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Entry version 112 (16 Oct 2019)
Sequence version 3 (26 Jun 2013)
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Protein
Submitted name:

Still life, isoform K

Gene

sif

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factorSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Still life, isoform KImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sifImported
Synonyms:CG32414Imported, CG5256Imported, CG5406Imported, Dm_3L:26493Imported, Dmel\CG34418Imported, lincRNA.447Imported, RhoGEFImported, SIFImported, SifImported, slfImported, StilllifeImported
ORF Names:CG34418Imported, Dmel_CG34418Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0085447 sif

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A8JNL5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0085447 Expressed in 22 organ(s), highest expression level in head

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A8JNL5 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A8JNL5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini822 – 935PHInterPro annotationAdd BLAST114
Domaini1101 – 1168RBDInterPro annotationAdd BLAST68
Domaini1184 – 1260PDZInterPro annotationAdd BLAST77
Domaini1425 – 1619DHInterPro annotationAdd BLAST195

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 56DisorderedSequence analysisAdd BLAST56
Regioni181 – 241DisorderedSequence analysisAdd BLAST61
Regioni259 – 399DisorderedSequence analysisAdd BLAST141
Regioni453 – 474DisorderedSequence analysisAdd BLAST22
Regioni536 – 600DisorderedSequence analysisAdd BLAST65
Regioni1068 – 1099DisorderedSequence analysisAdd BLAST32
Regioni1391 – 1414DisorderedSequence analysisAdd BLAST24
Regioni1792 – 1821DisorderedSequence analysisAdd BLAST30
Regioni1833 – 2049DisorderedSequence analysisAdd BLAST217
Regioni2069 – 2107DisorderedSequence analysisAdd BLAST39
Regioni2125 – 2165DisorderedSequence analysisAdd BLAST41
Regioni2200 – 2270DisorderedSequence analysisAdd BLAST71
Regioni2287 – 2480DisorderedSequence analysisAdd BLAST194
Regioni2505 – 2544DisorderedSequence analysisAdd BLAST40
Regioni2560 – 2602DisorderedSequence analysisAdd BLAST43

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili985 – 1005Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 35PolyampholyteSequence analysisAdd BLAST35
Compositional biasi289 – 306PolyampholyteSequence analysisAdd BLAST18
Compositional biasi328 – 353PolyampholyteSequence analysisAdd BLAST26
Compositional biasi572 – 586PolarSequence analysisAdd BLAST15
Compositional biasi1077 – 1092PolarSequence analysisAdd BLAST16
Compositional biasi1902 – 1931PolarSequence analysisAdd BLAST30
Compositional biasi1940 – 1980PolyampholyteSequence analysisAdd BLAST41
Compositional biasi1981 – 2024PolarSequence analysisAdd BLAST44
Compositional biasi2069 – 2106PolarSequence analysisAdd BLAST38
Compositional biasi2137 – 2165PolyampholyteSequence analysisAdd BLAST29
Compositional biasi2207 – 2254PolarSequence analysisAdd BLAST48
Compositional biasi2327 – 2359PolarSequence analysisAdd BLAST33
Compositional biasi2427 – 2442PolarSequence analysisAdd BLAST16
Compositional biasi2443 – 2463PolyampholyteSequence analysisAdd BLAST21
Compositional biasi2509 – 2540PolarSequence analysisAdd BLAST32
Compositional biasi2588 – 2602PolarSequence analysisAdd BLAST15

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ITS1 Eukaryota
ENOG410XPCM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000174094

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160 RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR003116 RBD_dom
IPR040655 TIAM1_CC-Ex

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00169 PH, 1 hit
PF02196 RBD, 1 hit
PF00621 RhoGEF, 1 hit
PF18385 Tiam_CC_Ex, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 2 hits
SM00455 RBD, 1 hit
SM00325 RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065 SSF48065, 1 hit
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50898 RBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All

A8JNL5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQKCIRRKG SVRLTEPTGH AHVRIEQRPQ LPPRRQKSAE EVATMPKSAL
60 70 80 90 100
RQPPEQLEWF DRRAQQRHSA RSAEGGQVRE ETMEWLKLQK TASPIQPVRT
110 120 130 140 150
SSGPSEITVL KDELPDWLLD HLPRKKERER DRLPSDADKA VGSAYAKALA
160 170 180 190 200
DLLKKPLSRQ GSGPCEFSLL KTDIVEWLTK MQSSSGTDRG KSRRSHHRRN
210 220 230 240 250
GSGGDAQPRS NSQEDAQDQS KTSHRKRHSL GHSGAVSEEE QQQLTADWIA
260 270 280 290 300
YPLHKLQSLG KQPPPAQPPE RMSIPSGYAV PSALSHTPLC QRREERSRER
310 320 330 340 350
RLRHSASEVV GSGGAGAAST SNTAHLERLY AKPHKERYQY VPKTKESSGR
360 370 380 390 400
KERSRRHQTQ RSATVSDMSA QRSGGHKRKS SSAERAPRSP SPGPCTDPDC
410 420 430 440 450
PLLPICTDPH CRYQECQARQ CITSSVSSVN LARHQQLAQV QLHAVPAHLV
460 470 480 490 500
GAMGSDVPTT PSTTATPPPP TGGGTMGVGA TGAGAGATSE RRLVICHDCR
510 520 530 540 550
SCAPLLSCRN RKCLNAAKCN SLPRCAADFN RLRTQLSQPP TTLDDIEPAP
560 570 580 590 600
LDDLEMQPLP SPPHPHPHHH YRSNSQPNTL QRGDSASSAG MGAGVGGAGH
610 620 630 640 650
GGLGGPGSGL AWLEPTTTLV QPLPAYVHHS NGKLMKSASA ASLNSRRRRH
660 670 680 690 700
KTVHFGENLL REVCQNRKLI KTEAQVPSGS APMKANIQML YNFVEGVLSA
710 720 730 740 750
WVDDDEDQVR SGAESEPEHG VVPMQPIHRC NRLRYQCIRR VVEEAADLQG
760 770 780 790 800
TLKLGNSRYR HRHWRSTAKQ CNEMFLRKIS DDDRMSLTTA VSDEDDGESV
810 820 830 840 850
MASPYKAKAT GTAASSFNCT GAVRKAGFLS VKKWLLRKKH QIELARKRGW
860 870 880 890 900
KGYWVCLKGT TLLFYPCDSR EGRSVEAAPK HLIIVDGAIM QPIPEHPKRD
910 920 930 940 950
YIFCLSTAFG DAYLFQAPCQ VELENWVNSI HSACAAAFAR HRGKTGTLHL
960 970 980 990 1000
LQEEIFRLEK AIESDHKLKH MAELQQSVVT DQETRHQIQT QILQWEENLE
1010 1020 1030 1040 1050
RLHCEQFRLR CYMASLQSGE LPNPKSLLTH VSRPTKNTLN KLGVFTVSSF
1060 1070 1080 1090 1100
HAFICARSPS LLNNLLAGRG ATKRRPPMLS RSNSGSSRRS MQMNSRDEPE
1110 1120 1130 1140 1150
KTFKVAMPDN AYSTVYLRDA MSVEEFLASA CARRNLNPME HFVRVKKRRD
1160 1170 1180 1190 1200
MEDHNYFVPH RNDLIENYLH NHEFVEVCMK ILYQVELQRT TLEQMWGFSV
1210 1220 1230 1240 1250
EAELIENAER QDELCCYVSR VEDKSVAMHN GIIKGDEIMV INGAIVSDLD
1260 1270 1280 1290 1300
MMYLESVLQE EQSLSMMMRS SRTEPPDLVG IMRVTDDMID SLVCPPPPTD
1310 1320 1330 1340 1350
PPVMSEEMIT GLIVPAPGWN GTSKDLYSPE AESSPATSFV DPAAMAAQLA
1360 1370 1380 1390 1400
VGGVGGVVVG GLGVAKPTSR TSSFEIENLL KTAEQVTGFC RSPQETRKSS
1410 1420 1430 1440 1450
PTGSVTSSVS TTALTPSRQL TDAEKLRKVV MELVDTERTY VKHLNNLLEH
1460 1470 1480 1490 1500
YLEPMKRETF LSNAEINALF GNIHEIVTFQ RQFLQNLEES LDLEPDFNKF
1510 1520 1530 1540 1550
EHCGQFRNVL FAIGSAFLYY VNHFKLYSSF CASHSKAQKV LHPNEGNHAL
1560 1570 1580 1590 1600
QEFLAARNPK QQHSSTLESY LIKPIQRILK YPLLLQQMRN LTDTRADEHV
1610 1620 1630 1640 1650
HLCEALKGME KVAEHINEMQ RIHEEYGAIF DHLFRQHQKS CKQPIDLSPG
1660 1670 1680 1690 1700
DLLYYGGVEW LNISDFLGKI KKGLELHAMC FVFKSAVVFL CKERLRQKKK
1710 1720 1730 1740 1750
LMGVSSKNAT NEVEIIRYQV LIPVTEVQVR ASSAKDMDSH FLWELIHLRS
1760 1770 1780 1790 1800
QLQRRSEKVY VLSNSTADFR NAFLKTIRQI IRESVRNMSI PMKNFGGSSG
1810 1820 1830 1840 1850
SVSGHSSQGM GSMGYPGNSQ TLERPKQQIT IVHGSHTLGK PKKKSGSQRH
1860 1870 1880 1890 1900
SAGNIDYDNL SGSQEADDLP PSVGVVHYAS GHTHGQQMQP AGFRGRSKTV
1910 1920 1930 1940 1950
GDVTEITCSS PEPHQQQQQQ QQQQQQLMQQ GHAHAHPHPH PHPREPPPPP
1960 1970 1980 1990 2000
IRQPHLHHHS SDIERIDPGT KSEGEEDSQQ GTIRPKATLG RTPNHLTLST
2010 2020 2030 2040 2050
TSTLSVGSTG SQARLIQSSH PPASYQPVLM KDLGKPSPDE SELESESEVH
2060 2070 2080 2090 2100
AAQVAASFNL SLGSSGSLFA SDARDNQTQS RTQSQIHSLH PSPRQSPRQS
2110 2120 2130 2140 2150
PRQSPKQDIE VIEIFESEAE RLAASQQVAV VHQHPSDQAR ESGHKQRRDR
2160 2170 2180 2190 2200
DRNPTETDAT ARFMDKHLSD LEQENLTDGT CDIVAYMESL REKAFDPQDL
2210 2220 2230 2240 2250
AEDTGDHQQN DSSLSPEPQT IVENTQQTVV VDIESPSRPA TESDSTGNTT
2260 2270 2280 2290 2300
GPSERSGDET EEEATTSSLA SHIVVIDKKV DKIFKAKSPE RPASTKVKGG
2310 2320 2330 2340 2350
RRQIYISPDR CKSQGSSPVR IIKIKSPRTS LSDQGKRLSV CSSRDNSQDR
2360 2370 2380 2390 2400
LSAGRRTPSP RRSSEGGGIL KHTTGPDPGI LKPPSSPAKS KSPDRSCLKK
2410 2420 2430 2440 2450
GGPSHVCSVE TLSPRVSPRG SMDHLSPDRG MTSSSCLRHS PRSSFDSHGE
2460 2470 2480 2490 2500
SDHNLDVPHG SRKRSMSAHG SFETGTRPRA QETYQYYPVY DNQTCSDHYV
2510 2520 2530 2540 2550
AAAPTGRYGG GTSSRSRLSK SLERSTSRDS TTTSSSYGHR AYGVSPDRNY
2560 2570 2580 2590 2600
VVFSSGPLRS QSAENTFSSQ PIYDPLPRHP PQPLHQPPMH HQQQQQQQQQ
2610 2620 2630 2640
QQYMSYAPEM GGYTGCQHDP QGGYQLSSSA PEYTTCIDCL YQKRPS
Length:2,646
Mass (Da):294,057
Last modified:June 26, 2013 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD20541A82771203A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P91621SIF1_DROME
Protein still life, isoform SIF typ...
sif CG34418
2,072Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
P91620SIF2_DROME
Protein still life, isoforms C/SIF ...
sif CG34418
2,061Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8JNL4A8JNL4_DROME
Still life, isoform N
sif CG32414, CG5256, CG5406, Dm_3L:26493, Dmel\CG34418
2,081Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8JNL6A8JNL6_DROME
Still life, isoform I
sif CG32414, CG5256, CG5406, Dm_3L:26493, Dmel\CG34418
2,072Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8IQ62Q8IQ62_DROME
Still life, isoform F
sif CG32414, CG5256, CG5406, Dm_3L:26493, Dmel\CG34418
2,657Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PBR2M9PBR2_DROME
Still life, isoform L
sif CG32414, CG5256, CG5406, Dm_3L:26493, Dmel\CG34418
1,270Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PE98M9PE98_DROME
Still life, isoform M
sif CG32414, CG5256, CG5406, Dm_3L:26493, Dmel\CG34418
2,091Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X2JC30X2JC30_DROME
Still life, isoform O
sif CG32414, CG5256, CG5406, Dm_3L:26493, Dmel\CG34418
2,088Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X2JCJ4X2JCJ4_DROME
Still life, isoform P
sif CG32414, CG5256, CG5406, Dm_3L:26493, Dmel\CG34418
2,476Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PHI5M9PHI5_DROME
Still life, isoform J
sif CG32414, CG5256, CG5406, Dm_3L:26493, Dmel\CG34418
2,734Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014296 Genomic DNA Translation: ABW08472.3

NCBI Reference Sequences

More...
RefSeqi
NP_001097516.3, NM_001104046.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0330126; FBpp0303159; FBgn0085447

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
43892

UCSC genome browser

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UCSCi
CG34418-RD d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: ABW08472.3
RefSeqiNP_001097516.3, NM_001104046.4

3D structure databases

SMRiA8JNL5
ModBaseiSearch...

Proteomic databases

PRIDEiA8JNL5

Genome annotation databases

EnsemblMetazoaiFBtr0330126; FBpp0303159; FBgn0085447
GeneIDi43892
UCSCiCG34418-RD d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
43892
FlyBaseiFBgn0085447 sif

Phylogenomic databases

eggNOGiENOG410ITS1 Eukaryota
ENOG410XPCM LUCA
GeneTreeiENSGT00940000174094

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
sif fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
43892

Gene expression databases

BgeeiFBgn0085447 Expressed in 22 organ(s), highest expression level in head
GenevisibleiA8JNL5 DM

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR003116 RBD_dom
IPR040655 TIAM1_CC-Ex
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF02196 RBD, 1 hit
PF00621 RhoGEF, 1 hit
PF18385 Tiam_CC_Ex, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 2 hits
SM00455 RBD, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50898 RBD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA8JNL5_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8JNL5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: June 26, 2013
Last modified: October 16, 2019
This is version 112 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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