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Entry version 94 (02 Jun 2021)
Sequence version 1 (04 Dec 2007)
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Protein
Submitted name:

cDNA FLJ75496, highly similar to Homo sapiens restin-like 2 (RSNL2), mRNA

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
cDNA FLJ75496, highly similar to Homo sapiens restin-like 2 (RSNL2), mRNAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
A8K6D0

PeptideAtlas

More...
PeptideAtlasi
A8K6D0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
1867

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini92 – 223ANK_REP_REGIONInterPro annotationAdd BLAST132
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati186 – 218ANKPROSITE-ProRule annotationAdd BLAST33
Domaini303 – 345CAP-GlyInterPro annotationAdd BLAST43
Domaini514 – 549CAP-GlyInterPro annotationAdd BLAST36
Domaini646 – 688CAP-GlyInterPro annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni391 – 410DisorderedSequence analysisAdd BLAST20
Regioni431 – 479DisorderedSequence analysisAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi391 – 408Polar residuesSequence analysisAdd BLAST18

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeatPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
EMATVRY

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit
2.30.30.190, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR036859, CAP-Gly_dom_sf
IPR000938, CAP-Gly_domain
IPR028397, CLIP4

The PANTHER Classification System

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PANTHERi
PTHR18916:SF32, PTHR18916:SF32, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF12796, Ank_2, 1 hit
PF01302, CAP_GLY, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 3 hits
SM01052, CAP_GLY, 3 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48403, SSF48403, 1 hit
SSF74924, SSF74924, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 1 hit
PS00845, CAP_GLY_1, 2 hits
PS50245, CAP_GLY_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A8K6D0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTIEDLPDFP LEGNPLFGRY PFIFSASDTP VIFSISAAPM PSDCEFSFFD
60 70 80 90 100
PNDASCQEIL FDPKTSVSEL FAILRQWVPQ VQQNIDIIGN EILKRGCNVN
110 120 130 140 150
DRDGLTDMTL LHYTCKSGAH GIGDVETAVK FATQLIDLGA DISLRSRWTN
160 170 180 190 200
MNALHYAAYF DVPELIRVIL KTSKPKDVDA TCSDFNFGTA LHIAAYNLCA
210 220 230 240 250
GAVKCLLEQG ANPAFRNDKG QIPADVVPDP VDMPLEMADA AATAKEIKQM
260 270 280 290 300
LLDAVPLSCN ISKAMLPNYD HVTGKAMLTS LGLKLGDRVV IAGQKVGTLR
310 320 330 340 350
FCGTTEFASG QWAGIELDEP EGKNNGSVGK VQYFKCAPKY GIFAPLSKIS
360 370 380 390 400
KAKGRRKNIT HTPSTKAAVP LIRSQKIDVA HVTSKVNTGL MTSKKDSASE
410 420 430 440 450
STLSLPPGEE LKTVTEKDVA LLGSVSSCSS TSSLEHRQSY PKKQNAISSN
460 470 480 490 500
KKTMSKSPSL SSRASAGLNS SATSTANNSR CEGELRLGER VLVVGQRLGT
510 520 530 540 550
IRFFGTTNFA PVLGYWYGIE LEKPHGKNDG SVGGVQYFSC SPRYGIFAPP
560 570 580 590 600
SRVQRVTDSL DTLSEISSNK QNHSYPGFRR SFSTTSASSQ KEINRRNAFS
610 620 630 640 650
KSKAALRRSW SSTPTAGGIE GSVKLHEGSQ VLLTSSNEMG TVRYVGPTDF
660 670 680 690 700
ASGIWLGLEL RSAKGKNDGS VGDKRYFTCK PNHGVLVRPS RVTYRGINGS

KLVDENC
Length:707
Mass (Da):76,529
Last modified:December 4, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0BB4E365C8538719
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK291595 mRNA Translation: BAF84284.1

NCBI Reference Sequences

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RefSeqi
NP_001274457.1, NM_001287528.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
79745

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291595 mRNA Translation: BAF84284.1
RefSeqiNP_001274457.1, NM_001287528.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

MaxQBiA8K6D0
PeptideAtlasiA8K6D0
ProteomicsDBi1867

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
79745

Genome annotation databases

GeneIDi79745

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79745

Phylogenomic databases

OMAiEMATVRY

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
79745, 3 hits in 991 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79745

Family and domain databases

Gene3Di1.25.40.20, 1 hit
2.30.30.190, 3 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR036859, CAP-Gly_dom_sf
IPR000938, CAP-Gly_domain
IPR028397, CLIP4
PANTHERiPTHR18916:SF32, PTHR18916:SF32, 1 hit
PfamiView protein in Pfam
PF12796, Ank_2, 1 hit
PF01302, CAP_GLY, 3 hits
SMARTiView protein in SMART
SM00248, ANK, 3 hits
SM01052, CAP_GLY, 3 hits
SUPFAMiSSF48403, SSF48403, 1 hit
SSF74924, SSF74924, 3 hits
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 1 hit
PS00845, CAP_GLY_1, 2 hits
PS50245, CAP_GLY_2, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA8K6D0_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8K6D0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: June 2, 2021
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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