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UniProtKB - A8K6K4 (A8K6K4_HUMAN)
Protein
Submitted name:
cDNA FLJ77565, highly similar to Homo sapiens interleukin 1 receptor accessory protein (IL1RAP), transcript variant 1, mRNA
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- interleukin-1 receptor activity Source: InterPro
- NAD+ nucleosidase activity Source: InterPro
Keywordsi
Molecular function | HydrolaseARBA annotation, ReceptorImported |
Ligand | NADARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: cDNA FLJ77565, highly similar to Homo sapiens interleukin 1 receptor accessory protein (IL1RAP), transcript variant 1, mRNAImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 363 – 383 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_5002725529 | 21 – 570 | Sequence analysisAdd BLAST | 550 |
Proteomic databases
PeptideAtlasi | A8K6K4 |
PRIDEi | A8K6K4 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 141 – 230 | Ig-likeInterPro annotationAdd BLAST | 90 | |
Domaini | 242 – 348 | Ig-likeInterPro annotationAdd BLAST | 107 | |
Domaini | 403 – 546 | TIRInterPro annotationAdd BLAST | 144 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 549 – 570 | DisorderedSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Belongs to the interleukin-1 receptor family.ARBA annotation
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
OMAi | KRSHRWS |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits 3.40.50.10140, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR015621, IL-1_rcpt_fam IPR004074, IL-1_rcpt_I/II-typ IPR041416, IL-1RAcP-like_ig IPR000157, TIR_dom IPR035897, Toll_tir_struct_dom_sf |
PANTHERi | PTHR11890, PTHR11890, 1 hit |
Pfami | View protein in Pfam PF18452, Ig_6, 1 hit PF01582, TIR, 1 hit |
PRINTSi | PR01536, INTRLKN1R12F |
SMARTi | View protein in SMART SM00409, IG, 3 hits SM00255, TIR, 1 hit |
SUPFAMi | SSF48726, SSF48726, 3 hits SSF52200, SSF52200, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 2 hits PS50104, TIR, 1 hit |
i Sequence
Sequence statusi: Complete.
A8K6K4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTLLWCVVSL YFYGILQSDA SERCDDWGLD TMRQIQVFED EPARIKCPLF
60 70 80 90 100
EHFLKFNYST AHSAGLTLIW YWTRQDRDLE EPINFRLPEN RISKEKDVLW
110 120 130 140 150
FRPTLLNDTG NYTCMLRNTT YCSKVAFPLE VVQKDSCFNS PMKLPVHKLY
160 170 180 190 200
IEYGIQRITC PNVDGYFPSS VKPTITWYMG CYKIQNFNNV IPEGMNLSFL
210 220 230 240 250
IALISNNGNY TCVVTYPENG RTFHLTRTLT VKVVGSPKNA VPPVIHSPND
260 270 280 290 300
HVVYEKEPGE ELLIPCTVYF SFLMDSRNEV WWTIDGKKPD DITIDVTINE
310 320 330 340 350
SISHSRTEDE TRTQILSIKK VTSEDLKRSY VCHARSAKGE VAKAAKVKQK
360 370 380 390 400
VPAPRYTVEL ACGFGATVLL VVILIVVYHV YWLEMVLFYR AHFGTDETIL
410 420 430 440 450
DGKEYDIYVS YARKAEEEEF VLLTLRGVLE NEFGYKLCIF DRDSLPGGIV
460 470 480 490 500
TDETLSFIQK SRRLLVVLSP NYVLQGTQAL LELKAGLENM ASRGNINVIL
510 520 530 540 550
VQYKAVKETK VKELKRAKTV LTVIKWKGEK SKYPQGRFWK QLQVAMPVKK
560 570
SPRRSSSDEQ GLSYSSLKNV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK291669 mRNA Translation: BAF84358.1 |
RefSeqi | NP_001161400.1, NM_001167928.1 |
Genome annotation databases
GeneIDi | 3556 |
KEGGi | hsa:3556 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK291669 mRNA Translation: BAF84358.1 |
RefSeqi | NP_001161400.1, NM_001167928.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | A8K6K4 |
PRIDEi | A8K6K4 |
Protocols and materials databases
DNASUi | 3556 |
Genome annotation databases
GeneIDi | 3556 |
KEGGi | hsa:3556 |
Organism-specific databases
CTDi | 3556 |
PharmGKBi | PA29811 |
Phylogenomic databases
OMAi | KRSHRWS |
Miscellaneous databases
BioGRID-ORCSi | 3556, 11 hits in 1038 CRISPR screens |
GenomeRNAii | 3556 |
Gene expression databases
Genevisiblei | A8K6K4, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits 3.40.50.10140, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR015621, IL-1_rcpt_fam IPR004074, IL-1_rcpt_I/II-typ IPR041416, IL-1RAcP-like_ig IPR000157, TIR_dom IPR035897, Toll_tir_struct_dom_sf |
PANTHERi | PTHR11890, PTHR11890, 1 hit |
Pfami | View protein in Pfam PF18452, Ig_6, 1 hit PF01582, TIR, 1 hit |
PRINTSi | PR01536, INTRLKN1R12F |
SMARTi | View protein in SMART SM00409, IG, 3 hits SM00255, TIR, 1 hit |
SUPFAMi | SSF48726, SSF48726, 3 hits SSF52200, SSF52200, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 2 hits PS50104, TIR, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A8K6K4_HUMAN | |
Accessioni | A8K6K4Primary (citable) accession number: A8K6K4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 4, 2007 |
Last sequence update: | December 4, 2007 | |
Last modified: | January 19, 2022 | |
This is version 83 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |