UniProtKB - A8K5M4 (A8K5M4_HUMAN)
Protein
Non-specific serine/threonine protein kinase
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein serine/threonine kinase activity Source: InterPro
GO - Biological processi
- regulation of apoptotic process Source: InterPro
Keywordsi
Molecular function | Allosteric enzymeARBA annotation, KinaseImported, Transferase |
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Enzyme and pathway databases
SignaLinki | A8K5M4 |
Names & Taxonomyi
Protein namesi | Recommended name: Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation) |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 74 – 87 | CRIBInterPro annotationAdd BLAST | 14 | |
Domaini | 249 – 500 | Protein kinaseInterPro annotationAdd BLAST | 252 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 81 | DisorderedSequence analysisAdd BLAST | 81 | |
Regioni | 143 – 164 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 169 – 188 | DisorderedSequence analysisAdd BLAST | 20 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 41 – 78 | PolyampholyteSequence analysisAdd BLAST | 38 |
Family and domain databases
CDDi | cd01093, CRIB_PAK_like, 1 hit cd06655, STKc_PAK2, 1 hit |
Gene3Di | 3.90.810.10, 1 hit |
InterProi | View protein in InterPro IPR000095, CRIB_dom IPR036936, CRIB_dom_sf IPR011009, Kinase-like_dom_sf IPR035065, PAK2 IPR033923, PAK_BD IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR035064, STK_PAK2 |
PANTHERi | PTHR45832:SF1, PTHR45832:SF1, 1 hit |
Pfami | View protein in Pfam PF00786, PBD, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00285, PBD, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50108, CRIB, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
A8K5M4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDNGELEDK PPAPPVRMSS TIFSTGGKDP LSANHSLKPL PSVPEEKKPR
60 70 80 90 100
HKIISIFSGT EKGSKKKEKE RPEISPPSDF EHTIHVGFDA VTGEFTGMPE
110 120 130 140 150
QWARLLQTSD ITKLEQKKNP QAVLDVLKFY DSNTVKQKYL SFTPPEKDGF
160 170 180 190 200
PSGTPALNAK GTEAPAVVTE EEDDDEETAP PVIAPRPDHT KSIYTRSVID
210 220 230 240 250
PVPAPVGDSH VDGAAKSLDK QKKKTKMTDE EIMEKLRTIV SIGDPKKKYT
260 270 280 290 300
RYEKIGQGAS GTVFTATDVA LGQEVAIKQI NLQKQPKKEL IINEILVMKE
310 320 330 340 350
LKNPNIVNFL DSYLVGDELF VVMEYLAGGS LTDVVTETCM DEAQIAAVCR
360 370 380 390 400
ECLQALEFLH ANQVIHRDIK SDNVLLGMEG SVKLTDFGFC AQITPEQSKR
410 420 430 440 450
STMVGTPYWM APEVVTRKAY GPKVDIWSLG IMAIEMVEGE PPYLNENPLR
460 470 480 490 500
ALYLIATNGT PELQNPEKLS PIFRDFLNRC LEMDVEKRGS AKELLQHPFL
510 520
KLAKPLSSLT PLIMAAKEAM KSNR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK291339 mRNA Translation: BAF84028.1 |
RefSeqi | NP_002568.2, NM_002577.4 |
Genome annotation databases
GeneIDi | 5062 |
KEGGi | hsa:5062 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK291339 mRNA Translation: BAF84028.1 |
RefSeqi | NP_002568.2, NM_002577.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | A8K5M4, 1 interactor |
Proteomic databases
PeptideAtlasi | A8K5M4 |
PRIDEi | A8K5M4 |
Protocols and materials databases
DNASUi | 5062 |
Genome annotation databases
GeneIDi | 5062 |
KEGGi | hsa:5062 |
Organism-specific databases
CTDi | 5062 |
PharmGKBi | PA32918 |
Enzyme and pathway databases
SignaLinki | A8K5M4 |
Miscellaneous databases
BioGRID-ORCSi | 5062, 86 hits in 875 CRISPR screens |
GenomeRNAii | 5062 |
Gene expression databases
Genevisiblei | A8K5M4, HS |
Family and domain databases
CDDi | cd01093, CRIB_PAK_like, 1 hit cd06655, STKc_PAK2, 1 hit |
Gene3Di | 3.90.810.10, 1 hit |
InterProi | View protein in InterPro IPR000095, CRIB_dom IPR036936, CRIB_dom_sf IPR011009, Kinase-like_dom_sf IPR035065, PAK2 IPR033923, PAK_BD IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR035064, STK_PAK2 |
PANTHERi | PTHR45832:SF1, PTHR45832:SF1, 1 hit |
Pfami | View protein in Pfam PF00786, PBD, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00285, PBD, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50108, CRIB, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A8K5M4_HUMAN | |
Accessioni | A8K5M4Primary (citable) accession number: A8K5M4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 4, 2007 |
Last sequence update: | December 4, 2007 | |
Last modified: | December 2, 2020 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |