UniProtKB - A8K0S8 (ME3L2_HUMAN)
Protein
Putative homeobox protein Meis3-like 2
Gene
MEIS3P2
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Although defined as a pseudogene by HGNC, it is clearly expressed.Curated
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 245 – 307 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 63 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- animal organ morphogenesis Source: GO_Central
- brain development Source: GO_Central
- embryonic pattern specification Source: GO_Central
- eye development Source: GO_Central
- positive regulation of cell population proliferation Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Enzyme and pathway databases
PathwayCommonsi | A8K0S8 |
Names & Taxonomyi
Protein namesi | Recommended name: Putative homeobox protein Meis3-like 2 |
Gene namesi | Name:MEIS3P2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17638, MEIS3P2 |
neXtProti | NX_A8K0S8 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nuclear chromatin Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Miscellaneous databases
Pharosi | A8K0S8, Tdark |
Polymorphism and mutation databases
BioMutai | HGNC:17638 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000347056 | 1 – 358 | Putative homeobox protein Meis3-like 2Add BLAST | 358 |
Proteomic databases
EPDi | A8K0S8 |
jPOSTi | A8K0S8 |
MassIVEi | A8K0S8 |
MaxQBi | A8K0S8 |
PeptideAtlasi | A8K0S8 |
PRIDEi | A8K0S8 |
ProteomicsDBi | 1841 |
PTM databases
iPTMneti | A8K0S8 |
PhosphoSitePlusi | A8K0S8 |
Family & Domainsi
Sequence similaritiesi
Belongs to the TALE/MEIS homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
InParanoidi | A8K0S8 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR001356, Homeobox_dom IPR008422, Homeobox_KN_domain IPR032453, PKNOX/Meis_N |
Pfami | View protein in Pfam PF05920, Homeobox_KN, 1 hit PF16493, Meis_PKNOX_N, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A8K0S8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARRYDELPH YPSIADGPAA LAGFPEAVPA APGPYGPHRP PQPLPPGLDS
60 70 80 90 100
DGLKRDKDEI YGHPLFPLLA LVFEKCELAT CSPRDGAGAG LGTPRGGDVC
110 120 130 140 150
SSDSFNEDNT AFAKQVRSER PFFSSNPELD NLMIQAIQVL RFHLLELEKG
160 170 180 190 200
KMPIDLVIED RDGGCREDFE DYPASCLSLP DQNNIWIRDH EDSGSVHLGT
210 220 230 240 250
PGPSSGGLAS QSGDNSSDQG VGLDTSVASP SSGGEDEDLD QEPRRNKKRG
260 270 280 290 300
IFPKVATNIM RAWLFQHLWH PYPSEEQKKQ LVQDTGLTIL QVNNWFINAR
310 320 330 340 350
RRMVQPMIDQ SNRIGQGAAF SPEGQPIGGY TETEPHVAFR PPASVGMSLN
LEGEWHYL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK289643 mRNA Translation: BAF82332.1 AC087499 Genomic DNA No translation available. |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK289643 mRNA Translation: BAF82332.1 AC087499 Genomic DNA No translation available. |
3D structure databases
SMRi | A8K0S8 |
ModBasei | Search... |
PTM databases
iPTMneti | A8K0S8 |
PhosphoSitePlusi | A8K0S8 |
Polymorphism and mutation databases
BioMutai | HGNC:17638 |
Proteomic databases
EPDi | A8K0S8 |
jPOSTi | A8K0S8 |
MassIVEi | A8K0S8 |
MaxQBi | A8K0S8 |
PeptideAtlasi | A8K0S8 |
PRIDEi | A8K0S8 |
ProteomicsDBi | 1841 |
Organism-specific databases
GeneCardsi | MEIS3P2 |
HGNCi | HGNC:17638, MEIS3P2 |
neXtProti | NX_A8K0S8 |
GenAtlasi | Search... |
Phylogenomic databases
InParanoidi | A8K0S8 |
Enzyme and pathway databases
PathwayCommonsi | A8K0S8 |
Miscellaneous databases
Pharosi | A8K0S8, Tdark |
PROi | PR:A8K0S8 |
RNActi | A8K0S8, protein |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR001356, Homeobox_dom IPR008422, Homeobox_KN_domain IPR032453, PKNOX/Meis_N |
Pfami | View protein in Pfam PF05920, Homeobox_KN, 1 hit PF16493, Meis_PKNOX_N, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ME3L2_HUMAN | |
Accessioni | A8K0S8Primary (citable) accession number: A8K0S8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 2, 2008 |
Last sequence update: | December 4, 2007 | |
Last modified: | December 2, 2020 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM