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Protein

Calcium-activated chloride channel regulator 1

Gene

CLCA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi156Zinc; catalytic1 Publication1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1571 Publication1
Metal bindingi160Zinc; catalytic1 Publication1
Metal bindingi167Zinc; catalytic1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chloride channel activity Source: ProtInc
  • intracellular calcium activated chloride channel activity Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • metalloendopeptidase activity Source: Reactome

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
Biological processCalcium transport, Ion transport, Transport
LigandCalcium, Chloride, Metal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2672351 Stimuli-sensing channels

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M87.001

Transport Classification Database

More...
TCDBi
1.A.13.1.6 the epithelial chloride channel (e-clc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium-activated chloride channel regulator 1 (EC:3.4.-.-1 Publication)
Alternative name(s):
Calcium-activated chloride channel family member 1
Short name:
hCLCA1
Calcium-activated chloride channel protein 1
Short name:
CaCC-1
Short name:
hCaCC-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CLCA1
Synonyms:CACC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000016490.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2015 CLCA1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603906 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A8K7I4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi150Q → A: Reduces proteolytic cleavage. 1 Publication1
Mutagenesisi156H → A: Abolishes proteolytic cleavage. 1 Publication1
Mutagenesisi157E → Q: Abolishes proteolytic cleavage. 1 Publication1
Mutagenesisi160H → A: Abolishes proteolytic cleavage. 1 Publication1
Mutagenesisi167D → A: Abolishes proteolytic cleavage. 1 Publication1
Mutagenesisi168E → A: Abolishes proteolytic cleavage. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
1179

Open Targets

More...
OpenTargetsi
ENSG00000016490

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26542

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2364708

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CLCA1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000033369022 – 914Calcium-activated chloride channel regulator 1Add BLAST893

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi503N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi585N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi770N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi804N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi810N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi831N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi836N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi890N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.1 Publication
The 125-kDa product is autoproteolytically processed by the metalloprotease domain and yields to two cell-surface-associated subunits, a 90-kDa protein and a group of 37-to 41-kDa proteins. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei694 – 695Cleavage; by autolysis1 Publication2

Keywords - PTMi

Autocatalytic cleavage, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A8K7I4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A8K7I4

PRoteomics IDEntifications database

More...
PRIDEi
A8K7I4

ProteomicsDB human proteome resource

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ProteomicsDBi
1869

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A8K7I4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A8K7I4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet cells, and appendix. Weakly expressed in uterus, testis and kidney. Expressed in the airways epithelium of both asthmatic and healthy patients. Expressed in the bronchial epithelium, especially in mucus-producing goblet cells. Expressed in normal turbinate mucosa and nasal polyp. Expressed in.5 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By IL13/interleukin-13 in tracheobronchial epithelial cells. Up-regulated by histamine in a dose-dependent manner. Significantly down-regulated in colorectal cancer. Significantly up-regulated in the IL9-responsive mucus-producing epithelium of asthmatic patients. Significantly decreased in nasal polyp. Significantly increased by TNF in upper airway mucosa.7 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000016490 Expressed in 65 organ(s), highest expression level in sigmoid colon

CleanEx database of gene expression profiles

More...
CleanExi
HS_CLCA1

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
A8K7I4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA052787
HPA059301

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107593, 2 interactors

Protein interaction database and analysis system

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IntActi
A8K7I4, 1 interactor

STRING: functional protein association networks

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STRINGi
9606.ENSP00000234701

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A8K7I4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A8K7I4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini306 – 475VWFAPROSITE-ProRule annotationAdd BLAST170

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni46 – 199Metalloprotease domain1 PublicationAdd BLAST154

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The metalloprotease region is responsible for autoproteolytic processing. It can also cross-cleave other CLCA substrates.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CLCR family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEPS Eukaryota
ENOG410XPSZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154682

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000015107

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG005560

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
A8K7I4

KEGG Orthology (KO)

More...
KOi
K05027

Identification of Orthologs from Complete Genome Data

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OMAi
LFPPCQI

Database of Orthologous Groups

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OrthoDBi
685640at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A8K7I4

TreeFam database of animal gene trees

More...
TreeFami
TF328396

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004727 CLCA_chordata
IPR013642 CLCA_N
IPR013783 Ig-like_fold
IPR002035 VWF_A
IPR036465 vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08434 CLCA, 1 hit
PF13519 VWA_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00327 VWA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300 SSF53300, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00868 hCaCC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50234 VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

A8K7I4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPFKSSVFI LILHLLEGAL SNSLIQLNNN GYEGIVVAID PNVPEDETLI
60 70 80 90 100
QQIKDMVTQA SLYLLEATGK RFYFKNVAIL IPETWKTKAD YVRPKLETYK
110 120 130 140 150
NADVLVAEST PPGNDEPYTE QMGNCGEKGE RIHLTPDFIA GKKLAEYGPQ
160 170 180 190 200
GRAFVHEWAH LRWGVFDEYN NDEKFYLSNG RIQAVRCSAG ITGTNVVKKC
210 220 230 240 250
QGGSCYTKRC TFNKVTGLYE KGCEFVLQSR QTEKASIMFA QHVDSIVEFC
260 270 280 290 300
TEQNHNKEAP NKQNQKCNLR STWEVIRDSE DFKKTTPMTT QPPNPTFSLL
310 320 330 340 350
QIGQRIVCLV LDKSGSMATG NRLNRLNQAG QLFLLQTVEL GSWVGMVTFD
360 370 380 390 400
SAAHVQNELI QINSGSDRDT LAKRLPAAAS GGTSICSGLR SAFTVIRKKY
410 420 430 440 450
PTDGSEIVLL TDGEDNTISG CFNEVKQSGA IIHTVALGPS AAQELEELSK
460 470 480 490 500
MTGGLQTYAS DQVQNNGLID AFGALSSGNG AVSQRSIQLE SKGLTLQNSQ
510 520 530 540 550
WMNGTVIVDS TVGKDTLFLI TWTMQPPQIL LWDPSGQKQG GFVVDKNTKM
560 570 580 590 600
AYLQIPGIAK VGTWKYSLQA SSQTLTLTVT SRASNATLPP ITVTSKTNKD
610 620 630 640 650
TSKFPSPLVV YANIRQGASP ILRASVTALI ESVNGKTVTL ELLDNGAGAD
660 670 680 690 700
ATKDDGVYSR YFTTYDTNGR YSVKVRALGG VNAARRRVIP QQSGALYIPG
710 720 730 740 750
WIENDEIQWN PPRPEINKDD VQHKQVCFSR TSSGGSFVAS DVPNAPIPDL
760 770 780 790 800
FPPGQITDLK AEIHGGSLIN LTWTAPGDDY DHGTAHKYII RISTSILDLR
810 820 830 840 850
DKFNESLQVN TTALIPKEAN SEEVFLFKPE NITFENGTDL FIAIQAVDKV
860 870 880 890 900
DLKSEISNIA RVSLFIPPQT PPETPSPDET SAPCPNIHIN STIPGIHILK
910
IMWKWIGELQ LSIA
Length:914
Mass (Da):100,226
Last modified:November 2, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8D8999E855822711
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti393F → S in BAF84688 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05465465L → F4 PublicationsCorresponds to variant dbSNP:rs2145412Ensembl.1
Natural variantiVAR_054655152R → K1 PublicationCorresponds to variant dbSNP:rs2753386Ensembl.1
Natural variantiVAR_043146357N → S4 PublicationsCorresponds to variant dbSNP:rs2734705Ensembl.1
Natural variantiVAR_054656406E → V. Corresponds to variant dbSNP:rs1142185Ensembl.1
Natural variantiVAR_054657426K → R. Corresponds to variant dbSNP:rs4647852Ensembl.1
Natural variantiVAR_043147524M → T4 PublicationsCorresponds to variant dbSNP:rs2791494Ensembl.1
Natural variantiVAR_054658661Y → H. Corresponds to variant dbSNP:rs5744409Ensembl.1
Natural variantiVAR_054659760K → N1 PublicationCorresponds to variant dbSNP:rs2791483Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF039400 mRNA Translation: AAC95428.1
AF039401 Genomic DNA Translation: AAC95429.1
AF127036 mRNA Translation: AAD25487.1
AK291999 mRNA Translation: BAF84688.1
AK314375 mRNA Translation: BAG37002.1
AL122002 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73186.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS709.1

NCBI Reference Sequences

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RefSeqi
NP_001276.2, NM_001285.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.194659

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000234701; ENSP00000234701; ENSG00000016490
ENST00000394711; ENSP00000378200; ENSG00000016490

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1179

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1179

UCSC genome browser

More...
UCSCi
uc001dlt.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039400 mRNA Translation: AAC95428.1
AF039401 Genomic DNA Translation: AAC95429.1
AF127036 mRNA Translation: AAD25487.1
AK291999 mRNA Translation: BAF84688.1
AK314375 mRNA Translation: BAG37002.1
AL122002 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73186.1
CCDSiCCDS709.1
RefSeqiNP_001276.2, NM_001285.3
UniGeneiHs.194659

3D structure databases

ProteinModelPortaliA8K7I4
SMRiA8K7I4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107593, 2 interactors
IntActiA8K7I4, 1 interactor
STRINGi9606.ENSP00000234701

Chemistry databases

ChEMBLiCHEMBL2364708

Protein family/group databases

MEROPSiM87.001
TCDBi1.A.13.1.6 the epithelial chloride channel (e-clc) family

PTM databases

iPTMnetiA8K7I4
PhosphoSitePlusiA8K7I4

Polymorphism and mutation databases

BioMutaiCLCA1

Proteomic databases

jPOSTiA8K7I4
PaxDbiA8K7I4
PRIDEiA8K7I4
ProteomicsDBi1869

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1179
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000234701; ENSP00000234701; ENSG00000016490
ENST00000394711; ENSP00000378200; ENSG00000016490
GeneIDi1179
KEGGihsa:1179
UCSCiuc001dlt.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1179
DisGeNETi1179
EuPathDBiHostDB:ENSG00000016490.15

GeneCards: human genes, protein and diseases

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GeneCardsi
CLCA1
HGNCiHGNC:2015 CLCA1
HPAiHPA052787
HPA059301
MIMi603906 gene
neXtProtiNX_A8K7I4
OpenTargetsiENSG00000016490
PharmGKBiPA26542

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEPS Eukaryota
ENOG410XPSZ LUCA
GeneTreeiENSGT00940000154682
HOGENOMiHOG000015107
HOVERGENiHBG005560
InParanoidiA8K7I4
KOiK05027
OMAiLFPPCQI
OrthoDBi685640at2759
PhylomeDBiA8K7I4
TreeFamiTF328396

Enzyme and pathway databases

ReactomeiR-HSA-2672351 Stimuli-sensing channels

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CLCA1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CLCA1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1179

Protein Ontology

More...
PROi
PR:A8K7I4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000016490 Expressed in 65 organ(s), highest expression level in sigmoid colon
CleanExiHS_CLCA1
GenevisibleiA8K7I4 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR004727 CLCA_chordata
IPR013642 CLCA_N
IPR013783 Ig-like_fold
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF08434 CLCA, 1 hit
PF13519 VWA_2, 1 hit
SMARTiView protein in SMART
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
TIGRFAMsiTIGR00868 hCaCC, 1 hit
PROSITEiView protein in PROSITE
PS50234 VWFA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLCA1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8K7I4
Secondary accession number(s): B2RAV5
, O95151, Q5TDF4, Q9UNF6, Q9UPC6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 2, 2010
Last modified: January 16, 2019
This is version 98 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
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