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Entry version 54 (02 Dec 2020)
Sequence version 1 (04 Dec 2007)
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Protein

Cilia- and flagella-associated protein 65

Gene

CFAP65

Organism
Chlamydomonas reinhardtii (Chlamydomonas smithii)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in flagellar formation and mobility.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cilia- and flagella-associated protein 65Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CFAP65By similarity
Synonyms:FAP651 Publication
ORF Names:CHLREDRAFT_153955Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiChlamydomonas reinhardtii (Chlamydomonas smithii)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3055 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeChlorophytacore chlorophytesChlorophyceaeChlamydomonadalesChlamydomonadaceaeChlamydomonas

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 26HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Cytoplasm, Flagellum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_50027224091 – 2118Cilia- and flagella-associated protein 65Add BLAST2118

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A8JFU2

PRoteomics IDEntifications database

More...
PRIDEi
A8JFU2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3055.EDO97267

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini615 – 736MSPPROSITE-ProRule annotationAdd BLAST122

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2016 – 2045Sequence analysisAdd BLAST30

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CFAP65 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QSJW, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_232155_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A8JFU2

Database of Orthologous Groups

More...
OrthoDBi
87636at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 8 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013783, Ig-like_fold

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

A8JFU2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSSRGSLRA LLLAAAAAAA AAAGAVSNKL GYWFSCRRFG LDCPEQLEWR
60 70 80 90 100
HWNPGTEYVK QLVLKNVSTS VLKIRFKQPT SKAFGMDFPE PFKLRPGMSQ
110 120 130 140 150
PLKVVFRPLK QQHYSDNVEL FVGNVSCLVP VHAYTPVTHI EVPPALDFGF
160 170 180 190 200
TPTKETVTAQ LPVRNTGDVR VDVLWKLDAP FSISPLFASL APGEVVAFTA
210 220 230 240 250
SFTPPEACSY TASAACQLES GAAAICKISG IGKFPYLSVE QAGVDFGAVV
260 270 280 290 300
VGQRVERLVR FGNHSVVPAH FAVTHDEAGP DDGVFTVGPA RGTLGPEEYS
310 320 330 340 350
MLKLSYTPRA TGTFSSETFH IGTAGGNRVA LNLRGTAVAP LVTLSTRAFN
360 370 380 390 400
FGNVAAGATA SRVLYIRNHS AVPVPYDFQV DPLDVFAISR TRGVLAPDST
410 420 430 440 450
AHVTITFRPM AGLAANLWRR VTLLLKDAEP QGVDLVATAY TDKSRPPPLS
460 470 480 490 500
QRHVERYMAR VLSGGPAVEE SQLDSKPPSA ATGDPAAALT VDSDALDFGS
510 520 530 540 550
CSRLSASEYR SVTVTNHTPA KLTAFVLVPE WADPGAAPGD APQRVFQVFP
560 570 580 590 600
ESADMRPYGQ ATFKVAFRPP RDAAFFSQQL ALVAHTKSQR NFRLVAEHQV
610 620 630 640 650
LPAWCVPLRA TGNTFLHSNP EFGPKVELSS RAVAFPPCRP GERVHQTLLI
660 670 680 690 700
ANSGDTPVAF SFGAAGAALG PLFSAKPAAG VVPPQGHVLV ALRFAPTDTR
710 720 730 740 750
PAAANALVTF NGVASNAVSV SLRGAAHTPR LTTDLPSSTL YFRPTCVGAS
760 770 780 790 800
SQRAVTLHNP SRVPVAFRWR LPARLQGLVT VSPAAGALRG NESVQLQWSF
810 820 830 840 850
TPAAQKLYEA RAACLVMSPP EAANGNAAGA TASAASLFPG AGLATGIEWY
860 870 880 890 900
EGAGATAALA GMGEEEAADA VLLSLVGEGT QGAVALEPPS LELGDLRVGH
910 920 930 940 950
PVRRPLLLQN CSDGVLRYSL EVGPAEDDQP PAGDATLVDF TAGLDSAAEG
960 970 980 990 1000
GVGGGAGGAG GAALECWVDE PEGALPARAS KTVMVTLFPR YRKRYSLQVR
1010 1020 1030 1040 1050
CRSSTVAPLL TGPNRPPSGG AGPRPLDAGS EAAAAAAAAA AAAAAPLPPP
1060 1070 1080 1090 1100
VIAPLTASTT FPTLEVTDVY CEGLPKQLLW QLLGLNDLNH HLRTEVTATE
1110 1120 1130 1140 1150
LRLRAAQDRG ALTTEAASAA MRPFLMEFGT HGLGGRPRVV HVEISNPTPL
1160 1170 1180 1190 1200
PASWQLHSFD DPDGVELENW VEPGRPRTEG ERMRDLIAEY KLFEMRPRSG
1210 1220 1230 1240 1250
ELEPGARCTV TIEFRPSVEG SFELPVFLHI TDGKRLRLQL QAVTTPEPLQ
1260 1270 1280 1290 1300
LLALPPPLRT FRLEPVALGE RAPPLQMYVL RNGGPAPLHW RLDTAPLAAL
1310 1320 1330 1340 1350
AEASWGHPVL ELVGPEEGDI EEGGVAAINW RFSPLEAKEY RVEVPVLLGD
1360 1370 1380 1390 1400
GGIEVIELLG RGFAPPPAPP HGAAAVQLIG PGAATSPAAP TTAAEDDDTP
1410 1420 1430 1440 1450
AAALDSVGGD AEAEAARAAA AADRDWITWR GLSSAPSAGM AGRLALVDHD
1460 1470 1480 1490 1500
LVSLGVTPVR GLTRRIIVLT NKSRYPLAFD WDLGCLAPPP PPGLAATQRA
1510 1520 1530 1540 1550
AAASAMMGLG GGSLLPASQL QLLAGRPLQG ALAISPAAGS LEPGERLVCR
1560 1570 1580 1590 1600
VSLHAGVTPQ VFEGEVRCHV RIDDDAVAEA EAAAAAAAAA GAAAVAAELP
1610 1620 1630 1640 1650
FVEQVEEVIA EAPVRGPPAP PPAVAAAQRA SRLRSRLPVH QYMTTAVRTR
1660 1670 1680 1690 1700
IEPLNAAFTA TMEARTRRLA DATRPPSWPE PQSISVTLRG RILDERQLGA
1710 1720 1730 1740 1750
LRYVPPHERA AARAAVVAGA AWVPPAMVPF WEEEGRSTPA VSAQPSSQGG
1760 1770 1780 1790 1800
GGYGVGGYGG GYGSGGSQGG EASVAPSGGD PGGYSPRGGM ADSWPSLEPG
1810 1820 1830 1840 1850
LGMEETVVGP PTVGLDLSLS LQHAGGAGGA PGGDGDSDSR PGTPSMTAAA
1860 1870 1880 1890 1900
HHHHHHPRHA GPAPGSGTAE VMEVTFSGDQ QPTGGPMPSP PSISGAPDPD
1910 1920 1930 1940 1950
SATPDDDFAT SDAAVNAAAA VRAAGGGMGS PQPVDPGGSA AAAASELAPP
1960 1970 1980 1990 2000
ALPPAPPRGG DIEYDALVSA REVLAGLFAE LMEDADVVRA VAFLPEHEVP
2010 2020 2030 2040 2050
SFAEVRATPP PCYDPAVRAA AEAARAEAEA RAAAEAATKA AAEAEAGAAF
2060 2070 2080 2090 2100
AIPAAAAQAA TEPPALEDEL AADTELARVL VAPEWRAFAD FVLESAVLGL
2110
MQESAAGDWE MPEEEVGR
Length:2,118
Mass (Da):220,136
Last modified:December 4, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEBE3014374EC5C07
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei21181

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DS496178 Genomic DNA Translation: EDO97267.1

NCBI Reference Sequences

More...
RefSeqi
XP_001702074.1, XM_001702022.1

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
PNW81405; PNW81405; CHLRE_07g354551v5

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5727614

Gramene; a comparative resource for plants

More...
Gramenei
PNW81405; PNW81405; CHLRE_07g354551v5

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cre:CHLREDRAFT_153955

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS496178 Genomic DNA Translation: EDO97267.1
RefSeqiXP_001702074.1, XM_001702022.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi3055.EDO97267

Proteomic databases

PaxDbiA8JFU2
PRIDEiA8JFU2

Genome annotation databases

EnsemblPlantsiPNW81405; PNW81405; CHLRE_07g354551v5
GeneIDi5727614
GrameneiPNW81405; PNW81405; CHLRE_07g354551v5
KEGGicre:CHLREDRAFT_153955

Phylogenomic databases

eggNOGiENOG502QSJW, Eukaryota
HOGENOMiCLU_232155_0_0_1
InParanoidiA8JFU2
OrthoDBi87636at2759

Family and domain databases

Gene3Di2.60.40.10, 8 hits
InterProiView protein in InterPro
IPR013783, Ig-like_fold

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCFA65_CHLRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8JFU2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2016
Last sequence update: December 4, 2007
Last modified: December 2, 2020
This is version 54 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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