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Protein
Submitted name:

Bone morphogenetic protein 7 (Osteogenic protein 1), isoform CRA_b

Gene

BMP7

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factorUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Bone morphogenetic protein 7 (Osteogenic protein 1), isoform CRA_bImported
Submitted name:
cDNA FLJ78019, highly similar to Homo sapiens bone morphogenetic protein 7 (osteogenic protein 1), mRNAImported
Submitted name:
cDNA, FLJ92758, Homo sapiens bone morphogenetic protein 7 (osteogenic protein 1)(BMP7), mRNAImported
Gene namesi
Name:BMP7Imported
ORF Names:hCG_40100Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000101144.12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25384

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_501429753830 – 431Sequence analysisAdd BLAST402

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PRIDEiA8K571

Expressioni

Gene expression databases

BgeeiENSG00000101144
ExpressionAtlasiA8K571 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiA8K571, 8 interactors

Structurei

3D structure databases

SMRiA8K571
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini312 – 431TGF_BETA_2InterPro annotationAdd BLAST120

Sequence similaritiesi

Belongs to the TGF-beta family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
HOVERGENiHBG004860
KOiK16621
OMAiETFQISV
OrthoDBiEOG091G0C2J

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

A8K571-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHVRSLRAAA PHSFVALWAP LFLLRSALAD FSLDNEVHSS FIHRRLRSQE
60 70 80 90 100
RREMQREILS ILGLPHRPRP HLQGKHNSAP MFMLDLYNAM AVEEGGGPGG
110 120 130 140 150
QGFSYPYKAV FSTQGPPLAS LQDSHFLTDA DMVMSFVNLV EHDKEFFHPR
160 170 180 190 200
YHHREFRFDL SKIPEGEAVT AAEFRIYKDY IRERFDNETF RISVYQVLQE
210 220 230 240 250
HLGRESDLFL LDSRTLWASE EGWLVFDITA TSNHWVVNPR HNLGLQLSVE
260 270 280 290 300
TLDGQSINPK LAGLIGRHGP QNKQPFMVAF FKATEVHFRS IRSTGSKQRS
310 320 330 340 350
QNRSKTPKNQ EALRMANVAE NSSSDQRQAC KKHELYVSFR DLGWQDWIIA
360 370 380 390 400
PEGYAAYYCE GECAFPLNSY MNATNHAIVQ TLVHFINPET VPKPCCAPTQ
410 420 430
LNAISVLYFD DSSNVILKKY RNMVVRACGC H
Length:431
Mass (Da):49,313
Last modified:December 4, 2007 - v1
Checksum:i47A05E45C6815F8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291186 mRNA Translation: BAF83875.1
AK312419 mRNA Translation: BAG35329.1
CH471077 Genomic DNA Translation: EAW75530.1
CH471077 Genomic DNA Translation: EAW75531.1
RefSeqiNP_001710.1, NM_001719.2
UniGeneiHs.473163

Genome annotation databases

GeneIDi655
KEGGihsa:655

Similar proteinsi

Entry informationi

Entry nameiA8K571_HUMAN
AccessioniPrimary (citable) accession number: A8K571
Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: June 20, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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