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Entry version 105 (03 Jul 2019)
Sequence version 1 (04 Dec 2007)
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Protein
Submitted name:

Ankyrin 2, isoform J

Gene

Ank2

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
A8JNM6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ankyrin 2, isoform JImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ank2Imported
Synonyms:ank2Imported, ank2-LImported, CG18025Imported, CG18227Imported, CG18768Imported, CG32373Imported, CG32375Imported, CG32377Imported, CG34121Imported, CG34158Imported, CG34416Imported, CG42734Imported, CG7462Imported, CG7493Imported, DAnk2Imported, Dank2Imported, dank2Imported, Dmel\CG42734Imported, ESTS:149B10SImported, SP2523Imported, sp2523Imported
ORF Names:CG42734Imported, Dmel_CG42734Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0261788 Ank2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0261788 Expressed in 26 organ(s), highest expression level in head

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
A8JNM6 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A8JNM6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 785ANK_REP_REGIONInterPro annotationAdd BLAST776
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati43 – 75ANKPROSITE-ProRule annotationAdd BLAST33
Repeati76 – 108ANKPROSITE-ProRule annotationAdd BLAST33
Repeati109 – 141ANKPROSITE-ProRule annotationAdd BLAST33
Repeati142 – 164ANKPROSITE-ProRule annotationAdd BLAST23
Repeati204 – 236ANKPROSITE-ProRule annotationAdd BLAST33
Repeati237 – 269ANKPROSITE-ProRule annotationAdd BLAST33
Repeati270 – 302ANKPROSITE-ProRule annotationAdd BLAST33
Repeati303 – 335ANKPROSITE-ProRule annotationAdd BLAST33
Repeati336 – 368ANKPROSITE-ProRule annotationAdd BLAST33
Repeati369 – 401ANKPROSITE-ProRule annotationAdd BLAST33
Repeati402 – 434ANKPROSITE-ProRule annotationAdd BLAST33
Repeati435 – 467ANKPROSITE-ProRule annotationAdd BLAST33
Repeati468 – 500ANKPROSITE-ProRule annotationAdd BLAST33
Repeati501 – 533ANKPROSITE-ProRule annotationAdd BLAST33
Repeati534 – 566ANKPROSITE-ProRule annotationAdd BLAST33
Repeati567 – 599ANKPROSITE-ProRule annotationAdd BLAST33
Repeati600 – 632ANKPROSITE-ProRule annotationAdd BLAST33
Repeati633 – 665ANKPROSITE-ProRule annotationAdd BLAST33
Repeati666 – 698ANKPROSITE-ProRule annotationAdd BLAST33
Repeati699 – 731ANKPROSITE-ProRule annotationAdd BLAST33
Repeati732 – 764ANKPROSITE-ProRule annotationAdd BLAST33
Domaini928 – 1085ZU5InterPro annotationAdd BLAST158
Domaini1087 – 1234ZU5InterPro annotationAdd BLAST148
Domaini1419 – 1501DeathInterPro annotationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni862 – 881DisorderedSequence analysisAdd BLAST20
Regioni1541 – 1562DisorderedSequence analysisAdd BLAST22
Regioni1657 – 1678DisorderedSequence analysisAdd BLAST22
Regioni1852 – 1892DisorderedSequence analysisAdd BLAST41
Regioni1927 – 1956DisorderedSequence analysisAdd BLAST30
Regioni2082 – 2126DisorderedSequence analysisAdd BLAST45
Regioni2142 – 2161DisorderedSequence analysisAdd BLAST20
Regioni2340 – 2362DisorderedSequence analysisAdd BLAST23
Regioni2525 – 2624DisorderedSequence analysisAdd BLAST100
Regioni2677 – 2707DisorderedSequence analysisAdd BLAST31
Regioni2782 – 2944DisorderedSequence analysisAdd BLAST163
Regioni3113 – 3174DisorderedSequence analysisAdd BLAST62
Regioni3233 – 3260DisorderedSequence analysisAdd BLAST28
Regioni3378 – 3507DisorderedSequence analysisAdd BLAST130
Regioni3579 – 3605DisorderedSequence analysisAdd BLAST27
Regioni3619 – 3643DisorderedSequence analysisAdd BLAST25
Regioni3698 – 3742DisorderedSequence analysisAdd BLAST45
Regioni3960 – 3994DisorderedSequence analysisAdd BLAST35
Regioni4151 – 4189DisorderedSequence analysisAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1657 – 1675PolyampholyteSequence analysisAdd BLAST19
Compositional biasi2082 – 2117PolarSequence analysisAdd BLAST36
Compositional biasi2530 – 2549PolarSequence analysisAdd BLAST20
Compositional biasi2556 – 2574PolarSequence analysisAdd BLAST19
Compositional biasi2684 – 2705PolyampholyteSequence analysisAdd BLAST22
Compositional biasi2787 – 2812PolyampholyteSequence analysisAdd BLAST26
Compositional biasi2813 – 2833PolarSequence analysisAdd BLAST21
Compositional biasi2869 – 2887PolyampholyteSequence analysisAdd BLAST19
Compositional biasi2905 – 2935PolyampholyteSequence analysisAdd BLAST31
Compositional biasi3427 – 3479PolyampholyteSequence analysisAdd BLAST53
Compositional biasi3487 – 3503PolyampholyteSequence analysisAdd BLAST17
Compositional biasi3619 – 3637PolyampholyteSequence analysisAdd BLAST19
Compositional biasi3716 – 3740PolarSequence analysisAdd BLAST25
Compositional biasi3964 – 3987PolyampholyteSequence analysisAdd BLAST24
Compositional biasi4153 – 4169PolarSequence analysisAdd BLAST17
Compositional biasi4170 – 4189PolyampholyteSequence analysisAdd BLAST20

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeatPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4177 Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000167243

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 7 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR040745 Ankyrin_UPA
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR000906 ZU5_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 7 hits
PF00531 Death, 1 hit
PF17809 UPA_2, 1 hit
PF00791 ZU5, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 24 hits
SM00218 ZU5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986 SSF47986, 1 hit
SSF48403 SSF48403, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 21 hits
PS50017 DEATH_DOMAIN, 1 hit
PS51145 ZU5, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 19 potential isoforms that are computationally mapped.Show allAlign All

A8JNM6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVTENGAQGD GNTSFLRAAR AGNLERVLEH LKNNIDINTS NANGLNALHL
60 70 80 90 100
ASKDGHIHVV SELLRRGAIV DSATKKGNTA LHIASLAGQE EVVKLLLEHN
110 120 130 140 150
ASVNVQSQNG FTPLYMAAQE NHDAVVRLLL SNGANQSLAT EDGFTPLAVA
160 170 180 190 200
MQQGHDKVVA VLLESDTRGK VRLPALHIAA KKDDVKAATL LLDNDHNPDV
210 220 230 240 250
TSKSGFTPLH IASHYGNQNI ANLLIQKGAD VNYSAKHNIS PLHVAAKWGK
260 270 280 290 300
TNMVSLLLEK GGNIEAKTRD GLTPLHCAAR SGHEQVVDML LERGAPISAK
310 320 330 340 350
TKNGLAPLHM AAQGEHVDAA RILLYHRAPV DEVTVDYLTA LHVAAHCGHV
360 370 380 390 400
RVAKLLLDRN ADANARALNG FTPLHIACKK NRLKVVELLL RHGASISATT
410 420 430 440 450
ESGLTPLHVA AFMGCMNIVI YLLQHDASPD VPTVRGETPL HLAARANQTD
460 470 480 490 500
IIRILLRNGA QVDARAREQQ TPLHIASRLG NVDIVMLLLQ HGAQVDATTK
510 520 530 540 550
DMYTALHIAA KEGQDEVAAV LIENGAALDA ATKKGFTPLH LTAKYGHIKV
560 570 580 590 600
AQLLLQKEAD VDAQGKNGVT PLHVACHYNN QQVALLLLEK GASPHATAKN
610 620 630 640 650
GHTPLHIAAR KNQMDIATTL LEYGALANAE SKAGFTPLHL SSQEGHAEIS
660 670 680 690 700
NLLIEHKAAV NHPAKNGLTP MHLCAQEDNV NVAEILEKNG ANIDMATKAG
710 720 730 740 750
YTPLHVASHF GQANMVRFLL QNGANVDAAT SIGYTPLHQT AQQGHCHIVN
760 770 780 790 800
LLLEHKANAN AQTVNGQTPL HIARKLGYIS VLDSLKTITK EDETAAAPSQ
810 820 830 840 850
AEEKYRVVAP EAMHESFMSD SEEEGGEDNM LSDQPYRYLT VDEMKSLGDD
860 870 880 890 900
SLPIDVTRDE RMDSNRMTQS AEYASGVPPT IGEEVISPHK TQVYGSSPKA
910 920 930 940 950
TVDGVYIANG SGHDEPPHVG RKLSWKSFLV SFLVDARGGA MRGCRHSGVR
960 970 980 990 1000
MIIPSRSTCQ PTRVTCRYVK PQRTMHPPQL MEGEALASRV LELGPCSTKF
1010 1020 1030 1040 1050
IGPVVMEVPH FASLRGKERE IIILRSDNGE TWREHTIDNS EEIIHDVLQQ
1060 1070 1080 1090 1100
CFEPEEIAQL EEQAGNHVCR FVTYDFPQYF AVVSRIRQEV HAIGPEGGMV
1110 1120 1130 1140 1150
SSTVVPQVQA VFPQGALTKK IKVGLQAQPV DPDLTAKLLG RGVAVSPIVT
1160 1170 1180 1190 1200
VEPRRRKFHK AITLSMPAPK AHSQGMINQY SGNTPTLRLL CSITGGPSRA
1210 1220 1230 1240 1250
QWEDVTGSTP LTFVNDCVSF TTTVSARFWL MDCRNISDAT KMATELYKEV
1260 1270 1280 1290 1300
IHVPFIAKFV VFAKKVEPFE AKLRVFCMTD DREDKTLEKH ELYTEVAKSR
1310 1320 1330 1340 1350
DVEVLEGKPQ YIEMAGNLVP VTKSGDQLQV QFKAFRENRL PFTVRVKDQH
1360 1370 1380 1390 1400
ADIVGRTLFM KEPKVAKGEP PQQPICILNI VLPEAVIPDS TTAFSDRVTS
1410 1420 1430 1440 1450
AYRTSMFSLS KHQNDHYIGD IRIVDLSNLL GKDWIQLAPE IGINGEEIDE
1460 1470 1480 1490 1500
IINQNTDSIA RQAQSMIRLY KDKPNYDILS LETALKNIGR DDIMKKCKSG
1510 1520 1530 1540 1550
RLSHSREFDE ADLMKNSESV EELVRRESKR IQQINEREEV KYSAEEKEVE
1560 1570 1580 1590 1600
ESESDEEAAK RTVAERREKI VKRLSIERSI PASTQKKEIT REITEIKRKS
1610 1620 1630 1640 1650
LIEDKKAHHE SEILMQLPAD NVIIKTTTVP DQVIKMKMGK MDSTEVSKSE
1660 1670 1680 1690 1700
FDKELTHKFK TSGRSSEEED QPSYPDQTDK IVQDISAAEK KEKDGVTFSR
1710 1720 1730 1740 1750
VTTITRQEAR DITEDFLEIE KRSQLPATST TATVHEKFVE EIKEKTSPLA
1760 1770 1780 1790 1800
SVPQETVKEV QQVISEVTEI ASKKVENIIS SFESSKSVDA TTVLPTQPSV
1810 1820 1830 1840 1850
ESTKVSETIK NLEDAKAVSA EQVKTVHVVE SSSIEETIAE FEAKKVKYDF
1860 1870 1880 1890 1900
HGGEPKTQIP KFTRKPSDDS MKPTAAPRAT VESETESVLE TKAEKPISKI
1910 1920 1930 1940 1950
PVKTIPTEAQ KVSEVDARKI TQDFLQGEKL AAEPKPSPAA SKIPKVEPRK
1960 1970 1980 1990 2000
SVDKQVDRES KILDDVVAST ATIMTAGLGD EQLKDQLVDH SEIIAKSETV
2010 2020 2030 2040 2050
AEKVTELLDT FHKIEEKVTK SEKTSEISSK VEELVKIEEK PLSQVQPKED
2060 2070 2080 2090 2100
KVAEKVAEVI ETFHKIEEKI TTADARELTR DFLSMEQQNQ LPSMPQAAEK
2110 2120 2130 2140 2150
PLESSLTSTS ASEPESIVTV KPSPPASKIP VVEPRKIVFD ESTKPLIEPE
2160 2170 2180 2190 2200
PVKTTEKKPL NERQLTADFL SMEQQTQLVS EPAKSLVEEV MKSAEQMVEQ
2210 2220 2230 2240 2250
PKQQKSLNER QLTEDFLLME QQTQLPSDIV KPTDKLIDGI ESAAPVGDEA
2260 2270 2280 2290 2300
SPFHTPKLTT SVVTQEPQQL ASEYDSDTFG KQATIPLGDS KIDQGLIAPV
2310 2320 2330 2340 2350
SMEPRKSLTD AEFCKSVGET ITKKMSVGVI EISDELKKIE SEIPHSQTPP
2360 2370 2380 2390 2400
PTPSDNKTDK QNEEPELISL ERDYLADTVT TLHTTTESTL ERVSAITKIE
2410 2420 2430 2440 2450
TLHERKVELS NLDTEKISHE IDPVAVLESV PVSFPVASSR NQTEDESETR
2460 2470 2480 2490 2500
ARRIDHKIEK LSTDMDDVSA RFDEAFEMSV PEDEISALQG DFSKLSWDES
2510 2520 2530 2540 2550
VSPTTNTMAD MAQNQITPDN DIQDLIAETG GDLPNSSETD TTPVPPSKES
2560 2570 2580 2590 2600
ESKTETEPTV VTNAFTTTSH DTPTPKPRVL KASSPVSEGT DSTTIPGPVP
2610 2620 2630 2640 2650
KPEIPIDISF DANAPVPKPR APIKHTEPFE NLAALAEQSD SISLRSFELT
2660 2670 2680 2690 2700
EDISKTDEPS TELSIRSQLR DIVTTTTVSE DHTESFEPTS EISVDDADTE
2710 2720 2730 2740 2750
KSEGAEKTTS FYIGESSRNV IIKTSTRSAS VTPQEEEAQG EIGIDAKDIS
2760 2770 2780 2790 2800
LMKEVSVDSD EANDVFKEFI TMKPEDPIAM DSKITRQGSE TRNDILEFEN
2810 2820 2830 2840 2850
ADKDKTAEQK LSKVTTEESL TTSTGSSGRA IIEIAPSSSE DPDESSKEIP
2860 2870 2880 2890 2900
EIVNTISEKA AASDNFELPL EKSEWETSEK EIPTEGKPKV VHSPQQPQEA
2910 2920 2930 2940 2950
SMKSTLDRFH VDEILAEEQV TDEHSSSDHK SFKDQTPSEL GSSTVPQEYT
2960 2970 2980 2990 3000
FAVESEDISS FIGIPEASMQ TSTLDSTQPP EGLFDTTIKE TLNKQAAMAH
3010 3020 3030 3040 3050
YAQDVFGRGE RRDDHGSLGF ISTGTAEELS SMEEHMAKEE QASLGFISTE
3060 3070 3080 3090 3100
TAEDFSSMED YYSEKLAIAS VVADEVATEK SLTTSTFEEL SSDQSMKPID
3110 3120 3130 3140 3150
VVVHRLKTET SPDSINRWSI PDVDTSSSSE SFHRSFDKTQ SRPLSSDLDN
3160 3170 3180 3190 3200
LVTTTGTGTS SDYQTAREFT TTGRTEGTEY ISAVSTLGSS SLDSQSETSA
3210 3220 3230 3240 3250
NLASIDVSEL SETLVASSAE VDAFEAEEMS RLRDLRADDE DSDESVELPG
3260 3270 3280 3290 3300
TAGYPSIEQQ SLMKRSQEMI FKPKTLDDEP LAVQVAQIEE YPKPKEAERT
3310 3320 3330 3340 3350
WGLAYPLEDS KVDSPRESEK GEDILLYHGD PRRSIDESKL ASSLDEGSIL
3360 3370 3380 3390 3400
SVSMSSTSNI DTVVENFDDI IGSAGSSSLT GIEGFQYGHD ESIPSASVPE
3410 3420 3430 3440 3450
DATFMLEMES KEHSPQDSNA STPPGGESKR RGHKRNESIS GDALKNLDKE
3460 3470 3480 3490 3500
VALLGEGKES ESESDTDPYE SEYARQFRSP KERKSKKKKQ AAAEMDHSGE
3510 3520 3530 3540 3550
LEKRPFTPSQ LVAEVIVEDS ITEELEAEAA MIEERRPSQN MQDYSNIPDI
3560 3570 3580 3590 3600
MVTEDIKSPI LEEETDEFPE KMLYKVRTEE ELHKASDTSV YQKAKAEEKE
3610 3620 3630 3640 3650
QDFQRRVQEQ YRQKLEELKR AEVGAEYDDR KAPDSPDSFE MVEQPDISDE
3660 3670 3680 3690 3700
FVIIEEVAKE ANEVDLGGQS IKIKPVKYEQ KHDEDVEKII IKSAPADPKL
3710 3720 3730 3740 3750
GSQLYKDDLN FEFEESPPTG ASSSSEQQEE SDSSETAAAN KRWVEMQLTD
3760 3770 3780 3790 3800
NQLRYPYDLA GAVLEDIKEE DGEFEVGSSR ISSFKDSFSS TPEYDVAARR
3810 3820 3830 3840 3850
YHSRGEHDDV SMSSLQEFES LEQAISLENR NRTHQGSTDS SNGSFTRRYV
3860 3870 3880 3890 3900
VRHSGSGTAP GDDVSVSSLK DFEGLENACI EAHLIEIKAR EEAALLSRSD
3910 3920 3930 3940 3950
ESNKSNGSDK GATGNVVVTK VTRTVTRTEV VPSSQVESIE ALLKQKLERE
3960 3970 3980 3990 4000
EGSVQGRVTD IGTTELDTKS KIDSQDSEKD SIDSMEISKS HDMMTSSIES
4010 4020 4030 4040 4050
FDISKDATTR SDVDSLEIDK RHSRQESIES FGDEQLDLMT KFVSGGGVTL
4060 4070 4080 4090 4100
GDGLTTTTTT TTTSTDADGH EHTVTRVITT ITNVGGGIQE LPMDESGMSK
4110 4120 4130 4140 4150
DVSVDSLNMC VEQTTSSAGT TATYQTSAGN SQMSGSVTSC ASSTLMEDSF
4160 4170 4180
PGVGGMSSSQ MSASFWSHDE STVVEDEGRD LAKKPQQGH
Length:4,189
Mass (Da):460,660
Last modified:December 4, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i06E4AD3107CA8730
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 19 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9MRX4M9MRX4_DROME
Ankyrin 2, isoform U
Ank2 ank2, ank2-L, CG18025, CG18227, CG18768
13,559Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8JNM5A8JNM5_DROME
Ankyrin 2, isoform K
Ank2 ank2, ank2-L, CG18025, CG18227, CG18768
4,264Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q7KU92Q7KU92_DROME
Ankyrin 2, isoform L
Ank2 ank2, ank2-L, CG18025, CG18227, CG18768
4,083Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8JNM4A8JNM4_DROME
Ankyrin 2, isoform G
Ank2 ank2, ank2-L, CG18025, CG18227, CG18768
2,532Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q7KU95Q7KU95_DROME
Ankyrin 2, isoform M
Ank2 ank2, ank2-L, CG18025, CG18227, CG18768
2,404Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8JNM7A8JNM7_DROME
Ankyrin 2, isoform F
Ank2 ank2, ank2-L, CG18025, CG18227, CG18768
4,114Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9MS19M9MS19_DROME
Ankyrin 2, isoform P
Ank2 ank2, ank2-L, CG18025, CG18227, CG18768
4,230Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X2JGD3X2JGD3_DROME
Ankyrin 2, isoform Y
Ank2 ank2, ank2-L, CG18025, CG18227, CG18768
2,566Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X2JC49X2JC49_DROME
Ankyrin 2, isoform Z
Ank2 ank2, ank2-L, CG18025, CG18227, CG18768
4,233Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X2JCM1X2JCM1_DROME
Ankyrin 2, isoform AA
Ank2 ank2, ank2-L, CG18025, CG18227, CG18768
11,634Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AE014296 Genomic DNA Translation: ABW08487.1

NCBI Reference Sequences

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RefSeqi
NP_001097538.1, NM_001104068.2

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0303123; FBpp0292242; FBgn0261788

Database of genes from NCBI RefSeq genomes

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GeneIDi
38863

UCSC genome browser

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UCSCi
CG34416-RJ d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: ABW08487.1
RefSeqiNP_001097538.1, NM_001104068.2

3D structure databases

SMRiA8JNM6
ModBaseiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0303123; FBpp0292242; FBgn0261788
GeneIDi38863
UCSCiCG34416-RJ d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
287
FlyBaseiFBgn0261788 Ank2

Phylogenomic databases

eggNOGiKOG4177 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000167243

Enzyme and pathway databases

SignaLinkiA8JNM6

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
38863

Gene expression databases

BgeeiFBgn0261788 Expressed in 26 organ(s), highest expression level in head
ExpressionAtlasiA8JNM6 baseline and differential

Family and domain databases

CDDicd00204 ANK, 7 hits
Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR040745 Ankyrin_UPA
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR000906 ZU5_dom
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 7 hits
PF00531 Death, 1 hit
PF17809 UPA_2, 1 hit
PF00791 ZU5, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 24 hits
SM00218 ZU5, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF48403 SSF48403, 3 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 21 hits
PS50017 DEATH_DOMAIN, 1 hit
PS51145 ZU5, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA8JNM6_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8JNM6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: July 3, 2019
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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