PTPN1

Functionⁱ

Catalytic activityⁱ

Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate.UniRule annotationSAAS annotation

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	181	SubstrateUniRule annotation	1
Active siteⁱ	215	Phosphocysteine intermediateUniRule annotation	1
Binding siteⁱ	262	SubstrateUniRule annotation	1

GO - Molecular functionⁱ

insulin receptor binding Source: Ensembl
protein phosphatase 2A binding Source: Ensembl
protein tyrosine phosphatase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of JUN kinase activity Source: Ensembl
insulin receptor signaling pathway Source: Ensembl
IRE1-mediated unfolded protein response Source: Ensembl
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: Ensembl
negative regulation of ERK1 and ERK2 cascade Source: Ensembl
negative regulation of PERK-mediated unfolded protein response Source: Ensembl
negative regulation of vascular endothelial growth factor receptor signaling pathway Source: Ensembl
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity Source: Ensembl
platelet-derived growth factor receptor-beta signaling pathway Source: Ensembl
regulation of insulin receptor signaling pathway Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protein phosphataseUniRule annotationSAAS annotation, ReceptorImported

Molecular function

Hydrolase, Protein phosphataseUniRule annotationSAAS annotation, ReceptorImported

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tyrosine-protein phosphatase non-receptor typeUniRule annotation (EC:3.1.3.48UniRule annotation)
Gene namesⁱ	Name:PTPN1Imported ORF Names:hCG_37134Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000196396.9

EuPathDBⁱ

HostDB:ENSG00000196396.9

Subcellular locationⁱ

GO - Cellular component

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	409 – 430	HelicalSequence analysisAdd BLAST		22

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA33985

PharmGKBⁱ

PA33985

PTM / Processingⁱ

Proteomic databases

PRIDEⁱ	A8K3M3

PRIDEⁱ

A8K3M3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000196396 Expressed in 185 organ(s), highest expression level in upper lobe of left lung
ExpressionAtlasⁱ	A8K3M3 baseline and differential

Interactionⁱ

GO - Molecular functionⁱ

insulin receptor binding Source: Ensembl
protein phosphatase 2A binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Structureⁱ

3D structure databases

SMRⁱ	A8K3M3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	3 – 277	Tyrosine-protein phosphataseInterPro annotationAdd BLAST		275
Domainⁱ	189 – 268	TYR_PHOSPHATASE_2InterPro annotationAdd BLAST		80

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	215 – 221	Substrate bindingUniRule annotation		7

Sequence similaritiesⁱ

Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.UniRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG0789 Eukaryota COG5599 LUCA
HOVERGENⁱ	HBG008321
KEGG Orthology (KO) More...KOⁱ	K05696
OMAⁱ	PHNGKCK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G082B

Family and domain databases

Gene3Dⁱ	3.90.190.10, 1 hit
InterProⁱ	View protein in InterPro IPR029021 Prot-tyrosine_phosphatase-like IPR000242 PTPase_domain IPR012265 Ptpn1/Ptpn2 IPR016130 Tyr_Pase_AS IPR003595 Tyr_Pase_cat IPR000387 TYR_PHOSPHATASE_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00102 Y_phosphatase, 1 hit
PIRSFⁱ	PIRSF000926 Tyr-Ptase_nr1, 1 hit
PRINTSⁱ	PR00700 PRTYPHPHTASE
SMARTⁱ	View protein in SMART SM00194 PTPc, 1 hit SM00404 PTPc_motif, 1 hit
SUPFAMⁱ	SSF52799 SSF52799, 1 hit
PROSITEⁱ	View protein in PROSITE PS00383 TYR_PHOSPHATASE_1, 1 hit PS50056 TYR_PHOSPHATASE_2, 1 hit PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A8K3M3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEMEKEFEQI DKSGSWAAIY QDIRHEASDF PCRVAKLPKN KNRNRYRDVS 
        60         70         80         90        100
PFDHSRIKLH QEDNDYINAS LIKMEEAQRS YILTQGPLPN TCGHFWEMVW 
       110        120        130        140        150
EQKSRGVVML NRVMEKGSLK CAQYWPQKEE KEMIFEDTNL KLTLISEDIK 
       160        170        180        190        200
SYYTVRQLEL ENLTTQETRE ILHFHYTTWP DFGVPESPAS FLNFLFKVRE 
       210        220        230        240        250
SGSLSPEHGP VVVHCSAGIG RSGTFCLADT CLLLMDKRKD PSSVDIKKVL 
       260        270        280        290        300
LEMRKFRMGL IQTADQLRFS YLAVIEGAKF IMGDSSVQDQ WKELSHEDLE 
       310        320        330        340        350
PPPEHIPPPP RPPKRILEPH NGKCREFFPN HQWVKEETQE DKDCPIKEEK 
       360        370        380        390        400
GSPLNAAPYG IESMSQDTEV RSRVVGGSLR GAQAASPAKG EPSLPEKDED 
       410        420        430 
HALSYWKPFL VNMCVATVLT AGAYLCYRFL FNSNT

Length:435

Mass (Da):49,967

Last modified:December 4, 2007 - v1

Checksum:ⁱ802377DCD33F41FD

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK290638 mRNA Translation: BAF83327.1 AK316563 mRNA Translation: BAG38152.1 CH471077 Genomic DNA Translation: EAW75626.1
NCBI Reference Sequences More...RefSeqⁱ	NP_002818.1, NM_002827.3
UniGeneⁱ	Hs.417549

Genome annotation databases

GeneIDⁱ	5770
KEGGⁱ	hsa:5770

Protein	Similar proteins		Species	Score	Length	Source
A8K3M3	Tyrosine-protein phosphatase non-receptor type 1	)	HUMAN		435	UniRef100_P18031
Tyrosine-protein phosphatase non-receptor type		PANTR		435
Tyrosine-protein phosphatase non-receptor type		PANPA		435
Tyrosine-protein phosphatase non-receptor type		HUMAN		362
Tyrosine-protein phosphatase non-receptor type		PANTR		362
+1

Protein	Similar proteins		Species	Score	Length	Source
A8K3M3	Tyrosine-protein phosphatase non-receptor type 1	)	HUMAN		435	UniRef90_P18031
Tyrosine-protein phosphatase non-receptor type		PANTR		435
Tyrosine-protein phosphatase non-receptor type		PANPA		435
Tyrosine-protein phosphatase non-receptor type		MACMU		465
Tyrosine-protein phosphatase non-receptor type		COLAP		465
+29

Protein	Similar proteins		Species	Score	Length	Source
A8K3M3	Tyrosine-protein phosphatase non-receptor type 1	)	HUMAN		435	UniRef50_P18031
Tyrosine-protein phosphatase non-receptor type 1		MOUSE		432
Tyrosine-protein phosphatase non-receptor type 1		RAT		432
Tyrosine-protein phosphatase non-receptor type 1		CHICK		434
Tyrosine-protein phosphatase non-receptor type		PANTR		435
+590

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK290638 mRNA Translation: BAF83327.1 AK316563 mRNA Translation: BAG38152.1 CH471077 Genomic DNA Translation: EAW75626.1
RefSeqⁱ	NP_002818.1, NM_002827.3
UniGeneⁱ	Hs.417549

3D structure databases

SMRⁱ	A8K3M3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PRIDEⁱ	A8K3M3

PRIDEⁱ

A8K3M3

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5770
Structural Biology Knowledgebase	Search...

Genome annotation databases

GeneIDⁱ	5770
KEGGⁱ	hsa:5770

Organism-specific databases

CTDⁱ	5770
EuPathDBⁱ	HostDB:ENSG00000196396.9
PharmGKBⁱ	PA33985

Phylogenomic databases

eggNOGⁱ	KOG0789 Eukaryota COG5599 LUCA
HOVERGENⁱ	HBG008321
KOⁱ	K05696
OMAⁱ	PHNGKCK
OrthoDBⁱ	EOG091G082B

Miscellaneous databases

ChiTaRSⁱ	PTPN1 human
GenomeRNAiⁱ	5770

Gene expression databases

Bgeeⁱ	ENSG00000196396 Expressed in 185 organ(s), highest expression level in upper lobe of left lung
ExpressionAtlasⁱ	A8K3M3 baseline and differential

Family and domain databases

Gene3Dⁱ	3.90.190.10, 1 hit
InterProⁱ	View protein in InterPro IPR029021 Prot-tyrosine_phosphatase-like IPR000242 PTPase_domain IPR012265 Ptpn1/Ptpn2 IPR016130 Tyr_Pase_AS IPR003595 Tyr_Pase_cat IPR000387 TYR_PHOSPHATASE_dom
Pfamⁱ	View protein in Pfam PF00102 Y_phosphatase, 1 hit
PIRSFⁱ	PIRSF000926 Tyr-Ptase_nr1, 1 hit
PRINTSⁱ	PR00700 PRTYPHPHTASE
SMARTⁱ	View protein in SMART SM00194 PTPc, 1 hit SM00404 PTPc_motif, 1 hit
SUPFAMⁱ	SSF52799 SSF52799, 1 hit
PROSITEⁱ	View protein in PROSITE PS00383 TYR_PHOSPHATASE_1, 1 hit PS50056 TYR_PHOSPHATASE_2, 1 hit PS50055 TYR_PHOSPHATASE_PTP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A8K3M3_HUMAN
Accessionⁱ	A8K3M3Primary (citable) accession number: A8K3M3
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	December 4, 2007
	Last sequence update:	December 4, 2007
	Last modified:	September 12, 2018
	This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - A8K3M3 (A8K3M3_HUMAN)

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Tyrosine-protein phosphatase non-receptor type

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Endoplasmic reticulum

Endosome

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ