UniProtKB - A8K257 (A8K257_HUMAN)
Protein
Submitted name:
cDNA FLJ75298, highly similar to Homo sapiens caspase 1, apoptosis-related cysteine protease(interleukin 1, beta, convertase) (CASP1), transcript variant beta,mRNA
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- cysteine-type endopeptidase activity Source: InterPro
GO - Biological processi
- regulation of apoptotic process Source: InterPro
Keywordsi
Molecular function | Hydrolase, Protease, Thiol proteaseARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: cDNA FLJ75298, highly similar to Homo sapiens caspase 1, apoptosis-related cysteine protease(interleukin 1, beta, convertase) (CASP1), transcript variant beta,mRNAImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
PTM / Processingi
Keywords - PTMi
ZymogenARBA annotationProteomic databases
PeptideAtlasi | A8K257 |
PRIDEi | A8K257 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 91 | CARDInterPro annotationAdd BLAST | 91 | |
Domaini | 140 – 268 | CASPASE_P20InterPro annotationAdd BLAST | 129 | |
Domaini | 296 – 381 | CASPASE_P10InterPro annotationAdd BLAST | 86 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 26 – 46 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysisFamily and domain databases
CDDi | cd00032, CASc, 1 hit |
InterProi | View protein in InterPro IPR001315, CARD IPR029030, Caspase-like_dom_sf IPR033139, Caspase_cys_AS IPR016129, Caspase_his_AS IPR011029, DEATH-like_dom_sf IPR002398, Pept_C14 IPR002138, Pept_C14_p10 IPR001309, Pept_C14_p20 IPR015917, Pept_C14A |
PANTHERi | PTHR10454, PTHR10454, 2 hits |
Pfami | View protein in Pfam PF00619, CARD, 1 hit |
PRINTSi | PR00376, IL1BCENZYME |
SMARTi | View protein in SMART SM00114, CARD, 1 hit SM00115, CASc, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF52129, SSF52129, 1 hit |
PROSITEi | View protein in PROSITE PS50209, CARD, 1 hit PS01122, CASPASE_CYS, 1 hit PS01121, CASPASE_HIS, 1 hit PS50207, CASPASE_P10, 1 hit PS50208, CASPASE_P20, 1 hit |
i Sequence
Sequence statusi: Complete.
A8K257-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADKVLKEKR KLFIRSMGEG TINGLLDELL QTRVLNKEEM EKVKRENATV
60 70 80 90 100
MDKTRALIDS VIPKGAQACQ ICITYICEED SYLAGTLGLS AAPQAVQDNP
110 120 130 140 150
AMPTSSGSEG NVKLCSLEEA QRIWKQKSAE IYPIMDKSSR TRLALIICNE
160 170 180 190 200
EFDSIPRRTG AEVDITGMTM LLQNLGYSVD VKKNLTASDM TTELEAFAHR
210 220 230 240 250
PEHKTSDSTF LVFMSHGIRE GICGKKHSEQ VPDILQLNAI FNMLNTKNCP
260 270 280 290 300
SLKDKPKVII IQACRGDSPG VVWFKDSVGA SGNLSLPTTE EFEDDAIKKA
310 320 330 340 350
HIEKDFIAFC SSTPDNVSWR HPTMGSVFIG RLIEHMQEYA CSCDVEEIFR
360 370 380
KVRFSFEQPD GRAQMPTTER VTLTRCFYLF PGH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK290122 mRNA Translation: BAF82811.1 |
RefSeqi | NP_001244048.1, NM_001257119.2 |
Genome annotation databases
GeneIDi | 834 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK290122 mRNA Translation: BAF82811.1 |
RefSeqi | NP_001244048.1, NM_001257119.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | A8K257 |
PRIDEi | A8K257 |
Genome annotation databases
GeneIDi | 834 |
Organism-specific databases
CTDi | 834 |
Miscellaneous databases
BioGRID-ORCSi | 834, 2 hits in 844 CRISPR screens |
GenomeRNAii | 834 |
Family and domain databases
CDDi | cd00032, CASc, 1 hit |
InterProi | View protein in InterPro IPR001315, CARD IPR029030, Caspase-like_dom_sf IPR033139, Caspase_cys_AS IPR016129, Caspase_his_AS IPR011029, DEATH-like_dom_sf IPR002398, Pept_C14 IPR002138, Pept_C14_p10 IPR001309, Pept_C14_p20 IPR015917, Pept_C14A |
PANTHERi | PTHR10454, PTHR10454, 2 hits |
Pfami | View protein in Pfam PF00619, CARD, 1 hit |
PRINTSi | PR00376, IL1BCENZYME |
SMARTi | View protein in SMART SM00114, CARD, 1 hit SM00115, CASc, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF52129, SSF52129, 1 hit |
PROSITEi | View protein in PROSITE PS50209, CARD, 1 hit PS01122, CASPASE_CYS, 1 hit PS01121, CASPASE_HIS, 1 hit PS50207, CASPASE_P10, 1 hit PS50208, CASPASE_P20, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A8K257_HUMAN | |
Accessioni | A8K257Primary (citable) accession number: A8K257 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 4, 2007 |
Last sequence update: | December 4, 2007 | |
Last modified: | December 2, 2020 | |
This is version 83 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |