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Protein
Submitted name:

WAP four-disulfide core domain 2, isoform CRA_c

Gene

WFDC2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
WAP four-disulfide core domain 2, isoform CRA_cImported
Submitted name:
WAP four-disulfide core domain protein 2Imported
Submitted name:
cDNA FLJ76533, highly similar to Homo sapiens WAP four-disulfide core domain 2 (WFDC2), transcript variant 3, mRNAImported
Gene namesi
Name:WFDC2Imported
ORF Names:hCG_38370Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101443.17
HGNCiHGNC:15939 WFDC2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000101443

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_501408418431 – 79Sequence analysisAdd BLAST49

Proteomic databases

PeptideAtlasiA8K2M3

Expressioni

Gene expression databases

BgeeiENSG00000101443 Expressed in 113 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiA8K2M3 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 74WAPInterPro annotationAdd BLAST46

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410J36N Eukaryota
ENOG41125F3 LUCA
GeneTreeiENSGT00730000111410
HOGENOMiHOG000115819
HOVERGENiHBG018073

Family and domain databases

Gene3Di4.10.75.10, 1 hit
InterProiView protein in InterPro
IPR036645 Elafin-like_sf
IPR008197 WAP_dom
PfamiView protein in Pfam
PF00095 WAP, 1 hit
PRINTSiPR00003 4DISULPHCORE
SMARTiView protein in SMART
SM00217 WAP, 1 hit
SUPFAMiSSF57256 SSF57256, 1 hit
PROSITEiView protein in PROSITE
PS51390 WAP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A8K2M3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPACRLGPLA AALLLSLLLF GFTLVSGTGA EKTGVCPELQ ADQNCTQECV
60 70
SDSECADNLK CCSAGCATFC SLPNGQLAE
Length:79
Mass (Da):8,072
Last modified:April 8, 2008 - v1
Checksum:i9E34AF6DADEBACC6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q14508WFDC2_HUMAN
WAP four-disulfide core domain prot...
WFDC2 HE4, WAP5
124Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031663 Genomic DNA No translation available.
AK290288 mRNA Translation: BAF82977.1
CH471077 Genomic DNA Translation: EAW75838.1
UniGeneiHs.2719

Genome annotation databases

EnsembliENST00000447118; ENSP00000404760; ENSG00000101443
UCSCiuc061xie.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031663 Genomic DNA No translation available.
AK290288 mRNA Translation: BAF82977.1
CH471077 Genomic DNA Translation: EAW75838.1
UniGeneiHs.2719

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiA8K2M3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000447118; ENSP00000404760; ENSG00000101443
UCSCiuc061xie.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000101443.17
HGNCiHGNC:15939 WFDC2
OpenTargetsiENSG00000101443
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J36N Eukaryota
ENOG41125F3 LUCA
GeneTreeiENSGT00730000111410
HOGENOMiHOG000115819
HOVERGENiHBG018073

Miscellaneous databases

ChiTaRSiWFDC2 human

Gene expression databases

BgeeiENSG00000101443 Expressed in 113 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiA8K2M3 baseline and differential

Family and domain databases

Gene3Di4.10.75.10, 1 hit
InterProiView protein in InterPro
IPR036645 Elafin-like_sf
IPR008197 WAP_dom
PfamiView protein in Pfam
PF00095 WAP, 1 hit
PRINTSiPR00003 4DISULPHCORE
SMARTiView protein in SMART
SM00217 WAP, 1 hit
SUPFAMiSSF57256 SSF57256, 1 hit
PROSITEiView protein in PROSITE
PS51390 WAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA8K2M3_HUMAN
AccessioniPrimary (citable) accession number: A8K2M3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: September 12, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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