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Entry version 67 (08 May 2019)
Sequence version 1 (04 Dec 2007)
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Protein
Submitted name:

Dicer-like protein

Gene

DCL2

Organism
Chlamydomonas reinhardtii (Chlamydomonas smithii)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • double-stranded RNA binding Source: GO_Central
  • ribonuclease III activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-bindingPROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Dicer-like proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DCL2Imported
ORF Names:CHLREDRAFT_18765Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiChlamydomonas reinhardtii (Chlamydomonas smithii)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3055 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeChlorophytaChlorophyceaeChlamydomonadalesChlamydomonadaceaeChlamydomonas

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4643 – 4668HelicalSequence analysisAdd BLAST26
Transmembranei4680 – 4699HelicalSequence analysisAdd BLAST20
Transmembranei5558 – 5580HelicalSequence analysisAdd BLAST23
Transmembranei5601 – 5622HelicalSequence analysisAdd BLAST22
Transmembranei5642 – 5668HelicalSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A8JA83

Protein Mass spectra EXtraction

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ProMEXi
A8JA83

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A8JA83 differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3055.EDO99203

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 321Helicase ATP-bindingInterPro annotationAdd BLAST301
Domaini827 – 1034Helicase C-terminalInterPro annotationAdd BLAST208
Domaini1665 – 1786Dicer dsRNA-binding foldInterPro annotationAdd BLAST122
Domaini3099 – 3122RNase IIIInterPro annotationAdd BLAST24
Domaini3490 – 3612RNase IIIInterPro annotationAdd BLAST123
Domaini3845 – 3864RNase IIIInterPro annotationAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3613 – 3647Sequence analysisAdd BLAST35

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the helicase family. Dicer subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0701 Eukaryota
COG0571 LUCA

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
A8JA83

Database of Orthologous Groups

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OrthoDBi
935825at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00079 HELICc, 1 hit
cd00593 RIBOc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.1520.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR005034 Dicer_dimerisation_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03368 Dicer_dimer, 1 hit
PF00271 Helicase_C, 1 hit
PF00636 Ribonuclease_3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00535 RIBOc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF69065 SSF69065, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51327 DICER_DSRBF, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS00517 RNASE_3_1, 2 hits
PS50142 RNASE_3_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A8JA83-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVPGQALRP LPALRSYQAE LLQLAGCHDA IVYLETGTGK TRIAVELIAA
60 70 80 90 100
ALPALRAAGQ SAVFLAPSVP LVRQQAEVLA STPVLVPEPE EPGAGEERER
110 120 130 140 150
QEQQLAAGAA GSAPCQPPEE EAGMAEPEPE AAAGAGAAGQ QERTQRPPAG
160 170 180 190 200
RRLRLRRLLR VEWLGGSCVH EGWGLAGWRE LLGRLDVLVC TPAVLLGALV
210 220 230 240 250
HAYVRVSDVG LLVLDEAHHC TRQHPYAVLL REFVGRAPLL PPGPPGPCRT
260 270 280 290 300
PLMLAGPPPG PAAVSSEPGM PAAQEQPSAQ EQPPPKQRAA PVRPRLLGLT
310 320 330 340 350
ASPLEPLALQ AAMCGARLIT PVDRSGCISA HASRPKAKII WVGADAPLPP
360 370 380 390 400
PPARQRHQCP QTLGLPSRWG PGSCPAPQAG TGASADAAAA AAVAAAAAAG
410 420 430 440 450
GSLRALFEAQ WQEEAQAAAL APLRDCLCRC RDLVLLAEGV VTRRDRLQRL
460 470 480 490 500
HLLEAVGWEE LGLLDPNVPP ALRPHPTSGY RLCDSLRGLR LLRTQLAALE
510 520 530 540 550
FALSDLGLWP ALALAAADLF ASGREALDGE EQGEEQGDGD LGAAAAGGGG
560 570 580 590 600
GEEEGDGAEA IPEPTDLGTL PSRDMAAAFV SDYGILLARL DESAIPLPPG
610 620 630 640 650
LVACPRRPSL CERVAAEVLS AVMEALITVA PPQQPGEAEA IAVGFGEALL
660 670 680 690 700
LRGGLRGRGR AVLRPWAVRL LRASVSPREL QRQVLGVEPP PPSAPSPSSA
710 720 730 740 750
PTPAAMPAPA STAGAAAAAS SSAPAQQQQQ QQQEQQQERS GGHVPLQLVT
760 770 780 790 800
HRVAWLMRQL HSRVVEAEAR AAEAGAAGGV GSGSGGGGSS WSAIVFCERK
810 820 830 840 850
STCEALQRLI TSLPALTAAV AAGPDTDLAP TTSPDQKQPT TVRNQSAAGP
860 870 880 890 900
LSGSEGTMTA TMAQGPLTQQ MHGDNGGKEQ EGGGGGGGGG GTGPGGWQGR
910 920 930 940 950
QQPRRPLLRS AVFVGTAGGG TAVGRHGGRL AGHKRQDAVR RAFSAGRLNL
960 970 980 990 1000
LLSTSVGSEG LDFRSCALVA MLDLPRQVPQ FVQSGGRARA QGSEHWLLVS
1010 1020 1030 1040 1050
TPEQEAAALE LLASEEAMAR DALTVALTNM AELLPLTPAL NDGSSGNGCS
1060 1070 1080 1090 1100
LHATSTRTGT GGNGPHHTTP AAPPPPLPPP AVPTGSRKRG GAGGAACATT
1110 1120 1130 1140 1150
VAADPASAAA AGNATGTGSA FLPKRHRVLL NPAPVTSAVT AVPSSAHADV
1160 1170 1180 1190 1200
TTVAGTGGAP AARLEPPPPQ QQHTDRRAAR RHQQQQRLLQ RLASQRRRQL
1210 1220 1230 1240 1250
GDGLTSAAAA LAAAAAAAAD VEEVRREGMC GDSDDGEIRG GEDGGSSGHA
1260 1270 1280 1290 1300
SAGSSDDDEG VEGWADDAGD LTAEEDTGPA EVAEVAAVAA TAAEAAQPKP
1310 1320 1330 1340 1350
GALQEQRVAD GRGGAQQPRQ LVDVACGEGE LQNAEGSEWD PDSVAAGSFV
1360 1370 1380 1390 1400
VPGAAVCFRR AGQPLLCLSA GPSCAPTLGT HGPQQHPQHL PQQQPLQQPM
1410 1420 1430 1440 1450
QLPPGVSLSF PASEQPPAAL LLQPHHRGRP LHSVVPGRSV EVMEAEAPAA
1460 1470 1480 1490 1500
AARAEVMEAE APAAAARAEV MEAEAPAAAA RAEVMEAEAP AAAARAELME
1510 1520 1530 1540 1550
AGAEAVAAGP EVMGAGAEAG AAGAELMEAG AEAERGDGGC DVMMEQGENG
1560 1570 1580 1590 1600
GGTGAGDGNG GEGGGGRSGV DEEGQQQQQQ QQQQQAARAA GPAGVAAAAA
1610 1620 1630 1640 1650
TATGGEATTG EAAAAATPAR SRSGKDAAGG SGSNGNASSS VFVTDERLEA
1660 1670 1680 1690 1700
LEVPATGARL PAVWAVNLLT QLCSQLPGND GCTVLQPLCS WEASDPPPGS
1710 1720 1730 1740 1750
LGRSGVGGSS DLLGSSRARR PLLQLRYCRC RVFLPANLGA SAVLGPACRS
1760 1770 1780 1790 1800
KDAAKKSAWL AAVRLLWLRG DLDDHLRLRF TRRAVTQAAR HAELGGLAHT
1810 1820 1830 1840 1850
IPSAVLTHQL PRALLPKALL LPAEEAAATA IAATEPAVAA AAVAPPVPDT
1860 1870 1880 1890 1900
CPPQPAVAAP EDGGAVAATA PAAPSHGGAQ EPPVTAMAVA VPAVAVAVAD
1910 1920 1930 1940 1950
TQPVVSPVAP DATAMDGAGD GSSASRRSTL ALPTAVASDG VPSDAGISSG
1960 1970 1980 1990 2000
SSSGSPSNLS SSIGGSSRTE PYRLHLYGFV VRPKDPHVSL LPPPGVTADG
2010 2020 2030 2040 2050
SSSCSSSSGV TRDKEAEAAL AAAAAADPAA AAGICGMLSW PTRPADEPLE
2060 2070 2080 2090 2100
PRPPPGAAAA ANPAPAATPP PSTALPPSAP TGAVAVAALD AATHATCMTA
2110 2120 2130 2140 2150
AAVAEPMTGG TVVDAPGYAV SRAAGSTQQE ACADPAACDT AQQPKLERPQ
2160 2170 2180 2190 2200
HAPLHAAIVG EYMPPPEAGM CYSSGSSSSG RPHDHSPRHG GGESCYSRQC
2210 2220 2230 2240 2250
AAAAVHPWGV LLHGLLPAGL PPMQLLLPEG DVDIPIEVRL VYLGPLDCGN
2260 2270 2280 2290 2300
SSSSSSSSSG SGNATTDGGT ETPADAGPPP AAAGATLPQP QPQFPPSTAA
2310 2320 2330 2340 2350
VAGGRHLPPL AHALACLAHT VLRLMAYPCP AAIARAVVNA VAAARGEAPG
2360 2370 2380 2390 2400
AACATAEDRA AWEGFMGFGQ LQQALEELLP LQASPQQRPP LAGAAAGPRG
2410 2420 2430 2440 2450
GEGCCGAEAH VATAGGACGV AAPAPAQAAA AAESASPVVT AQNVGHDFHE
2460 2470 2480 2490 2500
AAAGAAAAHV LHGGAQQQQQ PQLELPGGGY WWMPVPLRAP PAPAANTRSQ
2510 2520 2530 2540 2550
QVQEPVAPPL AAAAAGANTA PNLARPDARS GAAGALAASA EVLDRMAAEL
2560 2570 2580 2590 2600
SAAAARDTGG AAAAAALIDW RLVAELAVGP LPLSLLLPDA AAATAENDNG
2610 2620 2630 2640 2650
GASRITTAEA LSSQSAKECD TVDAGTTVVS SSSGGPGSAA AKGGRFQALA
2660 2670 2680 2690 2700
AAAAAALAAA PPAGTYAATP LAAPLLDCYR RLVEPHGLVV TLDTGRLYSL
2710 2720 2730 2740 2750
PQVGTVQEPT QEALAAAAAA AAATGGGAPP RPPRPDAPRP GDAVVSAAPS
2760 2770 2780 2790 2800
YGRGRQDWLR SQKQQKEEEA AAGGEETGKR PPPSAGGAGA GAQKQQQQRQ
2810 2820 2830 2840 2850
GVPAGTSASA QPGAILVPSP TGPVPAPHAC QSQPSTKPQP PQPPAPPPPP
2860 2870 2880 2890 2900
HLSRRERVKA FRAPLPLLPG RLGLYPLDAG RWRALHGLPC LAWRLEGWAA
2910 2920 2930 2940 2950
AAEALTCRLE AAGYSAGGLP PSEAEDAVES ATEEAAKEEK DVMLHTPASA
2960 2970 2980 2990 3000
RAPALTPGVA ASAPPAAPMT PAAPAGGGSC SGGDGTGSRE GPAATAAPPL
3010 3020 3030 3040 3050
AGPCAAATTT TTTLAAAAPR ITYPPPPPPT PAPLPKATAA LPGEGTPAPP
3060 3070 3080 3090 3100
TYPPSSTPPI PPPPPPLLLP PPPRFTAAAL SLTAAALTCP SCRDPGVGNY
3110 3120 3130 3140 3150
DRLEFLGDAA LKLLAQVYVF LRESRLPPPP HKPNPPTTHP QTLAHHALGP
3160 3170 3180 3190 3200
RLRLAACLRA LPLDPGRALR QAALQPDEDA ASGAPLPHRL TPLPPPLMHL
3210 3220 3230 3240 3250
FSRALDAAEA KAAEAAVEVV GSGATAAAGA ATTPSATSAP ATAATPGTAA
3260 3270 3280 3290 3300
ATAGAGAAAP AAAVPAAAAA VPVAAAVMPL ERPSQQPPKK GSSSSPRDKE
3310 3320 3330 3340 3350
RERRRLEKRA QAEQRLAATR VLGGVRGKRL ADCVEALIGA HLLQPLEGQE
3360 3370 3380 3390 3400
EEGAAEGCVV EGREEAGVEG GVEVGAAAGG SEAEGAVAVV PGGGGGSGKD
3410 3420 3430 3440 3450
DGGGSDGGGG AWAVANTRVW SPQLQDAMQA SLRFLGFAEL DAAAAASQAR
3460 3470 3480 3490 3500
QAARAAAAAA AAVVAADARS LGGGQGTGGG GGDAAAARSV CELEALLGYR
3510 3520 3530 3540 3550
FRNPDLCVQA LTHVSHPRAA GCGGGYQRLE FLGDAVLGLV VSFWVFSAGG
3560 3570 3580 3590 3600
SAEAMSTRRR DLVSNGPLAE AAARLGLQRH LRAGSGALVA AVARFVDIYL
3610 3620 3630 3640 3650
AAAPGSVVVT TAERHAKNKR AEHRAQLRQQ RQQQDRERER EKEKEKEGAA
3660 3670 3680 3690 3700
AAGDEAADRA DKEEAARLAG TEQSAGAGLA GSVEVVSGRE GAGAAGTALT
3710 3720 3730 3740 3750
AGPAAGMGLE DAAAAAALGR ERPQKRRRRD EGNGQQQEQV QETLQEAPDT
3760 3770 3780 3790 3800
QQEVQQQGMG MEVDGATKQQ QQQQPQKQQQ PQQDGESDQQ QQDGDKHSLQ
3810 3820 3830 3840 3850
VQQRQVDTPA GSGRKRARDG GGTAAGGTGG SGGGKKAEPR ILLAPKALAD
3860 3870 3880 3890 3900
LVEALVGAVY LDSGGHLGVS ERAVAVLLRL QPPPASQEAA VATVAATHVQ
3910 3920 3930 3940 3950
RAVAMELYEQ VISPLVVYWC RTTVYLGIIL AGPNTAPSMV AQAYLQQSQA
3960 3970 3980 3990 4000
VVAYHIIMFA SLLGAWDVDA RVELAAVLLE AACALTCLSW HGAKVPGGSP
4010 4020 4030 4040 4050
HPAALLAGRA LVPLVNLSLA YAAGRWRPGG LGTGRRGGGS ALALDKCISM
4060 4070 4080 4090 4100
RASGAAGGSS SKGKGKGKDM GAGPVEECAG DGDKSLGLSL MPPAEQAVRQ
4110 4120 4130 4140 4150
GAEPSGSGCG GSSSSSRTEP QPLPALPLPA PMLERSSGTV TVAAPQAAGH
4160 4170 4180 4190 4200
QSQPSAPAGS SVLRPHKPYR SYLRGRTKHY FKFKERRVLL SQIPWAELED
4210 4220 4230 4240 4250
ITPGFEERLA ALCAARGRVL TGVYVRAGCI ELTIHLAEYG AGTTRAGVHA
4260 4270 4280 4290 4300
GPAAAAGALS HSDAAVLSVE EVIAALGLSL PSGPADAALQ AVSVQQELVD
4310 4320 4330 4340 4350
RAASEPEASG DGARSQARVV RVSPRVLLLT PADAAASSAA ALRVRVAFGG
4360 4370 4380 4390 4400
STGPATAFNV AMLGAAGVLA TRVTAKELQA ASKEGAEAGS EEWEYAIELL
4410 4420 4430 4440 4450
EAPPHPQLLT VQLAFPAAAA GAAAEDSAAA ATPSPYVQWL SVPVLAVDDA
4460 4470 4480 4490 4500
AVAAELSAAL QLLQTSEAGA EVGAAAEWAH PLLCDLGLWL ASAAASGAAG
4510 4520 4530 4540 4550
CSEAVRRLPA EWVSEVGACL LAYTEGAGLV ATAARIRADT QRLAALPAVA
4560 4570 4580 4590 4600
EAIAAKESPR VADDDAAVGT CQHAAASTSG SATAAMAWQK PNTNALRQRC
4610 4620 4630 4640 4650
KGSSRGKCAS KGAECGGKEE ESSSSAGGGS DCSPDGLQQY TQAWIVAMCF
4660 4670 4680 4690 4700
TCQIVECLVA LGFAVRGVRA GQPLWSAESA VVYTGLGVGV VTTLAGLWMT
4710 4720 4730 4740 4750
PRAWSRLALA ARLPRFLGFM FGKALVSVGA LPPPAGAATY GSGPGILLLE
4760 4770 4780 4790 4800
GVILPSGCLL PPRTALAMSC LKLPLNIMSG LVVGAFENLL PAVLMALAVE
4810 4820 4830 4840 4850
ALAMGTTLAC HGYCPPWVRH GGGMQWARGH LGVSVRAVAV PHAVAMEVEL
4860 4870 4880 4890 4900
YEQVISPLVV YWCRTTVYLG IILAGPNTAP SMVAQAYLQQ SQAVVAYHII
4910 4920 4930 4940 4950
MFASLLGAWD VDARVELAAV LLEAACALTC LSWHGAKVPG GSPHPAALLA
4960 4970 4980 4990 5000
GRALVPVVNL SLAYAAGRWR PGGLGTGRRG GGSALALDKC ISMRASGAAG
5010 5020 5030 5040 5050
GSSSKGKGKG EDMGAGPMEE CADYSDMSLG LSLMPPAEQA VRQGAEPSGS
5060 5070 5080 5090 5100
GGGGSSSSCT EPQPLPALPL PAPMPERSSG TVTVAVPQAA GHQQSQPSAP
5110 5120 5130 5140 5150
AGSSVLRPHK PYRSYLRGRT KHYFKIPWAE PEDITPGFEE RLAALCAARG
5160 5170 5180 5190 5200
RVLTGVYVRA AAAGALSHSG PAVLSVEEVL AALGLSLPSG PANAALQAVS
5210 5220 5230 5240 5250
VQQELVDRAA SEPEASGDGS RSRVVGVSPR VLLLTPADAA ASSAAVLRVR
5260 5270 5280 5290 5300
VAFGGSTGPA TASNVAMLGA AGVLATRVTA KELQAASKEG ADAGSEEWEY
5310 5320 5330 5340 5350
AIELLEAPPH PQLLTVQLAF PAAAAGAAAE DSAAAATPSP YVQWLSVPVL
5360 5370 5380 5390 5400
AVDDAAVAAE LSAALQLLQI SEAGAEEGAA AEWAHPLLCD LGLWLASAAA
5410 5420 5430 5440 5450
SGAAGFSEAV RRLPAEWVSE LGACLLAYTE GAGLVATAAR IRADTQRLVT
5460 5470 5480 5490 5500
GAAGTVPYIH QQQQQQQQQQ QQEEGEAAAV GLHRRGPLSN AAGGSGKGTG
5510 5520 5530 5540 5550
CSDDAPGHHG DGTDAKSGAG GLQDYLDSWI VTTCTTGQLT ECLMFITFTL
5560 5570 5580 5590 5600
RGLKAGQLLW SAEAAVVYTA LGMGTLVMLA GLWMPARQRS RLTLAARIPR
5610 5620 5630 5640 5650
FAAALASKVL VSAGVLPPPL LLCCLKLPLN AIGAFRAGAF PTLLSAALQA
5660 5670 5680
LAVEALAMGT TLAFHSYLRR QYRVHLQRQA AAPA
Length:5,684
Mass (Da):573,291
Last modified:December 4, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6B72AAE76B2975DD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
DS496149 Genomic DNA Translation: EDO99203.1

NCBI Reference Sequences

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RefSeqi
XP_001698921.1, XM_001698869.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
5724419

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cre:CHLREDRAFT_18765

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS496149 Genomic DNA Translation: EDO99203.1
RefSeqiXP_001698921.1, XM_001698869.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi3055.EDO99203

Proteomic databases

PaxDbiA8JA83
ProMEXiA8JA83

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5724419
KEGGicre:CHLREDRAFT_18765

Phylogenomic databases

eggNOGiKOG0701 Eukaryota
COG0571 LUCA
InParanoidiA8JA83
OrthoDBi935825at2759

Gene expression databases

ExpressionAtlasiA8JA83 differential

Family and domain databases

CDDicd00079 HELICc, 1 hit
cd00593 RIBOc, 1 hit
Gene3Di1.10.1520.10, 1 hit
InterProiView protein in InterPro
IPR005034 Dicer_dimerisation_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF03368 Dicer_dimer, 1 hit
PF00271 Helicase_C, 1 hit
PF00636 Ribonuclease_3, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00535 RIBOc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
SSF69065 SSF69065, 2 hits
PROSITEiView protein in PROSITE
PS51327 DICER_DSRBF, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS00517 RNASE_3_1, 2 hits
PS50142 RNASE_3_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA8JA83_CHLRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8JA83
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: May 8, 2019
This is version 67 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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