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Entry version 75 (07 Apr 2021)
Sequence version 1 (04 Dec 2007)
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Protein
Submitted name:

cDNA FLJ75576, highly similar to Homo sapiens brain-specific angiogenesis inhibitor 3 (BAI3), mRNA

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptorARBA annotation, Receptor, Transducer

Protein family/group databases

MEROPS protease database

More...
MEROPSi
P02.027

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
cDNA FLJ75576, highly similar to Homo sapiens brain-specific angiogenesis inhibitor 3 (BAI3), mRNAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 25HelicalSequence analysisAdd BLAST19
Transmembranei879 – 901HelicalSequence analysisAdd BLAST23
Transmembranei913 – 931HelicalSequence analysisAdd BLAST19
Transmembranei943 – 961HelicalSequence analysisAdd BLAST19
Transmembranei982 – 1001HelicalSequence analysisAdd BLAST20
Transmembranei1021 – 1044HelicalSequence analysisAdd BLAST24
Transmembranei1099 – 1120HelicalSequence analysisAdd BLAST22
Transmembranei1126 – 1150HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

GlycoproteinARBA annotation, PhosphoproteinARBA annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A8K0Y1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 159CUBInterPro annotationAdd BLAST130
Domaini491 – 571G_PROTEIN_RECEP_F2_3InterPro annotationAdd BLAST81
Domaini816 – 868GPSInterPro annotationAdd BLAST53
Domaini877 – 1151G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST275

Keywords - Domaini

SignalARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
LWDDSRT

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 4 hits
4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043838, AGRB_N
IPR000859, CUB_dom
IPR032471, GAIN_dom_N
IPR017981, GPCR_2-like
IPR008077, GPCR_2_brain_angio_inhib
IPR036445, GPCR_2_extracell_dom_sf
IPR001879, GPCR_2_extracellular_dom
IPR000832, GPCR_2_secretin-like
IPR017983, GPCR_2_secretin-like_CS
IPR000203, GPS
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00002, 7tm_2, 1 hit
PF19188, AGRB_N, 1 hit
PF16489, GAIN, 1 hit
PF01825, GPS, 1 hit
PF02793, HRM, 1 hit
PF00090, TSP_1, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01694, BAIPRECURSOR
PR00249, GPCRSECRETIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00303, GPS, 1 hit
SM00008, HormR, 1 hit
SM00209, TSP1, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82895, SSF82895, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01180, CUB, 1 hit
PS00650, G_PROTEIN_RECEP_F2_2, 1 hit
PS50227, G_PROTEIN_RECEP_F2_3, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit
PS50221, GPS, 1 hit
PS50092, TSP1, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A8K0Y1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKAVRNLLIY IFSTYLLVMF GFNAAQDFWC STLVKGVIYG SYSVSEMFPK
60 70 80 90 100
NFTNCTWTLE NPDPTKYSIY LKFSKKDLSC SNFSLLAYQF DHFSHEKIKD
110 120 130 140 150
LLRKNHSIMQ LCNSKNAFVF LQYDKNFIQI RRVFPTNFPG LQKKGEEDQK
160 170 180 190 200
SFFEFLVLNK VSPSQFGCHV LCTWLESCLK SENGRTESCG IMYTKCTCPQ
210 220 230 240 250
HLGEWGIDDQ SLILLNNVVL PLNEQTEGCL TQELQTTQVC NLTREAKRPP
260 270 280 290 300
KEEFGMMGDH TIKSQRPRSV YEKRVPQEQA DAAKFMAQTG ESGVEEWSQW
310 320 330 340 350
STCSVTCGQG SQVRTRTCVS PYGTHCSGPL RESRVCNNTA LCPVHGVWEE
360 370 380 390 400
WSPWSLCSFT CGRGQRTRTR SCTPPQYGGR PCEGPETHHK PCNIALCPVD
410 420 430 440 450
GQWQEWSSWS QCSVTCSNGT QQRSRQCTAA AHGGSECRGP WAESRECYNP
460 470 480 490 500
ECTANGQWNQ WGHWSGCSKS CDGGWERRIR TCQGAVITGQ QCEGTGEEVR
510 520 530 540 550
RCSEQRCPAP YEICPEDYLM SMVWKRTPAG DLAFNQCPLN ATGTTSRRCS
560 570 580 590 600
LSLHGVAFWE QPSFARCISN EYRHLQHSIK EHLAKGQRML AGDGMSQVTK
610 620 630 640 650
TLLDLTQRKN FYAGDLLMSV EILRNVTDTF KRASYISASD GVQNFFQIVS
660 670 680 690 700
NLLDEENKEK WEDAQQIYPG SIELMQVIED FIHIVGMGMM DFQNSYLMTG
710 720 730 740 750
NVVASIQKLP AASVLTDINF PMKGRKGMVD WARNSEDRVV IPKSIFTPVS
760 770 780 790 800
SKELDESSVF VLGAVLYKNL DLILPTLRNY TVINSKIIVV TIRPEPKTTD
810 820 830 840 850
SFLEIELAHL ANGTLNPYCV LWDDSKTNES LGTWSTQGCK TVLTDASHTK
860 870 880 890 900
CLCDRLSTFA ILAQQPREII MESSGTPSVT LIVGSGLSCL ALITLAVVYA
910 920 930 940 950
ALWRYIRSER SIILINFCLS IISSSILILV GQTQTHNKSI CTTTTAFLHF
960 970 980 990 1000
FFLASFCWVL TEAWQSYMAV TGKIRTRLIR KRFLCLGWGL PALVVATSVG
1010 1020 1030 1040 1050
FTRTKGYGTD HYCWLSLEGG LLYAFVGPAA AVVLVNMVIG ILVFNKLVSR
1060 1070 1080 1090 1100
DGILDKKLKH RAGQMSEPHS GLTLKCAKCG VVSTTALSAT TASNAMASLW
1110 1120 1130 1140 1150
SSCVVLPLLA LTWMSAVLAM TDKRSILFQI LFAVFDSLQG FVIVMVHCIL
1160 1170 1180 1190 1200
RREVQDAFRC RLRNCQDPIN ADSSSSFPNG HAQIMTDFEK DVDIACRSVL
1210 1220 1230 1240 1250
HKDIGPCRAA TITGTLSRIS LNDDEEEKGT NPEGLSYSTL PGNVISKVII
1260 1270 1280 1290 1300
QQPTGLHMPM SMNELSNPCL KKENSELRRT VYLCTDDNLR GADMDIVHPQ
1310 1320 1330 1340 1350
ERMMESDYIV MPRSSVNNQP SMKEESKMNI GMETLPHERL LHYKVNPEFN
1360 1370 1380 1390 1400
MNPPVMDQFN MNLEQHLAPQ EHMQNLPFEP RTAVKNFMAS ELDDNAGLSR
1410 1420 1430 1440 1450
SETGSTISMS SLERRKSRYS DLDFEKVMHT RKRHMELFQE LNQKFQTLDR
1460 1470 1480 1490 1500
FRDIPNTSSM ENPAPNKNPW DTFKNPSEYP HYTTINVLDT EAKDALELRP
1510 1520
AEWEKCLNLP LDVQEGDFQT EV
Length:1,522
Mass (Da):171,480
Last modified:December 4, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5C34AA0BF2C2CAE6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK289696 mRNA Translation: BAF82385.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289696 mRNA Translation: BAF82385.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiP02.027

Proteomic databases

PeptideAtlasiA8K0Y1

Phylogenomic databases

OMAiLWDDSRT

Family and domain databases

Gene3Di2.20.100.10, 4 hits
4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR043838, AGRB_N
IPR000859, CUB_dom
IPR032471, GAIN_dom_N
IPR017981, GPCR_2-like
IPR008077, GPCR_2_brain_angio_inhib
IPR036445, GPCR_2_extracell_dom_sf
IPR001879, GPCR_2_extracellular_dom
IPR000832, GPCR_2_secretin-like
IPR017983, GPCR_2_secretin-like_CS
IPR000203, GPS
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
PfamiView protein in Pfam
PF00002, 7tm_2, 1 hit
PF19188, AGRB_N, 1 hit
PF16489, GAIN, 1 hit
PF01825, GPS, 1 hit
PF02793, HRM, 1 hit
PF00090, TSP_1, 4 hits
PRINTSiPR01694, BAIPRECURSOR
PR00249, GPCRSECRETIN
SMARTiView protein in SMART
SM00303, GPS, 1 hit
SM00008, HormR, 1 hit
SM00209, TSP1, 4 hits
SUPFAMiSSF82895, SSF82895, 4 hits
PROSITEiView protein in PROSITE
PS01180, CUB, 1 hit
PS00650, G_PROTEIN_RECEP_F2_2, 1 hit
PS50227, G_PROTEIN_RECEP_F2_3, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit
PS50221, GPS, 1 hit
PS50092, TSP1, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA8K0Y1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8K0Y1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: April 7, 2021
This is version 75 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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