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Entry version 96 (08 May 2019)
Sequence version 1 (05 Feb 2008)
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Protein

EF-hand calcium-binding domain-containing protein 7

Gene

EFCAB7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2:EVC subcomplex at the base of primary cilia.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi416 – 4273PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5635838 Activation of SMO

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
EF-hand calcium-binding domain-containing protein 7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EFCAB7
Synonyms:KIAA1799
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29379 EFCAB7

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617632 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A8K855

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84455

Open Targets

More...
OpenTargetsi
ENSG00000203965

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162384389

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EFCAB7

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003172661 – 629EF-hand calcium-binding domain-containing protein 7Add BLAST629

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei200PhosphoserineCombined sources1
Modified residuei212PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A8K855

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A8K855

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A8K855

PRoteomics IDEntifications database

More...
PRIDEi
A8K855

ProteomicsDB human proteome resource

More...
ProteomicsDBi
1875
1876 [A8K855-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A8K855

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A8K855

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000203965 Expressed in 193 organ(s), highest expression level in quadriceps femoris

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A8K855 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA029611
HPA029612
HPA029613

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the EvC complex composed of EFCAB7, IQCE, EVC2 and EVC; built from two subcomplexes, EVC2:EVC and EFCAB7:IQCE. Interacts (via EF-hand 1 and 2) with IQCE (via N-terminus); this interaction anchors the EVC-EVC2 complex in a signaling microdomain at the base of cilia and stimulates the Hedgehog (Hh) pathway. Interacts with EVC2 (via N-terminal end). Interacts with EVC.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124090, 7 interactors

Protein interaction database and analysis system

More...
IntActi
A8K855, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000360129

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A8K855

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini102 – 137EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini138 – 173EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini403 – 438EF-hand 3PROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0027 Eukaryota
COG5126 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015466

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007278

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A8K855

Identification of Orthologs from Complete Genome Data

More...
OMAi
MCFTELR

Database of Orthologous Groups

More...
OrthoDBi
1059411at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A8K855

TreeFam database of animal gene trees

More...
TreeFami
TF329354

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00051 EFh, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13499 EF-hand_7, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054 EFh, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: A8K855-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAISPRSDAT FSSQKSTPSE SPRTKKFPLT EEEIFYMNCR AAYLTVFKSS
60 70 80 90 100
LENIISKDQL YLALQHAGRN PSQKTINKYW TPQTAKLNFD DFCIILRKEK
110 120 130 140 150
PTSKAELLKS FKQLDVNDDG CILHTDLYKF LTKRGEKMTR EEVNAIINLA
160 170 180 190 200
DVNADGKFDY IKFCKLYMTT NEQCLKTTLE KLEVDSKLMR HQFGNHIEGS
210 220 230 240 250
PERDPSPVPK PSPKITRKTD PETFLNKGDT RSSLLSATRK FKTSVSFTVT
260 270 280 290 300
MGANGNRNSK LMEPNLIKDW QHMQSKGCFF LEEDGEIISH QYRMQIAQRS
310 320 330 340 350
MVYLTIKPLN LSQVEGKPSP WLSVDTALYI LKENESQANL QLVCFTELRN
360 370 380 390 400
REVFGWTGEL GPGIYWLIPS TTGCRLRKKI KPVTDEAQLV YRDETGELFL
410 420 430 440 450
TKEFKSTLSD IFEVIDLDGN GLLSLEEYNF FELRTSGEKC DEDAWAVCRE
460 470 480 490 500
NFDTKRNELT RQGFMDLNLM EANDREGDPC DLWVTLHSMG YNKALELTEA
510 520 530 540 550
CPFVIDIYAE KCKPKIKAVH MEACSGQLEK AICKSVLSNG DAKVMDGYEN
560 570 580 590 600
IIVHTYSCDT WITSVIENKS DEKVIIHISN ELSKNCINNR GLNIFAVEVG
610 620
PKSTMVCQHV MPLNERQEWI YYCIYSLIS
Length:629
Mass (Da):71,981
Last modified:February 5, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0C91918C36D7E0B8
GO
Isoform 2 (identifier: A8K855-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     606-629: VCQHVMPLNERQEWIYYCIYSLIS → P

Note: No experimental confirmation available.
Show »
Length:606
Mass (Da):69,108
Checksum:i5B45F56F35DC0A17
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB47428 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03849327F → I. Corresponds to variant dbSNP:rs17125106Ensembl.1
Natural variantiVAR_038494186S → G. Corresponds to variant dbSNP:rs9436246Ensembl.1
Natural variantiVAR_038495248T → I1 PublicationCorresponds to variant dbSNP:rs6693255Ensembl.1
Natural variantiVAR_038496262M → T1 PublicationCorresponds to variant dbSNP:rs6657480Ensembl.1
Natural variantiVAR_038497375R → K2 PublicationsCorresponds to variant dbSNP:rs2273367Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_030930606 – 629VCQHV…YSLIS → P in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB058702 mRNA Translation: BAB47428.1 Different initiation.
AK292220 mRNA Translation: BAF84909.1
AK315850 mRNA Translation: BAF98741.1
AL109925 Genomic DNA No translation available.
BX004807 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06570.1
BC015814 mRNA Translation: AAH15814.1
AL833720 mRNA Translation: CAH56237.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30737.1 [A8K855-1]

NCBI Reference Sequences

More...
RefSeqi
NP_115813.2, NM_032437.3 [A8K855-1]
XP_005271331.1, XM_005271274.3 [A8K855-2]
XP_006711040.1, XM_006710977.1 [A8K855-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000371088; ENSP00000360129; ENSG00000203965 [A8K855-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84455

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84455

UCSC genome browser

More...
UCSCi
uc001dbf.4 human [A8K855-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058702 mRNA Translation: BAB47428.1 Different initiation.
AK292220 mRNA Translation: BAF84909.1
AK315850 mRNA Translation: BAF98741.1
AL109925 Genomic DNA No translation available.
BX004807 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06570.1
BC015814 mRNA Translation: AAH15814.1
AL833720 mRNA Translation: CAH56237.1
CCDSiCCDS30737.1 [A8K855-1]
RefSeqiNP_115813.2, NM_032437.3 [A8K855-1]
XP_005271331.1, XM_005271274.3 [A8K855-2]
XP_006711040.1, XM_006710977.1 [A8K855-1]

3D structure databases

SMRiA8K855
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124090, 7 interactors
IntActiA8K855, 1 interactor
STRINGi9606.ENSP00000360129

PTM databases

iPTMnetiA8K855
PhosphoSitePlusiA8K855

Polymorphism and mutation databases

BioMutaiEFCAB7

Proteomic databases

jPOSTiA8K855
MaxQBiA8K855
PaxDbiA8K855
PRIDEiA8K855
ProteomicsDBi1875
1876 [A8K855-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
84455
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371088; ENSP00000360129; ENSG00000203965 [A8K855-1]
GeneIDi84455
KEGGihsa:84455
UCSCiuc001dbf.4 human [A8K855-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84455
DisGeNETi84455

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EFCAB7

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0000663
HGNCiHGNC:29379 EFCAB7
HPAiHPA029611
HPA029612
HPA029613
MIMi617632 gene
neXtProtiNX_A8K855
OpenTargetsiENSG00000203965
PharmGKBiPA162384389

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00390000015466
HOGENOMiHOG000007278
InParanoidiA8K855
OMAiMCFTELR
OrthoDBi1059411at2759
PhylomeDBiA8K855
TreeFamiTF329354

Enzyme and pathway databases

ReactomeiR-HSA-5635838 Activation of SMO

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
EFCAB7 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84455

Protein Ontology

More...
PROi
PR:A8K855

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000203965 Expressed in 193 organ(s), highest expression level in quadriceps femoris
GenevisibleiA8K855 HS

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF47473 SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEFCB7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8K855
Secondary accession number(s): Q658P0, Q96B95, Q96JM6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 5, 2008
Last modified: May 8, 2019
This is version 96 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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