UniProtKB - A8K647 (A8K647_HUMAN)
Protein
Submitted name:
cDNA FLJ77143, highly similar to Homo sapiens Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5) (BLR1), transcript variant 1, mRNA
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- C-X-C chemokine receptor activity Source: InterPro
GO - Biological processi
- B cell activation Source: InterPro
- chemotaxis Source: InterPro
- immune response Source: InterPro
- lymph node development Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptorUniRule annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Submitted name: cDNA FLJ77143, highly similar to Homo sapiens Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5) (BLR1), transcript variant 1, mRNAImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 52 – 76 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 88 – 108 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 131 – 150 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 162 – 182 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 220 – 239 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 260 – 281 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 301 – 325 | HelicalSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
MembraneFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 68 – 322 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 255 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
OrthoDBi | 794531at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR001053, Chemokine_CXCR5 IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00564, CXCCHMKINER5 PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A8K647-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNYPLTLEMD LENLEDLFWE LDRLDNYNDT SLVENHLCPA TEGPLMASFK
60 70 80 90 100
AVFVPVAYSL IFLLGVIGNV LVLVILERHR QTRSSTETFL FHLAVADLLL
110 120 130 140 150
VFILPFAVAE GSVGWVLGTF LCKTVIALHK VNFYCSSLLL ACIAVDRYLA
160 170 180 190 200
IVHAVHAYRH RLLLSIHITC GTIWLVGFLL ALPEILFAKV SQGHHNNSLP
210 220 230 240 250
RCTFSQENQA ETHAWFTSRF LYHVAGFLLP MLVMGWCYVG VVHRLRQAQR
260 270 280 290 300
RPQRQKAVRV AILVTSIFFL CWSPYHIVIF LDTLARLKAV DNTCKLNGSL
310 320 330 340 350
PVAITMCEFL GLAHCCLNPM LYTFAGVKFR SDLSRLLTKL GCTGPASLCQ
360 370
LFPSWRRSSL SESENATSLT TF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK291512 mRNA Translation: BAF84201.1 |
RefSeqi | NP_001707.1, NM_001716.4 |
Genome annotation databases
GeneIDi | 643 |
KEGGi | hsa:643 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK291512 mRNA Translation: BAF84201.1 |
RefSeqi | NP_001707.1, NM_001716.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
GPCRDBi | Search... |
Protocols and materials databases
DNASUi | 643 |
Genome annotation databases
GeneIDi | 643 |
KEGGi | hsa:643 |
Organism-specific databases
CTDi | 643 |
PharmGKBi | PA162383046 |
Phylogenomic databases
OrthoDBi | 794531at2759 |
Miscellaneous databases
BioGRID-ORCSi | 643, 4 hits in 838 CRISPR screens |
GenomeRNAii | 643 |
Gene expression databases
Genevisiblei | A8K647, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001053, Chemokine_CXCR5 IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00564, CXCCHMKINER5 PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A8K647_HUMAN | |
Accessioni | A8K647Primary (citable) accession number: A8K647 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 4, 2007 |
Last sequence update: | December 4, 2007 | |
Last modified: | December 2, 2020 | |
This is version 65 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |