UniProtKB - A8K3E0 (A8K3E0_HUMAN)
Protein
Submitted name:
Nuclear factor (Erythroid-derived 2), 45kDa, isoform CRA_a
Gene
NFE2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity Source: InterPro
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: InterPro
Keywordsi
Molecular function | DNA-bindingARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Nuclear factor (Erythroid-derived 2), 45kDa, isoform CRA_aImportedSubmitted name: cDNA FLJ78141, highly similar to nuclear factor erythroid 2 isoform f=basic leucine zipper proteinImportedSubmitted name: cDNA FLJ78153, highly similar to nuclear factor erythroid 2 isoform f=basic leucine zipper proteinImportedSubmitted name: cDNA, FLJ93708, Homo sapiens nuclear factor (erythroid-derived 2), 45kDa (NFE2),mRNAImported |
Gene namesi | Name:NFE2Imported ORF Names:hCG_37258Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000123405.13 |
Expressioni
Gene expression databases
Bgeei | ENSG00000123405, Expressed in blood and 114 other tissues |
ExpressionAtlasi | A8K3E0, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 266 – 329 | BZIPInterPro annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 127 – 150 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 205 – 226 | DisorderedSequence analysisAdd BLAST | 22 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 284 – 318 | Sequence analysisAdd BLAST | 35 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
HOGENOMi | CLU_058451_0_0_1 |
OMAi | ELYCDIF |
OrthoDBi | 1095280at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR004826, bZIP_Maf IPR029853, NF-E2_p45 IPR008917, TF_DNA-bd_sf |
PANTHERi | PTHR24411:SF26, PTHR24411:SF26, 1 hit |
Pfami | View protein in Pfam PF03131, bZIP_Maf, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF47454, SSF47454, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
i Sequence
Sequence statusi: Complete.
A8K3E0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSPCPPQQSR NRVIQLSTSE LGEMELTWQE IMSITELQGL NAPSEPSFEP
60 70 80 90 100
QAPAPYLGPP PPTTYCPCSI HPDSGFPLPP PPYELPASTS HVPDPPYSYG
110 120 130 140 150
NMAIPVSKPL SLSGLLSEPL QDPLALLDIG LPAGPPKPQE DPESDSGLSL
160 170 180 190 200
NYSDAESLEL EGTEAGRRRS EYVEMYPVEY PYSLMPNSLA HSNYTLPAAE
210 220 230 240 250
TPLALEPSSG PVRAKPTARG EAGSRDERRA LAMKIPFPTD KIVNLPVDDF
260 270 280 290 300
NELLARYPLT ESQLALVRDI RRRGKNKVAA QNCRKRKLET IVQLERELER
310 320 330 340 350
LTNERERLLR ARGEADRTLE VMRQQLTELY RDIFQHLRDE SGNSYSPEEY
360 370
ALQQAADGTI FLVPRGTKME ATD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK290555 mRNA Translation: BAF83244.1 AK290564 mRNA Translation: BAF83253.1 AK313207 mRNA Translation: BAG36023.1 CH471054 Genomic DNA Translation: EAW96771.1 CH471054 Genomic DNA Translation: EAW96772.1 |
RefSeqi | NP_001129495.1, NM_001136023.2 NP_001248390.1, NM_001261461.1 NP_006154.1, NM_006163.2 XP_005268963.1, XM_005268906.4 |
Genome annotation databases
GeneIDi | 4778 |
KEGGi | hsa:4778 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK290555 mRNA Translation: BAF83244.1 AK290564 mRNA Translation: BAF83253.1 AK313207 mRNA Translation: BAG36023.1 CH471054 Genomic DNA Translation: EAW96771.1 CH471054 Genomic DNA Translation: EAW96772.1 |
RefSeqi | NP_001129495.1, NM_001136023.2 NP_001248390.1, NM_001261461.1 NP_006154.1, NM_006163.2 XP_005268963.1, XM_005268906.4 |
3D structure databases
SMRi | A8K3E0 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 907, 139 antibodies |
DNASUi | 4778 |
Genome annotation databases
GeneIDi | 4778 |
KEGGi | hsa:4778 |
Organism-specific databases
CTDi | 4778 |
EuPathDBi | HostDB:ENSG00000123405.13 |
PharmGKBi | PA31586 |
Phylogenomic databases
HOGENOMi | CLU_058451_0_0_1 |
OMAi | ELYCDIF |
OrthoDBi | 1095280at2759 |
Miscellaneous databases
BioGRID-ORCSi | 4778, 12 hits in 868 CRISPR screens |
ChiTaRSi | NFE2, human |
GenomeRNAii | 4778 |
Gene expression databases
Bgeei | ENSG00000123405, Expressed in blood and 114 other tissues |
ExpressionAtlasi | A8K3E0, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR004826, bZIP_Maf IPR029853, NF-E2_p45 IPR008917, TF_DNA-bd_sf |
PANTHERi | PTHR24411:SF26, PTHR24411:SF26, 1 hit |
Pfami | View protein in Pfam PF03131, bZIP_Maf, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF47454, SSF47454, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A8K3E0_HUMAN | |
Accessioni | A8K3E0Primary (citable) accession number: A8K3E0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 4, 2007 |
Last sequence update: | December 4, 2007 | |
Last modified: | December 2, 2020 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |