGPG LSTAGSLDLE
1160 1170 1180 1190 1200
AELEEIQQQL LHYQTTKQNL WSCRRQASSL RRWLELNREE PGPEDQEVEQ
1210 1220 1230 1240
QVQKELEQVE MQIQLLAEEL QAQRQPIGAC VARIQALRQA LC
Length:1,242
Mass (Da):147,664
Last modified:May 20, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7BE570BDD7F72B6E
GO
Isoform 2 (identifier: A8K8P3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     386-416: Missing.

Show »
Length:1,211
Mass (Da):143,978
Checksum:i4F7038E1D184A505
GO
Isoform 3 (identifier: A8K8P3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-112: Missing.

Note: No experimental confirmation available.
Show »
Length:1,160
Mass (Da):138,070
Checksum:iC3560EAD4217A72E
GO
Isoform 4 (identifier: A8K8P3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-112: Missing.
     150-220: Missing.
     1145-1242: GSLDLEAELE...RIQALRQALC → AWTLRLNLRR...KRAACAGGWS

Note: No experimental confirmation available.
Show »
Length:1,031
Mass (Da):121,826
Checksum:i108E39A21FE58AC5
GO
Isoform 5 (identifier: A8K8P3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-112: Missing.
     678-904: Missing.

Note: No experimental confirmation available.
Show »
Length:991
Mass (Da):117,079
Checksum:i677D443FAF8A82E5
GO
Isoform 9 (identifier: A8K8P3-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-112: Missing.
     386-416: Missing.

Note: No experimental confirmation available.
Show »
Length:1,187
Mass (Da):141,050
Checksum:i517294BE383E1B0F
GO
Isoform 10 (identifier: A8K8P3-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-112: Missing.
     708-719: Missing.

Note: No experimental confirmation available.
Show »
Length:1,148
Mass (Da):136,666
Checksum:i1859FC8789A47186
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YTJ2D3YTJ2_HUMAN
Protein SFI1 homolog
SFI1
1,089Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBU4F8WBU4_HUMAN
Developmentally-regulated GTP-bindi...
DRG1 SFI1
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJU6E5RJU6_HUMAN
Protein SFI1 homolog
SFI1
389Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5I7H0Y5I7_HUMAN
Protein SFI1 homolog
SFI1
605Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZF3H7BZF3_HUMAN
Protein SFI1 homolog
SFI1
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2F1H7C2F1_HUMAN
Protein SFI1 homolog
SFI1
489Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RJF9X6RJF9_HUMAN
Protein SFI1 homolog
SFI1
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y836H0Y836_HUMAN
Protein SFI1 homolog
SFI1
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI10815 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI29927 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA25468 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti353R → W in AAI10815 (PubMed:15489334).Curated1
Sequence conflicti622W → R in AAI29927 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04343913H → L. Corresponds to variant dbSNP:rs5749290Ensembl.1
Natural variantiVAR_04344072R → H. Corresponds to variant dbSNP:rs16989698Ensembl.1
Natural variantiVAR_043441167Q → H. Corresponds to variant dbSNP:rs7511430Ensembl.1
Natural variantiVAR_043442322Y → H3 PublicationsCorresponds to variant dbSNP:rs5753700Ensembl.1
Natural variantiVAR_043443330W → R. Corresponds to variant dbSNP:rs16989291Ensembl.1
Natural variantiVAR_043444549R → Q2 PublicationsCorresponds to variant dbSNP:rs2006771Ensembl.1
Natural variantiVAR_062234760R → H. Corresponds to variant dbSNP:rs9621295Ensembl.1
Natural variantiVAR_0434451087L → P3 PublicationsCorresponds to variant dbSNP:rs12171042Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03369931 – 112Missing in isoform 3, isoform 4 and isoform 10. 2 PublicationsAdd BLAST82
Alternative sequenceiVSP_03370089 – 112Missing in isoform 5 and isoform 9. 2 PublicationsAdd BLAST24
Alternative sequenceiVSP_033701150 – 220Missing in isoform 4. 1 PublicationAdd BLAST71
Alternative sequenceiVSP_033702386 – 416Missing in isoform 2 and isoform 9. 2 PublicationsAdd BLAST31
Alternative sequenceiVSP_033703678 – 904Missing in isoform 5. 1 PublicationAdd BLAST227
Alternative sequenceiVSP_038325708 – 719Missing in isoform 10. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_0337081145 – 1242GSLDL…RQALC → AWTLRLNLRRSSSNYCTTRP PSRTSGPVGGKRAACAGGWS in isoform 4. 1 PublicationAdd BLAST98

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB011114 mRNA Translation: BAA25468.2 Different initiation.
AK292408 mRNA Translation: BAF85097.1
AK293987 mRNA Translation: BAH11642.1
AK303362 mRNA Translation: BAH13949.1
AL096701 Genomic DNA No translation available.
AL096768 Genomic DNA No translation available.
AL109802 Genomic DNA No translation available.
BC021576 mRNA Translation: AAH21576.1
BC110814 mRNA Translation: AAI10815.1 Different initiation.
BC129926 mRNA Translation: AAI29927.1 Different initiation.
BC129945 mRNA Translation: AAI29946.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43004.1 [A8K8P3-1]
CCDS43005.1 [A8K8P3-2]
CCDS58803.1 [A8K8P3-9]
CCDS58804.1 [A8K8P3-3]

Protein sequence database of the Protein Information Resource

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PIRi
T00322

NCBI Reference Sequences

More...
RefSeqi
NP_001007468.1, NM_001007467.2 [A8K8P3-1]
NP_001245254.1, NM_001258325.1 [A8K8P3-9]
NP_001245255.1, NM_001258326.1 [A8K8P3-3]
NP_001245256.1, NM_001258327.1 [A8K8P3-10]
NP_055590.2, NM_014775.3 [A8K8P3-2]
XP_006724453.1, XM_006724390.2 [A8K8P3-3]
XP_016884640.1, XM_017029151.1 [A8K8P3-2]
XP_016884643.1, XM_017029154.1 [A8K8P3-9]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.62209
Hs.742373

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000400288; ENSP00000383145; ENSG00000198089 [A8K8P3-1]
ENST00000400289; ENSP00000383146; ENSG00000198089 [A8K8P3-3]
ENST00000432498; ENSP00000402679; ENSG00000198089 [A8K8P3-2]
ENST00000540643; ENSP00000443025; ENSG00000198089 [A8K8P3-9]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9814

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9814

UCSC genome browser

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UCSCi
uc003ale.5 human [A8K8P3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011114 mRNA Translation: BAA25468.2 Different initiation.
AK292408 mRNA Translation: BAF85097.1
AK293987 mRNA Translation: BAH11642.1
AK303362 mRNA Translation: BAH13949.1
AL096701 Genomic DNA No translation available.
AL096768 Genomic DNA No translation available.
AL109802 Genomic DNA No translation available.
BC021576 mRNA Translation: AAH21576.1
BC110814 mRNA Translation: AAI10815.1 Different initiation.
BC129926 mRNA Translation: AAI29927.1 Different initiation.
BC129945 mRNA Translation: AAI29946.1
CCDSiCCDS43004.1 [A8K8P3-1]
CCDS43005.1 [A8K8P3-2]
CCDS58803.1 [A8K8P3-9]
CCDS58804.1 [A8K8P3-3]
PIRiT00322
RefSeqiNP_001007468.1, NM_001007467.2 [A8K8P3-1]
NP_001245254.1, NM_001258325.1 [A8K8P3-9]
NP_001245255.1, NM_001258326.1 [A8K8P3-3]
NP_001245256.1, NM_001258327.1 [A8K8P3-10]
NP_055590.2, NM_014775.3 [A8K8P3-2]
XP_006724453.1, XM_006724390.2 [A8K8P3-3]
XP_016884640.1, XM_017029151.1 [A8K8P3-2]
XP_016884643.1, XM_017029154.1 [A8K8P3-9]
UniGeneiHs.62209
Hs.742373

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K2INMR-B641-660[»]
ProteinModelPortaliA8K8P3
SMRiA8K8P3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115153, 21 interactors
CORUMiA8K8P3
IntActiA8K8P3, 16 interactors
MINTiA8K8P3
STRINGi9606.ENSP00000383145

PTM databases

iPTMnetiA8K8P3
PhosphoSitePlusiA8K8P3

Polymorphism and mutation databases

BioMutaiSFI1

Proteomic databases

EPDiA8K8P3
jPOSTiA8K8P3
MaxQBiA8K8P3
PaxDbiA8K8P3
PRIDEiA8K8P3
ProteomicsDBi1880
1881 [A8K8P3-10]
1882 [A8K8P3-2]
1883 [A8K8P3-3]
1884 [A8K8P3-4]
1885 [A8K8P3-5]
1886 [A8K8P3-9]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9814
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400288; ENSP00000383145; ENSG00000198089 [A8K8P3-1]
ENST00000400289; ENSP00000383146; ENSG00000198089 [A8K8P3-3]
ENST00000432498; ENSP00000402679; ENSG00000198089 [A8K8P3-2]
ENST00000540643; ENSP00000443025; ENSG00000198089 [A8K8P3-9]
GeneIDi9814
KEGGihsa:9814
UCSCiuc003ale.5 human [A8K8P3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9814
DisGeNETi9814
EuPathDBiHostDB:ENSG00000198089.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SFI1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0016393
HGNCiHGNC:29064 SFI1
MIMi612765 gene
neXtProtiNX_A8K8P3
OpenTargetsiENSG00000198089
PharmGKBiPA142670930

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4775 Eukaryota
ENOG4111JHQ LUCA
GeneTreeiENSGT00940000154110
HOVERGENiHBG108479
InParanoidiA8K8P3
KOiK16489
OMAiMLWKQKV
OrthoDBi941268at2759
PhylomeDBiA8K8P3
TreeFamiTF328940

Enzyme and pathway databases

ReactomeiR-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-8854518 AURKA Activation by TPX2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SFI1 human
EvolutionaryTraceiA8K8P3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9814

Protein Ontology

More...
PROi
PR:A8K8P3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198089 Expressed in 177 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiA8K8P3 baseline and differential
GenevisibleiA8K8P3 HS

Family and domain databases

InterProiView protein in InterPro
IPR030516 SFI1
PANTHERiPTHR22028:SF4 PTHR22028:SF4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSFI1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8K8P3
Secondary accession number(s): A1L373
, A1L387, A2A2L2, B1AKL9, B5MDB7, B7Z1V6, B7Z8G3, B7ZBE2, B7ZBE3, O60289, Q2TAN8, Q5W1B5, Q86TK0, Q8N4U8, Q8N8C1, Q8WU14
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: February 13, 2019
This is version 101 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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