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UniProtKB - A8JNM1 (A8JNM1_DROME)
Protein
Submitted name:
Formin 3, isoform B
Gene
form3
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Molecular functioni
- actin binding Source: InterPro
GO - Biological processi
- actin cytoskeleton organization Source: InterPro
- branch fusion, open tracheal system Source: FlyBase
Names & Taxonomyi
Protein namesi | Submitted name: Formin 3, isoform BImported |
Gene namesi | Name:form3Imported Synonyms:ah1644Imported, CG14824Imported, CG18138Imported, CG32384Imported, CG8633Imported, DIA-likeImported, Dmel\CG33556Imported, Form3Imported, forminImported, INF2Imported ORF Names:CG33556Imported, Dmel_CG33556Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0053556, form3 |
VEuPathDBi | VectorBase:FBgn0053556 |
Expressioni
Gene expression databases
Bgeei | FBgn0053556, Expressed in capitellum (Drosophila) and 29 other tissues |
ExpressionAtlasi | A8JNM1, baseline and differential |
Genevisiblei | A8JNM1, DM |
Interactioni
GO - Molecular functioni
- actin binding Source: InterPro
Protein-protein interaction databases
STRINGi | 7227.FBpp0112380 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 312 | GBD/FH3InterPro annotationAdd BLAST | 312 | |
Domaini | 415 – 828 | FH2InterPro annotationAdd BLAST | 414 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 138 – 176 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 312 – 400 | DisorderedSequence analysisAdd BLAST | 89 | |
Regioni | 477 – 502 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 810 – 850 | DisorderedSequence analysisAdd BLAST | 41 | |
Regioni | 914 – 1028 | DisorderedSequence analysisAdd BLAST | 115 | |
Regioni | 1063 – 1114 | DisorderedSequence analysisAdd BLAST | 52 | |
Regioni | 1147 – 1257 | DisorderedSequence analysisAdd BLAST | 111 | |
Regioni | 1276 – 1717 | DisorderedSequence analysisAdd BLAST | 442 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 751 – 771 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 312 – 338 | Polar residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 339 – 394 | Pro residuesSequence analysisAdd BLAST | 56 | |
Compositional biasi | 810 – 833 | Basic and acidic residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 914 – 938 | Basic and acidic residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 973 – 1022 | Polar residuesSequence analysisAdd BLAST | 50 | |
Compositional biasi | 1063 – 1081 | Basic and acidic residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 1085 – 1113 | Polar residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 1170 – 1216 | Basic and acidic residuesSequence analysisAdd BLAST | 47 | |
Compositional biasi | 1224 – 1250 | Polar residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 1280 – 1302 | Basic and acidic residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 1319 – 1335 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1343 – 1377 | Basic and acidic residuesSequence analysisAdd BLAST | 35 | |
Compositional biasi | 1417 – 1508 | Polar residuesSequence analysisAdd BLAST | 92 | |
Compositional biasi | 1525 – 1575 | Polar residuesSequence analysisAdd BLAST | 51 | |
Compositional biasi | 1584 – 1717 | Polar residuesSequence analysisAdd BLAST | 134 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG1922, Eukaryota |
InParanoidi | A8JNM1 |
OrthoDBi | 1204639at2759 |
PhylomeDBi | A8JNM1 |
Family and domain databases
Gene3Di | 1.20.58.2220, 1 hit 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR015425, FH2_Formin IPR042201, FH2_Formin_sf IPR010472, FH3_dom IPR014768, GBD/FH3_dom IPR027649, Inf2 |
PANTHERi | PTHR46345, PTHR46345, 2 hits |
Pfami | View protein in Pfam PF06367, Drf_FH3, 2 hits PF02181, FH2, 1 hit |
SMARTi | View protein in SMART SM01139, Drf_FH3, 1 hit SM00498, FH2, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS51444, FH2, 1 hit PS51232, GBD_FH3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
A8JNM1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDSRIGLDYI VENRDYIAKL GAALDTQNAT VKKQVFELLS ALCAYSPDGY
60 70 80 90 100
ARAIETLEFY KNLKKQRYRF KIVINELELS SAAAHPPLDY QAALLAFINC
110 120 130 140 150
VIISAATLQE RIRIRNEFIG LKVLPLLNNL RLLEAGNVES SASPSPPPSL
160 170 180 190 200
SSESASSATS PVSGSASTSV TPSPSPLHLQ RRLTFCGSLS RYSCAALQLV
210 220 230 240 250
QNLKKVAQSV GDIIVQLDVF VEQQECDEAQ SLQAPDGINL NSHLDVFYAI
260 270 280 290 300
LRQVADTPQE VPFLNILQHL LRIDPKEPLS DIIWDTTERL VHRATLLESH
310 320 330 340 350
EDSVRLLRTP SSQKFACQSC RGSDASSPTR KPSQPVGVSA KTTPPPPPPP
360 370 380 390 400
MAPAAPPPPP PPINGAAPPP PPPPMINGGA LPPPPPPPSM QMASRPRTPD
410 420 430 440 450
PLAAEAVATA ILLPQQDTPA PKAKMKTINW GKIPHNKVLG KQNIWSIVAS
460 470 480 490 500
NHQDSPMQDI DWNEMEGLFC LQTASAQGSP KLGRDGSQAA AGSNGCDTLD
510 520 530 540 550
RKSKKESTEI TLLDGKRSLN VNIFLKQFRT SNDDIIQLIR QGAHEEIGAE
560 570 580 590 600
RLRGLLKIMP EVDELDMLKG FNGDKARLGN AEKFLLQLLE VPNYKLRIES
610 620 630 640 650
MLLKEEFAAN VAYLEPCINS MLYAGDDLLN NKTLQEVLYM VVVAGNFLNS
660 670 680 690 700
GGYAGNAAGV KLSSLQKLTD IRANKPGMNL IHFVALQAEK RNPELLQFTG
710 720 730 740 750
QLSNLESASK TTSEQINNEI NTLDGRIRRI ARQIEQPATD VDIKEQMADF
760 770 780 790 800
LQAAESELSV LQAGMKQVES MRLKMSEFFC DDAATFRLEE CFKIFHNFCD
810 820 830 840 850
KFKQAVKENE RRQQQEQQAT LRRKQREEQL ARRARQIGQA GTPVSDSEHS
860 870 880 890 900
FLGDAIFDPR ASPALSRRHL GSGEISNGFI RLEQDGASPD ITPNGSLRRR
910 920 930 940 950
RSRVLAEEDD LMEFLRSSTG PHHDGHNSRE RKAAYGSLDR SWARRARSGS
960 970 980 990 1000
SSRKRPDLLN IDFGMDRERA SSPAPLLQQQ QQNVQERLQS PLASTAGTPT
1010 1020 1030 1040 1050
TAANTPTGSG SAIAQTPSNN EDAKPRISRE WRQKIETWLQ SNESDEKQNE
1060 1070 1080 1090 1100
EYRRKRRLVN ANRRSLENET ENERKLDPLP EEKILPSTTT ATPTNTPTTT
1110 1120 1130 1140 1150
NPTNSTNRMD QESGKYQRVY ADWKPSRTLE QTDVVANLQA IADAQPHDAL
1160 1170 1180 1190 1200
RQHRRQRSQE QPSPIALQSI AEEDRRKSLI QKQGERDKSN ERLQIYIRRS
1210 1220 1230 1240 1250
SSRELQPAKT EEHPLPPKSP KPQVSDDTFA SLLSHHKTQN EMQGSSKDVD
1260 1270 1280 1290 1300
ADNIETPPVS RRVIATPTTT VVTVSMTDKP KAATEEKINP AEQDAPGHFD
1310 1320 1330 1340 1350
RHALARRTRR YKRPTDYSSG NEEALTTSTA EAKTSPSKPE PPAPEKSKQK
1360 1370 1380 1390 1400
ERTINKLEKV GRHISSINQE DVREAIRNLK SPTGTPERPW SPPRDITPSK
1410 1420 1430 1440 1450
LKLSASGHHE LNDEGFEETQ SLVSDTPSHG KGESTNSSCN EGVNETPARQ
1460 1470 1480 1490 1500
RPMQKQKPTT TSISQMGSRL ADRLQQARMK SSGSSGSAAS KSQNQIPATQ
1510 1520 1530 1540 1550
TATVKRSLSA SRPLRMPNGQ PLASAAPLRS ASTVRRSPQE QQVLAGVERS
1560 1570 1580 1590 1600
SSRNSLRSSR SSINSGASTQ TVVRRLPAVQ RAGATVSVDS SPSKRPLAAQ
1610 1620 1630 1640 1650
NLRPTQGRGV PASRSSSSGS SVGPSVILVR SKMSNTAPKS SIHGSTSFKE
1660 1670 1680 1690 1700
NQSQSQPQSQ SRMSAARSVV LVKNALNQQQ QARMSANPSP QQRSTSSSRS
1710
VSSFMRPTAS SATKRQK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ86C16 | Q86C16_DROME | Ah1644 protein | form3 ah1644, CG14824, CG18138, CG32384, CG8633 | 1,644 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: ABW08480.1 |
RefSeqi | NP_001097527.1, NM_001104057.1 |
Genome annotation databases
EnsemblMetazoai | FBtr0113469; FBpp0112380; FBgn0053556 |
GeneIDi | 3346238 |
UCSCi | CG33556-RB, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: ABW08480.1 |
RefSeqi | NP_001097527.1, NM_001104057.1 |
3D structure databases
SMRi | A8JNM1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7227.FBpp0112380 |
Proteomic databases
PaxDbi | A8JNM1 |
Genome annotation databases
EnsemblMetazoai | FBtr0113469; FBpp0112380; FBgn0053556 |
GeneIDi | 3346238 |
UCSCi | CG33556-RB, d. melanogaster |
Organism-specific databases
CTDi | 3346238 |
FlyBasei | FBgn0053556, form3 |
VEuPathDBi | VectorBase:FBgn0053556 |
Phylogenomic databases
eggNOGi | KOG1922, Eukaryota |
InParanoidi | A8JNM1 |
OrthoDBi | 1204639at2759 |
PhylomeDBi | A8JNM1 |
Miscellaneous databases
BioGRID-ORCSi | 3346238, 0 hits in 3 CRISPR screens |
ChiTaRSi | form3, fly |
GenomeRNAii | 3346238 |
Gene expression databases
Bgeei | FBgn0053556, Expressed in capitellum (Drosophila) and 29 other tissues |
ExpressionAtlasi | A8JNM1, baseline and differential |
Genevisiblei | A8JNM1, DM |
Family and domain databases
Gene3Di | 1.20.58.2220, 1 hit 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR015425, FH2_Formin IPR042201, FH2_Formin_sf IPR010472, FH3_dom IPR014768, GBD/FH3_dom IPR027649, Inf2 |
PANTHERi | PTHR46345, PTHR46345, 2 hits |
Pfami | View protein in Pfam PF06367, Drf_FH3, 2 hits PF02181, FH2, 1 hit |
SMARTi | View protein in SMART SM01139, Drf_FH3, 1 hit SM00498, FH2, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS51444, FH2, 1 hit PS51232, GBD_FH3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A8JNM1_DROME | |
Accessioni | A8JNM1Primary (citable) accession number: A8JNM1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 4, 2007 |
Last sequence update: | December 4, 2007 | |
Last modified: | September 29, 2021 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |