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Entry version 81 (02 Jun 2021)
Sequence version 1 (04 Dec 2007)
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Protein
Submitted name:

Voltage-gated Ca2+ channel, alpha subunit

Gene

CAV2

Organism
Chlamydomonas reinhardtii (Chlamydomonas smithii)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channelUniRule annotationARBA annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.1.10.14, the voltage-gated ion channel (vic) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Voltage-gated Ca2+ channel, alpha subunitImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAV2Imported
ORF Names:CHLREDRAFT_194451Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiChlamydomonas reinhardtii (Chlamydomonas smithii)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3055 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeChlorophytacore chlorophytesChlorophyceaeCS cladeChlamydomonadalesChlamydomonadaceaeChlamydomonas

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei29 – 47HelicalSequence analysisAdd BLAST19
Transmembranei68 – 89HelicalSequence analysisAdd BLAST22
Transmembranei101 – 122HelicalSequence analysisAdd BLAST22
Transmembranei143 – 174HelicalSequence analysisAdd BLAST32
Transmembranei302 – 327HelicalSequence analysisAdd BLAST26
Transmembranei444 – 465HelicalSequence analysisAdd BLAST22
Transmembranei477 – 500HelicalSequence analysisAdd BLAST24
Transmembranei572 – 593HelicalSequence analysisAdd BLAST22
Transmembranei731 – 754HelicalSequence analysisAdd BLAST24
Transmembranei1193 – 1212HelicalSequence analysisAdd BLAST20
Transmembranei1232 – 1254HelicalSequence analysisAdd BLAST23
Transmembranei1266 – 1286HelicalSequence analysisAdd BLAST21
Transmembranei1322 – 1348HelicalSequence analysisAdd BLAST27
Transmembranei1463 – 1484HelicalSequence analysisAdd BLAST22
Transmembranei1552 – 1569HelicalSequence analysisAdd BLAST18
Transmembranei1581 – 1604HelicalSequence analysisAdd BLAST24
Transmembranei1616 – 1642HelicalSequence analysisAdd BLAST27
Transmembranei1663 – 1691HelicalSequence analysisAdd BLAST29
Transmembranei1812 – 1834HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A8JF90

PRoteomics IDEntifications database

More...
PRIDEi
A8JF90

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A8JF90, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3055.EDO97472

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 335Ion_transInterPro annotationAdd BLAST308
Domaini443 – 760Ion_transInterPro annotationAdd BLAST318
Domaini1192 – 1498Ion_transInterPro annotationAdd BLAST307
Domaini1547 – 1837Ion_transInterPro annotationAdd BLAST291
Domaini1855 – 1909GPHHInterPro annotationAdd BLAST55

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni336 – 394DisorderedSequence analysisAdd BLAST59
Regioni767 – 813DisorderedSequence analysisAdd BLAST47
Regioni828 – 853DisorderedSequence analysisAdd BLAST26
Regioni890 – 1088DisorderedSequence analysisAdd BLAST199
Regioni1995 – 2027DisorderedSequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi372 – 394Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi786 – 800Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2301, Eukaryota
KOG2302, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000540_5_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A8JF90

Identification of Orthologs from Complete Genome Data

More...
OMAi
FECVSMM

Database of Orthologous Groups

More...
OrthoDBi
172471at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031649, GPHH_dom
IPR005821, Ion_trans_dom
IPR000048, IQ_motif_EF-hand-BS
IPR002077, VDCCAlpha1
IPR043203, VGCC_Ca_Na
IPR027359, Volt_channel_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10037, PTHR10037, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16905, GPHH, 1 hit
PF00520, Ion_trans, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00167, CACHANNEL

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096, IQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A8JF90-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTYPEYSLLF LRKSNFVRKW CVYTTHTRVF EWTILAAIIA NCVTLAVSSN
60 70 80 90 100
RQDFDETPLG RTLVNLEYLW VAIFTTEALL KIVAMGFVLA PGTYLRDGWN
110 120 130 140 150
IVDFTVVALG FVDIFSSGNL TALRTVRVLR PLRAITRIRG MRILVTTMIA
160 170 180 190 200
ALPMLIDVFA LCAFTFFIFG LVAVQLFSGR MTHRCAVPVF DGSYTEVVGG
210 220 230 240 250
STFYRNVTYV VQDEESGDGC SGPMSEGLEW VDVNGTAVAL AGGDGLGRAC
260 270 280 290 300
PDGLYCTNYG NPNYGITSFD HILWAWLTIF QMITQEGWTD IMYFTSDTIT
310 320 330 340 350
WWVWPFFVAL VAFGSFYIIN LALAVLFMQF SNDNHADDPS KKKSGRQGSG
360 370 380 390 400
DGQRQGDKAG AGGGGAANSG GEHKDSDSES SMSDVGSEED ERLRPTMAEV
410 420 430 440 450
TGLRTVGQHS TKLKSATSSP LTMDEVERLS PFRRRLYRVA ASRWLELFTM
460 470 480 490 500
SLIILNTVLM CINWFEMPES VERATNYINY VFTVYFLVEM ILKMTAFGLV
510 520 530 540 550
RYFRDGMNIF DCLVVVISVT EMVLDIIPSV SGLGPLSVLR AFRLLRIFRL
560 570 580 590 600
ARSWKELNLI IRAIFKSITS TTYLLLLMLL FMFIASLMGM QLFGYKFMFC
610 620 630 640 650
DYVEGAAPTC PLGWNVWGQC PDHFHCYLPC MSADYGSWVN ATGSFYNDLA
660 670 680 690 700
YCERFCANDQ AAAAADANAT SPDVAAAGGC EYLAMVGKSE VPRANFDNIF
710 720 730 740 750
WSMYTVFQIL TMENWNNIMY DGMRSTTPWC AAYFVAVVLI GTYLVFNLFV
760 770 780 790 800
AILLDNFSSV FGESDDSDGS GSGSLKADGQ AAGSGKHKSR RSSSSSSDTD
810 820 830 840 850
SLHDSDLDAG EAGDAFGSMR SHCEYAGNEF ADSPHADDAS RPSSPGGTYY
860 870 880 890 900
STEGYHTRFS REYERAHGAG TGRGSGEGGG AGYTTHEAHA QRATGGPGGG
910 920 930 940 950
HAPTGASPAP QQGEGEDVAA AGGADGPGAG AGPGIGIGIG GSRRAPPTLH
960 970 980 990 1000
LPDSPSAVGA LPPIGPAHQP VPSPKTPFSA GIGYAHPSPG AKGGHPVTQS
1010 1020 1030 1040 1050
PSDLSRGLRG VLRKVVPVDD EGRPGSSHSG SQPPRPSLRP VSAAPRPLSS
1060 1070 1080 1090 1100
VRGGGGNRVR PVSGRPPVKF DGVDSGREGG GGGGVTFAND AVSRRASFIA
1110 1120 1130 1140 1150
AHQTAAAGSQ GAGEANGGST SQGGLAASIS RSIGRSIGRS VSRTLQRAMS
1160 1170 1180 1190 1200
SIRSIREVRH NEHLAKQIKG RSLLLLDPEH WVRWRAARMV HHTHFETVIL
1210 1220 1230 1240 1250
GLIVLSSITL ALDSPGLDPD SQLAQALRYL DYIFLGAFTL EAALKIITFG
1260 1270 1280 1290 1300
FAFTGKHAYI RNGWNVLDFI IVLAGYALLA VELSGANGED LKMLRILRTL
1310 1320 1330 1340 1350
RALRPLRAAS RYEGLKLVVN TLFAVLPAMA DVALVCALFY IIFSILAVNL
1360 1370 1380 1390 1400
FKGQLYNCID ADSGERLDPY YLLPPGQTLE RGMCEAGSIT VNSSVYTAAR
1410 1420 1430 1440 1450
NISLMPYNIT TSWVNPVANF DNVAISMLTL FQIATLELWV DIMFTAVDVA
1460 1470 1480 1490 1500
GVGKQPLWNN HPVVILFFIL VVIVCCFFVL NLFIGVTLDK FTELQQAQTA
1510 1520 1530 1540 1550
SSVFVTPQQQ NWVDVQKLLL RTGMTSRPAR FEEPAWRAGL YDFVMGSVFE
1560 1570 1580 1590 1600
EFILITIVVN VLFMAMVHAD MSPQWQACMT YTNLIFTCVF VIEAALKIMA
1610 1620 1630 1640 1650
FGAFAYFRDR WNAFDFFVVV ISVASVVLDF SGTQNLSFMP VLRVLRVVRV
1660 1670 1680 1690 1700
VRLIRRAVGM RRLLLTLVQS LPALGNVGGV MVLFFFVYAV IGMNLFGGIK
1710 1720 1730 1740 1750
FGDYISRHAN FNNFGKAMLL LFRQASMARY YEARFLAVSP GRMITGESWS
1760 1770 1780 1790 1800
GVMQDCMITH NCVLITANVT APATNATLVE GTYLSPNDPS MSGLPPDVHQ
1810 1820 1830 1840 1850
NQCSLSPWAA VVYFPTFIVL CGFILLNLVI AIILENMITS ENDEGLTVSK
1860 1870 1880 1890 1900
SLVGQFVDAW SQVDNCATGY VHASKLPLII SHIEPPLGTR GQGNARAVTQ
1910 1920 1930 1940 1950
AVIMSVDVPI HENNTVTFVE TLHALAGRVA GTELPEIEEE WLVEKYSKRL
1960 1970 1980 1990 2000
PDGGAAFPKL TAAHFHAALY VQAAIRGFMA RHKMRGMMQT LAGGPGGAGG
2010 2020
GTGSGSGADA DGLHNGGKAF EKGGKVA
Length:2,027
Mass (Da):219,710
Last modified:December 4, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i070424CC74B72529
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DS496174 Genomic DNA Translation: EDO97472.1

NCBI Reference Sequences

More...
RefSeqi
XP_001701475.1, XM_001701423.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5726990

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cre:CHLREDRAFT_194451

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS496174 Genomic DNA Translation: EDO97472.1
RefSeqiXP_001701475.1, XM_001701423.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi3055.EDO97472

Protein family/group databases

TCDBi1.A.1.10.14, the voltage-gated ion channel (vic) superfamily

Proteomic databases

PaxDbiA8JF90
PRIDEiA8JF90

Genome annotation databases

GeneIDi5726990
KEGGicre:CHLREDRAFT_194451

Phylogenomic databases

eggNOGiKOG2301, Eukaryota
KOG2302, Eukaryota
HOGENOMiCLU_000540_5_3_1
InParanoidiA8JF90
OMAiFECVSMM
OrthoDBi172471at2759

Gene expression databases

ExpressionAtlasiA8JF90, baseline and differential

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR031649, GPHH_dom
IPR005821, Ion_trans_dom
IPR000048, IQ_motif_EF-hand-BS
IPR002077, VDCCAlpha1
IPR043203, VGCC_Ca_Na
IPR027359, Volt_channel_dom_sf
PANTHERiPTHR10037, PTHR10037, 1 hit
PfamiView protein in Pfam
PF16905, GPHH, 1 hit
PF00520, Ion_trans, 4 hits
PRINTSiPR00167, CACHANNEL
PROSITEiView protein in PROSITE
PS50096, IQ, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA8JF90_CHLRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8JF90
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: June 2, 2021
This is version 81 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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