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UniProtKB - A8K3M3 (A8K3M3_HUMAN)
Protein
Tyrosine-protein phosphatase non-receptor type
Gene
PTPN1
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:3.1.3.48UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 181 | SubstrateUniRule annotation | 1 | |
Active sitei | 215 | Phosphocysteine intermediateUniRule annotation | 1 | |
Binding sitei | 262 | SubstrateUniRule annotation | 1 |
GO - Molecular functioni
- insulin receptor binding Source: Ensembl
- protein phosphatase 2A binding Source: Ensembl
- protein tyrosine phosphatase activity Source: UniProtKB-EC
GO - Biological processi
- insulin receptor signaling pathway Source: Ensembl
- IRE1-mediated unfolded protein response Source: Ensembl
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: Ensembl
- negative regulation of ERK1 and ERK2 cascade Source: Ensembl
- negative regulation of PERK-mediated unfolded protein response Source: Ensembl
- negative regulation of vascular endothelial growth factor receptor signaling pathway Source: Ensembl
- peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity Source: Ensembl
- platelet-derived growth factor receptor-beta signaling pathway Source: Ensembl
- positive regulation of JUN kinase activity Source: Ensembl
- regulation of insulin receptor signaling pathway Source: Ensembl
Keywordsi
Molecular function | Hydrolase, Protein phosphataseUniRule annotation, ReceptorImported |
Names & Taxonomyi
Protein namesi | Recommended name: Tyrosine-protein phosphatase non-receptor typeUniRule annotation (EC:3.1.3.48UniRule annotation) |
Gene namesi | Name:PTPN1Imported ORF Names:hCG_37134Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000196396 |
Subcellular locationi
Cytosol
- cytosol Source: Ensembl
Endoplasmic reticulum
- endoplasmic reticulum Source: HPA
Endosome
- early endosome Source: Ensembl
- sorting endosome Source: Ensembl
Mitochondrion
- mitochondrial crista Source: Ensembl
- mitochondrial matrix Source: Ensembl
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 409 – 430 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
Endoplasmic reticulumARBA annotation, MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000196396, Expressed in upper lobe of left lung and 199 other tissues |
Interactioni
GO - Molecular functioni
- insulin receptor binding Source: Ensembl
- protein phosphatase 2A binding Source: Ensembl
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 277 | Tyrosine-protein phosphataseInterPro annotationAdd BLAST | 275 | |
Domaini | 189 – 268 | TYR_PHOSPHATASE_2InterPro annotationAdd BLAST | 80 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 215 – 221 | Substrate bindingUniRule annotation | 7 | |
Regioni | 338 – 359 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 378 – 398 | DisorderedSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.UniRule annotationARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
HOGENOMi | CLU_001645_9_0_1 |
OMAi | FQDIRHE |
OrthoDBi | 411281at2759 |
Family and domain databases
Gene3Di | 3.90.190.10, 1 hit |
InterProi | View protein in InterPro IPR029021, Prot-tyrosine_phosphatase-like IPR000242, PTP_cat IPR012265, Ptpn1/Ptpn2 IPR016130, Tyr_Pase_AS IPR003595, Tyr_Pase_cat IPR000387, Tyr_Pase_dom |
Pfami | View protein in Pfam PF00102, Y_phosphatase, 1 hit |
PIRSFi | PIRSF000926, Tyr-Ptase_nr1, 1 hit |
PRINTSi | PR00700, PRTYPHPHTASE |
SMARTi | View protein in SMART SM00194, PTPc, 1 hit SM00404, PTPc_motif, 1 hit |
SUPFAMi | SSF52799, SSF52799, 1 hit |
PROSITEi | View protein in PROSITE PS00383, TYR_PHOSPHATASE_1, 1 hit PS50056, TYR_PHOSPHATASE_2, 1 hit PS50055, TYR_PHOSPHATASE_PTP, 1 hit |
i Sequence
Sequence statusi: Complete.
A8K3M3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEMEKEFEQI DKSGSWAAIY QDIRHEASDF PCRVAKLPKN KNRNRYRDVS
60 70 80 90 100
PFDHSRIKLH QEDNDYINAS LIKMEEAQRS YILTQGPLPN TCGHFWEMVW
110 120 130 140 150
EQKSRGVVML NRVMEKGSLK CAQYWPQKEE KEMIFEDTNL KLTLISEDIK
160 170 180 190 200
SYYTVRQLEL ENLTTQETRE ILHFHYTTWP DFGVPESPAS FLNFLFKVRE
210 220 230 240 250
SGSLSPEHGP VVVHCSAGIG RSGTFCLADT CLLLMDKRKD PSSVDIKKVL
260 270 280 290 300
LEMRKFRMGL IQTADQLRFS YLAVIEGAKF IMGDSSVQDQ WKELSHEDLE
310 320 330 340 350
PPPEHIPPPP RPPKRILEPH NGKCREFFPN HQWVKEETQE DKDCPIKEEK
360 370 380 390 400
GSPLNAAPYG IESMSQDTEV RSRVVGGSLR GAQAASPAKG EPSLPEKDED
410 420 430
HALSYWKPFL VNMCVATVLT AGAYLCYRFL FNSNT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK290638 mRNA Translation: BAF83327.1 AK316563 mRNA Translation: BAG38152.1 CH471077 Genomic DNA Translation: EAW75626.1 |
RefSeqi | NP_002818.1, NM_002827.3 |
Genome annotation databases
GeneIDi | 5770 |
KEGGi | hsa:5770 |
MANE-Selecti | ENST00000371621.5; ENSP00000360683.3; NM_002827.4; NP_002818.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK290638 mRNA Translation: BAF83327.1 AK316563 mRNA Translation: BAG38152.1 CH471077 Genomic DNA Translation: EAW75626.1 |
RefSeqi | NP_002818.1, NM_002827.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 2724, 784 antibodies from 43 providers |
DNASUi | 5770 |
Genome annotation databases
GeneIDi | 5770 |
KEGGi | hsa:5770 |
MANE-Selecti | ENST00000371621.5; ENSP00000360683.3; NM_002827.4; NP_002818.1 |
Organism-specific databases
CTDi | 5770 |
PharmGKBi | PA33985 |
VEuPathDBi | HostDB:ENSG00000196396 |
Phylogenomic databases
HOGENOMi | CLU_001645_9_0_1 |
OMAi | FQDIRHE |
OrthoDBi | 411281at2759 |
Miscellaneous databases
BioGRID-ORCSi | 5770, 87 hits in 1059 CRISPR screens |
ChiTaRSi | PTPN1, human |
GenomeRNAii | 5770 |
Gene expression databases
Bgeei | ENSG00000196396, Expressed in upper lobe of left lung and 199 other tissues |
Family and domain databases
Gene3Di | 3.90.190.10, 1 hit |
InterProi | View protein in InterPro IPR029021, Prot-tyrosine_phosphatase-like IPR000242, PTP_cat IPR012265, Ptpn1/Ptpn2 IPR016130, Tyr_Pase_AS IPR003595, Tyr_Pase_cat IPR000387, Tyr_Pase_dom |
Pfami | View protein in Pfam PF00102, Y_phosphatase, 1 hit |
PIRSFi | PIRSF000926, Tyr-Ptase_nr1, 1 hit |
PRINTSi | PR00700, PRTYPHPHTASE |
SMARTi | View protein in SMART SM00194, PTPc, 1 hit SM00404, PTPc_motif, 1 hit |
SUPFAMi | SSF52799, SSF52799, 1 hit |
PROSITEi | View protein in PROSITE PS00383, TYR_PHOSPHATASE_1, 1 hit PS50056, TYR_PHOSPHATASE_2, 1 hit PS50055, TYR_PHOSPHATASE_PTP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A8K3M3_HUMAN | |
Accessioni | A8K3M3Primary (citable) accession number: A8K3M3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 4, 2007 |
Last sequence update: | December 4, 2007 | |
Last modified: | January 19, 2022 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |