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Entry version 75 (07 Oct 2020)
Sequence version 1 (04 Dec 2007)
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Protein
Submitted name:

Intraflagellar transport particle protein 88

Gene

IFT88

Organism
Chlamydomonas reinhardtii (Chlamydomonas smithii)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • kinesin binding Source: GO_Central

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Intraflagellar transport particle protein 88Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IFT88Imported
ORF Names:CHLRE_07g335750v5Imported, CHLREDRAFT_24421Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiChlamydomonas reinhardtii (Chlamydomonas smithii)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3055 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeChlorophytacore chlorophytesChlorophyceaeChlamydomonadalesChlamydomonadaceaeChlamydomonas
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006906 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection, ChloroplastARBA annotation, Cilium, FlagellumImported, Plastid

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A8JCJ2

PRoteomics IDEntifications database

More...
PRIDEi
A8JCJ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A8JCJ2, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3055.EDO98394

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini185 – 293TPR_REGIONInterPro annotationAdd BLAST109
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati185 – 218TPRPROSITE-ProRule annotationAdd BLAST34
Repeati221 – 254TPRPROSITE-ProRule annotationAdd BLAST34
Repeati260 – 293TPRPROSITE-ProRule annotationAdd BLAST34
Domaini404 – 710TPR_REGIONInterPro annotationAdd BLAST307
Repeati439 – 472TPRPROSITE-ProRule annotationAdd BLAST34
Repeati473 – 506TPRPROSITE-ProRule annotationAdd BLAST34
Repeati507 – 540TPRPROSITE-ProRule annotationAdd BLAST34
Repeati541 – 574TPRPROSITE-ProRule annotationAdd BLAST34
Repeati575 – 608TPRPROSITE-ProRule annotationAdd BLAST34
Repeati609 – 642TPRPROSITE-ProRule annotationAdd BLAST34
Repeati643 – 676TPRPROSITE-ProRule annotationAdd BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 112DisorderedSequence analysisAdd BLAST112
Regioni756 – 782DisorderedSequence analysisAdd BLAST27

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili142 – 162Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi71 – 106PolarSequence analysisAdd BLAST36

Keywords - Domaini

Coiled coilSequence analysis, TPR repeatPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2003, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010738_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A8JCJ2

KEGG Orthology (KO)

More...
KOi
K16474

Identification of Orthologs from Complete Genome Data

More...
OMAi
TKNKMFP

Database of Orthologous Groups

More...
OrthoDBi
259837at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019412, Iml2/TPR_39
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10300, DUF3808, 1 hit
PF13181, TPR_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028, TPR, 10 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452, SSF48452, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005, TPR, 10 hits
PS50293, TPR_REGION, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A8JCJ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYGGTEEDD LYGGYDEQSN PLAGSGGAAF KALGADGAPP GTAMMGPPGT
60 70 80 90 100
AMKSFVPGTA MRGGTAMQQD PSLARPMTSN RGAGFTSAPN KKFDPLNRSM
110 120 130 140 150
GSTLGSSGGG AMLVARKGDT SPEEQARGME KTVHELLEKS AADAAKNDIN
160 170 180 190 200
SALENAMEAK KNERKLCRFR EQNNMADQIN LELMYAVDFN LAHMYHMNKN
210 220 230 240 250
YSEALNLYTA IVRNKNFPQS GWLRVNMGNI HFEQKKYPSA IKMYRMALDQ
260 270 280 290 300
ISATAKEVRF KIMRNIGLSF VRMGQYPDAL QSFATVMDNV PDHQTGYNLV
310 320 330 340 350
MCNYALSDRE GMKNAFIKLL KVSPPSEMDD DDDDDPMGDD DMQVMTMDDG
360 370 380 390 400
LKDEMRKRNT IITRLIVKAA QLISEKVDRA NGFEGGFMWC CEQLRDAGYT
410 420 430 440 450
KLANEVELAK ATRFMGQKQF DKAVGVFKDF EKKEPRVKAR AATNLAFLYF
460 470 480 490 500
LEGETDQADK YSEMALKSDR YNARAYVNKG CVLVERGDLE GARSLFNEAA
510 520 530 540 550
GIDPYCVEAI YNLGLVSQRL NELPYALAAF KKLHNMVPDN VEVIHQIATT
560 570 580 590 600
YDMMGDFKNA VKWFELLTSL VSNDPGVLAR LGAIHARFDD EAKALHYYQE
610 620 630 640 650
SHRVYPVNMD VISWLGAYHV KSEVYEKAMP FFDLASKIQP QEVKWALMVA
660 670 680 690 700
SCYRRTNNLP AALGKYKQIH TQHPDNVECL RYLVHLCSEL GRRAEAAEYM
710 720 730 740 750
TKLKKAEKAA VPEATTAAAP AAAAAGSGMG GMGGLDDDIG SSAVSAQNRG
760 770 780
KKMLVKEHMG GGGGKDNDDW GNEQLGDDLL PM
Length:782
Mass (Da):86,310
Last modified:December 4, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBECDF89A90925CA4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DS496157 Genomic DNA Translation: EDO98394.1
CM008968 Genomic DNA Translation: PNW80931.1

NCBI Reference Sequences

More...
RefSeqi
XP_001700100.1, XM_001700048.1

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
PNW80931; PNW80931; CHLRE_07g335750v5

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5725696

Gramene; a comparative resource for plants

More...
Gramenei
PNW80931; PNW80931; CHLRE_07g335750v5

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cre:CHLREDRAFT_24421

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS496157 Genomic DNA Translation: EDO98394.1
CM008968 Genomic DNA Translation: PNW80931.1
RefSeqiXP_001700100.1, XM_001700048.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi3055.EDO98394

Proteomic databases

PaxDbiA8JCJ2
PRIDEiA8JCJ2

Genome annotation databases

EnsemblPlantsiPNW80931; PNW80931; CHLRE_07g335750v5
GeneIDi5725696
GrameneiPNW80931; PNW80931; CHLRE_07g335750v5
KEGGicre:CHLREDRAFT_24421

Phylogenomic databases

eggNOGiKOG2003, Eukaryota
HOGENOMiCLU_010738_1_0_1
InParanoidiA8JCJ2
KOiK16474
OMAiTKNKMFP
OrthoDBi259837at2759

Gene expression databases

ExpressionAtlasiA8JCJ2, baseline and differential

Family and domain databases

Gene3Di1.25.40.10, 4 hits
InterProiView protein in InterPro
IPR019412, Iml2/TPR_39
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
PfamiView protein in Pfam
PF10300, DUF3808, 1 hit
PF13181, TPR_8, 1 hit
SMARTiView protein in SMART
SM00028, TPR, 10 hits
SUPFAMiSSF48452, SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005, TPR, 10 hits
PS50293, TPR_REGION, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA8JCJ2_CHLRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8JCJ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: October 7, 2020
This is version 75 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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