UniProtKB - A8K860 (A8K860_HUMAN)
Protein
DNA polymerase
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.UniRule annotation
Catalytic activityi
- EC:2.7.7.7UniRule annotation
Cofactori
Mn2+ARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 220 | Schiff-base intermediate with DNAUniRule annotation | 1 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-UniRule
- DNA-directed DNA polymerase activity Source: UniProtKB-UniRule
- metal ion binding Source: UniProtKB-UniRule
GO - Biological processi
- DNA repair Source: UniProtKB-KW
- DNA replication Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-directed DNA polymeraseUniRule annotation, Nucleotidyltransferase, Transferase |
Biological process | DNA damage, DNA repairUniRule annotation, DNA replicationARBA annotation, DNA synthesisARBA annotation |
Names & Taxonomyi
Protein namesi | |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Keywords - Cellular componenti
NucleusUniRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 36 – 132 | BRCTInterPro annotationAdd BLAST | 97 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 161 – 212 | DisorderedSequence analysisAdd BLAST | 52 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 165 – 179 | Pro-richSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Phylogenomic databases
OrthoDBi | 1328151at2759 |
Family and domain databases
CDDi | cd00141, NT_POLXc, 1 hit |
Gene3Di | 1.10.150.110, 1 hit 3.30.210.10, 1 hit 3.30.460.10, 1 hit 3.40.50.10190, 1 hit |
InterProi | View protein in InterPro IPR001357, BRCT_dom IPR036420, BRCT_dom_sf IPR002054, DNA-dir_DNA_pol_X IPR019843, DNA_pol-X_BS IPR028207, DNA_pol_B_palm_palm IPR018944, DNA_pol_lambd_fingers_domain IPR027421, DNA_pol_lamdba_lyase_dom_sf IPR037160, DNA_Pol_thumb_sf IPR022312, DNA_pol_X IPR002008, DNA_pol_X_beta-like IPR043519, NT_sf IPR029398, PolB_thumb |
Pfami | View protein in Pfam PF14792, DNA_pol_B_palm, 1 hit PF14791, DNA_pol_B_thumb, 1 hit PF10391, DNA_pol_lambd_f, 1 hit |
PRINTSi | PR00869, DNAPOLX PR00870, DNAPOLXBETA |
SMARTi | View protein in SMART SM00483, POLXc, 1 hit |
SUPFAMi | SSF47802, SSF47802, 1 hit SSF52113, SSF52113, 1 hit SSF81301, SSF81301, 1 hit |
PROSITEi | View protein in PROSITE PS50172, BRCT, 1 hit PS00522, DNA_POLYMERASE_X, 1 hit |
i Sequence
Sequence statusi: Complete.
A8K860-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDPRGILKAF PKRQKIHADA SSKVLAKIPR REEGEEAEEW LSSLRAHVVR
60 70 80 90 100
TGIGRARAEL FEKQIVQHGG QLCPAQGPGV THIVVDEGMD YERALRLLRL
110 120 130 140 150
PQLPPGAQLV KSAWLSLCLQ ERRLVDVAGF SIFIPSRYLD HPQPSKAEQD
160 170 180 190 200
ASIPPGTHEA LLQTALSPPP PPTRPVSPPQ KAKEAPNTQA QPISDDEASD
210 220 230 240 250
GEETQEACSI PGIGKRMAEK IIEILESGHL RKLDHISESV PVLELFSNIW
260 270 280 290 300
GAGTKTAQMW YQQGFRSLED IRSQASLTTQ QAIGLKHYSD FLERMPREEA
310 320 330 340 350
TEIEQTVQKA AQAFNSGLLC VACGSYRRGK ATCGDVDVLI THPDGRSHRG
360 370 380 390 400
IFSRLLDSLR QEGFLTDDLV SQEENGQQQK YLGVCRLPGP GRRHRRLDII
410 420 430 440 450
VVPYSEFACA LLYFTGSAHF NRSMRALAKT KGMSLSEHAL STAVVRNTHG
460 470 480
CKVGPGRVLP TPTEKDVFRL LGLPYREPAE RDW
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK292225 mRNA Translation: BAF84914.1 |
RefSeqi | NP_001167556.1, NM_001174085.1 XP_011537957.1, XM_011539655.1 |
Genome annotation databases
GeneIDi | 27343 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK292225 mRNA Translation: BAF84914.1 |
RefSeqi | NP_001167556.1, NM_001174085.1 XP_011537957.1, XM_011539655.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | A8K860 |
PeptideAtlasi | A8K860 |
Genome annotation databases
GeneIDi | 27343 |
Organism-specific databases
CTDi | 27343 |
PharmGKBi | PA33504 |
Phylogenomic databases
OrthoDBi | 1328151at2759 |
Miscellaneous databases
BioGRID-ORCSi | 27343, 3 hits in 847 CRISPR screens |
GenomeRNAii | 27343 |
Gene expression databases
Genevisiblei | A8K860, HS |
Family and domain databases
CDDi | cd00141, NT_POLXc, 1 hit |
Gene3Di | 1.10.150.110, 1 hit 3.30.210.10, 1 hit 3.30.460.10, 1 hit 3.40.50.10190, 1 hit |
InterProi | View protein in InterPro IPR001357, BRCT_dom IPR036420, BRCT_dom_sf IPR002054, DNA-dir_DNA_pol_X IPR019843, DNA_pol-X_BS IPR028207, DNA_pol_B_palm_palm IPR018944, DNA_pol_lambd_fingers_domain IPR027421, DNA_pol_lamdba_lyase_dom_sf IPR037160, DNA_Pol_thumb_sf IPR022312, DNA_pol_X IPR002008, DNA_pol_X_beta-like IPR043519, NT_sf IPR029398, PolB_thumb |
Pfami | View protein in Pfam PF14792, DNA_pol_B_palm, 1 hit PF14791, DNA_pol_B_thumb, 1 hit PF10391, DNA_pol_lambd_f, 1 hit |
PRINTSi | PR00869, DNAPOLX PR00870, DNAPOLXBETA |
SMARTi | View protein in SMART SM00483, POLXc, 1 hit |
SUPFAMi | SSF47802, SSF47802, 1 hit SSF52113, SSF52113, 1 hit SSF81301, SSF81301, 1 hit |
PROSITEi | View protein in PROSITE PS50172, BRCT, 1 hit PS00522, DNA_POLYMERASE_X, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A8K860_HUMAN | |
Accessioni | A8K860Primary (citable) accession number: A8K860 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 4, 2007 |
Last sequence update: | December 4, 2007 | |
Last modified: | December 2, 2020 | |
This is version 79 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |