UniProtKB - A8K5I0 (A8K5I0_HUMAN)
Protein
Submitted name:
Epididymis secretory protein Li 103
Gene
HEL-S-103
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATP binding Source: UniProtKB-KW
Keywordsi
Biological process | Stress responseImported |
Ligand | ATP-bindingUniRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: Epididymis secretory protein Li 103ImportedSubmitted name: Epididymis secretory sperm binding proteinImportedSubmitted name: HSPA1AImportedSubmitted name: HSPA1BImportedSubmitted name: Heat shock 70kDa protein 1AImportedSubmitted name: Heat shock 70kDa protein 1BImportedSubmitted name: cDNA FLJ75127, highly similar to Homo sapiens heat shock 70kDa protein 1A, mRNAImported |
Gene namesi | Name:HEL-S-103Imported Synonyms:HSPA1AImported, HSPA1BImported ORF Names:hCG_1820593Imported, hCG_43726Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000204388.6 HostDB:ENSG00000204389.9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000204388, Expressed in adenohypophysis and 250 other tissues |
ExpressionAtlasi | A8K5I0, baseline and differential |
Interactioni
Protein-protein interaction databases
IntActi | A8K5I0, 3 interactors |
Chemistry databases
BindingDBi | A8K5I0 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 614 – 641 | DisorderedSequence analysisAdd BLAST | 28 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 512 – 535 | Sequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
HOGENOMi | CLU_005965_2_1_1 |
OMAi | HIEVEYK |
OrthoDBi | 288077at2759 |
Family and domain databases
Gene3Di | 1.20.1270.10, 1 hit 2.60.34.10, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR018181, Heat_shock_70_CS IPR029048, HSP70_C_sf IPR029047, HSP70_peptide-bd_sf IPR013126, Hsp_70_fam |
PANTHERi | PTHR19375, PTHR19375, 1 hit |
Pfami | View protein in Pfam PF00012, HSP70, 1 hit |
SUPFAMi | SSF100920, SSF100920, 1 hit SSF100934, SSF100934, 1 hit SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00297, HSP70_1, 1 hit PS00329, HSP70_2, 1 hit PS01036, HSP70_3, 1 hit |
i Sequence
Sequence statusi: Complete.
A8K5I0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAKAAAIGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTDTERL
60 70 80 90 100
IGDAAKNQVA LNPQNTVFDA KRLIGRKFGD PVVQSDMKHW PFQVINDGDK
110 120 130 140 150
PKVQVSYKGE TKAFYPEEIS SMVLTKMKEI AEAYLGYPVT NAVITVPAYF
160 170 180 190 200
NDSQRQATKD AGVIAGLNVL RIINEPTAAA IAYGLDRTGK GERNVLIFDL
210 220 230 240 250
GGGTFDVSIL TIDDGIFEVK ATAGDTHLGG EDFDNRLVNH FVEEFKRKHK
260 270 280 290 300
KDISQNKRAV RRLRTACERA KRTLSSSTQA SLEIDSLFEG IDFYTSITRA
310 320 330 340 350
RFEELCSDLF RSTLEPVEKA LRDAKLDKAQ IHDLVLVGGS TRIPKVQKLL
360 370 380 390 400
QDFFNGRDLN KSINPDEAVA YGAAVQAAIL MGDKSENVQD LLLLDVAPLS
410 420 430 440 450
LGLETAGGVM TALIKRNSTI PTKQTQIFTT YSDNQPGVLI QVYEGERAMT
460 470 480 490 500
KDNNLLGRFE LSGIPPAPRG VPQIEVTFDI DANGILNVTA TDKSTGKANK
510 520 530 540 550
ITITNDKGRL SKEEIERMVQ EAEKYKAEDE VQRERVSAKN ALESYAFNMK
560 570 580 590 600
SAVEDEGLKG KISEADKKKV LDKCQEVISW LDANTLAEKD EFEHKRKELE
610 620 630 640
QVCNPIISGL YQGAGGPGPG GFGAQGPKGG SGSGPTIEEV D
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FJ224292 mRNA Translation: ACI45984.1 GQ891470 mRNA Translation: ADO22332.1 KY500377 Genomic DNA Translation: AQY76864.1 KY500378 Genomic DNA Translation: AQY76865.1 KY500379 Genomic DNA Translation: AQY76866.1 KY500381 Genomic DNA Translation: AQY76868.1 KY500382 Genomic DNA Translation: AQY76869.1 KY500383 Genomic DNA Translation: AQY76870.1 KY500384 Genomic DNA Translation: AQY76871.1 KY500387 Genomic DNA Translation: AQY76874.1 KY500388 Genomic DNA Translation: AQY76875.1 KY500389 Genomic DNA Translation: AQY76876.1 KY500390 Genomic DNA Translation: AQY76877.1 KY500392 Genomic DNA Translation: AQY76879.1 KY500393 Genomic DNA Translation: AQY76880.1 KY500394 Genomic DNA Translation: AQY76881.1 KY500395 Genomic DNA Translation: AQY76882.1 KY500396 Genomic DNA Translation: AQY76883.1 KY500397 Genomic DNA Translation: AQY76884.1 AK291295 mRNA Translation: BAF83984.1 CH471081 Genomic DNA Translation: EAX03528.1 CH471081 Genomic DNA Translation: EAX03529.1 |
RefSeqi | NP_005336.3, NM_005345.5 NP_005337.2, NM_005346.4 |
Genome annotation databases
GeneIDi | 3303 3304 |
KEGGi | hsa:3303 hsa:3304 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FJ224292 mRNA Translation: ACI45984.1 GQ891470 mRNA Translation: ADO22332.1 KY500377 Genomic DNA Translation: AQY76864.1 KY500378 Genomic DNA Translation: AQY76865.1 KY500379 Genomic DNA Translation: AQY76866.1 KY500381 Genomic DNA Translation: AQY76868.1 KY500382 Genomic DNA Translation: AQY76869.1 KY500383 Genomic DNA Translation: AQY76870.1 KY500384 Genomic DNA Translation: AQY76871.1 KY500387 Genomic DNA Translation: AQY76874.1 KY500388 Genomic DNA Translation: AQY76875.1 KY500389 Genomic DNA Translation: AQY76876.1 KY500390 Genomic DNA Translation: AQY76877.1 KY500392 Genomic DNA Translation: AQY76879.1 KY500393 Genomic DNA Translation: AQY76880.1 KY500394 Genomic DNA Translation: AQY76881.1 KY500395 Genomic DNA Translation: AQY76882.1 KY500396 Genomic DNA Translation: AQY76883.1 KY500397 Genomic DNA Translation: AQY76884.1 AK291295 mRNA Translation: BAF83984.1 CH471081 Genomic DNA Translation: EAX03528.1 CH471081 Genomic DNA Translation: EAX03529.1 |
RefSeqi | NP_005336.3, NM_005345.5 NP_005337.2, NM_005346.4 |
3D structure databases
SMRi | A8K5I0 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | A8K5I0, 3 interactors |
Chemistry databases
BindingDBi | A8K5I0 |
Proteomic databases
PRIDEi | A8K5I0 |
Protocols and materials databases
Antibodypediai | 27819, 2248 antibodies 65941, 104 antibodies |
DNASUi | 3303 |
Genome annotation databases
GeneIDi | 3303 3304 |
KEGGi | hsa:3303 hsa:3304 |
Organism-specific databases
CTDi | 3303 3304 |
PharmGKBi | PA29499 |
VEuPathDBi | HostDB:ENSG00000204388.6 HostDB:ENSG00000204389.9 |
Phylogenomic databases
HOGENOMi | CLU_005965_2_1_1 |
OMAi | HIEVEYK |
OrthoDBi | 288077at2759 |
Miscellaneous databases
BioGRID-ORCSi | 3303, 13 hits in 570 CRISPR screens 3304, 5 hits in 567 CRISPR screens |
ChiTaRSi | HSPA1B, human |
Gene expression databases
Bgeei | ENSG00000204388, Expressed in adenohypophysis and 250 other tissues |
ExpressionAtlasi | A8K5I0, baseline and differential |
Family and domain databases
Gene3Di | 1.20.1270.10, 1 hit 2.60.34.10, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR018181, Heat_shock_70_CS IPR029048, HSP70_C_sf IPR029047, HSP70_peptide-bd_sf IPR013126, Hsp_70_fam |
PANTHERi | PTHR19375, PTHR19375, 1 hit |
Pfami | View protein in Pfam PF00012, HSP70, 1 hit |
SUPFAMi | SSF100920, SSF100920, 1 hit SSF100934, SSF100934, 1 hit SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00297, HSP70_1, 1 hit PS00329, HSP70_2, 1 hit PS01036, HSP70_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A8K5I0_HUMAN | |
Accessioni | A8K5I0Primary (citable) accession number: A8K5I0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 4, 2007 |
Last sequence update: | December 4, 2007 | |
Last modified: | April 7, 2021 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |