Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dynein regulatory complex subunit 2

Gene

DRC2

Organism
Chlamydomonas reinhardtii (Chlamydomonas smithii)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (PubMed:23427265, PubMed:25411337). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules (PubMed:29167384).3 Publications

GO - Biological processi

  • axonemal dynein complex assembly Source: UniProtKB
  • cilium-dependent cell motility Source: GO_Central
  • regulation of cilium movement Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein regulatory complex subunit 21 Publication
Alternative name(s):
Coiled-coil domain-containing protein 65 homolog
Flagellar-associated protein 2501 Publication
Gene namesi
Name:DRC21 Publication
Synonyms:CCDC65, FAP2501 Publication
ORF Names:CHLREDRAFT_106450Imported
OrganismiChlamydomonas reinhardtii (Chlamydomonas smithii)
Taxonomic identifieri3055 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeChlorophytaChlorophyceaeChlamydomonadalesChlamydomonadaceaeChlamydomonas

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum

Pathology & Biotechi

Disruption phenotypei

Defects in DRC2 give the ida6 and sup-pf5 phenotypes characterized by reduced swimming speed, disruption of the assembly of several other N-DRC subunits and destabilization of the assembly of several closely associated structures such as the inner dynein arms and the radial spokes.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004319541 – 573Dynein regulatory complex subunit 2Add BLAST573

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei96Asymmetric dimethylarginine1 Publication1
Modified residuei142Asymmetric dimethylarginine1 Publication1

Post-translational modificationi

Asymmetrically dimethylated at Arg-96 and Arg-142 during flagellum resorption. Probably methylated by PRMT1.1 Publication

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiA8JB22

PTM databases

iPTMnetiA8JB22

Interactioni

Subunit structurei

Component of the nexin-dynein regulatory complex (N-DRC), composed of at least DRC1, DRC2, DRC3, DRC4, DRC5, DRC6, DRC7, DRC8, DRC9, DRC10 and DRC11 (PubMed:23427265, PubMed:25411337, PubMed:29167384). Interacts with DRC4 and DRC5 (PubMed:23427265).3 Publications

Protein-protein interaction databases

STRINGi3055.EDO98958

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili15 – 231Sequence analysisAdd BLAST217
Coiled coili258 – 359Sequence analysisAdd BLAST102
Coiled coili470 – 501Sequence analysisAdd BLAST32

Sequence similaritiesi

Belongs to the DRC2 family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IE4Y Eukaryota
ENOG410XQTS LUCA
InParanoidiA8JB22
OMAiQMKKIQR

Family and domain databases

InterProiView protein in InterPro
IPR039505 DRC1/2_N
IPR039750 DRC1/DRC2
IPR029440 DRC1_C
PANTHERiPTHR21625 PTHR21625, 1 hit
PfamiView protein in Pfam
PF14772 NYD-SP28, 1 hit
PF14775 NYD-SP28_assoc, 1 hit

Sequencei

Sequence statusi: Complete.

A8JB22-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKAGKKVKG ASKVRENETE EEKKIRLEME ALAADEAERK AQEAARVALR
60 70 80 90 100
ERQLREQRYA HLNGIKIHNQ WRKIMRMAKV EELRREIEIL SQNHEREVDR
110 120 130 140 150
KDAIMQMLDR DLEEAEEQYS LAVRSHMLVV DNLLDLQYQR MRALEAEFAA
160 170 180 190 200
DLKALEDEFE TERTEIVNAH TRQRKDMGDM IAAMEGEFAD AEAELRQEYE
210 220 230 240 250
AQREEIKNRN SEEYNVLKIQ LEGIIEELEK SFELAHRAYL ESTEHRTNTF
260 270 280 290 300
RTLTKDDAKA ALKIERQMRK LVRLQEALQH WRTKIATNGR EWEERNRALR
310 320 330 340 350
NEKEIMARHY AKLKSSMDAF RAGQAERLKQ LSLASSGAME TLRGKLAVAE
360 370 380 390 400
NVLKLAELAR KYETEQEKVL PFWNPAQAVP SGEQGDEEAA AQAEAEAAAL
410 420 430 440 450
EPSAAELGEL GLRASMPEDS SKEAPGPSKS SAGPGKPKFS SYGLDPSSGS
460 470 480 490 500
EVDEWDYLNC FFRRYNKALL DKTAIDKEKS RLERENADLR SILKQYLDGI
510 520 530 540 550
SVNDDVLNNP VNPLLVVNNR LQITLTERNK ARAAAMAQRA AAATGAGLSV
560 570
TGQGAGGGGQ KQLVEVQVVS RVS
Length:573
Mass (Da):64,885
Last modified:April 25, 2018 - v2
Checksum:i59BC1F8AD000484A
GO

Sequence cautioni

The sequence EDO98958 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS496151 Genomic DNA Translation: EDO98958.1 Sequence problems.

Genome annotation databases

EnsemblPlantsiPNW74416; PNW74416; CHLRE_13g607750v5
GrameneiPNW74416; PNW74416; CHLRE_13g607750v5
KEGGicre:CHLREDRAFT_106450

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS496151 Genomic DNA Translation: EDO98958.1 Sequence problems.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3055.EDO98958

PTM databases

iPTMnetiA8JB22

Proteomic databases

PaxDbiA8JB22

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiPNW74416; PNW74416; CHLRE_13g607750v5
GrameneiPNW74416; PNW74416; CHLRE_13g607750v5
KEGGicre:CHLREDRAFT_106450

Phylogenomic databases

eggNOGiENOG410IE4Y Eukaryota
ENOG410XQTS LUCA
InParanoidiA8JB22
OMAiQMKKIQR

Family and domain databases

InterProiView protein in InterPro
IPR039505 DRC1/2_N
IPR039750 DRC1/DRC2
IPR029440 DRC1_C
PANTHERiPTHR21625 PTHR21625, 1 hit
PfamiView protein in Pfam
PF14772 NYD-SP28, 1 hit
PF14775 NYD-SP28_assoc, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDRC2_CHLRE
AccessioniPrimary (citable) accession number: A8JB22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 4, 2015
Last sequence update: April 25, 2018
Last modified: November 7, 2018
This is version 37 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again