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Protein

CMRF35-like molecule 7

Gene

CD300LB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2.2 Publications

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processImmunity

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-2172127 DAP12 interactions

Names & Taxonomyi

Protein namesi
Recommended name:
CMRF35-like molecule 7
Short name:
CLM-7
Alternative name(s):
CD300 antigen-like family member B
CMRF35-A2
Immune receptor expressed on myeloid cells 3
Short name:
IREM-3
Leukocyte mono-Ig-like receptor 5
Triggering receptor expressed on myeloid cells 5
Short name:
TREM-5
CD_antigen: CD300b
Gene namesi
Name:CD300LB
Synonyms:CD300B, CLM7, CMRF35A2, IREM3, LMIR5, TREM5
ORF Names:UNQ2530/PRO6029
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000178789.8
HGNCiHGNC:30811 CD300LB
MIMi610705 gene
neXtProtiNX_A8K4G0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 151ExtracellularSequence analysisAdd BLAST134
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 201CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi158K → L: Abolishes interaction with TYROBP, and strongly reduces activation properties. 1 Publication1
Mutagenesisi188Y → F: No effect on interaction with TYROBP, but strongly reduces activation properties. 1 Publication1

Organism-specific databases

DisGeNETi124599
OpenTargetsiENSG00000178789
PharmGKBiPA142672151

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000032013018 – 201CMRF35-like molecule 7Add BLAST184

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 104PROSITE-ProRule annotation
Modified residuei188Phosphotyrosine; by FYN2 Publications1

Post-translational modificationi

Phosphorylation on Tyr-188 by FYN is required for interaction with GRB2.2 Publications

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiA8K4G0
PRIDEiA8K4G0
ProteomicsDBi1861

PTM databases

iPTMnetiA8K4G0
PhosphoSitePlusiA8K4G0

Expressioni

Tissue specificityi

Expressed exclusively in myeloid lineages.1 Publication

Gene expression databases

BgeeiENSG00000178789 Expressed in 81 organ(s), highest expression level in leukocyte
CleanExiHS_CD300LB
ExpressionAtlasiA8K4G0 baseline and differential
GenevisibleiA8K4G0 HS

Interactioni

Subunit structurei

Interacts with TYROBP, which enhances cell surface expression and activation properties. Interacts with GRB2 in the presence of FYN.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei158Interaction with TYROBP1

Protein-protein interaction databases

BioGridi125877, 3 interactors
STRINGi9606.ENSP00000376397

Structurei

3D structure databases

ProteinModelPortaliA8K4G0
SMRiA8K4G0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 120Ig-like V-typeAdd BLAST103

Sequence similaritiesi

Belongs to the CD300 family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JBZ0 Eukaryota
ENOG41114E0 LUCA
GeneTreeiENSGT00470000042273
HOGENOMiHOG000231065
HOVERGENiHBG103081
InParanoidiA8K4G0
KOiK20395
OMAiCFSIQGP
OrthoDBiEOG091G0O8X
PhylomeDBiA8K4G0
TreeFamiTF334441

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A8K4G0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWLPPALLLL SLSGCFSIQG PESVRAPEQG SLTVQCHYKQ GWETYIKWWC
60 70 80 90 100
RGVRWDTCKI LIETRGSEQG EKSDRVSIKD NQKDRTFTVT MEGLRRDDAD
110 120 130 140 150
VYWCGIERRG PDLGTQVKVI VDPEGAASTT ASSPTNSNMA VFIGSHKRNH
160 170 180 190 200
YMLLVFVKVP ILLILVTAIL WLKGSQRVPE EPGEQPIYMN FSEPLTKDMA

T
Length:201
Mass (Da):22,689
Last modified:February 26, 2008 - v2
Checksum:i2B8027A488B97CAF
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J9JID3J9JID3_HUMAN
CMRF35-like molecule 7
CD300LB
148Annotation score:

Sequence cautioni

The sequence AAH28091 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAF83614 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAW89170 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti144G → R in AAV69612 (PubMed:16920917).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY646929 mRNA Translation: AAV69612.1
AF427618 mRNA Translation: AAN86133.1
AY359025 mRNA Translation: AAQ89384.1
AK290925 mRNA Translation: BAF83614.1 Different initiation.
AC079325 Genomic DNA No translation available.
CH471099 Genomic DNA Translation: EAW89170.1 Different initiation.
BC028091 mRNA Translation: AAH28091.1 Different initiation.
CCDSiCCDS11700.2
RefSeqiNP_777552.3, NM_174892.3
UniGeneiHs.313343

Genome annotation databases

EnsembliENST00000392621; ENSP00000376397; ENSG00000178789
GeneIDi124599
KEGGihsa:124599
UCSCiuc002jkx.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY646929 mRNA Translation: AAV69612.1
AF427618 mRNA Translation: AAN86133.1
AY359025 mRNA Translation: AAQ89384.1
AK290925 mRNA Translation: BAF83614.1 Different initiation.
AC079325 Genomic DNA No translation available.
CH471099 Genomic DNA Translation: EAW89170.1 Different initiation.
BC028091 mRNA Translation: AAH28091.1 Different initiation.
CCDSiCCDS11700.2
RefSeqiNP_777552.3, NM_174892.3
UniGeneiHs.313343

3D structure databases

ProteinModelPortaliA8K4G0
SMRiA8K4G0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125877, 3 interactors
STRINGi9606.ENSP00000376397

PTM databases

iPTMnetiA8K4G0
PhosphoSitePlusiA8K4G0

Proteomic databases

PaxDbiA8K4G0
PRIDEiA8K4G0
ProteomicsDBi1861

Protocols and materials databases

DNASUi124599
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392621; ENSP00000376397; ENSG00000178789
GeneIDi124599
KEGGihsa:124599
UCSCiuc002jkx.4 human

Organism-specific databases

CTDi124599
DisGeNETi124599
EuPathDBiHostDB:ENSG00000178789.8
GeneCardsiCD300LB
H-InvDBiHIX0014146
HGNCiHGNC:30811 CD300LB
MIMi610705 gene
neXtProtiNX_A8K4G0
OpenTargetsiENSG00000178789
PharmGKBiPA142672151
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JBZ0 Eukaryota
ENOG41114E0 LUCA
GeneTreeiENSGT00470000042273
HOGENOMiHOG000231065
HOVERGENiHBG103081
InParanoidiA8K4G0
KOiK20395
OMAiCFSIQGP
OrthoDBiEOG091G0O8X
PhylomeDBiA8K4G0
TreeFamiTF334441

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-2172127 DAP12 interactions

Miscellaneous databases

ChiTaRSiCD300LB human
GenomeRNAii124599
PROiPR:A8K4G0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000178789 Expressed in 81 organ(s), highest expression level in leukocyte
CleanExiHS_CD300LB
ExpressionAtlasiA8K4G0 baseline and differential
GenevisibleiA8K4G0 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLM7_HUMAN
AccessioniPrimary (citable) accession number: A8K4G0
Secondary accession number(s): Q1EG73, Q8IX40, Q8N6D1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: September 12, 2018
This is version 86 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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