UniProtKB - A8K4S9 (A8K4S9_HUMAN)
Protein
Signal transducer and activator of transcription
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity Source: InterPro
GO - Biological processi
- signal transduction Source: InterPro
Keywordsi
Molecular function | ActivatorUniRule annotationARBA annotation, DNA-bindingUniRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Enzyme and pathway databases
SignaLinki | A8K4S9 |
Names & Taxonomyi
Protein namesi | Recommended name: Signal transducer and activator of transcriptionUniRule annotation |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmUniRule annotationARBA annotation, NucleusUniRule annotationARBA annotationPTM / Processingi
Keywords - PTMi
PhosphoproteinUniRule annotationARBA annotationProteomic databases
PeptideAtlasi | A8K4S9 |
PRIDEi | A8K4S9 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 517 – 632 | SH2InterPro annotationAdd BLAST | 116 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 809 – 847 | DisorderedSequence analysisAdd BLAST | 39 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 824 – 847 | PolarSequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Keywords - Domaini
SH2 domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
OrthoDBi | 327469at2759 |
Family and domain databases
CDDi | cd10377, SH2_STAT6, 1 hit |
Gene3Di | 1.10.532.10, 1 hit 2.60.40.630, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR000980, SH2 IPR036860, SH2_dom_sf IPR001217, STAT IPR028187, STAT6_C IPR035857, STAT6_SH2 IPR036535, STAT_N_sf IPR013800, STAT_TF_alpha IPR015988, STAT_TF_coiled-coil IPR013801, STAT_TF_DNA-bd IPR012345, STAT_TF_DNA-bd_N IPR013799, STAT_TF_prot_interaction |
PANTHERi | PTHR11801, PTHR11801, 1 hit |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF14596, STAT6_C, 1 hit PF01017, STAT_alpha, 1 hit PF02864, STAT_bind, 1 hit PF02865, STAT_int, 1 hit |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00964, STAT_int, 1 hit |
SUPFAMi | SSF47655, SSF47655, 1 hit SSF48092, SSF48092, 1 hit SSF49417, SSF49417, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit |
i Sequence
Sequence statusi: Complete.
A8K4S9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLWGLVSKM PPEKVQRLYV DFPQHLRHLL GDWLESQPWE FLVGSDAFCC
60 70 80 90 100
NLASALLSDT VQHLQASVGE QGEGSTILQH ISTLESIYQR DPLKLVATFR
110 120 130 140 150
QILQGEKKAV MEQFRHLPMP FHWKQEELKF KTGLRRLQHR VGEIHLLREA
160 170 180 190 200
LQKGAEAGQV SLHSLIETPA NGTGPSEALA MLLQETTGEL EAAKALVLKR
210 220 230 240 250
IQIWKRQQQL AGNGAPFEES LAPLQERCES LVDIYSQLQQ EVGAAGGELE
260 270 280 290 300
PKTRASLTGR LDEVLRTLVT SCFLVEKQPP QVLKTQTKFQ AGVRFLLGLR
310 320 330 340 350
FLGAPAKPPL VRADMVTEKQ ARELSVPQGP GAGAESTGEI INNTVPLENS
360 370 380 390 400
IPGNCCSALF KNLLLKKIKR CERKGTESVT EEKCAVLFSA SFTLGPGKLP
410 420 430 440 450
IQLQALSLPL VVIVHGNQDN NAKATILWDN AFSEMDRVPF VVAERVPWEK
460 470 480 490 500
MCETLNLKFM AEVGTNRGLL PEHFLFLAQK IFNDNSLSME AFQHRSVSWS
510 520 530 540 550
QFNKEILLGR GFTFWQWFDG VLDLTKRCLR SYWSDRLIIG FISKQYVTSL
560 570 580 590 600
LLNEPDGTFL LRFSDSEIGG ITIAHVIRGQ DGSPQIENIQ PFSAKDLSIR
610 620 630 640 650
SLGNRIRDLA QLKNLYPKKP KDEAFRSHYK PEQMGKDGRG YVPATIKMTV
660 670 680 690 700
ERDQPLPTPE LQMPTMVPSY DLGMAPDSSM SMQLGPDMVP QVYPPHSHSI
710 720 730 740 750
PPYQGLSPEE SVNVLSAFQE PHLQMPPSLG QMSLPFDQPH PQGLLPCQPQ
760 770 780 790 800
EHAVSSPDPL LCSDVTMVED SCLSQPVTAF PQGTWIGEDI FPPLLPPTEQ
810 820 830 840
DLTKLLLEGQ GESGGGSLGA QPLLQPSHYG QSGISMSHMD LRANPSW
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK291044 mRNA Translation: BAF83733.1 |
RefSeqi | NP_001171550.1, NM_001178079.1 |
Genome annotation databases
GeneIDi | 6778 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK291044 mRNA Translation: BAF83733.1 |
RefSeqi | NP_001171550.1, NM_001178079.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | A8K4S9 |
PRIDEi | A8K4S9 |
Protocols and materials databases
DNASUi | 6778 |
Genome annotation databases
GeneIDi | 6778 |
Organism-specific databases
CTDi | 6778 |
Phylogenomic databases
OrthoDBi | 327469at2759 |
Enzyme and pathway databases
SignaLinki | A8K4S9 |
Miscellaneous databases
BioGRID-ORCSi | 6778, 4 hits in 869 CRISPR screens |
GenomeRNAii | 6778 |
Gene expression databases
Genevisiblei | A8K4S9, HS |
Family and domain databases
CDDi | cd10377, SH2_STAT6, 1 hit |
Gene3Di | 1.10.532.10, 1 hit 2.60.40.630, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR000980, SH2 IPR036860, SH2_dom_sf IPR001217, STAT IPR028187, STAT6_C IPR035857, STAT6_SH2 IPR036535, STAT_N_sf IPR013800, STAT_TF_alpha IPR015988, STAT_TF_coiled-coil IPR013801, STAT_TF_DNA-bd IPR012345, STAT_TF_DNA-bd_N IPR013799, STAT_TF_prot_interaction |
PANTHERi | PTHR11801, PTHR11801, 1 hit |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF14596, STAT6_C, 1 hit PF01017, STAT_alpha, 1 hit PF02864, STAT_bind, 1 hit PF02865, STAT_int, 1 hit |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00964, STAT_int, 1 hit |
SUPFAMi | SSF47655, SSF47655, 1 hit SSF48092, SSF48092, 1 hit SSF49417, SSF49417, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A8K4S9_HUMAN | |
Accessioni | A8K4S9Primary (citable) accession number: A8K4S9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 4, 2007 |
Last sequence update: | December 4, 2007 | |
Last modified: | December 2, 2020 | |
This is version 81 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |