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Entry version 104 (10 Feb 2021)
Sequence version 1 (04 Dec 2007)
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Protein
Submitted name:

RNA-binding protein 4F, isoform D

Gene

Rnp4F

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-bindingPROSITE-ProRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
RNA-binding protein 4F, isoform DImported
Submitted name:
RNA-binding protein 4F, isoform FImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rnp4FImported
Synonyms:4F-rnpImported, 4f-rnpImported, Dmel\CG3312Imported, RNP-4FImported, Rnp-4FImported, rnp-4fImported
ORF Names:CG3312Imported, Dmel_CG3312Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0014024, Rnp4F

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0014024, Expressed in female gonad and 64 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini724 – 801RRMInterPro annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 149DisorderedSequence analysisAdd BLAST149
Regioni629 – 713DisorderedSequence analysisAdd BLAST85
Regioni862 – 941DisorderedSequence analysisAdd BLAST80

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 16PolyampholyteSequence analysisAdd BLAST16
Compositional biasi17 – 32AcidicSequence analysisAdd BLAST16
Compositional biasi51 – 66PolyampholyteSequence analysisAdd BLAST16
Compositional biasi67 – 88PolarSequence analysisAdd BLAST22
Compositional biasi127 – 149PolarSequence analysisAdd BLAST23
Compositional biasi631 – 658PolarSequence analysisAdd BLAST28

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_361804_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
LWAQVEY

Database of Orthologous Groups

More...
OrthoDBi
867827at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003107, HAT
IPR008669, LSM_interact
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR011990, TPR-like_helical_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05391, Lsm_interact, 1 hit
PF00076, RRM_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00386, HAT, 3 hits
SM00360, RRM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452, SSF48452, 1 hit
SSF54928, SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102, RRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A8JUY0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDADKQLERQ LEKELDEMPA EDLDDDAYDE YDLIVIPDQG KGSPQQGHSE
60 70 80 90 100
SPQQEEEHKS EELRQRSRPT WPPSSAGGDM TTIELISSDD EPSVEETEGG
110 120 130 140 150
NAAGRGRARN DSSSSSDDVG VIEGSELESN SEVSSDSDSD SDNAGGGNQL
160 170 180 190 200
ERSYQELNAL PSKKFAQMVS LIGIAFKLND LEKIESSVLE LQNLATVPAH
210 220 230 240 250
VWLKYLKARL VVTQTDEERK AFEEQCAKAL GYYYSIPLSE YVVNYLVDQG
260 270 280 290 300
NVQNHVLWAK LLADYDVERP DFGDKLRSLI STITDENEAA AFVEMLQKHC
310 320 330 340 350
VTWTCNVEQR QMIKSVVDKF KQHLDETTRG WDWSEQHKAH VYDVETLSLD
360 370 380 390 400
DDLKNAVIRF IFERSVAKFP IVDVLWLSYI EFIQFEGVTV PENEDENEVT
410 420 430 440 450
AEMVAKRAKR LGKGFLRNTE LDLANRGVRS HPSVQLNHRF LDLMERSDFE
460 470 480 490 500
LAEVDEEIRL ILQRIVTDMD MTVELHLDYL AYRIRNTNAS DEQQVASLRA
510 520 530 540 550
AFNHAWEELT VLYGDQADTR YEVLQLWAQV EYTQLGSPDN GREIWRQIMG
560 570 580 590 600
YPGSSIRGLL WLNFAQMESE YNGGHGTRDV LRKALSQPVL ENGLMVQEFF
610 620 630 640 650
RRYERCYGTY ESIAACQALD LPVEYVKPRS RIKPNSQSAY PRQQKLKPRQ
660 670 680 690 700
QQQQTNREPL NREQRRRQAH EQQQQQQQQQ KHGIKKSRTE PSGGATSPPS
710 720 730 740 750
KVKGPANAEA KESNFKYSPN MEINKIFVRN LHPACSKEEL HELFSPFGTI
760 770 780 790 800
KDVRLVHKLN KQFKGIAYVE FEKPGEAQRA VAGRDGCLFK GMNISVAISN
810 820 830 840 850
PPPRGTSAVK PSVAPKRRVP TSLIPTTLVR QEVAAKKLRL LLPEPGDISS
860 870 880 890 900
TSASVDVAIK REANGEEQKG DVQERDEQKG EEQKGEEQKG EEPKGEEQKG
910 920 930 940
DDQIGEEQSG VEQKGDEKKE EEMPAAVPKS NDDFRKLFLK D
Length:941
Mass (Da):106,740
Last modified:December 4, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEAF2775B499FECFD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9W4D2RNP4F_DROME
RNA-binding protein 4F
Rnp4F 4f-rnp, CG3312
941Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014298 Genomic DNA Translation: ABW09339.3
AE014298 Genomic DNA Translation: ABW09340.1

NCBI Reference Sequences

More...
RefSeqi
NP_001096883.3, NM_001103413.3
NP_001096884.1, NM_001103414.3
NP_511047.2, NM_078492.4
NP_996353.1, NM_206630.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0070752; FBpp0070720; FBgn0014024
FBtr0070753; FBpp0089396; FBgn0014024
FBtr0112876; FBpp0111789; FBgn0014024
FBtr0340477; FBpp0309418; FBgn0014024

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
31448

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG3312

UCSC genome browser

More...
UCSCi
CG3312-RC, d. melanogaster
CG3312-RD, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: ABW09339.3
AE014298 Genomic DNA Translation: ABW09340.1
RefSeqiNP_001096883.3, NM_001103413.3
NP_001096884.1, NM_001103414.3
NP_511047.2, NM_078492.4
NP_996353.1, NM_206630.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblMetazoaiFBtr0070752; FBpp0070720; FBgn0014024
FBtr0070753; FBpp0089396; FBgn0014024
FBtr0112876; FBpp0111789; FBgn0014024
FBtr0340477; FBpp0309418; FBgn0014024
GeneIDi31448
KEGGidme:Dmel_CG3312
UCSCiCG3312-RC, d. melanogaster
CG3312-RD, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
31448
FlyBaseiFBgn0014024, Rnp4F

Phylogenomic databases

HOGENOMiCLU_361804_0_0_1
OMAiLWAQVEY
OrthoDBi867827at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
31448, 1 hit in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
31448

Gene expression databases

BgeeiFBgn0014024, Expressed in female gonad and 64 other tissues

Family and domain databases

Gene3Di1.25.40.10, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR003107, HAT
IPR008669, LSM_interact
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR011990, TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF05391, Lsm_interact, 1 hit
PF00076, RRM_1, 1 hit
SMARTiView protein in SMART
SM00386, HAT, 3 hits
SM00360, RRM, 1 hit
SUPFAMiSSF48452, SSF48452, 1 hit
SSF54928, SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102, RRM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA8JUY0_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8JUY0
Secondary accession number(s): A8JUY2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: February 10, 2021
This is version 104 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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