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Protein

Lactoylglutathione lyase

Gene

CHLREDRAFT_106176

Organism
Chlamydomonas reinhardtii (Chlamydomonas smithii)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.UniRule annotation

Catalytic activityi

(R)-S-lactoylglutathione = glutathione + methylglyoxal.UniRule annotation

Cofactori

Zn2+UniRule annotation

Pathwayi: methylglyoxal degradation

This protein is involved in step 1 of the subpathway that synthesizes (R)-lactate from methylglyoxal.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Lactoylglutathione lyase (CHLRE_04g216100v5), Lactoylglutathione lyase (CHLREDRAFT_106176)
  2. no protein annotated in this organism
This subpathway is part of the pathway methylglyoxal degradation, which is itself part of Secondary metabolite metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-lactate from methylglyoxal, the pathway methylglyoxal degradation and in Secondary metabolite metabolism.

GO - Molecular functioni

Keywordsi

Molecular functionLyaseUniRule annotation
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00619; UER00675

Names & Taxonomyi

Protein namesi
Recommended name:
Lactoylglutathione lyaseUniRule annotation (EC:4.4.1.5UniRule annotation)
Alternative name(s):
Glyoxalase IUniRule annotation
Gene namesi
ORF Names:CHLREDRAFT_106176Imported
OrganismiChlamydomonas reinhardtii (Chlamydomonas smithii)
Taxonomic identifieri3055 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeChlorophytaChlorophyceaeChlamydomonadalesChlamydomonadaceaeChlamydomonas

PTM / Processingi

Proteomic databases

PaxDbiA8J9P4
ProMEXiA8J9P4

Interactioni

Protein-protein interaction databases

STRINGi3055.EDO99335

Structurei

3D structure databases

ProteinModelPortaliA8J9P4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 173VOCInterPro annotationAdd BLAST148

Sequence similaritiesi

Belongs to the glyoxalase I family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IU7X Eukaryota
ENOG4111FDV LUCA
InParanoidiA8J9P4
KOiK01759

Family and domain databases

Gene3Di3.10.180.10, 1 hit
InterProiView protein in InterPro
IPR029068 Glyas_Bleomycin-R_OHBP_Dase
IPR004360 Glyas_Fos-R_dOase_dom
IPR004361 Glyoxalase_1
IPR018146 Glyoxalase_1_CS
IPR037523 VOC
PfamiView protein in Pfam
PF00903 Glyoxalase, 1 hit
SUPFAMiSSF54593 SSF54593, 1 hit
TIGRFAMsiTIGR00068 glyox_I, 1 hit
PROSITEiView protein in PROSITE
PS00934 GLYOXALASE_I_1, 1 hit
PS00935 GLYOXALASE_I_2, 1 hit
PS51819 VOC, 1 hit

Sequencei

Sequence statusi: Complete.

A8J9P4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSLSELHA IPGVCVNPDP STQNFVFQQT MFRIRDPAKS LDFYTRVLGM
60 70 80 90 100
RLLAKLDFPD MKFSLYFLGY EDVKDIPEDP ADRTVWMFRR KACLELTHNW
110 120 130 140 150
GTESDPNFAG YHSGNSDPRG FGHIGFSVPD VYAACKRFEE LGVEFQKKPD
160 170 180
DGKMKGIAFI KDPDGYWIEI LNADNARQFV GWGK
Length:184
Mass (Da):20,958
Last modified:December 4, 2007 - v1
Checksum:i8738709E2401AA51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS496147 Genomic DNA Translation: EDO99335.1
RefSeqiXP_001698653.1, XM_001698601.1
UniGeneiCre.14053

Genome annotation databases

EnsemblPlantsiEDO99335; EDO99335; CHLREDRAFT_106176
GeneIDi5724253
GrameneiEDO99335; EDO99335; CHLREDRAFT_106176
KEGGicre:CHLREDRAFT_106176

Similar proteinsi

Entry informationi

Entry nameiA8J9P4_CHLRE
AccessioniPrimary (citable) accession number: A8J9P4
Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: April 25, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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