UniProtKB - A8K161 (A8K161_HUMAN)
Protein
Calcium/calmodulin-dependent protein kinase
Gene
CAMK2A
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- calmodulin binding Source: UniProtKB-KW
- calmodulin-dependent protein kinase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Calmodulin-bindingARBA annotation, Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase |
Ligand | ATP-bindingUniRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Calcium/calmodulin-dependent protein kinaseARBA annotation (EC:2.7.11.17ARBA annotation) |
Gene namesi | Name:CAMK2AImported ORF Names:hCG_38614Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000070808.15 |
Expressioni
Gene expression databases
Bgeei | ENSG00000070808, Expressed in right frontal lobe and 154 other tissues |
ExpressionAtlasi | A8K161, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 271 | Protein kinaseInterPro annotationAdd BLAST | 259 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 314 – 352 | DisorderedSequence analysisAdd BLAST | 39 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 331 – 345 | PolarSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the protein kinase superfamily.UniRule annotation
Phylogenomic databases
OMAi | CIAYVRV |
OrthoDBi | 330091at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR013543, Ca/CaM-dep_prot_kinase-assoc IPR011009, Kinase-like_dom_sf IPR032710, NTF2-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF08332, CaMKII_AD, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF54427, SSF54427, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
A8K161-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATITCTRFT EEYQLFEELG KGAFSVVRRC VKVLAGQEYA AKIINTKKLS
60 70 80 90 100
ARDHQKLERE ARICRLLKHP NIVRLHDSIS EEGHHYLIFD LVTGGELFED
110 120 130 140 150
IVAREYYSEA DASHCIQQIL EAVLHCHQMG VVHRDLKPEN LLLASKLKGA
160 170 180 190 200
AVKLADFGLA IEVEGEQQAW FGFAGTPGYL SPEVLRKDPY GKPVDLWACG
210 220 230 240 250
VILYILLVGY PPFWDEDQHR LYQQIKAGAY DFPSPEWDTV TPEAKDLINK
260 270 280 290 300
MLTINPSKRI TAAEALKHPW ISHRSTVASC MHRQETVDCL KKFNARRKLK
310 320 330 340 350
GAILTTMLAT RNFSGGKSGG NKKSDGVKKR KSSSSVQLME SSESTNTTIE
360 370 380 390 400
DEDTKVRKQE IIKVTEQLIE AISNGDFESY TKMCDPGMTA FEPEALGNLV
410 420 430 440 450
EGLDFHRFYF ENLWSRNSKP VHTTILNPHI HLMGDESACI AYIRITQYLD
460 470 480
AGGIPRTAQS EETRVWHRRD GKWQIVHFHR SGAPSVLPH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK289776 mRNA Translation: BAF82465.1 CH471062 Genomic DNA Translation: EAW61742.1 |
RefSeqi | NP_057065.2, NM_015981.3 NP_741960.1, NM_171825.2 |
Genome annotation databases
GeneIDi | 815 |
KEGGi | hsa:815 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK289776 mRNA Translation: BAF82465.1 CH471062 Genomic DNA Translation: EAW61742.1 |
RefSeqi | NP_057065.2, NM_015981.3 NP_741960.1, NM_171825.2 |
3D structure databases
SMRi | A8K161 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 3814, 847 antibodies |
DNASUi | 815 |
Genome annotation databases
GeneIDi | 815 |
KEGGi | hsa:815 |
Organism-specific databases
CTDi | 815 |
PharmGKBi | PA90 |
VEuPathDBi | HostDB:ENSG00000070808.15 |
Phylogenomic databases
OMAi | CIAYVRV |
OrthoDBi | 330091at2759 |
Miscellaneous databases
BioGRID-ORCSi | 815, 3 hits in 902 CRISPR screens |
ChiTaRSi | CAMK2A, human |
GenomeRNAii | 815 |
Gene expression databases
Bgeei | ENSG00000070808, Expressed in right frontal lobe and 154 other tissues |
ExpressionAtlasi | A8K161, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR013543, Ca/CaM-dep_prot_kinase-assoc IPR011009, Kinase-like_dom_sf IPR032710, NTF2-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF08332, CaMKII_AD, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF54427, SSF54427, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A8K161_HUMAN | |
Accessioni | A8K161Primary (citable) accession number: A8K161 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 4, 2007 |
Last sequence update: | December 4, 2007 | |
Last modified: | February 10, 2021 | |
This is version 114 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |