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Protein
Submitted name:

cDNA FLJ77564

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ77564Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24507

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_500272466129 – 735Sequence analysisAdd BLAST707

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi479 ↔ 499PROSITE-ProRule annotation
Disulfide bondi657 ↔ 667PROSITE-ProRule annotation
Disulfide bondi675 ↔ 684PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PeptideAtlasiA8K6G4
PRIDEiA8K6G4

Expressioni

Gene expression databases

GenevisibleiA8K6G4 HS

Structurei

3D structure databases

ProteinModelPortaliA8K6G4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini211 – 413Peptidase M12BInterPro annotationAdd BLAST203
Domaini421 – 507DisintegrinInterPro annotationAdd BLAST87
Domaini653 – 685EGF-likeInterPro annotationAdd BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili698 – 718Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

eggNOGiKOG3607 Eukaryota
ENOG410XX2M LUCA
HOGENOMiHOG000230883
HOVERGENiHBG006978

Family and domain databases

CDDicd04269 ZnMc_adamalysin_II_like, 1 hit
Gene3Di3.40.390.10, 1 hit
4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR006586 ADAM_Cys-rich
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
IPR000742 EGF-like_dom
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR034027 Reprolysin_adamalysin
PfamiView protein in Pfam
PF08516 ADAM_CR, 1 hit
PF00200 Disintegrin, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF01421 Reprolysin, 1 hit
PRINTSiPR00289 DISINTEGRIN
SMARTiView protein in SMART
SM00608 ACR, 1 hit
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS50214 DISINTEGRIN_2, 1 hit
PS50026 EGF_3, 1 hit

Sequencei

Sequence statusi: Complete.

A8K6G4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARPLPVSP ARALLLALAG ALLAPCEARG VSLWNQGRAD EVVSASVRSG
60 70 80 90 100
DLWIPVKSFD SKNHPEVLNI RLQRESKELI INLERNEGLI ASSFTETHYL
110 120 130 140 150
QDGTDVSLAR NYTGHCYYHG HVRGYSDSAV SLSTCSGLRG LIVFENESYV
160 170 180 190 200
LEPMKSATNR YKLFPAKKLK SVRGSCGSHH NTPNLAAKNV FPPPSQTWAR
210 220 230 240 250
RHKRETLKAT KYVELVIVAD NREFQRQGKD LEKVKQRLIE IANHVDKFYR
260 270 280 290 300
PLNIRIVLVG VEVWNDMDKC SVSQDPFTSL HEFLDWRKMK LLPRKSHDNA
310 320 330 340 350
QLVSGVYFQG TTIGMAPIMS MCTADQSGGI VMDHSDNPLG AAVTLAHELG
360 370 380 390 400
HNFGMNHDTL DRGCSCQMAV EKGGCIMNAS TGYPFPMVFS SCSRKDLETS
410 420 430 440 450
LEKGMGVCLF NLPEVRESFG GQKCGNRFVE EGEECDCGEP EECMNRCCNA
460 470 480 490 500
TTCTLKPDAV CAHGLCCEDR QLKPAGTACR DSSNSCDLPE FCTGASPHCP
510 520 530 540 550
ANVYLHDGHS CQDVDGYCYN GICQTHEQQC VTLWGPGAKP APGICFERVN
560 570 580 590 600
SAGDPYGNCG KVSKSSFAKC EMRDAKCGKI QCQGGASRPV IGTNAVSIET
610 620 630 640 650
NIPLQQGGRI LCRGTHVYLG DDMPDPGLVL AGTKCADGKI CLNRQCQNIS
660 670 680 690 700
VFGVHECAMQ CHGRGVCNNR KNCHCEAHWA PPFCDKFGFG GSTDSGPIRQ
710 720 730
AEARQEAAES NRERGQGQEP VGSQEHASTA SLTLI
Length:735
Mass (Da):80,230
Last modified:December 4, 2007 - v1
Checksum:iCD0F7616961ED240
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291629 mRNA Translation: BAF84318.1
RefSeqiNP_001275904.1, NM_001288975.1
NP_067673.2, NM_021641.4
UniGeneiHs.594351
Hs.741333

Genome annotation databases

GeneIDi8038

Similar proteinsi

Entry informationi

Entry nameiA8K6G4_HUMAN
AccessioniPrimary (citable) accession number: A8K6G4
Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: July 18, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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